LOCUS       NM_021589               2633 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus neurotrophic receptor tyrosine kinase 1 (Ntrk1),
            mRNA.
ACCESSION   NM_021589
VERSION     NM_021589.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2633)
  AUTHORS   Fukaya,M., Ibuchi,K., Sugawara,T., Itakura,M., Ito,A.,
            Shiroshima,T., Hara,Y., Okamoto,H., Luton,F. and Sakagami,H.
  TITLE     EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA
            Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
  JOURNAL   Traffic 25 (5), e12936 (2024)
   PUBMED   38725127
  REMARK    GeneRIF: EFA6A, an Exchange Factor for Arf6, Regulates
            NGF-Dependent TrkA Recycling From Early Endosomes and Neurite
            Outgrowth in PC12 Cells.
REFERENCE   2  (bases 1 to 2633)
  AUTHORS   Dong,X. and Tang,Y.
  TITLE     Ntrk1 promotes mesangial cell proliferation and inflammation in rat
            glomerulonephritis model by activating the STAT3 and p38/ERK MAPK
            signaling pathways
  JOURNAL   BMC Nephrol 23 (1), 413 (2022)
   PUBMED   36575400
  REMARK    GeneRIF: Ntrk1 promotes mesangial cell proliferation and
            inflammation in rat glomerulonephritis model by activating the
            STAT3 and p38/ERK MAPK signaling pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2633)
  AUTHORS   Paoletti,F. and Lamba,D.
  TITLE     Small Endogenous Ligands Modulation of Nerve Growth Factor
            Bioactivity: A Structural Biology Overview
  JOURNAL   Cells 10 (12), 3462 (2021)
   PUBMED   34943971
  REMARK    GeneRIF: Small Endogenous Ligands Modulation of Nerve Growth Factor
            Bioactivity: A Structural Biology Overview.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2633)
  AUTHORS   Ji,S., Wu,H., Ding,X., Chen,Q., Jin,X., Yu,J. and Yang,M.
  TITLE     Increased hippocampal TrkA expression ameliorates cranial
            radiation-induced neurogenesis impairment and cognitive deficit via
            PI3K/AKT signaling
  JOURNAL   Oncol Rep 44 (6), 2527-2536 (2020)
   PUBMED   33125501
  REMARK    GeneRIF: Increased hippocampal TrkA expression ameliorates cranial
            radiationinduced neurogenesis impairment and cognitive deficit via
            PI3K/AKT signaling.
REFERENCE   5  (bases 1 to 2633)
  AUTHORS   Artim,S.C., Kiyatkin,A. and Lemmon,M.A.
  TITLE     Comparison of tyrosine kinase domain properties for the
            neurotrophin receptors TrkA and TrkB
  JOURNAL   Biochem J 477 (20), 4053-4070 (2020)
   PUBMED   33043964
  REMARK    GeneRIF: Comparison of tyrosine kinase domain properties for the
            neurotrophin receptors TrkA and TrkB.
REFERENCE   6  (bases 1 to 2633)
  AUTHORS   Chen,F., Cooney,A.J., Wang,Y., Law,S.W. and O'Malley,B.W.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
REFERENCE   7  (bases 1 to 2633)
  AUTHORS   Jing,S., Tapley,P. and Barbacid,M.
  TITLE     Nerve growth factor mediates signal transduction through trk
            homodimer receptors
  JOURNAL   Neuron 9 (6), 1067-1079 (1992)
   PUBMED   1281417
REFERENCE   8  (bases 1 to 2633)
  AUTHORS   Parvinen,M., Pelto-Huikko,M., Soder,O., Schultz,R., Kaipia,A.,
            Mali,P., Toppari,J., Hakovirta,H., Lonnerberg,P., Ritzen,E.M. et
            al.
  TITLE     Expression of beta-nerve growth factor and its receptor in rat
            seminiferous epithelium: specific function at the onset of meiosis
  JOURNAL   J Cell Biol 117 (3), 629-641 (1992)
   PUBMED   1315318
REFERENCE   9  (bases 1 to 2633)
  AUTHORS   Meakin,S.O., Suter,U., Drinkwater,C.C., Welcher,A.A. and
            Shooter,E.M.
  TITLE     The rat trk protooncogene product exhibits properties
            characteristic of the slow nerve growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2374-2378 (1992)
   PUBMED   1312719
REFERENCE   10 (bases 1 to 2633)
  AUTHORS   Martin-Zanca,D., Oskam,R., Mitra,G., Copeland,T. and Barbacid,M.
