LOCUS       NM_001270869            1357 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neurotrophin 3 (Ntf3), transcript variant 2,
            mRNA.
ACCESSION   NM_001270869
VERSION     NM_001270869.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Briones-Vidal,M.G., Reyes-Garcia,S.E. and Escobar,M.L.
  TITLE     Neurotrophin-3 into the insular cortex strengthens conditioned
            taste aversion memory
  JOURNAL   Behav Brain Res 461, 114857 (2024)
   PUBMED   38211776
  REMARK    GeneRIF: Neurotrophin-3 into the insular cortex strengthens
            conditioned taste aversion memory.
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Zou,D., Wang,H., Hao,S. and Chen,F.
  TITLE     Repair effect of neurotrophic factor III (NT-3) on rats with spinal
            injury model and its mechanism
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 56-61 (2024)
   PUBMED   38372112
  REMARK    GeneRIF: Repair effect of neurotrophic factor III (NT-3) on rats
            with spinal injury model and its mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Yang,Y., Xu,H.Y., Deng,Q.W., Wu,G.H., Zeng,X., Jin,H., Wang,L.J.,
            Lai,B.Q., Li,G., Ma,Y.H., Jiang,B., Ruan,J.W., Wang,Y.Q., Ding,Y.
            and Zeng,Y.S.
  TITLE     Electroacupuncture facilitates the integration of a grafted
            TrkC-modified mesenchymal stem cell-derived neural network into
            transected spinal cord in rats via increasing neurotrophin-3
  JOURNAL   CNS Neurosci Ther 27 (7), 776-791 (2021)
   PUBMED   33763978
  REMARK    GeneRIF: Electroacupuncture facilitates the integration of a
            grafted TrkC-modified mesenchymal stem cell-derived neural network
            into transected spinal cord in rats via increasing neurotrophin-3.
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Xu,H., Yang,Y., Deng,Q.W., Zhang,B.B., Ruan,J.W., Jin,H.,
            Wang,J.H., Ren,J., Jiang,B., Sun,J.H., Zeng,Y.S. and Ding,Y.
  TITLE     Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth
            Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury
  JOURNAL   J Neurotrauma 38 (6), 734-745 (2021)
   PUBMED   33121345
  REMARK    GeneRIF: Governor Vessel Electro-Acupuncture Promotes the Intrinsic
            Growth Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury.
REFERENCE   5  (bases 1 to 1357)
  AUTHORS   Donsante,A., Xue,J., Poth,K.M., Hardcastle,N.S., Diniz,B.,
            O'Connor,D.M., Xia,Y. and Boulis,N.M.
  TITLE     Controlling the Release of Neurotrophin-3 and Chondroitinase ABC
            Enhances the Efficacy of Nerve Guidance Conduits
  JOURNAL   Adv Healthc Mater 9 (14), e2000200 (2020)
   PUBMED   32548984
  REMARK    GeneRIF: Controlling the Release of Neurotrophin-3 and
            Chondroitinase ABC Enhances the Efficacy of Nerve Guidance
            Conduits.
REFERENCE   6  (bases 1 to 1357)
  AUTHORS   Smith,M.A., Makino,S., Altemus,M., Michelson,D., Hong,S.K.,
            Kvetnansky,R. and Post,R.M.
  TITLE     Stress and antidepressants differentially regulate neurotrophin 3
            mRNA expression in the locus coeruleus
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8788-8792 (1995)
   PUBMED   7568018
REFERENCE   7  (bases 1 to 1357)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   8  (bases 1 to 1357)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   9  (bases 1 to 1357)
  AUTHORS   Ernfors,P., Ibanez,C.F., Ebendal,T., Olson,L. and Persson,H.
  TITLE     Molecular cloning and neurotrophic activities of a protein with
            structural similarities to nerve growth factor: developmental and
            topographical expression in the brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5454-5458 (1990)
   PUBMED   2164684
REFERENCE   10 (bases 1 to 1357)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Squinto,S., Ip,N.Y., Furth,M.E.,
            Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
  JOURNAL   Science 247 (4949 Pt 1), 1446-1451 (1990)
   PUBMED   2321006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, FM101680.1, M34643.1 and BC070504.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM101680.1, FM080103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000004.1  160668760-160668907 c
            149-669             FM101680.1         148-668
            670-1159            M34643.1           503-992
            1160-1357           BC070504.1         1242-1439
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1357
                     /gene="Ntf3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
     exon            1..218
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1016
                     /gene="Ntf3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; HDNF; NT-3; NGF-2; neurotrophic factor; nerve
                     growth factor 2; neurotrophin-3 (HDNF/NT-3)"
                     /codon_start=1
                     /product="neurotrophin-3 isoform 1 precursor"
                     /protein_id="NP_001257798.1"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
                     /translation="MVTSATILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSL
                     NSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATD
                     TELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGNPVVTNRTSPRRKRYAEHKSHR
                     GEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNG
                     CRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     exon            219..1332
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcctctcc ttacccagca tctccgcgca ccgccccgcg agatagcccg gcgcaacttt
       61 cttccctctt tctttcttcc tcccgttttt ttcccaccgc tgggtagtgg ctgcggcagg
      121 ggtgggcgag actgaatgac cgaactcgag tccacctttc tcttcatgtc gacgtccctg
      181 gaaatagtca tacggatgcc atggttactt ctgccacgat cttacaggtg aacaaggtga
      241 tgtccatctt gttttatgtg atatttcttg cttatctccg tggcatccaa ggcaacaaca
      301 tggatcaaag gagtttgcca gaagactctc tcaattccct cattatcaag ttgatccagg
      361 cggatatctt gaaaaacaag ctctccaagc agatggtaga tgttaaggaa aattaccaga
      421 gcaccctgcc caaagcagag gcacccagag aaccagagca gggagaggcc accaggtcag
      481 aattccagcc gatgattgca acagacacag aactactacg gcaacagaga cgctacaatt
      541 caccccgggt cctgctgagt gacagcaccc ctttggagcc ccctccctta tatctaatgg
      601 aagattatgt gggcaacccg gtggtaacca atagaacatc accacggagg aaacgctatg
      661 cagagcataa gagtcaccga ggagagtact cagtgtgtga cagtgagagc ctgtgggtga
      721 ccgacaagtc ctcagccatt gacattcggg gacaccaggt tacagtgttg ggagagatca
      781 aaaccggcaa ctctcctgtg aaacaatatt tttatgaaac gaggtgtaaa gaagccaggc
      841 cagtcaaaaa cggttgcagg gggattgatg acaaacactg gaactctcag tgcaaaacgt
      901 cgcaaaccta cgtccgagca ctgacttcag aaaacaacaa actcgtaggc tggcgctgga
      961 tacgaataga cacttcctgt gtgtgtgcct tgtcaagaaa aatcggaaga acatgaattg
     1021 gcatctgtcc ccacatataa attattactt taaattatat gatatgcatg tagcatataa
     1081 atgtttatat tgtttttata tattataagt tgacctttat ttattaaact tcagcaaccc
     1141 ttacagtata taagcttttt tttctcaata aaattcgtgt gcttgccttc gctcaggcct
     1201 ctcccatctg ttaaccttgt tttgtgattg ggctctcggg aacccttctg taaaacctgt
     1261 gtacaccagt atttggcatt cagtattgtc aaggccatga ctgtggtttc agtaaacttt
     1321 cttaaaatcg gaaaaaaaaa aaaaaaaaaa aaaaaaa
//
