LOCUS       NM_001106678            2563 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus NOP2/Sun RNA methyltransferase 4 (Nsun4), mRNA.
ACCESSION   NM_001106678 XM_001070636 XM_006238624 XM_238407
VERSION     NM_001106678.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Metodiev MD, Spahr H, Loguercio Polosa P, Meharg C, Becker C,
            Altmueller J, Habermann B, Larsson NG and Ruzzenente B.
  TITLE     NSUN4 is a dual function mitochondrial protein required for both
            methylation of 12S rRNA and coordination of mitoribosomal assembly
  JOURNAL   PLoS Genet 10 (2), e1004110 (2014)
   PUBMED   24516400
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Yakubovskaya E, Guja KE, Mejia E, Castano S, Hambardjieva E, Choi
            WS and Garcia-Diaz M.
  TITLE     Structure of the essential MTERF4:NSUN4 protein complex reveals how
            an MTERF protein collaborates to facilitate rRNA modification
  JOURNAL   Structure 20 (11), 1940-1947 (2012)
   PUBMED   23022348
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Camara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente
            B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T,
            Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM and
            Larsson NG.
  TITLE     MTERF4 regulates translation by targeting the methyltransferase
            NSUN4 to the mammalian mitochondrial ribosome
  JOURNAL   Cell Metab 13 (5), 527-539 (2011)
   PUBMED   21531335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006238624.1, XM_238407.4, XM_001070636.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132300,
                              SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2563
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /note="NOP2/Sun RNA methyltransferase 4"
                     /db_xref="GeneID:298426"
                     /db_xref="RGD:1559652"
     exon            1..195
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1248
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /note="NOL1/NOP2/Sun domain family, member 4; NOP2/Sun RNA
                     methyltransferase family member 4"
                     /codon_start=1
                     /product="5-methylcytosine rRNA methyltransferase NSUN4"
                     /protein_id="NP_001100148.1"
                     /db_xref="GeneID:298426"
                     /db_xref="RGD:1559652"
                     /translation="MAAPVLRGVRKLLKLADFTPVPRRHRYKKKWATTEPQFTPSRLA
                     LQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDSVSAKLEQLSAKDFVSEA
                     ISYQKLEPESGLSPTLSLDCSPNLRCFTFSKGDVSRFPPASVGSLGLMDYYLMDAASL
                     LPVLALGLQHGDIVLDLCAAPGGKTLALLQTGCCRNLAANDLSTSRTGRLQKVLHSYV
                     PQDIRKGNHIRVTSWDGRKWGELEGDTYDKVLVDVPCTTDRHSLHEDENNIFQRSRKK
                     ERQMLPMLQVQLLGAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYNIKVQ
                     VEDLSHFRKLFMDTFCFLPSCQVGELVIPNLMANFGPMYFCKLHRVP"
     exon            196..530
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
     exon            531..685
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
     exon            686..846
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
     exon            847..971
