LOCUS       NM_001105728            1084 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus nth-like DNA glycosylase 1 (Nthl1), mRNA.
ACCESSION   NM_001105728 XM_001058112 XM_213228
VERSION     NM_001105728.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1084)
  AUTHORS   Limpose KL, Trego KS, Li Z, Leung SW, Sarker AH, Shah JA,
            Ramalingam SS, Werner EM, Dynan WS, Cooper PK, Corbett AH and
            Doetsch PW.
  TITLE     Overexpression of the base excision repair NTHL1 glycosylase causes
            genomic instability and early cellular hallmarks of cancer
  JOURNAL   Nucleic Acids Res 46 (9), 4515-4532 (2018)
   PUBMED   29522130
REFERENCE   2  (bases 1 to 1084)
  AUTHORS   Ma H, Wang J, Abdel-Rahman SZ, Boor PJ and Khan MF.
  TITLE     Induction of base excision repair enzymes NTH1 and APE1 in rat
            spleen following aniline exposure
  JOURNAL   Toxicol Appl Pharmacol 267 (3), 276-283 (2013)
   PUBMED   23352893
  REMARK    GeneRIF: In an experimental condition preceding tumorigenesis, NTH1
            contributes to the repair of oxidative DNA lesions in the spleen.
REFERENCE   3  (bases 1 to 1084)
  AUTHORS   Sajankila SP, Manthena PV, Adhikari S, Choudhury S, Izumi K and Roy
            R.
  TITLE     Suppression of tumor suppressor Tsc2 and DNA repair glycosylase
            Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon
            rats
  JOURNAL   Mol Cell Biochem 338 (1-2), 233-239 (2010)
   PUBMED   20033472
  REMARK    GeneRIF: Results describe the expression of Nth1 and Tsc2 genes
            during disease progression in hepatitis/liver tumorigenesis the
            Long-Evans Cinnamon rat.
REFERENCE   4  (bases 1 to 1084)
  AUTHORS   Li W, Luo Y, Zhang F, Signore AP, Gobbel GT, Simon RP and Chen J.
  TITLE     Ischemic preconditioning in the rat brain enhances the repair of
            endogenous oxidative DNA damage by activating the base-excision
            repair pathway
  JOURNAL   J Cereb Blood Flow Metab 26 (2), 181-198 (2006)
   PUBMED   16001017
  REMARK    GeneRIF: The upregulation of base-excision repair activities after
            ischemic preconditioning was likely because of increased expression
            of AP Endonuclease.
REFERENCE   5  (bases 1 to 1084)
  AUTHORS   Oyama M, Wakasugi M, Hama T, Hashidume H, Iwakami Y, Imai R,
            Hoshino S, Morioka H, Ishigaki Y, Nikaido O and Matsunaga T.
  TITLE     Human NTH1 physically interacts with p53 and proliferating cell
            nuclear antigen
  JOURNAL   Biochem Biophys Res Commun 321 (1), 183-191 (2004)
   PUBMED   15358233
REFERENCE   6  (bases 1 to 1084)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1084)
  AUTHORS   Ikeda S, Kohmoto T, Tabata R and Seki Y.
  TITLE     Differential intracellular localization of the human and mouse
            endonuclease III homologs and analysis of the sorting signals
  JOURNAL   DNA Repair (Amst) 1 (10), 847-854 (2002)
   PUBMED   12531031
REFERENCE   8  (bases 1 to 1084)
  AUTHORS   Luna L, Bjoras M, Hoff E, Rognes T and Seeberg E.
  TITLE     Cell-cycle regulation, intracellular sorting and induced
            overexpression of the human NTH1 DNA glycosylase involved in
            removal of formamidopyrimidine residues from DNA
  JOURNAL   Mutat Res 460 (2), 95-104 (2000)
   PUBMED   10882850
REFERENCE   9  (bases 1 to 1084)
  AUTHORS   Sarker AH, Ikeda S, Nakano H, Terato H, Ide H, Imai K, Akiyama K,
            Tsutsui K, Bo Z, Kubo K, Yamamoto K, Yasui A, Yoshida MC and Seki
            S.
