LOCUS       NM_001271189             826 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus 5', 3'-nucleotidase, cytosolic (Nt5c), mRNA.
ACCESSION   NM_001271189 XM_003750961 XM_003752395
VERSION     NM_001271189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 826)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 826)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 826)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 826)
  AUTHORS   Rampazzo,C., Kost-Alimova,M., Ruzzenente,B., Dumanski,J.P. and
            Bianchi,V.
  TITLE     Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA
            cloning of the mitochondrial enzyme, gene structures, chromosomal
            mapping and comparison with the human orthologs
  JOURNAL   Gene 294 (1-2), 109-117 (2002)
   PUBMED   12234672
REFERENCE   5  (bases 1 to 826)
  AUTHORS   Rampazzo,C., Johansson,M., Gallinaro,L., Ferraro,P., Hellman,U.,
            Karlsson,A., Reichard,P. and Bianchi,V.
  TITLE     Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and
            overexpression of the enzyme in Escherichia coli and mammalian
            cells
  JOURNAL   J Biol Chem 275 (8), 5409-5415 (2000)
   PUBMED   10681516
REFERENCE   6  (bases 1 to 826)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 826)
  AUTHORS   Hoglund,L. and Reichard,P.
  TITLE     Cytoplasmic 5'(3')-nucleotidase from human placenta
  JOURNAL   J Biol Chem 265 (12), 6589-6595 (1990)
   PUBMED   2157703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ233678.1.
            
            On or before Sep 7, 2012 this sequence version replaced
            XM_003750961.1, XM_003752395.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ233678.1, FQ227491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680451, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               FQ233678.1         1-826
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..826
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /note="5', 3'-nucleotidase, cytosolic"
                     /db_xref="GeneID:100360582"
                     /db_xref="RGD:2321875"
     exon            1..198
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..621
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /EC_number="3.1.3.5"
                     /note="5,3-nucleotidase, cytosolic; uridine
                     5-monophosphate phosphohydrolase 2"
                     /codon_start=1
                     /product="5'(3')-deoxyribonucleotidase, cytosolic type"
                     /protein_id="NP_001258118.1"
                     /db_xref="GeneID:100360582"
                     /db_xref="RGD:2321875"
                     /translation="MAVKRPVRVLVDMDGVLADFESGLLQGFRRRFPGEPHVPLEQRR
                     GFLASEQYGALRPDLAEKVASVYEAPGFFLNLEPIPGALDALREMNAMQDTDVFICTT
                     PLRKYDHCVGEKYRWVEQNLGPQFVERIILTRDKTVVMGDLLIDDKDNIQGLEETPSW
                     EHILFTCCHNQHLALPPTRRRLLSWSDDWRGIIESKRASL"
     exon            199..299
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..360
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..475
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..809
                     /gene="Nt5c"
                     /gene_synonym="Umph2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccccgg gcgtggcaat ggcggtgaag cggccggtgc gcgtgctggt ggacatggac
       61 ggcgtgctag ctgacttcga gtccggcctt ctgcagggtt tccgccgtcg cttccccggg
      121 gaaccgcatg tgccgctgga acagcgccgg ggcttcctcg ccagcgagca gtacggagcc
      181 ctgcggccgg acctggcgga aaaagtggcc agtgtctatg aagctccggg ctttttccta
      241 aacttggagc ccatccctgg agccttggac gctttgcgag agatgaacgc catgcaagac
      301 accgatgtct tcatctgcac caccccactg cggaagtacg accactgtgt gggcgagaag
      361 taccgttggg tggagcagaa cctggggcca cagtttgtgg agcggattat cctgactagg
      421 gacaagacag tggtcatggg agacctgctc attgatgaca aagacaacat tcaaggccta
      481 gaggagaccc caagctggga gcacatcttg ttcacctgct gccacaatca gcacctggcc
      541 ctgcccccca ctaggagacg gctgctttcc tggagtgatg actggagggg catcatagag
      601 agcaagcgag ccagcctgtg aaggacgggg aggtgggtca gcaggaccct gcctggacag
      661 gtgactttaa tcagggagcc acggtaactg ccacttgaac aaactgcctt ccggccccac
      721 ccatgaaatc tacacccaga aggaacaagg ctagcacata aatacagtga gaaaatcagg
      781 tttttaataa aaataaaaac caaacacaaa aaaaaaaaaa aaaaaa
//