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2563
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccctttg ccgctgttat tctaagcagc tctcaattct ccccggaacc cgcgagagtg
       61 cagctactat ttcagtcgga gttattggcg ttgctagctg acatggctgc gcccgtatta
      121 agaggtgttc gaaagctgct gaagctcgcg gacttcacgc cagtcccgcg gagacatcga
      181 tataagaaga aatgggctac cacagaacca caattcactc ccagccggct tgctctgcag
      241 aattttgaca tgacttacag tgtacagttt ggggatcttt ggccatcaat ccgtgttagt
      301 cttctctcag agcagaagta tggtgcacta gtcaataatt ttgctgcctg ggatagtgtg
      361 agtgctaagc tggagcagct gagtgccaag gactttgtca gtgaagccat ctcttaccag
      421 aaactggagc ctgagagtgg cctctctcca actctatccc tggactgcag ccccaacctt
      481 cgatgcttca ctttttccaa aggggatgtc agccgcttcc ctcctgccag tgttggcagc
      541 ctgggtctca tggactacta cctgatggat gccgcctcct tgctacctgt gctggctctt
      601 ggtctgcagc atggagacat tgtgcttgac ctgtgtgccg ctcctggggg aaaaacactg
      661 gccctacttc agacgggctg ttgccgtaac ctagctgcca acgatctctc tacctcccga
      721 acaggcagac tacagaaggt ccttcacagt tatgtgcctc aagatattag gaaagggaac
      781 cacattcgag ttacctcatg ggatggcagg aagtggggag agctggaggg ggacacctat
      841 gataaggtgt tagtagatgt gccgtgtacc acggaccgcc actcccttca tgaggacgag
      901 aacaacatct ttcagcggtc aaggaagaag gagcgacaga tgttgcctat gctgcaggtg
      961 cagcttcttg gggctggact ccttgccacc aagcccggag gtcacgttgt ctattccact
     1021 tgttcactgt cacacttaca gaatgagtat gtggtgcagg gtgccatcga gcttctggcc
     1081 aatcaataca acatcaaggt tcaagtggaa gacctgtctc acttccgaaa gcttttcatg
     1141 gacacattct gtttcctccc atcctgccag gttggggagc tggtaatacc aaacctcatg
     1201 gccaattttg gacctatgta cttctgcaaa ttgcacaggg tgccatagtg tcaccccatc
     1261 cctgaagtag gaaggtgatg actccatcag aggcattgta acaggctggc ggcaggtgtg
     1321 tcccaggcct gtctccatcc attacatcta aagatcgctg tacacggcag tgggtaggga
     1381 ccgctgccca gctgagttag cagcaggctt ctaactcata ctctcacttc tagcttttag
     1441 cctctactaa ggccccagct tcagtacgga ttaagacaga ccctgtgaat aagcccatag
     1501 ttcaagctgt aaactgggga agaaacattt agccaataaa gttgttgaag tgctcaaagg
     1561 gcggggctgc agttgggaac atcacatcag tctaagttct gttacgtttg tgtcagctga
     1621 agctgccagg cacgctctcc aaagtgccca actgaggcct ccagtcctcc cacatggtga
     1681 gttccattta atcagcccac aggcctacca gcctcctcaa gcgtctccat atggcacata
     1741 gtctaattta agtctaagta actgaaatgg ttgagcctgt ggctgatgat cctcttacag
     1801 tgaggaagct ttcctaagct gaatgcttct ggctctcctt cagatgcggc tgcaaaagct
     1861 gcttctggta caggttgctt ttgtatgttt cttcctttat ttcttcatgt aacagtgggt
     1921 gttctgtgaa ttcccgtatg acagctacgg agctgttaca gagatgattg ggactatggg
     1981 gaatagttgg gtttcctcat cttcagaatg gcaacctact tcctttcact ttccaagtac
     2041 ctaggaattt cctgacattt tatttcaaat gtcttgtttt tctttctagt ctgtggtcca
     2101 gctctggcgc ctgctttggc ccatctccaa atccttcaga gttcttccgc agagcaggcc
     2161 tttaccccac acacagtgtt ttggggcgac cttacataag gtgctgactt gcatgctgat
     2221 tgttttgtaa cacttgtcaa aacaaagcaa cttttagtgc caggaagtag taaacattgc
     2281 ttatggtcaa ctctgtgtgt gtgtgtgtgt gtgtgtgtgt accttgtgaa taacttgaac
     2341 cttgaacgtt tctttttttt ttttcggagt tgaggaccga acccagggcc ttgcacttgc
     2401 tctaccgctg agctaaatcc ccaaccccaa cttgaatgtt tcttggctct tcccactttc
     2461 tttatccctc ctttattgcc attctttttg tctttcatgc cttccctgtg aatccttatt
     2521 tgataattag aagtatccat gggacattgg caaaggttaa gac
//
