LOCUS       NM_057190               2923 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus NMDA receptor synaptonuclear signaling and
            neuronal migration factor (Nsmf), transcript variant 1, mRNA.
ACCESSION   NM_057190
VERSION     NM_057190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2923)
  AUTHORS   Samer,S., Raman,R., Laube,G., Kreutz,M.R. and Karpova,A.
  TITLE     The nuclear lamina is a hub for the nuclear function of Jacob
  JOURNAL   Mol Brain 14 (1), 9 (2021)
   PUBMED   33436037
  REMARK    GeneRIF: The nuclear lamina is a hub for the nuclear function of
            Jacob.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2923)
  AUTHORS   Moon,H.Y.
  TITLE     N-methyl D-aspartate receptor synaptonuclear signaling and neuronal
            migration factor (Nsmf) plays a novel role in myoblast
            proliferation
  JOURNAL   In Vitro Cell Dev Biol Anim 51 (1), 79-84 (2015)
   PUBMED   25248434
  REMARK    GeneRIF: Nsmf is a novel myogenic factor that can enhance myoblast
            proliferation.
REFERENCE   3  (bases 1 to 2923)
  AUTHORS   Mikhaylova,M., Karpova,A., Bar,J., Bethge,P., YuanXiang,P.,
            Chen,Y., Zuschratter,W., Behnisch,T. and Kreutz,M.R.
  TITLE     Cellular distribution of the NMDA-receptor activated
            synapto-nuclear messenger Jacob in the rat brain
  JOURNAL   Brain Struct Funct 219 (3), 843-860 (2014)
   PUBMED   23539133
  REMARK    GeneRIF: data support a synaptic and nuclear role of Jacob that
            implicates long-distance NMDAR signaling to the nucleus in
            excitatory neurons
REFERENCE   4  (bases 1 to 2923)
  AUTHORS   Karpova,A., Mikhaylova,M., Bera,S., Bar,J., Reddy,P.P.,
            Behnisch,T., Rankovic,V., Spilker,C., Bethge,P., Sahin,J.,
            Kaushik,R., Zuschratter,W., Kahne,T., Naumann,M., Gundelfinger,E.D.
            and Kreutz,M.R.
  TITLE     Encoding and transducing the synaptic or extrasynaptic origin of
            NMDA receptor signals to the nucleus
  JOURNAL   Cell 152 (5), 1119-1133 (2013)
   PUBMED   23452857
  REMARK    GeneRIF: Study demonstrates that Jacob is a protein messenger that
            encodes the origin of synaptic versus extrasynaptic
            N-methyl-D-aspartate-receptors signals and delivers them to the
            nucleus.
REFERENCE   5  (bases 1 to 2923)
  AUTHORS   Behnisch,T., Yuanxiang,P., Bethge,P., Parvez,S., Chen,Y., Yu,J.,
            Karpova,A., Frey,J.U., Mikhaylova,M. and Kreutz,M.R.
  TITLE     Nuclear translocation of jacob in hippocampal neurons after stimuli
            inducing long-term potentiation but not long-term depression
  JOURNAL   PLoS One 6 (2), e17276 (2011)
   PUBMED   21364755
  REMARK    GeneRIF: Nuclear translocation of jacob in hippocampal neurons
            after stimuli inducing long-term potentiation but not long-term
            depression.
            Erratum:[PLoS One. 2011;6(3). doi:
            10.1371/annotation/8d9dd14e-08f6-4f7e-b881-ba2839724e23]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2923)
  AUTHORS   Kindler,S., Dieterich,D.C., Schutt,J., Sahin,J., Karpova,A.,
            Mikhaylova,M., Schob,C., Gundelfinger,E.D., Kreienkamp,H.J. and
            Kreutz,M.R.
  TITLE     Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced
            nuclear translocation after calpain-mediated proteolysis
  JOURNAL   J Biol Chem 284 (37), 25431-25440 (2009)
   PUBMED   19608740
  REMARK    GeneRIF: Calpain-mediated clipping of the myristoylated N terminus
            of Jacob is required for its nuclear translocation after
            N-methyl-d-aspartate receptor activation
REFERENCE   7  (bases 1 to 2923)
  AUTHORS   Fujita,T., Piuz,I. and Schlegel,W.
  TITLE     Negative elongation factor NELF controls transcription of immediate
            early genes in a stimulus-specific manner
  JOURNAL   Exp Cell Res 315 (2), 274-284 (2009)
   PUBMED   19014935
  REMARK    GeneRIF: NELF controls overall immediate early gene transcription
            via multiple mechanisms both directly and indirectly.
