LOCUS       NM_001107976            1156 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus 5'-nucleotidase, cytosolic IA (Nt5c1a), mRNA.
ACCESSION   NM_001107976 XM_001055008 XM_233494
VERSION     NM_001107976.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A and
            Zierath JR.
  TITLE     Suppression of 5'-nucleotidase enzymes promotes AMP-activated
            protein kinase (AMPK) phosphorylation and metabolism in human and
            mouse skeletal muscle
  JOURNAL   J Biol Chem 286 (40), 34567-34574 (2011)
   PUBMED   21873433
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Kaizer RR, Maldonado PA, Spanevello RM, Correa MC, Goncalves JF,
            Becker LV, Morsch VM and Schetinger MR.
  TITLE     The effect of aluminium on NTPDase and 5'-nucleotidase activities
            from rat synaptosomes and platelets
  JOURNAL   Int J Dev Neurosci 25 (6), 381-386 (2007)
   PUBMED   17686601
  REMARK    GeneRIF: Al increases NTPDase and 5'-nucleotidase activities, in
            synaptosomal fractions and platelets. Thus, we suggest that
            platelets could be sensitive peripheral markers of Al toxicity of
            the central nervous system.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Mackiewicz M, Nikonova EV, Zimmerman JE, Galante RJ, Zhang L, Cater
            JR, Geiger JD and Pack AI.
  TITLE     Enzymes of adenosine metabolism in the brain: diurnal rhythm and
            the effect of sleep deprivation
  JOURNAL   J Neurochem 85 (2), 348-357 (2003)
   PUBMED   12675911
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Hunsucker SA, Spychala J and Mitchell BS.
  TITLE     Human cytosolic 5'-nucleotidase I: characterization and role in
            nucleoside analog resistance
  JOURNAL   J Biol Chem 276 (13), 10498-10504 (2001)
   PUBMED   11133996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233494.4, XM_001055008.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1156
                     /gene="Nt5c1a"
                     /note="5'-nucleotidase, cytosolic IA"
                     /db_xref="GeneID:313574"
                     /db_xref="RGD:1310908"
     exon            1..193
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1156
                     /gene="Nt5c1a"
                     /EC_number="3.1.3.5"
                     /codon_start=1
                     /product="cytosolic 5'-nucleotidase 1A"
                     /protein_id="NP_001101446.1"
                     /db_xref="GeneID:313574"
                     /db_xref="RGD:1310908"
                     /translation="MEPRQPPEAREPGPGAETAAVPRWEEAKTFYDNLSPKKKPKSPK
                     PQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEA
                     VNKQLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYL
                     KAYHTNLYLSADAEKVREAIDEGIAAATIFSPSKDVVVSQSQLRVAFDGDAVLFSDES
                     ERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYL
                     VTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGA
                     QEMGTVAAHVPYGVAQNPRREKQSLGAQ"
     exon            194..361
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            362..491
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            492..614
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            615..799
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1156
                     /gene="Nt5c1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccttgag ctccctgtct ccgacgctgt cttctcccgc ccggccggat cggatccgag
       61 ccggaacatg gaaccaaggc agcccccgga ggcccgagaa cccggaccag gggcagagac
      121 cgccgcggtg ccgcgctggg aggaagccaa gacgttctat gacaatctct cgcccaagaa
      181 gaaacccaaa tcgccaaagc ctcagaatgc ggtcaccatc gcagtgtcct ccagagcctt
      241 gttccgaatg gatgaggaac agaggatcta cacggagcag ggtgtagagg agtacgtacg
      301 ataccagctg gagcacgaga acgagccctt cagccctggg cccgccttcc cctttgtaaa
      361 ggccctggag gctgtgaaca agcaacttcg agagctgtac cccgatagcg aagatatctt
      421 tgacatcgtc ctcatgacca acaaccatgc tcaggtgggg gttcgtctca tcaacagtat
      481 caaccattac gacctgttca ttgagcgatt ctgcatgaca ggtgggaata gccccatctg
      541 ctacctcaag gcctaccata ccaacctcta cttgtcagcc gatgcagaaa aagtgcgaga
      601 agccattgat gaggggattg cagctgccac catcttcagc cctagcaagg atgtggtcgt
      661 gtcccagagt cagctccgcg tggccttcga tggggacgca gtacttttct ccgatgagtc
      721 agagcgcatt gtcaaggccc atgggctgga cagattcttt gagcatgaga aggcccacga
      781 gaacaaacct ttggcgcagg gtcccctaaa gggcttcctg gaagcactag gtaggctgca
      841 gaagaaattc tactccaaag gcctgcggct ggagtgcccg attcgtactt acttggtgac
      901 agcgcgcagc gcagccagtt ctggagcccg ggccctcaag accctacgta gctggggcct
      961 ggagacggat gaggccttat tcctagctgg agcacccaag ggccctcttc ttgagaagat
     1021 ccgcccacac atcttctttg atgaccagat gtttcacgtg gccggagctc aggagatggg
     1081 caccgtggcc gcccacgtgc cttacggcgt agctcagaat ccacggaggg aaaagcagtc
     1141 cctaggcgca cagtag
//
