LOCUS       NM_001398841            1640 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus 5'-nucleotidase, cytosolic IIIA (Nt5c3a),
            transcript variant 1, mRNA.
ACCESSION   NM_001398841 XM_006236552
VERSION     NM_001398841.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554. PMID: 26153858]
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Mackiewicz,M., Nikonova,E.V., Zimmerman,J.E., Galante,R.J.,
            Zhang,L., Cater,J.R., Geiger,J.D. and Pack,A.I.
  TITLE     Enzymes of adenosine metabolism in the brain: diurnal rhythm and
            the effect of sleep deprivation
  JOURNAL   J Neurochem 85 (2), 348-357 (2003)
   PUBMED   12675911
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Amici,A. and Magni,G.
  TITLE     Human erythrocyte pyrimidine 5'-nucleotidase, PN-I
  JOURNAL   Arch Biochem Biophys 397 (2), 184-190 (2002)
   PUBMED   11795870
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Amici,A., Emanuelli,M., Raffaelli,N., Ruggieri,S., Saccucci,F. and
            Magni,G.
  TITLE     Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to
            p36, a protein associated to lupus inclusion formation in response
            to alpha-interferon
  JOURNAL   Blood 96 (4), 1596-1598 (2000)
   PUBMED   10942414
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Amici,A., Emanuelli,M., Magni,G., Raffaelli,N. and Ruggieri,S.
  TITLE     Pyrimidine nucleotidases from human erythrocyte possess
            phosphotransferase activities specific for pyrimidine nucleotides
  JOURNAL   FEBS Lett 419 (2-3), 263-267 (1997)
   PUBMED   9428647
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Rich,S.A., Bose,M., Tempst,P. and Rudofsky,U.H.
  TITLE     Purification, microsequencing, and immunolocalization of p36, a new
            interferon-alpha-induced protein that is associated with human
            lupus inclusions
  JOURNAL   J Biol Chem 271 (2), 1118-1126 (1996)
   PUBMED   8557639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 27, 2021 this sequence version replaced XM_006236552.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.18037.1,
                                           SRR26360172.719775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000004.1  87534604-87534838   c
            236-334             JAXUCZ010000004.1  87502637-87502735   c
            335-404             JAXUCZ010000004.1  87501384-87501453   c
            405-451             JAXUCZ010000004.1  87499457-87499503   c
            452-537             JAXUCZ010000004.1  87498292-87498377   c
            538-627             JAXUCZ010000004.1  87496787-87496876   c
            628-790             JAXUCZ010000004.1  87494396-87494558   c
            791-991             JAXUCZ010000004.1  87493102-87493302   c
            992-1640            JAXUCZ010000004.1  87491828-87492476   c
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1640
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /note="5'-nucleotidase, cytosolic IIIA"
                     /db_xref="GeneID:312373"
                     /db_xref="RGD:1312013"
     exon            1..235
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1093
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic 5'-nucleotidase 3; 5'-nucleotidase, cytosolic
                     III; cytosolic 5'-nucleotidase 3A"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 3A isoform 1"
                     /protein_id="NP_001385770.1"
                     /db_xref="GeneID:312373"
                     /db_xref="RGD:1312013"
                     /translation="MDRAAVARVGAVASASVCAVVAGVVLAQYIFTLKRKTGRKTKII
                     EMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYNGKRCPTCH
                     NIIDNCKLVTDECRRKLLQLKEQYYAIEVDPVLTVEEKFPYMVEWYTKSHGLLIEQGI
                     PKAKLKEIVADSDVMLKEGYENFFGKLQQHGIPVFIFSAGIGDVLEEVIRQAGVYHSN
                     VKVVSNFMDFDENGVLKGFKGELIHVFNKHDGALKNTDYFSQLKDNSNIILLGDSQGD
                     LRMADGVANVEHILKIGYLNDRVDELLEKYMDSYDIVLVKEESLEVVNSILQKTL"
     exon            236..334
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..404
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            405..451
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..537
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..627
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..790
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..991
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1640
                     /gene="Nt5c3a"
                     /gene_synonym="Nt5c3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggggc tccgggctag tgtgcggctt acggccgcgc ccctgggctc gtacccgcgg
       61 ctcctgggct ttcgcgccga gagcacgcgg gccttcaatg gaccgcgcgg ccgtggcgcg
      121 agtgggcgcg gtggcgagcg ccagtgtgtg cgcggtggtg gcgggcgtgg tgctggccca
      181 gtacatattc accttgaaga gaaagacggg ccgcaagacc aagatcatcg aaatgatgcc
      241 agaatttcag aaaagctcag ttcgtatcaa gaacccaacg agagtagaag aaattatctg
      301 tggtctcatt aaaggaggcg ctgccaaact tcagataata accgactttg atatgactct
      361 aagtaggttc tcctacaatg ggaaaagatg cccaacatgt cataatatca ttgacaactg
      421 taagctcgtt acagatgaat gtcgaagaaa gttactgcag ctaaaggagc agtactacgc
      481 tattgaggtt gatcctgttc tcaccgtgga agagaagttc ccttacatgg tagaatggta
      541 taccaaatcg catggtttgc ttattgaaca aggcatacca aaagctaaac ttaaagagat
      601 tgtggctgac tctgatgtca tgctcaagga aggatatgag aatttcttcg gtaaacttca
      661 acagcacggt atccctgtgt tcatattttc ggctggtatc ggtgacgtac ttgaagaagt
      721 tatccggcag gctggagttt atcactcaaa cgtcaaagta gtgtctaact tcatggattt
      781 tgatgaaaat ggagtgctga aaggattcaa aggagagcta attcatgtat tcaacaaaca
      841 tgatggtgcc ctgaagaata cagactactt cagccaactg aaagacaaca gcaacatcat
      901 tctgctgggg gactcccaag gagacttaag gatggccgat ggtgtagcca acgtcgaaca
      961 cattctgaaa attggttatc tgaatgacag agtagacgag cttttagaaa aatacatgga
     1021 ctcttatgat attgttttag taaaagaaga atcactggag gttgtcaact ctattttaca
     1081 gaagacatta taaacaagcc actgtggaag acttctccca ggggtacacc tgaatcaggc
     1141 attgtccctc ttgaggaaag actcttattt ataaaacagt cttgctcctg gtttccccct
     1201 ttcccccaac aaaggatctt gagtcgtgtg gaacctgtga accgcagccc ctcttccggc
     1261 ctccgtcact gtactcacca gatttttttt aaataattaa aaatgatctt aaggccaaga
     1321 ttaaaagaat agctcccctt tgcaaagtga attttggttt ggtgttctgc agtgtccggg
     1381 cactcccagg tgagtgtgga ggtgcacagg acgctgtcta ggcacatggc gtcctgattt
     1441 taaccactgc tagcttcgta attggggtgg actgtggccg tatcagctcc tgaaattgtg
     1501 ttttatttgg ttattttgtc tggaaaaaat attttccagg aagttgtatc tgaaaacctg
     1561 ttggtatcca catcattaac attataaata ctctgtgtga agcactgaaa ataaacccaa
     1621 aatggaaagc ttttttaaga
//
