LOCUS       NM_001270868            1395 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus neurotrophin 3 (Ntf3), transcript variant 3,
            mRNA.
ACCESSION   NM_001270868
VERSION     NM_001270868.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Briones-Vidal,M.G., Reyes-Garcia,S.E. and Escobar,M.L.
  TITLE     Neurotrophin-3 into the insular cortex strengthens conditioned
            taste aversion memory
  JOURNAL   Behav Brain Res 461, 114857 (2024)
   PUBMED   38211776
  REMARK    GeneRIF: Neurotrophin-3 into the insular cortex strengthens
            conditioned taste aversion memory.
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Zou,D., Wang,H., Hao,S. and Chen,F.
  TITLE     Repair effect of neurotrophic factor III (NT-3) on rats with spinal
            injury model and its mechanism
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 56-61 (2024)
   PUBMED   38372112
  REMARK    GeneRIF: Repair effect of neurotrophic factor III (NT-3) on rats
            with spinal injury model and its mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Yang,Y., Xu,H.Y., Deng,Q.W., Wu,G.H., Zeng,X., Jin,H., Wang,L.J.,
            Lai,B.Q., Li,G., Ma,Y.H., Jiang,B., Ruan,J.W., Wang,Y.Q., Ding,Y.
            and Zeng,Y.S.
  TITLE     Electroacupuncture facilitates the integration of a grafted
            TrkC-modified mesenchymal stem cell-derived neural network into
            transected spinal cord in rats via increasing neurotrophin-3
  JOURNAL   CNS Neurosci Ther 27 (7), 776-791 (2021)
   PUBMED   33763978
  REMARK    GeneRIF: Electroacupuncture facilitates the integration of a
            grafted TrkC-modified mesenchymal stem cell-derived neural network
            into transected spinal cord in rats via increasing neurotrophin-3.
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Xu,H., Yang,Y., Deng,Q.W., Zhang,B.B., Ruan,J.W., Jin,H.,
            Wang,J.H., Ren,J., Jiang,B., Sun,J.H., Zeng,Y.S. and Ding,Y.
  TITLE     Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth
            Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury
  JOURNAL   J Neurotrauma 38 (6), 734-745 (2021)
   PUBMED   33121345
  REMARK    GeneRIF: Governor Vessel Electro-Acupuncture Promotes the Intrinsic
            Growth Ability of Spinal Neurons through Activating Calcitonin
            Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein
            Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury.
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Donsante,A., Xue,J., Poth,K.M., Hardcastle,N.S., Diniz,B.,
            O'Connor,D.M., Xia,Y. and Boulis,N.M.
  TITLE     Controlling the Release of Neurotrophin-3 and Chondroitinase ABC
            Enhances the Efficacy of Nerve Guidance Conduits
  JOURNAL   Adv Healthc Mater 9 (14), e2000200 (2020)
   PUBMED   32548984
  REMARK    GeneRIF: Controlling the Release of Neurotrophin-3 and
            Chondroitinase ABC Enhances the Efficacy of Nerve Guidance
            Conduits.
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Smith,M.A., Makino,S., Altemus,M., Michelson,D., Hong,S.K.,
            Kvetnansky,R. and Post,R.M.
  TITLE     Stress and antidepressants differentially regulate neurotrophin 3
            mRNA expression in the locus coeruleus
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8788-8792 (1995)
   PUBMED   7568018
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Maisonpierre,P.C., Le Beau,M.M., Espinosa,R. 3rd, Ip,N.Y.,
            Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
            Yancopoulos,G.D.
  TITLE     Human and rat brain-derived neurotrophic factor and neurotrophin-3:
            gene structures, distributions, and chromosomal localizations
  JOURNAL   Genomics 10 (3), 558-568 (1991)
   PUBMED   1889806
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Ernfors,P., Ibanez,C.F., Ebendal,T., Olson,L. and Persson,H.
  TITLE     Molecular cloning and neurotrophic activities of a protein with
            structural similarities to nerve growth factor: developmental and
            topographical expression in the brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (14), 5454-5458 (1990)
   PUBMED   2164684
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Maisonpierre,P.C., Belluscio,L., Squinto,S., Ip,N.Y., Furth,M.E.,
            Lindsay,R.M. and Yancopoulos,G.D.
