LOCUS       NP_446183                604 aa            linear   ROD 10-APR-2024
DEFINITION  netrin-1 precursor [Rattus norvegicus].
ACCESSION   NP_446183 XP_006246629
VERSION     NP_446183.2
DBSOURCE    REFSEQ: accession NM_053731.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 604)
  AUTHORS   Gong,Z., Zhang,Y., Wang,W., Li,X., Wang,K., You,X. and Wu,J.
  TITLE     Netrin-1 Role in Nociceptive Neuron Sprouting through Activation of
            DCC Signaling in a Rat Model of Bone Cancer Pain
  JOURNAL   J Integr Neurosci 23 (3), 47 (2024)
   PUBMED   38538215
  REMARK    GeneRIF: Netrin-1 Role in Nociceptive Neuron Sprouting through
            Activation of DCC Signaling in a Rat Model of Bone Cancer Pain.
REFERENCE   2  (residues 1 to 604)
  AUTHORS   Yang,X., Liu,Y., Zhong,W., Li,Y. and Zhang,W.
  TITLE     Netrin-1 attenuates cerebral ischemia/reperfusion injury by
            limiting mitochondrial ROS and Ca2+ levels via activation of AKT
            phosphorylation and mitochondrial m-AAA protease AFG3L2
  JOURNAL   FASEB J 37 (3), e22805 (2023)
   PUBMED   36786711
  REMARK    GeneRIF: Netrin-1 attenuates cerebral ischemia/reperfusion injury
            by limiting mitochondrial ROS and Ca[2+] levels via activation of
            AKT phosphorylation and mitochondrial m-AAA protease AFG3L2.
REFERENCE   3  (residues 1 to 604)
  AUTHORS   Chen,J.T., Schmidt,L., Schurger,C., Hankir,M.K., Krug,S.M. and
            Rittner,H.L.
  TITLE     Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral
            Nerve after Injury
  JOURNAL   Int J Mol Sci 22 (18), 10090 (2021)
   PUBMED   34576252
  REMARK    GeneRIF: Netrin-1 as a Multitarget Barrier Stabilizer in the
            Peripheral Nerve after Injury.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 604)
  AUTHORS   Wu,G., Wang,Z., Shan,P., Huang,S., Lin,S., Huang,W. and Huang,Z.
  TITLE     Suppression of Netrin-1 attenuates angiotension II-induced cardiac
            remodeling through the PKC/MAPK signaling pathway
  JOURNAL   Biomed Pharmacother 130, 110495 (2020)
   PUBMED   32688140
  REMARK    GeneRIF: Suppression of Netrin-1 attenuates angiotension II-induced
            cardiac remodeling through the PKC/MAPK signaling pathway.
REFERENCE   5  (residues 1 to 604)
  AUTHORS   Gao,K., Niu,J. and Dang,X.
  TITLE     Neuroprotection of netrin-1 on neurological recovery via
            Wnt/beta-catenin signaling pathway after spinal cord injury
  JOURNAL   Neuroreport 31 (7), 537-543 (2020)
   PUBMED   32251100
  REMARK    GeneRIF: Neuroprotection of netrin-1 on neurological recovery via
            Wnt/beta-catenin signaling pathway after spinal cord injury.
REFERENCE   6  (residues 1 to 604)
  AUTHORS   Causeret,F., Danne,F., Ezan,F., Sotelo,C. and Bloch-Gallego,E.
  TITLE     Slit antagonizes netrin-1 attractive effects during the migration
            of inferior olivary neurons
  JOURNAL   Dev Biol 246 (2), 429-440 (2002)
   PUBMED   12051827
REFERENCE   7  (residues 1 to 604)
  AUTHORS   Manitt,C., Colicos,M.A., Thompson,K.M., Rousselle,E., Peterson,A.C.
            and Kennedy,T.E.
  TITLE     Widespread expression of netrin-1 by neurons and oligodendrocytes
            in the adult mammalian spinal cord
  JOURNAL   J Neurosci 21 (11), 3911-3922 (2001)
   PUBMED   11356879
REFERENCE   8  (residues 1 to 604)
  AUTHORS   Braisted,J.E., Catalano,S.M., Stimac,R., Kennedy,T.E.,
            Tessier-Lavigne,M., Shatz,C.J. and O'Leary,D.D.
