LOCUS       NP_001100148             381 aa            linear   ROD 22-MAR-2023
DEFINITION  5-methylcytosine rRNA methyltransferase NSUN4 [Rattus norvegicus].
ACCESSION   NP_001100148 XP_001070636 XP_006238686 XP_238407
VERSION     NP_001100148.1
DBSOURCE    REFSEQ: accession NM_001106678.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 381)
  AUTHORS   Metodiev MD, Spahr H, Loguercio Polosa P, Meharg C, Becker C,
            Altmueller J, Habermann B, Larsson NG and Ruzzenente B.
  TITLE     NSUN4 is a dual function mitochondrial protein required for both
            methylation of 12S rRNA and coordination of mitoribosomal assembly
  JOURNAL   PLoS Genet 10 (2), e1004110 (2014)
   PUBMED   24516400
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 381)
  AUTHORS   Yakubovskaya E, Guja KE, Mejia E, Castano S, Hambardjieva E, Choi
            WS and Garcia-Diaz M.
  TITLE     Structure of the essential MTERF4:NSUN4 protein complex reveals how
            an MTERF protein collaborates to facilitate rRNA modification
  JOURNAL   Structure 20 (11), 1940-1947 (2012)
   PUBMED   23022348
REFERENCE   3  (residues 1 to 381)
  AUTHORS   Camara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente
            B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T,
            Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM and
            Larsson NG.
  TITLE     MTERF4 regulates translation by targeting the methyltransferase
            NSUN4 to the mammalian mitochondrial ribosome
  JOURNAL   Cell Metab 13 (5), 527-539 (2011)
   PUBMED   21531335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Dec 15, 2013 this sequence version replaced
            XP_006238686.1, XP_238407.2, XP_001070636.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132300,
                              SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     Protein         1..381
                     /product="5-methylcytosine rRNA methyltransferase NSUN4"
                     /note="NOL1/NOP2/Sun domain family, member 4; NOP2/Sun RNA
                     methyltransferase family member 4"
                     /calculated_mol_wt=42481
     Region          152..323
                     /region_name="nop2p"
                     /note="NOL1/NOP2/sun family putative RNA methylase;
                     TIGR00446"
                     /db_xref="CDD:188051"
     CDS             1..381
                     /gene="Nsun4"
                     /gene_synonym="RGD1559652"
                     /coded_by="NM_001106678.1:103..1248"
                     /db_xref="GeneID:298426"
                     /db_xref="RGD:1559652"
ORIGIN      
        1 maapvlrgvr kllkladftp vprrhrykkk wattepqftp srlalqnfdm tysvqfgdlw
       61 psirvsllse qkygalvnnf aawdsvsakl eqlsakdfvs eaisyqklep esglsptlsl
      121 dcspnlrcft fskgdvsrfp pasvgslglm dyylmdaasl lpvlalglqh gdivldlcaa
      181 pggktlallq tgccrnlaan dlstsrtgrl qkvlhsyvpq dirkgnhirv tswdgrkwge
      241 legdtydkvl vdvpcttdrh slhedennif qrsrkkerqm lpmlqvqllg agllatkpgg
      301 hvvystcsls hlqneyvvqg aiellanqyn ikvqvedlsh frklfmdtfc flpscqvgel
      361 vipnlmanfg pmyfcklhrv p
//
