LOCUS       NM_017354               2039 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus neurotrimin (Ntm), mRNA.
ACCESSION   NM_017354
VERSION     NM_017354.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Sanz,R.L., Ferraro,G.B., Girouard,M.P. and Fournier,A.E.
  TITLE     Ectodomain shedding of Limbic System-Associated Membrane Protein
            (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG
            neurons
  JOURNAL   Sci Rep 7 (1), 7961 (2017)
   PUBMED   28801670
  REMARK    GeneRIF: Neurotrimin and LSAMP were identified as ADAM10 substrates
            that are shed from the cell surface of dorsal root ganglion (DRGs)
            neurons. Overexpression of LSAMP and NTM suppresses outgrowth from
            DRG neurons. Furthermore, LSAMP loss of function decreases the
            outgrowth sensitivity to an ADAM10 inhibitor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Krizsan-Agbas,D., Pedchenko,T. and Smith,P.G.
  TITLE     Neurotrimin is an estrogen-regulated determinant of peripheral
            sympathetic innervation
  JOURNAL   J Neurosci Res 86 (14), 3086-3095 (2008)
   PUBMED   18627025
  REMARK    GeneRIF: a role for neurotrimin in mediating estrogen-induced
            sympathetic pruning in some peripheral targets.
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Itoh,S., Hachisuka,A., Kawasaki,N., Hashii,N., Teshima,R.,
            Hayakawa,T., Kawanishi,T. and Yamaguchi,T.
  TITLE     Glycosylation analysis of IgLON family proteins in rat brain by
            liquid chromatography and multiple-stage mass spectrometry
  JOURNAL   Biochemistry 47 (38), 10132-10154 (2008)
   PUBMED   18729387
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Gil,O.D., Zhang,L., Chen,S., Ren,Y.Q., Pimenta,A., Zanazzi,G.,
            Hillman,D., Levitt,P. and Salzer,J.L.
  TITLE     Complementary expression and heterophilic interactions between
            IgLON family members neurotrimin and LAMP
  JOURNAL   J Neurobiol 51 (3), 190-204 (2002)
   PUBMED   11984841
  REMARK    GeneRIF: homophilic and heterophilic interactions between IgLON
            family members are likely to play a role in the specification of
            neuronal projections via growth promoting and inhibiting effects,
            respectively.
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Chen,S., Gil,O., Ren,Y.Q., Zanazzi,G., Salzer,J.L. and Hillman,D.E.
  TITLE     Neurotrimin expression during cerebellar development suggests roles
            in axon fasciculation and synaptogenesis
  JOURNAL   J Neurocytol 30 (11), 927-937 (2001)
   PUBMED   12373100
  REMARK    GeneRIF: The spatio-temporal expression pattern of neurotrimin
            suggests that it plays a role in axonal fasciculation of specific
            cerebellar systems and may also be involved in the formation of
            excitatory synapses and their stabilization into adulthood.
