LOCUS       NP_476538                532 aa            linear   ROD 29-MAR-2024
DEFINITION  NMDA receptor synaptonuclear signaling and neuronal migration
            factor isoform 1 [Rattus norvegicus].
ACCESSION   NP_476538
VERSION     NP_476538.2
DBSOURCE    REFSEQ: accession NM_057190.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 532)
  AUTHORS   Samer,S., Raman,R., Laube,G., Kreutz,M.R. and Karpova,A.
  TITLE     The nuclear lamina is a hub for the nuclear function of Jacob
  JOURNAL   Mol Brain 14 (1), 9 (2021)
   PUBMED   33436037
  REMARK    GeneRIF: The nuclear lamina is a hub for the nuclear function of
            Jacob.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 532)
  AUTHORS   Moon,H.Y.
  TITLE     N-methyl D-aspartate receptor synaptonuclear signaling and neuronal
            migration factor (Nsmf) plays a novel role in myoblast
            proliferation
  JOURNAL   In Vitro Cell Dev Biol Anim 51 (1), 79-84 (2015)
   PUBMED   25248434
  REMARK    GeneRIF: Nsmf is a novel myogenic factor that can enhance myoblast
            proliferation.
REFERENCE   3  (residues 1 to 532)
  AUTHORS   Mikhaylova,M., Karpova,A., Bar,J., Bethge,P., YuanXiang,P.,
            Chen,Y., Zuschratter,W., Behnisch,T. and Kreutz,M.R.
  TITLE     Cellular distribution of the NMDA-receptor activated
            synapto-nuclear messenger Jacob in the rat brain
  JOURNAL   Brain Struct Funct 219 (3), 843-860 (2014)
   PUBMED   23539133
  REMARK    GeneRIF: data support a synaptic and nuclear role of Jacob that
            implicates long-distance NMDAR signaling to the nucleus in
            excitatory neurons
REFERENCE   4  (residues 1 to 532)
  AUTHORS   Karpova,A., Mikhaylova,M., Bera,S., Bar,J., Reddy,P.P.,
            Behnisch,T., Rankovic,V., Spilker,C., Bethge,P., Sahin,J.,
            Kaushik,R., Zuschratter,W., Kahne,T., Naumann,M., Gundelfinger,E.D.
            and Kreutz,M.R.
  TITLE     Encoding and transducing the synaptic or extrasynaptic origin of
            NMDA receptor signals to the nucleus
  JOURNAL   Cell 152 (5), 1119-1133 (2013)
   PUBMED   23452857
  REMARK    GeneRIF: Study demonstrates that Jacob is a protein messenger that
            encodes the origin of synaptic versus extrasynaptic
            N-methyl-D-aspartate-receptors signals and delivers them to the
            nucleus.
REFERENCE   5  (residues 1 to 532)
  AUTHORS   Behnisch,T., Yuanxiang,P., Bethge,P., Parvez,S., Chen,Y., Yu,J.,
            Karpova,A., Frey,J.U., Mikhaylova,M. and Kreutz,M.R.
  TITLE     Nuclear translocation of jacob in hippocampal neurons after stimuli
            inducing long-term potentiation but not long-term depression
  JOURNAL   PLoS One 6 (2), e17276 (2011)
   PUBMED   21364755
  REMARK    GeneRIF: Nuclear translocation of jacob in hippocampal neurons
            after stimuli inducing long-term potentiation but not long-term
            depression.
            Erratum:[PLoS One. 2011;6(3). doi:
            10.1371/annotation/8d9dd14e-08f6-4f7e-b881-ba2839724e23]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 532)
  AUTHORS   Kindler,S., Dieterich,D.C., Schutt,J., Sahin,J., Karpova,A.,
            Mikhaylova,M., Schob,C., Gundelfinger,E.D., Kreienkamp,H.J. and
            Kreutz,M.R.
  TITLE     Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced
            nuclear translocation after calpain-mediated proteolysis
  JOURNAL   J Biol Chem 284 (37), 25431-25440 (2009)
   PUBMED   19608740
  REMARK    GeneRIF: Calpain-mediated clipping of the myristoylated N terminus
            of Jacob is required for its nuclear translocation after
            N-methyl-d-aspartate receptor activation
REFERENCE   7  (residues 1 to 532)
  AUTHORS   Fujita,T., Piuz,I. and Schlegel,W.
