LOCUS       NM_001024876            1072 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
            (Nsmce2), mRNA.
ACCESSION   NM_001024876 XM_216927
VERSION     NM_001024876.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Wu,N., Kong,X., Ji,Z., Zeng,W., Potts,P.R., Yokomori,K. and Yu,H.
  TITLE     Scc1 sumoylation by Mms21 promotes sister chromatid recombination
            through counteracting Wapl
  JOURNAL   Genes Dev 26 (13), 1473-1485 (2012)
   PUBMED   22751501
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Behlke-Steinert,S., Touat-Todeschini,L., Skoufias,D.A. and
            Margolis,R.L.
  TITLE     SMC5 and MMS21 are required for chromosome cohesion and mitotic
            progression
  JOURNAL   Cell Cycle 8 (14), 2211-2218 (2009)
   PUBMED   19502785
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     Human MMS21/NSE2 is a SUMO ligase required for DNA repair
  JOURNAL   Mol Cell Biol 25 (16), 7021-7032 (2005)
   PUBMED   16055714
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097477.1.
            
            On Jun 17, 2005 this sequence version replaced XM_216927.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097477.1, SRR8487231.3881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..1072
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /note="NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase"
                     /db_xref="GeneID:299957"
                     /db_xref="RGD:1305156"
     exon            1..70
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     exon            71..236
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..823
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /note="non-SMC element 2 homolog; non-structural
                     maintenance of chromosomes element 2 homolog; MMS21
                     homolog; non-SMC element 2, MMS21 homolog; E3 SUMO-protein
                     transferase NSE2"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase NSE2"
                     /protein_id="NP_001020047.1"
                     /db_xref="GeneID:299957"
                     /db_xref="RGD:1305156"
                     /translation="MPGRSSTNSGSTRYISFSGVESALSSLKTFQSCISSGMDTVSSV
                     ALDLVETQTEVSSEYSMDKAMVEFAKMDRELNHYVKAVQSTINHVKEERPEKVPDLKL
                     LVEKKFLALQDKNSDADFKENEKFVQFKQQLRELKKQYGIHADRENDGIEGMDEDMIV
                     TQSQTNFICPITQLEMKKPVKNKMCGHTYEEEAIVRMIESKHKRKKKACCPKIGCSHT
                     DMRMSDLIPDEALRRAIESHNKKKKRHSE"
     exon            237..343
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     exon            344..497
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     exon            498..598
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     exon            599..705
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1046
                     /gene="Nsmce2"
                     /gene_synonym="RGD1305156"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggaaagg aatcggggtc tgggtgtgcg acgttcggca agatatcgct gagctaggtg
       61 ggacagccag atttcaaaga tgccaggacg gtccagtaca aattcaggtt ctactcgtta
      121 catatccttc agtggtgtag agtcagctct ctcctcctta aaaaccttcc agtcctgtat
      181 cagctctggg atggacacag tttctagtgt tgccttggac cttgtggaga cccaaactga
      241 agtgagtagt gagtacagta tggacaaggc catggttgaa tttgctaaaa tggatcgaga
      301 actaaaccat tatgttaagg ctgtccagtc tacaataaat catgtaaaag aagaacgtcc
      361 agaaaaagta ccagatttaa aattactggt ggagaagaaa tttttggctt tacaggataa
      421 gaactctgac gccgacttta aagagaatga aaagttcgtg cagtttaagc agcagctgcg
      481 ggagctgaag aagcaatatg gtattcatgc agacagagag aatgatggga tagaaggaat
      541 ggatgaagat atgattgtga cccagagcca aaccaatttc atctgcccca taacacagtt
      601 ggaaatgaag aagccagtga aaaataaaat gtgtggccac acatacgaag aggaagccat
      661 tgttcgcatg attgaatcca agcataagag gaagaagaag gcttgttgcc caaaaattgg
      721 ctgtagccac acagacatga gaatgtcaga tctcattccg gatgaagccc tgagaagggc
      781 aatcgagagc cacaacaaga agaaaaagcg ccactccgag taggagccag ccccctgccc
      841 acaggggtgt cagcagccta cctccccaca gccaccagag agtgagcgtt cacagcaata
      901 ggcccggcaa gctctgcagt gaccctcaag gctaattgta attgaaagca ttttttaagt
      961 tacacaataa aaacacaagt acattatagt ctttattttc aagtgctctg aaattttaaa
     1021 taaaactttg ataatcttca gcacgaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