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_017354.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017354.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16845.1, SRR26643298.43355.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840109,
                                           SAMN12840110 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               JAXUCZ010000008.1  36061902-36062550   c
            650-882             JAXUCZ010000008.1  35817182-35817414   c
            883-1008            JAXUCZ010000008.1  35750039-35750164   c
            1009-1143           JAXUCZ010000008.1  35654194-35654328   c
            1144-1264           JAXUCZ010000008.1  35652166-35652286   c
            1265-1416           JAXUCZ010000008.1  35649255-35649406   c
            1417-2039           JAXUCZ010000008.1  35636119-35636741   c
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2039
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /note="neurotrimin"
                     /db_xref="GeneID:50864"
                     /db_xref="RGD:620958"
     exon            1..649
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1517
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /note="GP65; protein CEPU-1"
                     /codon_start=1
                     /product="neurotrimin precursor"
                     /protein_id="NP_059050.2"
                     /db_xref="GeneID:50864"
                     /db_xref="RGD:620958"
                     /translation="MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIAT
                     GRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGEYECSASNDVAAPVVRRVKVT
                     VNYPPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRLVEGKKGVKVENRPF
                     LSRLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVNNGTSRRAGCIWLLP
                     LLVLHLLLKF"
     exon            650..882
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1008
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1143
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1264
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1416
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..2039
                     /gene="Ntm"
                     /gene_synonym="Hnt; RNU16845"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacttaagaa agtgctggat ttcccgttgt tcgattgagg aaccgtagac cacatctggg
       61 tagctggatt cagcccagcc acagccccgt tggataccaa agtgcttact cctgtccaaa
      121 gtgccatgcc tgaactgcta cggggaagag gcagcttctg agacccgcac ctgtgcgcct
      181 gcttgcctgc cttgcgcttc tctctcctgg ccaccttcca ggccacaggc agcacggaga
      241 aagtccgcct cggatgtgtg tggaaactgg ttctcagagg ctgcgagctg aggctggatt
      301 taggggagga atattagact tggaggagtc tgcgcgcttt tctcctccca gtgcatcgcg
      361 cggtcgccgc tagttcatcg ctgggtcccc gcgctcactc cccaccccac ccacttcctg
      421 tgctcgcccg gggggcgtgt gcgtgccact accggagttc tgggaagttg tggctgtcga
      481 gaatgggggt ctgtgggtac ctgttcctgc cctggaagtg cctcgtggtc gtgtctctca
      541 ggctgctgtt ccttgtaccc acaggagtgc cggtgcgtag cggagatgcc acctttccca
      601 aagctatgga caacgtgacg gtcaggcagg gggagagcgc caccctcagg tgcacaattg
      661 acaaccgagt cacccgggtg gcctggctaa accgcagtac catcctctat gctggaaatg
      721 acaagtggtg cctagatcct cgtgtggttc tcctgagtaa cacccagacc cagtacagca
      781 ttgagatcca gaatgtggat gtgtatgatg agggccctta tacctgctcg gtgcagacag
      841 acaaccaccc taagacctcc agggtccacc tcattgtaca agtatctccc aaaattgtag
      901 agatttcttc agatatctcc attaatgaag ggaacaacat cagcctcact tgcatagcca
      961 caggtagacc ggagcctaca gtaacctgga gacatatttc tcccaaagct gtcggctttg
     1021 tgagtgagga tgagtacctg gagatccagg gcatcactcg ggagcagtca ggcgagtatg
     1081 agtgcagcgc ctccaacgac gtggcagcac cagtcgtacg aagagtgaag gtcaccgtga
     1141 actatccacc atacatctca gaagctaagg gtacaggtgt ccccgtgggg cagaagggga
     1201 ctctgcagtg tgaagcctcg gcagtccctt cagcagaatt tcagtggttc aaggatgaca
     1261 aaagactggt tgaagggaag aagggagtca aagtggaaaa cagacctttc ctttcaagac
     1321 tcaccttttt caacgtctct gaacacgact atgggaacta cacatgtgtg gcatccaaca
     1381 agttgggcca caccaatgcc agcatcatgc tatttggccc aggtgctgtc agcgaggtca
     1441 acaatgggac gtcaaggagg gcaggctgca tttggctcct ccctcttctg gtcttacacc
     1501 tgctcctcaa attttgatgt gagtgcccct tccctgccgg ggagagctgc tgccaccgca
     1561 tctcaattca acagcactgc aacatgaagc aacaagtcag aatcaaatga aattccgaga
     1621 atcacagcca atgagacaga aattcgaggg aggggaacaa agcatactgt ggtaaagggg
     1681 aaaaaaaagt ctaaaaaaag gaaatttgaa aattgccttg cagacatttc ggtaccactg
     1741 agttttcttt cttttcccaa atgggaagaa ggcgcaccta gcttggaccc acccacaagc
     1801 tgcactgtgt gacctctctg ttgccagggt gggcaagggc tcagccactc tgcccactaa
     1861 agtgccccac catggaacat tctggagtcg gccatcccaa atttcatcgg tccatagaca
     1921 caagcacaga gtgagaaaca ggggcccaga agtgccacgg agggcccttt ggtgggctgc
     1981 gcgatgatgg cgtgtgtcat gaagtgtgaa atccgaagta gaaaaaaaaa caagaataa
//
