LOCUS       NM_001107367            2063 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus NOP2/Sun RNA methyltransferase 6 (Nsun6), mRNA.
ACCESSION   NM_001107367 XM_001072946 XM_225588
VERSION     NM_001107367.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2063)
  AUTHORS   Liu RJ, Long T, Li J, Li H and Wang ED.
  TITLE     Structural basis for substrate binding and catalytic mechanism of a
            human RNA:m5C methyltransferase NSun6
  JOURNAL   Nucleic Acids Res 45 (11), 6684-6697 (2017)
   PUBMED   28531330
REFERENCE   2  (bases 1 to 2063)
  AUTHORS   Long T, Li J, Li H, Zhou M, Zhou XL, Liu RJ and Wang ED.
  TITLE     Sequence-specific and Shape-selective RNA Recognition by the Human
            RNA 5-Methylcytosine Methyltransferase NSun6
  JOURNAL   J Biol Chem 291 (46), 24293-24303 (2016)
   PUBMED   27703015
REFERENCE   3  (bases 1 to 2063)
  AUTHORS   Haag S, Warda AS, Kretschmer J, Gunnigmann MA, Hobartner C and
            Bohnsack MT.
  TITLE     NSUN6 is a human RNA methyltransferase that catalyzes formation of
            m5C72 in specific tRNAs
  JOURNAL   RNA 21 (9), 1532-1543 (2015)
   PUBMED   26160102
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162024.1.
            
            On Apr 6, 2008 this sequence version replaced NM_001107367.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162024.1, SRR8487230.133842.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2063
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..2063
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /note="NOP2/Sun RNA methyltransferase 6"
                     /db_xref="GeneID:307148"
                     /db_xref="RGD:1309535"
     exon            1..376
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1732
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /note="nucleolar protein (NOL1/NOP2/sun) and PUA domains
                     1; NOL1/NOP2/Sun domain family, member 6; putative
                     methyltransferase NSUN6; NOP2/Sun RNA methyltransferase
                     family member 6"
                     /codon_start=1
                     /product="tRNA (cytosine(72)-C(5))-methyltransferase
                     NSUN6"
                     /protein_id="NP_001100837.1"
                     /db_xref="GeneID:307148"
                     /db_xref="RGD:1309535"
                     /translation="MYVFPKISLRPEVENYLKESFLNEEVVSASSQQEAERNFETLLL
                     RLSHPPLFTTVRVNTHLGSVEHVRGLLLEELQKQFGGSSIPVLQHPALPDVLLIPMTG
                     PRKNIERQQCEVIVGAQCGNAVLRGAHVYVPGVVSASKFMKAGDVVSVYSDIKGKCKK
                     GAKEFDGTKVFLGNGISELSRKDIFNGLPDLKGIGIRMTEPIYLSPSFDNVLSGYIFL
                     QNLPSTVVAHVLDPQPGEKILDLCAAPGGKTTHIAALMRDQGEVIALDKILTKVTKLK
                     QNASLLGLHSIRAFCFDATKALKLEVMDGVDGAPPFLPESFDRILLDAPCSGLGQRPN
                     MACTWTLKEVTSYQPLQRKLLNVAVRLLKPGGVLVYSTCTVTLAENEEQVAWALRTFP
                     CLQLQPQEPQIGGEGMLGAGLSLEQLKQLQRFDPCVVPLESMDTNSLGDARREDVIWL
                     ANKDCIGFFIAKFLKCQSTERKVSRK"
     exon            377..532
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..612
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..722
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..876
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..958
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1078
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1223
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1372
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1498
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..2036
                     /gene="Nsun6"
                     /gene_synonym="Nopd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgactttg tgttccgaag ctggggcgcg gttttggaaa atagtgtgtg ggagtggacg
       61 tgctgttttc ctatctgcac ttaggtacac ttgttaccaa gccgcgtttg gcgcagtgtc
      121 gcagttcgga gctttctcac ggcatccccg agaaggacaa accttgggcc ccgctcactc
      181 cagaactcaa ccccgaaagg cattcttgtg ctcgtccatt ggctgacaac gctgtaattc
      241 ggaaagaaag aaaaagactg ctttccaaca ttttcttgga caattacagc agaaaaaaag
      301 aatgtatgta tttccaaaga tatctttgag acctgaagtt gaaaactatc tcaaagagag
      361 ctttttgaac gaggaggttg tgtctgcttc gagccaacag gaagcagaaa ggaactttga
      421 gactctgctg cttcgcctgt cacaccctcc gttgttcacg actgtcagag tgaatacgca
      481 tttaggctca gttgagcatg tcagaggtct gctgcttgaa gagcttcaga agcagtttgg
      541 tggatccagc attcccgttc ttcagcatcc agccctcccg gatgttctac tcatccccat
      601 gactggacca aggaagaata tagaaagaca acagtgtgaa gtgattgttg gtgcacagtg
      661 tggcaatgca gtattaagag gggcccatgt ctatgttcca ggagttgtat cagcttcaaa
      721 gtttatgaaa gctggagatg tcgtttctgt gtattctgat attaaaggga aatgtaagaa
      781 aggagccaaa gagttcgatg gaactaaagt atttctggga aacggaattt ctgaactaag
      841 ccgcaaagat atcttcaatg ggttacctga tctgaagggt ataggcataa gaatgacaga
      901 acccatatat ctcagtccct catttgacaa tgttctatct ggttatatat ttttacagaa
      961 tttgccatct acggttgtag ctcatgttct tgatcctcaa cctggagaga agattctaga
     1021 tttgtgtgca gcaccagggg gcaaaactac acacattgca gcactgatgc gcgaccaggg
     1081 agaagtaata gcattggaca aaatactgac taaagtgaca aaattaaagc agaatgcttc
     1141 attattagga ctgcattcta tccgggcgtt ttgctttgat gcaacaaagg ctcttaagct
     1201 ggaggtgatg gacggcgtag acggggcacc tccattctta ccagaatctt ttgaccgaat
     1261 tctccttgac gcgccctgca gtggactggg acagaggcca aatatggctt gcacttggac
     1321 tttgaaggaa gtgacatcct atcagccact gcagcgaaaa ctccttaatg tggcggttcg
     1381 actcctgaag ccagggggtg tgctggtcta cagcacgtgc acagtaactc tggcagaaaa
     1441 cgaagagcaa gtcgcctggg ccctcagaac attcccctgc cttcaacttc aaccccagga
     1501 accacagatc ggaggagaag ggatgctggg agctggcctg tcactggagc agctgaaaca
     1561 gctgcagcgc tttgacccgt gtgttgtgcc tctggagagc atggacacga actctcttgg
     1621 agatgccaga agggaagacg tgatttggct agccaacaag gattgtatag gcttctttat
     1681 tgcaaagttt ctaaaatgtc aaagcacaga aaggaaggtt tctcggaaat gaaaatcctg
     1741 aatgctgtct gcgtggtgct gtttcttaca ccaaaatgtt gtcaagccaa cggagtgatg
     1801 gcacggttgc tcaggaaaca ggatatgcta gcagttcccc ggattagaag gggcagtgtg
     1861 tatatgtggc cctgggaaag tgagggctag taaagcaaaa tcagcctcat gtttcctgaa
     1921 agggaaggag gagtcgcctg gggtctggag cacactttca gcactaactc atcagtatta
     1981 gtctttctaa tgtgaaaaaa tagtttaaaa acaaaagaat aaacctctaa accttcaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaa
//