  TITLE     Molecular and biochemical characterization of the human trk
            proto-oncogene
  JOURNAL   Mol Cell Biol 9 (1), 24-33 (1989)
   PUBMED   2927393
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M85214.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M85214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2633
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2633
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /note="neurotrophic receptor tyrosine kinase 1"
                     /db_xref="GeneID:59109"
                     /db_xref="RGD:620144"
     exon            1..273
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2461
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /EC_number="2.7.10.1"
                     /note="high affinity nerve growth factor receptor; TrkA
                     neurotrophin receptor; trk-A; p140-TrkA; slow nerve growth
                     factor receptor; neurotrophic tyrosine kinase, receptor,
                     type 1; trkA proto-oncogene receptor; tropomyosin-related
                     kinase A"
                     /codon_start=1
                     /product="high affinity nerve growth factor receptor
                     precursor"
                     /protein_id="NP_067600.1"
                     /db_xref="GeneID:59109"
                     /db_xref="RGD:620144"
                     /translation="MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVG
                     PSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSG
                     LRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQ
                     RWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQ
                     VEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRA
                     EVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQF
                     LESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPED
                     PIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSK
                     FGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHI
                     KRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAEL
                     LTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP
                     LGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD
                     YYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI
                     ECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVL
                     G"
     exon            274..348
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            349..420
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            421..489
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            490..641
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            642..784
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            785..917
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1247
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1265
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1321
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1424
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1571
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1702
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1875
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2116
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2275
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2623
                     /gene="Ntrk1"
                     /gene_synonym="Trk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgg ccaggagcgc acggacggcc gcgcggcccg agctaggcgg gcgccgccgc
       61 gatgctgcga ggccagcggc acgggcagct gggttggcat cgcccggccg cggggctagg
      121 cggtctggtg acttcgttga tgctggcttg tgcttgcgcc gcatcctgtc gtgagacctg
      181 ctgtcccgtg ggcccctcgg ggttgcgctg caccagggca gggaccctga ataccctccg
      241 cggcctgcgg ggcgccggga acctgacgga gctctatgtg gaaaaccagc gggatctgca
      301 acgcctggag tttgaggacc tgcagggcct gggggagttg agaagcctaa ccatcgtgaa
      361 gagtggcctc cgctttgtgg cccctgatgc cttccatttc acccctcggc tcagtcacct
      421 gaatctctcc tccaatgctt tggagtccct ctcctggaaa actgtgcagg gcctctccct
      481 acaggacttg accctgtcag ggaacccact gcactgttcc tgtgccctat tgtggctcca
      541 gcgctgggag caggaggatt tgtgtggtgt gtatacacaa aagcttcagg gctctgggtc
      601 tggagaccag ttcctcccac tgggacacaa caacagttgt ggtgtaccct cagtgaagat
      661 ccagatgccc aatgactctg tggaagtggg ggatgacgtt tttctgcagt gccaggtgga
      721 ggggcaggcc ctacagcagg ctgactggat cctcacagag ctggaaggga cagccaccat
      781 gaagaaatct ggagatctgc catccctggg gctaactctg gtcaatgtca ccagtgatct
      841 caacaagaag aatgtgacgt gctgggcaga gaatgatgtg ggccgggctg aggtctctgt
      901 ccaagtcagc gtctccttcc cagccagtgt gcatctgggc aaagccgtgg aacagcatca
      961 ctggtgcatt cccttctctg tggacgggca gccagcaccg tccctgcgct ggttcttcaa
     1021 cggctctgtg ctcaatgaga ccagcttcat cttcactcag ttcttggagt cagcgctgac
     1081 caatgagacc atgcggcatg gctgccttcg cctcaaccag cccacgcatg tcaacaacgg
     1141 gaactacacc ctgctggctg ccaaccccta tggccaggct gctgcctcca tcatggctgc
     1201 ctttatggac aacccttttg agttcaaccc tgaggacccc atccctgtct ccttctcgcc
     1261 agtggacact aacagcacat caagagaccc agtggagaag aaggacgaaa caccttttgg
     1321 ggtctctgtg gctgtgggcc tggccgtctc cgccgccctc ttcctttctg ccctcctcct
     1381 agtgctcaac aaatgtggac agaggagcaa atttgggatc aaccgccctg ctgtgctggc
     1441 gccagaggat gggctggcca tgtccctaca cttcatgaca ctgggtggca gttctctttc
     1501 ccctactgag ggcaaaggct ccggactcca gggccacatc atggagaacc cacagtactt
     1561 cagtgatacc tgtgtccacc atatcaagcg ccaggacatc attctcaagt gggagctagg
     1621 ggagggagcc tttggaaagg tctttcttgc tgagtgctac aaccttctga atgatcagga
     1681 caagatgctg gtggctgtca aggcactgaa ggagacatct gagaatgctc gtcaggactt
     1741 ccatcgtgag gcagagctgc tcaccatgct acagcaccaa cacatcgtac gcttctttgg
     1801 agtctgcacg gagggtggcc cattgctcat ggtcttcgag tacatgcgcc atggggacct
     1861 caaccgtttc ctccggtccc acggacctga tgcaaaactg ctggctggcg gcgaggatgt
     1921 ggctcctggt cctttgggcc ttgggcagct tctggctgtg gctagccagg tggctgctgg
     1981 tatggtgtac ctagccagcc tgcactttgt gcaccgggac ctggccacac gcaactgtct
     2041 ggtgggtcag ggactagtgg tcaagattgg agacttcggc atgagcaggg acatctacag
     2101 cacagactac taccgtgtgg gaggtcggac catgctgccc atccgctgga tgcctccaga
     2161 gagcatcctc taccgcaagt tcagcaccga gagtgatgtg tggagcttcg gggtggtgct
     2221 ctgggagatc ttcacctatg gaaagcaacc ctggtaccag ctctccaaca ctgaggcgat
     2281 cgagtgcatc acgcagggcc gggagctgga gcggccgcgc gcctgccctc ctgatgtcta
     2341 cgccatcatg cgcggctgct ggcagcgtga gccgcaacag cgcctcagca tgaaggatgt
     2401 gcacgcgcgg ctgcaggcct tggcacaggc gccaccgagt tacctggacg ttctgggcta
     2461 ggagtctgga tgtcaggcta ccctgggctc cctcagcgcc cagcagctat cacactcaag
     2521 tcttaccctc agcatgtgga ggggaccagc aggcggggag cagagggtgg ctttgcttca
     2581 tggccagcat ccatcataat agcaattata tttattatcc ctgaaaaaaa aaa
//