  TITLE     Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
  JOURNAL   Science 247 (4949 Pt 1), 1446-1451 (1990)
   PUBMED   2321006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, FM074856.1, M34643.1 and BC070504.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The resulting isoform (2) is
            of the same size but has a distinct N-terminus, compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM074856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680421, SAMN06680441
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000004.1  160668892-160668907 c
            17-599              FM074856.1         16-598
            600-1197            M34643.1           395-992
            1198-1395           BC070504.1         1242-1439
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1395
                     /gene="Ntf3"
                     /note="neurotrophin 3"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
     exon            1..218
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
     exon            219..256
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1054
                     /gene="Ntf3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; HDNF; NT-3; NGF-2; neurotrophic factor; nerve
                     growth factor 2; neurotrophin-3 (HDNF/NT-3)"
                     /codon_start=1
                     /product="neurotrophin-3 isoform 2 precursor"
                     /protein_id="NP_001257797.1"
                     /db_xref="GeneID:81737"
                     /db_xref="RGD:619728"
                     /translation="MLGFLKILQVNKVMSILFYVIFLAYLRGIQGNNMDQRSLPEDSL
                     NSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPEQGEATRSEFQPMIATD
                     TELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGNPVVTNRTSPRRKRYAEHKSHR
                     GEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNG
                     CRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT"
     exon            257..1370
                     /gene="Ntf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcctctcc ttacccagca tctccgcgca ccgccccgcg agatagcccg gcgcaacttt
       61 cttccctctt tctttcttcc tcccgttttt ttcccaccgc tgggtagtgg ctgcggcagg
      121 ggtgggcgag actgaatgac cgaactcgag tccacctttc tcttcatgtc gacgtccctg
      181 gaaatagtca tacggatgcc atggttactt ctgccacggc tcaacacccc tgccacggat
      241 gctgggcttc ctgaagatct tacaggtgaa caaggtgatg tccatcttgt tttatgtgat
      301 atttcttgct tatctccgtg gcatccaagg caacaacatg gatcaaagga gtttgccaga
      361 agactctctc aattccctca ttatcaagtt gatccaggcg gatatcttga aaaacaagct
      421 ctccaagcag atggtagatg ttaaggaaaa ttaccagagc accctgccca aagcagaggc
      481 acccagagaa ccagagcagg gagaggccac caggtcagaa ttccagccga tgattgcaac
      541 agacacagaa ctactacggc aacagagacg ctacaattca ccccgggtcc tgctgagtga
      601 cagcacccct ttggagcccc ctcccttata tctaatggaa gattatgtgg gcaacccggt
      661 ggtaaccaat agaacatcac cacggaggaa acgctatgca gagcataaga gtcaccgagg
      721 agagtactca gtgtgtgaca gtgagagcct gtgggtgacc gacaagtcct cagccattga
      781 cattcgggga caccaggtta cagtgttggg agagatcaaa accggcaact ctcctgtgaa
      841 acaatatttt tatgaaacga ggtgtaaaga agccaggcca gtcaaaaacg gttgcagggg
      901 gattgatgac aaacactgga actctcagtg caaaacgtcg caaacctacg tccgagcact
      961 gacttcagaa aacaacaaac tcgtaggctg gcgctggata cgaatagaca cttcctgtgt
     1021 gtgtgccttg tcaagaaaaa tcggaagaac atgaattggc atctgtcccc acatataaat
     1081 tattacttta aattatatga tatgcatgta gcatataaat gtttatattg tttttatata
     1141 ttataagttg acctttattt attaaacttc agcaaccctt acagtatata agcttttttt
     1201 tctcaataaa attcgtgtgc ttgccttcgc tcaggcctct cccatctgtt aaccttgttt
     1261 tgtgattggg ctctcgggaa cccttctgta aaacctgtgt acaccagtat ttggcattca
     1321 gtattgtcaa ggccatgact gtggtttcag taaactttct taaaatcgga aaaaaaaaaa
     1381 aaaaaaaaaa aaaaa
//
