LOCUS       NM_013184               1326 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus neurotrophin 4 (Ntf4), mRNA.
ACCESSION   NM_013184
VERSION     NM_013184.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Balanya-Segura,M., Polishchuk,A., Just-Borras,L., Cilleros-Mane,V.,
            Silvera,C., Ardevol,A., Tomas,M., Lanuza,M.A., Hurtado,E. and
            Tomas,J.
  TITLE     Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic
            Pathways in Ageing Neuromuscular Synapses
  JOURNAL   Int J Mol Sci 25 (15), 8018 (2024)
   PUBMED   39125587
  REMARK    GeneRIF: Molecular Adaptations of BDNF/NT-4 Neurotrophic and
            Muscarinic Pathways in Ageing Neuromuscular Synapses.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Muthu,S.J., Lakshmanan,G. and Seppan,P.
  TITLE     Influence of Testosterone Depletion on Neurotrophin-4 in
            Hippocampal Synaptic Plasticity and Its Effects on Learning and
            Memory
  JOURNAL   Dev Neurosci 44 (2), 102-112 (2022)
   PUBMED   35086088
  REMARK    GeneRIF: Influence of Testosterone Depletion on Neurotrophin-4 in
            Hippocampal Synaptic Plasticity and Its Effects on Learning and
            Memory.
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Esmaeili,A., Pakravan,G., Ghaedi,K. and Noorbakhshnia,M.
  TITLE     Alteration in messenger RNA neurotrophin 4 and tyrosine kinase
            receptors B expression levels following spinal cord injury
  JOURNAL   J Neurosurg Sci 62 (2), 146-152 (2018)
   PUBMED   25476166
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Huang,T. and Krimm,R.F.
  TITLE     BDNF and NT4 play interchangeable roles in gustatory development
  JOURNAL   Dev Biol 386 (2), 308-320 (2014)
   PUBMED   24378336
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Chung,J.Y., Kim,M.W., Bang,M.S. and Kim,M.
  TITLE     Increased expression of neurotrophin 4 following focal cerebral
            ischemia in adult rat brain with treadmill exercise
  JOURNAL   PLoS One 8 (3), e52461 (2013)
   PUBMED   23526925
  REMARK    GeneRIF: In a permanent middle cerebral artery occlusion model,
            ischemia decreased NT-4 and trkB expression. Immunohistochemistry
            showed their immunoreactivities around the region of the ischemic
            area.
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Liebl,D.J., Mbiene,J.P. and Parada,L.F.
  TITLE     NT4/5 mutant mice have deficiency in gustatory papillae and taste
            bud formation
  JOURNAL   Dev Biol 213 (2), 378-389 (1999)
   PUBMED   10479455
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Botchkarev,V.A., Botchkareva,N.V., Welker,P., Metz,M., Lewin,G.R.,
            Subramaniam,A., Bulfone-Paus,S., Hagen,E., Braun,A., Lommatzsch,M.,
            Renz,H. and Paus,A.R.
  TITLE     A new role for neurotrophins: involvement of brain-derived
            neurotrophic factor and neurotrophin-4 in hair cycle control
  JOURNAL   FASEB J 13 (2), 395-410 (1999)
   PUBMED   9973328
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Ip,N.Y., Ibanez,C.F., Nye,S.H., McClain,J., Jones,P.F., Gies,D.R.,
            Belluscio,L., Le Beau,M.M., Espinosa,R. 3rd, Squinto,S.P. et al.
  TITLE     Mammalian neurotrophin-4: structure, chromosomal localization,
            tissue distribution, and receptor specificity
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3060-3064 (1992)
   PUBMED   1313578
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Berkemeier,L.R., Winslow,J.W., Kaplan,D.R., Nikolics,K.,
            Goeddel,D.V. and Rosenthal,A.
  TITLE     Neurotrophin-5: a novel neurotrophic factor that activates trk and
            trkB
  JOURNAL   Neuron 7 (5), 857-866 (1991)
   PUBMED   1742028
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Bothwell,M.A. and Shooter,E.M.
