LOCUS       NM_001009271            1822 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus 5'-nucleotidase domain containing 2 (Nt5dc2),
            mRNA.
ACCESSION   NM_001009271 XM_214258
VERSION     NM_001009271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Yamaguchi,H., Hara,S., Ichinose,H., Nagasaki,H. and Nakashima,A.
  TITLE     Role of NT5DC2 in tyrosine hydroxylase phosphorylation based on the
            analysis of NT5DC2-binding proteins
  JOURNAL   Biochem Biophys Res Commun 703, 149698 (2024)
   PUBMED   38382359
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Nakashima,A., Yamaguchi,H., Kodani,Y., Kaneko,Y.S., Kawata,M.,
            Nagasaki,H., Nagatsu,T. and Ota,A.
  TITLE     Identification by nano-LC-MS/MS of NT5DC2 as a protein binding to
            tyrosine hydroxylase: Down-regulation of NT5DC2 by siRNA increases
            catecholamine synthesis in PC12D cells
  JOURNAL   Biochem Biophys Res Commun 516 (4), 1060-1065 (2019)
   PUBMED   31279527
  REMARK    GeneRIF: These results indicate that NT5DC2 inhibited the synthesis
            of dopamine by decreasing the enzymatic activity of tyrosine
            hydroxylase.
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088431.1.
            
            On Jan 7, 2005 this sequence version replaced XM_214258.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088431.1, AY569011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1822
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /note="5'-nucleotidase domain containing 2"
                     /db_xref="GeneID:290558"
                     /db_xref="RGD:1305524"
     exon            1..278
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1720
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /EC_number="3.1.3.5"
                     /note="eye irido-corneal angle unknown protein"
                     /codon_start=1
                     /product="5'-nucleotidase domain-containing protein 2"
                     /protein_id="NP_001009271.1"
                     /db_xref="GeneID:290558"
                     /db_xref="RGD:1305524"
                     /translation="MAGAGLRAAARRWLLCGGQGGPRAASSSPSCPGCGPPGPGAHCP
                     STPRSAPADGADLSAHLWARYQDMRRLVHDLLPPEVCSLLNPAAIYANNEISLSDVEV
                     YGFDYDYTLAQYADALHPEIFSAARDILIEHYKYPEGIRKYDYDPSFAIRGLHYDIQK
                     SLLMKIDAFHYVQLGTAYRGLQPVPDDEVVDLYGGTQHIPLYQMSGFYGKGPSIKQFM
                     DIFSLPEMALLSCVVDYFLGHGLEFDQVHLYKDVTDAIRDVHVKGLMYQWIEQDMEKY
                     ILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKP
                     NFFTDRRKPFRKLDEKGSLHWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDH
                     LYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDA
                     ESRQVLATWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSC
                     LLNYSVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR"
     exon            279..463
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            464..538
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            539..594
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            595..688
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            689..817
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            818..878
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            879..981
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1083
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1165
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1252
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1393
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1458
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1798
                     /gene="Nt5dc2"
                     /gene_synonym="RGD1305524"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgggcag gcgggtcagc ggacgggcgg agggcggccg gggcagcgcg cagggggcat
       61 ggcgggtgcg ggactgcggg cggcagctag gcgctggctg ctgtgcggag gccagggcgg
      121 accgcgggcc gcctcgtcct caccctcctg ccctggctgc ggcccgccgg gtcccggagc
      181 ccactgcccc agcaccccgc gctcggcgcc cgcagacggc gcggacctca gcgcgcactt
      241 gtgggctcgt taccaggaca tgcggaggct ggtgcacgac cttctgcccc ctgaggtctg
      301 cagcctctta aacccagcag ccatctatgc caacaatgag atcagcctga gcgacgtcga
      361 agtctacggc tttgactacg actacacgct ggcccagtac gcagacgcac tgcaccctga
      421 gatcttcagt gctgcccggg acatcttgat agagcactac aagtatcctg agggaattcg
      481 gaagtacgac tatgacccca gctttgccat ccgcggtctc cactacgaca ttcagaagag
      541 tcttctgatg aagattgatg ctttccatta tgtacaactg ggaacagcct acaggggcct
      601 ccagcctgtg cccgatgatg aggtggttga cctgtacggt ggcacccagc acatcccact
      661 ctaccagatg agcggcttct acggcaaggg cccttctatc aagcaattca tggacatctt
      721 ctcactccca gagatggctc tgctgtcttg tgtggtggac tactttctgg gccacggcct
      781 agagtttgac caagtacacc tctacaagga cgtgacggat gccatccggg atgtgcatgt
      841 gaaaggcctc atgtaccagt ggattgagca agacatggag aagtacatcc tgagagggga
      901 tgaaacattt gcggtcctga gccgcctggt ggcccatggg aaacagctgt tcctcattac
      961 caacagtccc ttcagctttg tggacaaagg gatgcggcac atggtgggtc ccgattggcg
     1021 ccaactcttc gatgtggtca tcgtgcaggc agacaagccc aactttttca ctgaccggcg
     1081 caagcctttc cgtaagcttg acgagaaggg ctccctccac tgggaccgga tcactcgctt
     1141 agaaaagggc aagatctatc ggcagggaaa cctgtttgat tttcttcgtc tgactgaatg
     1201 gcgagggcca cgtgtgctct acttcggtga ccacctttac agtgacctgg cggatctcat
     1261 gctgcggcac ggctggcgca cgggagccat catccctgag ctggagcgcg agatccgcat
     1321 catcaacaca gaacagtaca tgcactcgct gacctggcag caggctctca cggggctgct
     1381 ggaacgcatg cagacttatc aggatgctga gtcacggcag gtgctggcta cctggatgaa
     1441 ggagcggcaa gagctgaggt gcatcacgaa ggccctgttc aacgctcagt ttgggagcat
     1501 cttccgcacc ttccacaacc ccacctactt ctccaggcgt ctcgtgcgct tctctgacct
     1561 ctacatggcc tctctcagct gcttgctcaa ctacagtgta gacttcacgt tctacccacg
     1621 ccgcacacct ctgcagcatg aggcgcccct ctggatggac cagctgtgca ccggctgcat
     1681 gaagacaccc tttcttggtg acatggccca catccgctga gggcgctttt attgtcctgg
     1741 acaaactatc ggcctttcag ccaccctgac aaacaataaa agtagtctgt gtcgtccaaa
     1801 aaaaaaaaaa aaaaaaaaaa aa
//
