LOCUS       NM_001191593            1542 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NOP2/Sun RNA methyltransferase 5 (Nsun5), mRNA.
ACCESSION   NM_001191593 XM_213749
VERSION     NM_001191593.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Heissenberger,C., Liendl,L., Nagelreiter,F., Gonskikh,Y., Yang,G.,
            Stelzer,E.M., Krammer,T.L., Micutkova,L., Vogt,S., Kreil,D.P.,
            Sekot,G., Siena,E., Poser,I., Harreither,E., Linder,A., Ehret,V.,
            Helbich,T.H., Grillari-Voglauer,R., Jansen-Durr,P., Kos,M.,
            Polacek,N., Grillari,J. and Schosserer,M.
  TITLE     Loss of the ribosomal RNA methyltransferase NSUN5 impairs global
            protein synthesis and normal growth
  JOURNAL   Nucleic Acids Res 47 (22), 11807-11825 (2019)
   PUBMED   31722427
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Janin,M., Ortiz-Barahona,V., de Moura,M.C., Martinez-Cardus,A.,
            Llinas-Arias,P., Soler,M., Nachmani,D., Pelletier,J., Schumann,U.,
            Calleja-Cervantes,M.E., Moran,S., Guil,S., Bueno-Costa,A.,
            Pineyro,D., Perez-Salvia,M., Rossello-Tortella,M., Pique,L.,
            Bech-Serra,J.J., De La Torre,C., Vidal,A., Martinez-Iniesta,M.,
            Martin-Tejera,J.F., Villanueva,A., Arias,A., Cuartas,I.,
            Aransay,A.M., La Madrid,A.M., Carcaboso,A.M., Santa-Maria,V.,
            Mora,J., Fernandez,A.F., Fraga,M.F., Aldecoa,I., Pedrosa,L.,
            Graus,F., Vidal,N., Martinez-Soler,F., Tortosa,A., Carrato,C.,
            Balana,C., Boudreau,M.W., Hergenrother,P.J., Kotter,P.,
            Entian,K.D., Hench,J., Frank,S., Mansouri,S., Zadeh,G., Dans,P.D.,
            Orozco,M., Thomas,G., Blanco,S., Seoane,J., Preiss,T.,
            Pandolfi,P.P. and Esteller,M.
  TITLE     Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets
            ribosomes to drive a stress adaptive translational program
  JOURNAL   Acta Neuropathol 138 (6), 1053-1074 (2019)
   PUBMED   31428936
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jul 17, 2010 this sequence version replaced XM_213749.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.27944.1,
                                           SRR26643429.42856.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000012.1  26935731-26935823   c
            94-216              JAXUCZ010000012.1  26935500-26935622   c
            217-385             JAXUCZ010000012.1  26934678-26934846   c
            386-494             JAXUCZ010000012.1  26934489-26934597   c
            495-633             JAXUCZ010000012.1  26933085-26933223   c
            634-749             JAXUCZ010000012.1  26932886-26933001   c
            750-928             JAXUCZ010000012.1  26932065-26932243   c
            929-1139            JAXUCZ010000012.1  26931700-26931910   c
            1140-1283           JAXUCZ010000012.1  26931481-26931624   c
            1284-1542           JAXUCZ010000012.1  26930863-26931121   c
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1542
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /note="NOP2/Sun RNA methyltransferase 5"
                     /db_xref="GeneID:288595"
                     /db_xref="RGD:1309268"
     CDS             1..1356
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /note="NOP2/Sun domain family, member 5; NOP2/Sun RNA
                     methyltransferase family member 5; NOL1/NOP2/Sun domain
                     family, member 5; putative methyltransferase NSUN5;
                     probable 28S rRNA (cytosine-C(5))-methyltransferase"
                     /codon_start=1