  TITLE     Netrin-1 promotes thalamic axon growth and is required for proper
            development of the thalamocortical projection
  JOURNAL   J Neurosci 20 (15), 5792-5801 (2000)
   PUBMED   10908620
REFERENCE   9  (residues 1 to 604)
  AUTHORS   Alcantara,S., Ruiz,M., De Castro,F., Soriano,E. and Sotelo,C.
  TITLE     Netrin 1 acts as an attractive or as a repulsive cue for distinct
            migrating neurons during the development of the cerebellar system
  JOURNAL   Development 127 (7), 1359-1372 (2000)
   PUBMED   10704383
REFERENCE   10 (residues 1 to 604)
  AUTHORS   Livesey,F.J. and Hunt,S.P.
  TITLE     Netrin and netrin receptor expression in the embryonic mammalian
            nervous system suggests roles in retinal, striatal, nigral, and
            cerebellar development
  JOURNAL   Mol Cell Neurosci 8 (6), 417-429 (1997)
   PUBMED   9143559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 25, 2022 this sequence version replaced
            XP_006246629.1, NP_446183.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.24574.1,
                                           SRR26643285.42991.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..604
                     /product="netrin-1 precursor"
                     /calculated_mol_wt=65431
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2430
     mat_peptide     25..604
                     /product="Netrin-1. /id=PRO_0000320574"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924Z9.1)"
                     /calculated_mol_wt=65431
     Region          46..283
                     /region_name="LamNT"
                     /note="Laminin N-terminal domain (domain VI); smart00136"
                     /db_xref="CDD:214532"
     Site            95
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924Z9.1)"
     Site            116
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924Z9.1)"
     Site            131
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924Z9.1)"
     Region          284..329
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(285,287,297,304,306,315)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          341..401
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(341,343,350,368,371,380)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          404..>441
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(404,406,416,423,425,434)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Site            417
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q924Z9.1)"
     Region          487..601
                     /region_name="NTR_netrin-1_like"
                     /note="NTR domain, Netrin-1-like subfamily; The C-terminal
                     NTR domain of netrins is also called domain C in the
                     context of C. elegans netrin UNC-6. Netrins are secreted
                     proteins that function as tropic cues in the direction of
                     axon growth and cell migration...; cd03579"
                     /db_xref="CDD:239634"
     Region          530..532
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924Z9.1)"
     CDS             1..604
                     /gene="Ntn1"
                     /gene_synonym="netrin-1"
                     /coded_by="NM_053731.3:445..2259"
                     /db_xref="GeneID:114523"
                     /db_xref="RGD:619809"
ORIGIN      
        1 mmravweala alaavaclvg avrggpglsm fagqaaqpdp csdenghprr cipdfvnaaf
       61 gkdvrvsstc grpparycvv sergeerlrs chlcnssdpk kahppafltd lnnphnltcw
      121 qsenylqfph nvtltlslgk kfevtyvslq fcsprpesma iyksmdygrt wvpfqfystq
      181 crkmynrphr apitkqneqe avctdshtdm rplsggliaf stldgrpsah dfdnspvlqd
      241 wvtatdirva fsrlhtfgde neddselard syyyavsdlq vggrckcngh aarcvrdrdd
      301 slvcdcrhnt agpecdrckp fhydrpwqra tareanecva cncnlharrc rfnmelykls
      361 grksggvcln crhntagrhc hyckegfyrd mgkpithrka ckacdchpvg aagktcnqtt
      421 gqcpckdgvt gitcnrcakg yqqsrspiap cikipvappt taassmeepe dcdsyckask
      481 gklkmnmkky crkdyavqih ilkadkagdw wkftvniisv ykqgtsrirr gdqslwirsr
      541 diackcpkik plkkylllgn aedspdqsgi vadksslviq wrdtwarrlr kfqqrekkgk
      601 ckka
//
