LOCUS       NM_001270870            1329 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus neurotrophin 3 (Ntf3), transcript variant 4,
            mRNA.
ACCESSION   NM_001270870
VERSION     NM_001270870.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Briones-Vidal,M.G., Reyes-Garcia,S.E. and Escobar,M.L.
  TITLE     Neurotrophin-3 into the insular cortex strengthens conditioned
            taste aversion memory
  JOURNAL   Behav Brain Res 461, 114857 (2024)
   PUBMED   38211776
  REMARK    GeneRIF: Neurotrophin-3 into the insular cortex strengthens
            conditioned taste aversion memory.
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Zou,D., Wang,H., Hao,S. and Chen,F.
  TITLE     Repair effect of neurotrophic factor III (NT-3) on rats with spinal
            injury model and its mechanism
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 56-61 (2024)
   PUBMED   38372112
  REMARK    GeneRIF: Repair effect of neurotrophic factor III (NT-3) on rats
            with spinal injury model and its mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Yang,Y., Xu,H.Y., Deng,Q.W., Wu,G.H., Zeng,X., Jin,H., Wang,L.J.,
            Lai,B.Q., Li,G., Ma,Y.H., Jiang,B., Ruan,J.W., Wang,Y.Q., Ding,Y.
            and Zeng,Y.S.
  TITLE     Electroacupuncture facilitates the integration of a grafted
            TrkC-modified mesenchymal stem cell-derived neural network into
            transected spinal cord in rats via increasing neurotrophin-3
  JOURNAL   CNS Neurosci Ther 27 (7), 776-791 (2021)
   PUBMED   33763978
  REMARK    GeneRIF: Electroacupuncture facilitates the integration of a
            grafted TrkC-modified mesenchymal stem cell-derived neural network
            into transected spinal cord in rats via increasing neurotrophin-3.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Xu,H., Yang,Y., Deng,Q.W., Zhang,B.B., Ruan,J.W., Jin,H.,
            Wang,J.H., Ren,J., Jiang,B., Sun,J.H., Zeng,Y.S. and Ding,Y.
  TITLE     Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth
            Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury
  JOURNAL   J Neurotrauma 38 (6), 734-745 (2021)
   PUBMED   33121345
  REMARK    GeneRIF: Governor Vessel Electro-Acupuncture Promotes the Intrinsic
            Growth Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury.
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Donsante,A., Xue,J., Poth,K.M., Hardcastle,N.S., Diniz,B.,
            O'Connor,D.M., Xia,Y. and Boulis,N.M.
  TITLE     Controlling the Release of Neurotrophin-3 and Chondroitinase ABC
            Enhances the Efficacy of Nerve Guidance Conduits
  JOURNAL   Adv Healthc Mater 9 (14), e2000200 (2020)
   PUBMED   32548984
  REMARK    GeneRIF: Controlling the Release of Neurotrophin-3 and
            Chondroitinase ABC Enhances the Efficacy of Nerve Guidance
            Conduits.
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Smith,M.A., Makino,S., Altemus,M., Michelson,D., Hong,S.K.,
            Kvetnansky,R. and Post,R.M.
  TITLE     Stress and antidepressants differentially regulate neurotrophin 3
            mRNA expression in the locus coeruleus
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8788-8792 (1995)
   PUBMED   7568018
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Ernfors,P., Ibanez,C.F., Ebendal,T., Olson,L. and Persson,H.
  TITLE     Molecular cloning and neurotrophic activities of a protein with
            structural similarities to nerve growth factor: developmental and
            topographical expression in the brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5454-5458 (1990)
   PUBMED   2164684
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Squinto,S., Ip,N.Y., Furth,M.E.,
            Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
  JOURNAL   Science 247 (4949 Pt 1), 1446-1451 (1990)
   PUBMED   2321006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV778881.1, BC070504.1 and M34643.1.
            
            Transcript Variant: This variant (4) lacks an exon in the 5'
            region, which causes translation initiation at a downstream AUG,
            compared to variant 1. The resulting isoform (3) has a shorter
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV778881.1, EV780605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               EV778881.1         18-771
            755-862             BC070504.1         865-972
            863-1131            M34643.1           724-992
            1132-1329           BC070504.1         1242-1439
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1329
                     /gene="Ntf3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
     exon            1..190
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
     exon            191..1304
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..988
                     /gene="Ntf3"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 4; HDNF; NT-3; NGF-2; neurotrophic factor; nerve
                     growth factor 2; neurotrophin-3 (HDNF/NT-3)"
                     /codon_start=1
                     /product="neurotrophin-3 isoform 3 precursor"
                     /protein_id="NP_001257799.1"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
                     /translation="MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADIL
                     KNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATDTELLRQQRRYNSP
                     RVLLSDSTPLEPPPLYLMEDYVGNPVVTNRTSPRRKRYAEHKSHRGEYSVCDSESLWV
                     TDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQC
                     KTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
ORIGIN      
        1 tggcagggtg aaggggaaaa ctctgcagcc ggatcggatc ccgaggaaga agatattttg
       61 gccggaggga agcctttgaa ggagaaccca gcccttttga gggaccattc gaggtgacgt
      121 ccttgggcct ctgtgggtgc tgcaggccat tttcgatgtg gcagcccccg tcagccagga
      181 taatgatgag atcttacagg tgaacaaggt gatgtccatc ttgttttatg tgatatttct
      241 tgcttatctc cgtggcatcc aaggcaacaa catggatcaa aggagtttgc cagaagactc
      301 tctcaattcc ctcattatca agttgatcca ggcggatatc ttgaaaaaca agctctccaa
      361 gcagatggta gatgttaagg aaaattacca gagcaccctg cccaaagcag aggcacccag
      421 agaaccagag cagggagagg ccaccaggtc agaattccag ccgatgattg caacagacac
      481 agaactacta cggcaacaga gacgctacaa ttcaccccgg gtcctgctga gtgacagcac
      541 ccctttggag ccccctccct tatatctaat ggaagattat gtgggcaacc cggtggtaac
      601 caatagaaca tcaccacgga ggaaacgcta tgcagagcat aagagtcacc gaggagagta
      661 ctcagtgtgt gacagtgaga gcctgtgggt gaccgacaag tcctcagcca ttgacattcg
      721 gggacaccag gttacagtgt tgggagagat caaaaccggc aactctcctg tgaaacaata
      781 tttttatgaa acgaggtgta aagaagccag gccagtcaaa aacggttgca gggggattga
      841 tgacaaacac tggaactctc agtgcaaaac gtcgcaaacc tacgtccgag cactgacttc
      901 agaaaacaac aaactcgtag gctggcgctg gatacgaata gacacttcct gtgtgtgtgc
      961 cttgtcaaga aaaatcggaa gaacatgaat tggcatctgt ccccacatat aaattattac
     1021 tttaaattat atgatatgca tgtagcatat aaatgtttat attgttttta tatattataa
     1081 gttgaccttt atttattaaa cttcagcaac ccttacagta tataagcttt tttttctcaa
     1141 taaaattcgt gtgcttgcct tcgctcaggc ctctcccatc tgttaacctt gttttgtgat
     1201 tgggctctcg ggaacccttc tgtaaaacct gtgtacacca gtatttggca ttcagtattg
     1261 tcaaggccat gactgtggtt tcagtaaact ttcttaaaat cggaaaaaaa aaaaaaaaaa
     1321 aaaaaaaaa
//
