LOCUS       NM_001106780            2092 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus netrin 4 (Ntn4), mRNA.
ACCESSION   NM_001106780 XM_001080341
VERSION     NM_001106780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2092)
  AUTHORS   Honjo Y, Fujita Y, Niwa H and Yamashita T.
  TITLE     Increased expression of Netrin-4 is associated with allodynia in a
            trigeminal neuropathic pain model rats by infraorbital nerve injury
  JOURNAL   PLoS One 16 (4), e0251013 (2021)
   PUBMED   33914819
  REMARK    GeneRIF: Increased expression of Netrin-4 is associated with
            allodynia in a trigeminal neuropathic pain model rats by
            infraorbital nerve injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2092)
  AUTHORS   Hayano Y, Takasu K, Koyama Y, Yamada M, Ogawa K, Minami K, Asaki T,
            Kitada K, Kuwabara S and Yamashita T.
  TITLE     Dorsal horn interneuron-derived Netrin-4 contributes to spinal
            sensitization in chronic pain via Unc5B
  JOURNAL   J Exp Med 213 (13), 2949-2966 (2016)
   PUBMED   27856613
  REMARK    GeneRIF: the Unc5B receptor and subsequent activation of the
            tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling
            in the spinal cord.
REFERENCE   3  (bases 1 to 2092)
  AUTHORS   Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C,
            Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D,
            Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N,
            Kimata K, Hayashizaki Y and Sekiguchi K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (bases 1 to 2092)
  AUTHORS   Schneiders FI, Maertens B, Bose K, Li Y, Brunken WJ, Paulsson M,
            Smyth N and Koch M.
  TITLE     Binding of netrin-4 to laminin short arms regulates basement
            membrane assembly
  JOURNAL   J Biol Chem 282 (33), 23750-23758 (2007)
   PUBMED   17588941
REFERENCE   5  (bases 1 to 2092)
  AUTHORS   Liu Y, Stein E, Oliver T, Li Y, Brunken WJ, Koch M, Tessier-Lavigne
            M and Hogan BL.
  TITLE     Novel role for Netrins in regulating epithelial behavior during
            lung branching morphogenesis
  JOURNAL   Curr Biol 14 (10), 897-905 (2004)
   PUBMED   15186747
REFERENCE   6  (bases 1 to 2092)
  AUTHORS   Koch M, Murrell JR, Hunter DD, Olson PF, Jin W, Keene DR, Brunken
            WJ and Burgeson RE.
  TITLE     A novel member of the netrin family, beta-netrin, shares homology
            with the beta chain of laminin: identification, expression, and
            functional characterization
  JOURNAL   J Cell Biol 151 (2), 221-234 (2000)
   PUBMED   11038171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On Oct 4, 2007 this sequence version replaced XM_001080341.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2092
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /note="netrin 4"
                     /db_xref="GeneID:299737"
                     /db_xref="RGD:1565947"
     exon            1..224
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2062
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /codon_start=1
                     /product="netrin-4 precursor"
                     /protein_id="NP_001100250.1"
                     /db_xref="GeneID:299737"
                     /db_xref="RGD:1565947"
                     /translation="MGSCARLLLLWGCSAVAAGFNGVSGVNSRCEKACNPRMGNLALG
                     RKLQADTTCGQNATELFCFYSENADLTCRQPKCDKCNGAHSHLAHPPSAMADSSFRFP
                     RTWWQSAEDVHREKIQLDLEAEFYFTHLIMVFKSPRPAAMVLDRSQDFGKTWKPYKYF
                     ATNCSATFGLEDDVVKKGAICTSRYSNPFPCTGGEVIFRALSPPYDIENPYSAKVQEQ
                     LKITNLRVRLLKRQSCPCQRNDLNAKPHHFTHYAIYDFIVKGSCFCNGHADQCLPVEG
                     FRPVKAPGAFHVVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPNECRTCKC
                     NGHADTCHFDINVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDAC
                     KACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCD
                     CAGSCDPLTGDCISSNADVDWYHEVPAFHSLHNKSEPGWEWEDEQGFSALRHSGKCEC
                     KEQVLGNPKAFCGMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLQATKLKILRGKRTL
                     YPESWTNRGCTCPILNPGLEYLVAGYEDVRTGRLIVNMKSFVQPWKPALGRRVMHILK
                     RECVEH"
     exon            225..754
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            755..1033
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1160
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1349
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1563
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1679
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1748
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1919
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2092
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcgcgac ggtcaccccg ccgcctggcg cggccccggt ccgcgactct gcacccacgg
       61 tgcccactga gcgagcctgg cgccctggga ggaggaagaa ccacagagcc ccgggtgctc
      121 cggaggaccg ctgccgcttc atcccaccgg ctcccgcagc tgcccggcca tggggagctg
      181 cgcacggctg ctgctgctct ggggctgctc cgcggtggcc gcaggattca atggagtctc
      241 tggagtgaat tcccgctgcg agaaggcctg caaccctcga atgggaaact tggctttggg
      301 aagaaaactc caggcggaca ctacctgcgg gcagaacgcc accgaactgt tctgcttcta
      361 cagcgagaat gctgatctca cttgccggca gcccaagtgt gataagtgca acggggccca
      421 ttctcacctg gcccacccac cctctgcaat ggcagactcg tccttcaggt ttccccggac
      481 atggtggcag tcggcagagg atgtgcacag ggaaaagatc cagctagacc tggaagcaga
      541 attctatttt actcacctaa ttatggtgtt caagtccccc aggcctgcag ccatggtgct
      601 ggaccggtcc caggactttg ggaagacttg gaaaccttac aagtactttg caacaaactg
      661 ttctgctacg tttggcctgg aagatgatgt tgtcaagaag ggagctattt gcacgtcgag
      721 atactcaaat cctttcccat gtactggcgg agaggttatt ttcagagccc tgtcaccacc
      781 atatgacata gaaaaccctt acagtgccaa agtacaggag cagctgaaga tcaccaacct
      841 ccgcgtgcgg ctgctcaagc gacagtcctg cccttgtcag agaaacgact tgaatgcaaa
      901 gcctcaccat ttcactcact acgccatcta cgacttcatc gtcaagggca gctgcttctg
      961 caacggccac gctgaccagt gtttacctgt ggagggcttc agacccgtca aggccccagg
     1021 agcgttccat gtggtccatg ggaagtgcat gtgtaagcac aacacggcgg gcagccactg
     1081 ccagcactgt gcaccattat acaacgaccg gccctgggag gcagcggatg gcagaacagg
     1141 ggctcctaac gaatgcagaa cctgcaagtg caatgggcac gcggacacct gtcacttcga
     1201 catcaacgtg tgggaggcat ccgggaatcg cagcggtggt gtctgcaaca actgtcaaca
     1261 caacaccgag ggtcagcatt gtcagcgctg taagccgggt ttctaccgag acctcaggag
     1321 gcccttctct gcccccgatg cttgtaaagc atgttcctgc cacccagttg gctcggcgat
     1381 ccttcctttc agctcggtga ccttctgcga ccccagcaat ggtgactgcc cttgcaagcc
     1441 tggggtggca gggccacatt gtgacaggtg catggtggga tactggggct ttggagacta
     1501 cggctgcaga ccttgtgact gtgcggggag ctgcgacccg ctcacgggag actgcatcag
     1561 cagcaatgct gacgtggact ggtatcacga agtccccgcc tttcactctc tgcacaataa
     1621 gagtgagcca ggctgggagt gggaagatga gcagggattt tctgcacttc gacactcagg
     1681 taaatgtgaa tgtaaggaac aagtgttagg aaaccccaag gccttctgtg gaatgaagta
     1741 ttcatatgtg ttaaaaatca agattttatc agctcatgat aaaggttccc acgctgaggt
     1801 caacgtgaag attaagaaag tcttacaggc taccaaactg aagatcttac gaggcaagag
     1861 aacactctat cccgagtcct ggactaacag aggctgcacc tgcccgatcc tcaatccagg
     1921 cttggagtac ctggtagctg gctatgagga cgtgagaaca ggcagattaa ttgtgaatat
     1981 gaaaagcttc gtccagccct ggaaaccagc tcttgggaga agagtcatgc acatcttaaa
     2041 aagagaatgc gtggagcact gaagaaggtc ttaagcacac aggggctctt ct
//