  TITLE     Cloning and characterization of a mouse homologue (mNthl1) of
            Escherichia coli endonuclease III
  JOURNAL   J Mol Biol 282 (4), 761-774 (1998)
   PUBMED   9743625
REFERENCE   10 (bases 1 to 1084)
  AUTHORS   Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ,
            Cheadle JP, Sampson JR, Lindahl T, Harris PC and Hickson ID.
  TITLE     Cloning and characterization of a functional human homolog of
            Escherichia coli endonuclease III
  JOURNAL   Proc Natl Acad Sci U S A 94 (1), 109-114 (1997)
   PUBMED   8990169
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_001058112.1, XM_213228.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1084
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /note="nth-like DNA glycosylase 1"
                     /db_xref="GeneID:29541"
                     /db_xref="RGD:1309289"
     exon            1..169
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..969
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /EC_number="4.2.99.18"
                     /note="nth endonuclease III-like 1"
                     /codon_start=1
                     /product="endonuclease III-like protein 1"
                     /protein_id="NP_001099198.1"
                     /db_xref="GeneID:29541"
                     /db_xref="RGD:1309289"
                     /translation="MNSGLRIVTRSRSRATRIASEGCREELAPRETAAEGRKSHKPVR
                     RPRKKQKVHVAYEVANGEEGEDAEPLKVPVWEPQNWQQQLANIRIMRSKKDAPVDQLG
                     AEQCYDITAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVESILQTDDDLL
                     GRLIYPVGFWRSKVKFIKQTTAILQQRYEGDIPASVAELVALPGVGPKMAHLAMAVAW
                     GTVSGIAVDTHVHRIANRLKWTKKMTKSPEETRRNLEEWLPRVLWSEINGLLVGFGQQ
                     ICLPVHPRCQACLNKALCPAAQGL"
     exon            170..408
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..579
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..739
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..845
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1084
                     /gene="Nthl1"
                     /gene_synonym="Nth1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgtgcac gttgagcaag tgatggaccc gcgggaccgc ccggaggtgt agtttccagc
       61 ccaggcatga actcggggtt gcggatagtg actcgcagtc ggagccgcgc gactaggatc
      121 gcgtcggaag ggtgtaggga ggagctcgcc ccgcgagaga ctgctgcaga aggaagaaaa
      181 agccacaagc ctgtgagacg tccacggaag aaacagaaag tacatgtggc ctatgaggtt
      241 gctaacggtg aggaaggtga agatgctgaa cccctcaaag tgccagtttg ggagccccaa
      301 aactggcagc agcaactggc caacatccga atcatgagaa gcaagaagga cgcacctgtg
      361 gaccagctgg gcgctgagca gtgctatgat atcactgccc ccccaaaggt gaggaggtac
      421 caggtactct tgtcgctgat gctgtccagc cagaccaaag accaggttac agcgggtgcc
      481 atgcagcggc tacgggcccg gggcttgact gtggaaagta tcctgcagac cgatgatgac
      541 ttgctgggca gactcatcta ccccgtgggc ttctggagga gcaaggtaaa attcatcaag
      601 cagacgactg ccatcctgca gcagcgctat gaaggggaca tccctgcttc tgtggcagag
      661 ctggtagcct tgccaggtgt tgggcccaag atggcacact tggctatggc tgtggcctgg
      721 gggaccgtat caggcatagc agtggacaca catgtgcaca gaatagccaa cagactgaag
      781 tggaccaaga agatgaccaa gtccccagag gagacacgta ggaacctgga agagtggcta
      841 cccagggtgc tatggagtga gatcaatgga ctactggtgg gcttcggcca acagatttgc
      901 cttcctgtcc atccacgatg ccaggcctgc ctcaacaagg ccctgtgtcc tgctgcccag
      961 ggtctctgag ggttttgggc ttcctctggc tagtgtctcc aaagtgcctc tgtggggagg
     1021 ggtcgtaagg tttgggggtt gtttgcagag catgtaataa agctgagaag tttttccacg
     1081 gttg
//