  TITLE     Negative elongation factor NELF controls transcription of immediate
            early genes in a stimulus-specific manner
  JOURNAL   Exp Cell Res 315 (2), 274-284 (2009)
   PUBMED   19014935
  REMARK    GeneRIF: NELF controls overall immediate early gene transcription
            via multiple mechanisms both directly and indirectly.
REFERENCE   8  (residues 1 to 532)
  AUTHORS   Dieterich,D.C., Karpova,A., Mikhaylova,M., Zdobnova,I., Konig,I.,
            Landwehr,M., Kreutz,M., Smalla,K.H., Richter,K., Landgraf,P.,
            Reissner,C., Boeckers,T.M., Zuschratter,W., Spilker,C.,
            Seidenbecher,C.I., Garner,C.C., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Caldendrin-Jacob: a protein liaison that couples NMDA receptor
            signalling to the nucleus
  JOURNAL   PLoS Biol 6 (2), e34 (2008)
   PUBMED   18303947
  REMARK    Erratum:[PLoS Biol. 2009 Jan;7(1):e1000022]
REFERENCE   9  (residues 1 to 532)
  AUTHORS   Pitteloud,N., Quinton,R., Pearce,S., Raivio,T., Acierno,J.,
            Dwyer,A., Plummer,L., Hughes,V., Seminara,S., Cheng,Y.Z., Li,W.P.,
            Maccoll,G., Eliseenkova,A.V., Olsen,S.K., Ibrahimi,O.A.,
            Hayes,F.J., Boepple,P., Hall,J.E., Bouloux,P., Mohammadi,M. and
            Crowley,W.
  TITLE     Digenic mutations account for variable phenotypes in idiopathic
            hypogonadotropic hypogonadism
  JOURNAL   J Clin Invest 117 (2), 457-463 (2007)
   PUBMED   17235395
REFERENCE   10 (residues 1 to 532)
  AUTHORS   Kramer,P.R. and Wray,S.
  TITLE     Novel gene expressed in nasal region influences outgrowth of
            olfactory axons and migration of luteinizing hormone-releasing
            hormone (LHRH) neurons
  JOURNAL   Genes Dev 14 (14), 1824-1834 (2000)
   PUBMED   10898796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BC087719.1.
            
            On Jul 21, 2012 this sequence version replaced NP_476538.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087719.1, AJ293697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     Protein         1..532
                     /product="NMDA receptor synaptonuclear signaling and
                     neuronal migration factor isoform 1"
                     /note="nasal embryonic luteinizing hormone-releasing
                     hormone factor; juxtasynaptic attractor of caldendrin on
                     dendritic boutons protein; nasal embryonic LHRH factor"
                     /calculated_mol_wt=60151
     Region          2..235
                     /region_name="Necessary and sufficient to elicit dendritic
                     processes and synaptic contacts"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Region          34..67
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Region          127..174
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Site            206
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99NF2; propagated from
                     UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Region          247..252
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Region          275..315
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Site            292
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9EPI6.1)"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q9EPI6.1)"
     CDS             1..532
                     /gene="Nsmf"
                     /gene_synonym="Jac; Jacob; Nelf"
                     /coded_by="NM_057190.2:202..1800"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:117536"
                     /db_xref="RGD:619819"
ORIGIN      
        1 mgaaasrrra lrseamssva akvraarafg eylsqshpen rngadhllad aysghegspe
       61 mqpaphnkrr lslvsngrye gsisdeavsg ktategpqpr vytisrepal lpgseaeaie
      121 lavvkgrrqr erhphhhsqp lraspgssre disrpcqswa gsrqgskecp gcaqlvpgps
      181 prafgleqpp lpeasgrhkk lermysvdgv sddvpirtwf pkenpfsfqt atttmqaisv
      241 frgyaerkrr krendsasvi qrnfrkhlrm vgsrrvkaqt faerrersfs rswsdptpmk
      301 adtshdsrds sdlqsshctl deacedldwd tekgleatac dtegflppkv mlisskvpka
      361 eyiptiirrd dpsiipilyd hehatfedil eeiekklniy hkgakiwkml ifcqggpghl
      421 yllknkvatf akvekeedmi hfwkrlsrlm skvnpepnvi himgcyilgn pngeklfqnl
      481 rtlmtpykvt fesplelsaq gkqmietyfd frlyrlwksr qhsklldfdd vl
//