REFERENCE   8  (bases 1 to 2923)
  AUTHORS   Dieterich,D.C., Karpova,A., Mikhaylova,M., Zdobnova,I., Konig,I.,
            Landwehr,M., Kreutz,M., Smalla,K.H., Richter,K., Landgraf,P.,
            Reissner,C., Boeckers,T.M., Zuschratter,W., Spilker,C.,
            Seidenbecher,C.I., Garner,C.C., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin-Jacob: a protein liaison that couples NMDA receptor
            signalling to the nucleus
  JOURNAL   PLoS Biol 6 (2), e34 (2008)
   PUBMED   18303947
  REMARK    Erratum:[PLoS Biol. 2009 Jan;7(1):e1000022]
REFERENCE   9  (bases 1 to 2923)
  AUTHORS   Pitteloud,N., Quinton,R., Pearce,S., Raivio,T., Acierno,J.,
            Dwyer,A., Plummer,L., Hughes,V., Seminara,S., Cheng,Y.Z., Li,W.P.,
            Maccoll,G., Eliseenkova,A.V., Olsen,S.K., Ibrahimi,O.A.,
            Hayes,F.J., Boepple,P., Hall,J.E., Bouloux,P., Mohammadi,M. and
            Crowley,W.
  TITLE     Digenic mutations account for variable phenotypes in idiopathic
            hypogonadotropic hypogonadism
  JOURNAL   J Clin Invest 117 (2), 457-463 (2007)
   PUBMED   17235395
REFERENCE   10 (bases 1 to 2923)
  AUTHORS   Kramer,P.R. and Wray,S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BC087719.1.
            
            On Jul 21, 2012 this sequence version replaced NM_057190.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087719.1, AJ293697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000003.1  28260047-28260085
            40-2923             BC087719.1         1-2884
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2923
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /note="NMDA receptor synaptonuclear signaling and neuronal
                     migration factor"
                     /db_xref="GeneID:117536"
                     /db_xref="RGD:619819"
     exon            1..272
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1800
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /note="isoform 1 is encoded by transcript variant 1; nasal
                     embryonic luteinizing hormone-releasing hormone factor;
                     juxtasynaptic attractor of caldendrin on dendritic boutons
                     protein; nasal embryonic LHRH factor"
                     /codon_start=1
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform 1"
                     /protein_id="NP_476538.2"
                     /db_xref="GeneID:117536"
                     /db_xref="RGD:619819"
                     /translation="MGAAASRRRALRSEAMSSVAAKVRAARAFGEYLSQSHPENRNGA
                     DHLLADAYSGHEGSPEMQPAPHNKRRLSLVSNGRYEGSISDEAVSGKTATEGPQPRVY
                     TISREPALLPGSEAEAIELAVVKGRRQRERHPHHHSQPLRASPGSSREDISRPCQSWA
                     GSRQGSKECPGCAQLVPGPSPRAFGLEQPPLPEASGRHKKLERMYSVDGVSDDVPIRT
                     WFPKENPFSFQTATTTMQAISVFRGYAERKRRKRENDSASVIQRNFRKHLRMVGSRRV
                     KAQTFAERRERSFSRSWSDPTPMKADTSHDSRDSSDLQSSHCTLDEACEDLDWDTEKG
                     LEATACDTEGFLPPKVMLISSKVPKAEYIPTIIRRDDPSIIPILYDHEHATFEDILEE
                     IEKKLNIYHKGAKIWKMLIFCQGGPGHLYLLKNKVATFAKVEKEEDMIHFWKRLSRLM
                     SKVNPEPNVIHIMGCYILGNPNGEKLFQNLRTLMTPYKVTFESPLELSAQGKQMIETY
                     FDFRLYRLWKSRQHSKLLDFDDVL"
     exon            273..334
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            335..835
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            836..911
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            912..917
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            918..986
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1039
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1129
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1254
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1338
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1372
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1443
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1523