  TITLE     Dissociation equilibrium constant of beta nerve growth factor
  JOURNAL   J Biol Chem 252 (23), 8532-8536 (1977)
   PUBMED   925010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 24, 2020 this sequence version replaced NM_013184.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S69323.1, SRR26643299.2421.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000001.1  105030035-105030107
            74-194              JAXUCZ010000001.1  105031025-105031145
            195-1326            JAXUCZ010000001.1  105031735-105032866
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1326
                     /gene="Ntf4"
                     /gene_synonym="NT4P; Ntf5"
                     /note="neurotrophin 4"
                     /db_xref="GeneID:25730"
                     /db_xref="RGD:3212"
     exon            1..73
                     /gene="Ntf4"
                     /gene_synonym="NT4P; Ntf5"
                     /inference="alignment:Splign:2.1.0"
     exon            74..194
                     /gene="Ntf4"
                     /gene_synonym="NT4P; Ntf5"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1326
                     /gene="Ntf4"
                     /gene_synonym="NT4P; Ntf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..836
                     /gene="Ntf4"
                     /gene_synonym="NT4P; Ntf5"
                     /note="NT-4; NT-5; neurotrophin-5; neutrophic factor 4;
                     Neurotrophin 5 (neurotrophin 4/5)"
                     /codon_start=1
                     /product="neurotrophin-4 precursor"
                     /protein_id="NP_037316.3"
                     /db_xref="GeneID:25730"
                     /db_xref="RGD:3212"
                     /translation="MLPRHSCSLLLFLLLLPSVPMEPQPPSSTLPPFLAPEWDLLSPR
                     VALSRGTPAGPPLLFLLEAGAYGEPAGAPANRSRRGVSETAPASRRGELAVCDAVSGW
                     VTDRRTAVDLRGREVEVLGEVPAAGGSPLRQYFFETRCKAESAGEGGPGVGGGGCRGV
                     DRRHWLSECKAKQSYVRALTADSQGRVGWRWIRIDTACVCTLLSRTGRA"
ORIGIN      
        1 gagctgctag cgagccggag gaggagccgc agcggcgcca ggggcagccg gggagcagag
       61 aagggcgccc caggtggttg ccccctcctt ctcctgagat gtcagggagg agactacctg
      121 tatcctacac aggggcccca cacagcctgg gggcccccag ccccagagtg aggaggtgga
      181 ggtgctgttg acaggtgtgc aaagccatgc tccctcgcca ctcctgctct ctcctccttt
      241 tccttctcct cctccccagc gtccccatgg agccccaacc cccctcctcc accctgcccc
      301 cttttctggc tcctgagtgg gacctcttgt ctccccgagt ggccctgtca aggggcaccc
      361 ctgccgggcc ccctctcctc ttcctgctgg aggccggggc ctatggggag ccggcagggg
      421 ccccagccaa ccgcagccgg cgcggggtga gtgagacggc accggcaagc cgccggggtg
      481 agctggcagt gtgcgatgca gtgagtggct gggtgaccga ccggcggaca gctgtggact
      541 tgcgtgggcg cgaggtggag gtgctgggcg aggtgcctgc ggcaggtggc agtcccctgc
      601 gtcagtactt cttcgagacg cgctgcaagg ccgaaagcgc tggggaaggt ggcccaggtg
      661 tgggcggagg gggctgtcgc ggcgtggatc ggaggcactg gctctcagaa tgcaaggcta
      721 aacagtccta tgtgcgggcg ttgactgcag actctcaggg ccgcgtgggc tggcgctgga
      781 ttcggatcga caccgcttgc gtctgcacgc tcctcagccg aacaggccgt gcctgacgtc
      841 caggcttggg aaccgctcag gttgaggagg aaaaaaaaaa ccctggatgc tgaaaggacc
      901 acagggatgg ctcgactgct ctaccgtgcc ttctgactgt gaactgaaat aaccacagaa
      961 tcaaatctct ctcattttga gagctcagtc tgtgtggaat gtatgaggaa accaaatggg
     1021 gtttcaactg atgaatagga gttctcccga aggaacttga cattaataat agccaatgtt
     1081 tactatctac tgtgtatcag acctaatgtg tgactctgct aaccatttta acatcagagg
     1141 accctgactt accctggcaa gagagacgag gaaagactac gtgaaaaatc aatgtatgag
     1201 ctggggctag gcctcgatca gtaggctgtt tctggttgcc tagcatgcac acagtcctgg
     1261 gctctatcct gagcaccgta tcataaacca tgcacggtgg tactcatctg cagtgccagt
     1321 tcttgg
//
