LOCUS       NP_001100250             630 aa            linear   ROD 21-MAR-2023
DEFINITION  netrin-4 precursor [Rattus norvegicus].
ACCESSION   NP_001100250 XP_001080341
VERSION     NP_001100250.1
DBSOURCE    REFSEQ: accession NM_001106780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 630)
  AUTHORS   Honjo Y, Fujita Y, Niwa H and Yamashita T.
  TITLE     Increased expression of Netrin-4 is associated with allodynia in a
            trigeminal neuropathic pain model rats by infraorbital nerve injury
  JOURNAL   PLoS One 16 (4), e0251013 (2021)
   PUBMED   33914819
  REMARK    GeneRIF: Increased expression of Netrin-4 is associated with
            allodynia in a trigeminal neuropathic pain model rats by
            infraorbital nerve injury.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 630)
  AUTHORS   Hayano Y, Takasu K, Koyama Y, Yamada M, Ogawa K, Minami K, Asaki T,
            Kitada K, Kuwabara S and Yamashita T.
  TITLE     Dorsal horn interneuron-derived Netrin-4 contributes to spinal
            sensitization in chronic pain via Unc5B
  JOURNAL   J Exp Med 213 (13), 2949-2966 (2016)
   PUBMED   27856613
  REMARK    GeneRIF: the Unc5B receptor and subsequent activation of the
            tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling
            in the spinal cord.
REFERENCE   3  (residues 1 to 630)
  AUTHORS   Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C,
            Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D,
            Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N,
            Kimata K, Hayashizaki Y and Sekiguchi K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (residues 1 to 630)
  AUTHORS   Schneiders FI, Maertens B, Bose K, Li Y, Brunken WJ, Paulsson M,
            Smyth N and Koch M.
  TITLE     Binding of netrin-4 to laminin short arms regulates basement
            membrane assembly
  JOURNAL   J Biol Chem 282 (33), 23750-23758 (2007)
   PUBMED   17588941
REFERENCE   5  (residues 1 to 630)
  AUTHORS   Liu Y, Stein E, Oliver T, Li Y, Brunken WJ, Koch M, Tessier-Lavigne
            M and Hogan BL.
  TITLE     Novel role for Netrins in regulating epithelial behavior during
            lung branching morphogenesis
  JOURNAL   Curr Biol 14 (10), 897-905 (2004)
   PUBMED   15186747
REFERENCE   6  (residues 1 to 630)
  AUTHORS   Koch M, Murrell JR, Hunter DD, Olson PF, Jin W, Keene DR, Brunken
            WJ and Burgeson RE.
  TITLE     A novel member of the netrin family, beta-netrin, shares homology
            with the beta chain of laminin: identification, expression, and
            functional characterization
  JOURNAL   J Cell Biol 151 (2), 221-234 (2000)
   PUBMED   11038171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On Oct 4, 2007 this sequence version replaced XP_001080341.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..630
                     /product="netrin-4 precursor"
                     /calculated_mol_wt=68241
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1879
     Region          34..260
                     /region_name="Laminin_N"
                     /note="Laminin N-terminal (Domain VI); pfam00055"
                     /db_xref="CDD:459653"
     Region          261..320
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(262,264,271,293,295,304)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          332..392
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(332,334,341,359,362,371)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          395..446
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domai;
                     smart00180"
                     /db_xref="CDD:214543"
     Site            order(395,397,413,420,422,431)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          517..626
                     /region_name="NTR_netrin-4_like"
                     /note="NTR domain, Netrin-4-like subfamily; composed of
                     the C-terminal NTR domains of netrin-4 (beta netrin) and
                     similar proteins. Netrins are secreted proteins that
                     function as tropic cues in the direction of axon growth
                     and cell migration during neural...; cd03578"
                     /db_xref="CDD:239633"
     CDS             1..630
                     /gene="Ntn4"
                     /gene_synonym="RGD1565947"
                     /coded_by="NM_001106780.1:170..2062"
                     /db_xref="GeneID:299737"
                     /db_xref="RGD:1565947"
ORIGIN      
        1 mgscarllll wgcsavaagf ngvsgvnsrc ekacnprmgn lalgrklqad ttcgqnatel
       61 fcfysenadl tcrqpkcdkc ngahshlahp psamadssfr fprtwwqsae dvhrekiqld
      121 leaefyfthl imvfksprpa amvldrsqdf gktwkpykyf atncsatfgl eddvvkkgai
      181 ctsrysnpfp ctggevifra lsppydienp ysakvqeqlk itnlrvrllk rqscpcqrnd
      241 lnakphhfth yaiydfivkg scfcnghadq clpvegfrpv kapgafhvvh gkcmckhnta
      301 gshcqhcapl yndrpweaad grtgapnecr tckcnghadt chfdinvwea sgnrsggvcn
      361 ncqhntegqh cqrckpgfyr dlrrpfsapd ackacschpv gsailpfssv tfcdpsngdc
      421 pckpgvagph cdrcmvgywg fgdygcrpcd cagscdpltg dcissnadvd wyhevpafhs
      481 lhnksepgwe wedeqgfsal rhsgkcecke qvlgnpkafc gmkysyvlki kilsahdkgs
      541 haevnvkikk vlqatklkil rgkrtlypes wtnrgctcpi lnpgleylva gyedvrtgrl
      601 ivnmksfvqp wkpalgrrvm hilkrecveh
//