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1626
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1702
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2894
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccccgggt ccagccgcgc tctcctacag tggctggacg cgctgggcgc tgggtgcggc
       61 catgcggggc ccgggcctaa gtgtgaccct gaccctgagg ccaagaccta gcgcgacctc
      121 aggcaccgta cggctccccc ggcagaggcg gcgggcgcgg ggcgcgctct gaaacccggg
      181 ggatgcgcgg gcgccgtgac catgggtgcc gccgcctcca ggaggagggc gctgaggagc
      241 gaggccatgt cctcggtagc ggccaaagta agagcagccc gagcgtttgg agagtacctg
      301 tcccagagtc accctgagaa ccgcaacggt gcagaccacc tgctggccga cgcctactct
      361 ggccacgaag ggtccccaga gatgcagcct gcaccccaca acaagcgccg cctctccctc
      421 gtctccaatg gccgctatga gggcagcatc tcagatgagg cagtcagcgg gaagacggct
      481 acagagggcc cccagccccg tgtgtacacc atctctagag agccagccct gctgcctggc
      541 tctgaagccg aagccattga gctagcagtg gtgaaaggga ggaggcagcg ggagcggcac
      601 cctcaccacc acagccagcc cctgcgcgcc agcccaggca gcagccgtga ggacatcagc
      661 aggccctgcc aaagctgggc aggaagccgc cagggctcca aagaatgccc cggatgtgcc
      721 cagctggtcc ctggtccctc ccctcgggcc ttcgggttgg aacagccacc tctacctgag
      781 gcttccggcc gtcacaagaa gctggaaagg atgtatagtg ttgatggagt gtctgatgac
      841 gtccccatcc gtacctggtt ccccaaggaa aaccctttca gcttccagac ggcaaccaca
      901 actatgcaag ccatctcggt attcaggggc tacgcggaga ggaagcgtcg gaaacgggag
      961 aatgattccg cgtctgtaat ccagaggaac ttccgcaaac acctgcgcat ggttggcagt
     1021 cggcgggtga aggcccagac gttcgctgag cggcgcgaac ggagcttcag ccggtcctgg
     1081 agcgacccca cccctatgaa agccgacacc tcccacgact cccgagacag cagtgaccta
     1141 cagagctcac actgcaccct ggatgaggct tgtgaggacc tggactggga cacagagaaa
     1201 ggcctggagg ccacggcctg cgacactgag ggcttcttgc cacccaaggt catgctaatc
     1261 tcctccaagg tgcccaaggc cgagtacatc ccaaccatca tccgcagaga cgacccatcc
     1321 atcatcccca tcctctatga ccatgagcac gcaacgttcg aggacatcct ggaggaaata
     1381 gagaagaagt tgaacatcta tcacaagggg gccaagatct ggaagatgct gattttctgc
     1441 cagggcggcc ctgggcacct ttatttgctc aagaacaagg tggccacctt tgccaaagtg
     1501 gagaaggaag aggacatgat ccacttctgg aagaggctga gccgtctgat gagcaaagtg
     1561 aaccctgagc caaatgtcat ccacatcatg ggctgctaca tcctggggaa ccctaacggg
     1621 gagaagctat tccagaacct caggaccctc atgacccctt acaaggttac ctttgagtcg
     1681 cccctggagc tctctgccca agggaagcaa atgattgaga cctactttga tttccggctg
     1741 taccgcctgt ggaaaagccg ccagcactca aagctgctgg actttgatga cgtcctgtga
     1801 gaagcatggg tcatgtccag gcaccaccag gccatttcct ctgggctggg aacctagagc
     1861 tgggccacct cttgctccta ggaccatgtg gccctgccct tgcccacagc cacttcaggg
     1921 accctcagac gttgctcagg ttctcgtagg gtctagtcct cactgcacca gtggaccaca
     1981 gaggccacag tcctggtgcc tggattaaca atctcagctc atggccggtg gccacttaat
     2041 ggctagggca ttgacctgtc gcgcctcgcc tggaggctgc agcattgggg acccctccat
     2101 ggggtttcat agaaataagt gcaatttttt tacacccctg aaacaatctg aagggaagca
     2161 gcattactaa ctagttaagc actctgctac tagttacagt gtagacaact ggcccagtgt
     2221 gtgttcaggt cccccgtccc ccagcctctc agccctgctg tatttgatca ccagcaccag
     2281 gatggcccat caatgtgggg ctagctctgt caggccgcct agcctggccc ggtctacact
     2341 ggccaaatct ggcctgcttt cacccctctt gtcatccctg gcttactttg acctcgtcct
     2401 ggcaaggggt agcctgggca ctggaaggga agagcctcac cgtccctctt gtcagggaag
     2461 gcactgggtt gccacctgtt gcccacctcc tcaagccacc tcgtttccct tgctgctgtt
     2521 gaactcagct tttcccagcc ttggtctgaa agccacatcc cagagcagag gcttaggggt
     2581 gtggtagggc caactggggc tggaggcaag aacctcacca acattgtggt agggggccta
     2641 gatctgtcac cccaggctgg agagtcaagt agctggtgaa ctgtgaggtc cccatgactc
     2701 ccttcagtct tgcccagggt ctagcagggt gggctctctt gtacatagtt ggagcttggg
     2761 ggcaggcccc ccttttgtag agcctggggt ctgaggacac ctggctgtgt tcctgaccca
     2821 gaagagttag gattgggcgc tgaacaatgt acgatatccc ttagagtgac cattaaactc
     2881 gatcctttgc tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