                     /product="28S rRNA (cytosine-C(5))-methyltransferase"
                     /protein_id="NP_001178522.1"
                     /db_xref="GeneID:288595"
                     /db_xref="RGD:1309268"
                     /translation="MGLYATAAAVLAGVESRQGSLKGLVYSSNFQNLKQLYALVCETQ
                     RYSAVLDAVIASAGLLRAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARL
                     KAELARLKVHRGVSRNEDLLQERPGQAHQVPRFVRVNTLKTCPEDAIDYFKRQGFSYQ
                     GRASSLEDLRTLKGQHFLLDPLLPELLVFPAQTDLHEHPLYRAGHLILQDKASCLPAM
                     LLSPPPGSHVIDACAAPGNKTSYIAALLKNQGKIFAFDQDAKRLAAMATLLARAGVSC
                     CEVAEKDFLTVSPSDQRYGQVQYILLDPSCSGSGMLSRQLEEHGEGTPSKERLQALAG
                     FQQRALCHALRFPSLQRLVYSTCSLCQEENEDVVQEALQQNSGTFRLAPVLPTWPHRG
                     LSTFPGSEHCLRASPETTLTGGFFIAVFERAEVVPSPAPQTSAVVPEPLSKAPKRKRR
                     R"
     exon            1..93
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            94..216
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            217..385
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            386..494
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            495..633
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            634..749
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            750..928
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1139
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1283
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1542
                     /gene="Nsun5"
                     /gene_synonym="RGD1309268"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggctgt acgcgactgc cgctgcggtc ctggccggcg tggaaagccg ccagggctcc
       61 ctcaaggggt tagtgtattc cagcaacttc cagaatctga agcagttgta cgcgctggtg
      121 tgcgagacgc agcgctactc ggccgtgctg gacgccgtga tcgccagcgc cgggctcctt
      181 cgtgctgaga agaagctgcg gccgcatctt gccaaggtgc tagtgtatga attgttgctg
      241 gggaaggggt ttcgaggggg tggaggccga tggaaggctc tgctgggccg gcaccaggca
      301 aggctcaagg ccgagttggc ccgactcaag gttcatcggg gtgtgagccg aaacgaggac
      361 ctgttgcaag agagacccgg ccaagcccac caggtaccac ggttcgtgcg tgtgaacacg
      421 cttaagacct gccctgagga cgcgatcgat tatttcaaga gacaaggttt ctcctatcag
      481 ggtcgggcgt ccagcctgga ggacttacga actctcaagg ggcaacattt tcttttggat
      541 cccttgctgc ccgagcttct tgtatttcct gcacagacag atctgcatga gcatccactc
      601 taccgtgctg gccacctcat cctgcaggat aaggccagct gcctcccagc catgctgctg
      661 tctcctccac caggctccca tgtcattgat gcctgtgctg cccctggcaa caagaccagc
      721 tacattgcag cccttctgaa gaaccagggg aagatcttcg ctttcgacca ggatgctaag
      781 cggctggcag ccatggcgac actgttggct cgggctgggg tctcttgctg tgaggtagca
      841 gagaaggact tcctgacagt ttctccctct gaccagcgtt atggccaggt ccagtacatc
      901 ttgctggatc cttcttgtag tggctctggc atgctgagcc ggcagctgga ggaacacggg
      961 gaaggcacac ctagcaagga gcgcttgcag gccttggcag ggttccagca gcgggctctg
     1021 tgccatgcac tcaggttccc ctctctgcag cgcctcgtct attccacttg ttccctttgc
     1081 caagaggaga atgaagatgt ggtccaggag gctctacagc agaactctgg aacgttcagg
     1141 ctggctcctg tcttacccac atggcctcac cgaggtctga gcacctttcc agggtctgaa
     1201 cactgcctcc gggcttcccc tgagaccaca ctcactggcg gcttcttcat tgctgtgttt
     1261 gaacgtgcag aggtggtgcc gagcccagcc ccacagacca gtgcagtggt tccagaacct
     1321 ctcagcaaag caccaaaaag aaagagaaga cgctaagcag cggctcgtgc cggcctgcag
     1381 ccaagcacac aggcactgag tgccccaccc acagtccgag gaaggaaccc tgctcatctg
     1441 ggaaggggaa ggtgatatcc tggccatgtg aacctcactg ggcacagtcc taccattcaa
     1501 gagttctttg cttcacaaat aaagggcaaa ctcagaccta gg
//
