LOCUS       NM_001039611            1214 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NSE1 homolog, SMC5-SMC6 complex component
            (Nsmce1), mRNA.
ACCESSION   NM_001039611
VERSION     NM_001039611.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   van der Crabben,S.N., Hennus,M.P., McGregor,G.A., Ritter,D.I.,
            Nagamani,S.C., Wells,O.S., Harakalova,M., Chinn,I.K., Alt,A.,
            Vondrova,L., Hochstenbach,R., van Montfrans,J.M.,
            Terheggen-Lagro,S.W., van Lieshout,S., van Roosmalen,M.J.,
            Renkens,I., Duran,K., Nijman,I.J., Kloosterman,W.P., Hennekam,E.,
            Orange,J.S., van Hasselt,P.M., Wheeler,D.A., Palecek,J.J.,
            Lehmann,A.R., Oliver,A.W., Pearl,L.H., Plon,S.E., Murray,J.M. and
            van Haaften,G.
  TITLE     Destabilized SMC5/6 complex leads to chromosome breakage syndrome
            with severe lung disease
  JOURNAL   J Clin Invest 126 (8), 2881-2892 (2016)
   PUBMED   27427983
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Doyle,J.M., Gao,J., Wang,J., Yang,M. and Potts,P.R.
  TITLE     MAGE-RING protein complexes comprise a family of E3 ubiquitin
            ligases
  JOURNAL   Mol Cell 39 (6), 963-974 (2010)
   PUBMED   20864041
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol Cell Biol 28 (4), 1197-1206 (2008)
   PUBMED   18086888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099757.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1214
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /note="NSE1 homolog, SMC5-SMC6 complex component"
                     /db_xref="GeneID:361645"
                     /db_xref="RGD:1307760"
     exon            1..84
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            85..247
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1059
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /EC_number="2.3.2.27"
                     /note="non-SMC element 1 homolog"
                     /codon_start=1
                     /product="non-structural maintenance of chromosomes
                     element 1 homolog"
                     /protein_id="NP_001034700.1"
                     /db_xref="GeneID:361645"
                     /db_xref="RGD:1307760"
                     /translation="MKGVRHSARLACRVLERPCGSPSNMQGSTRRAGAMTDVHRRFLQ
                     LLMTHGVLEEWEVRRLQNHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKKGITED
                     DGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQL
                     KGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDAVKMCNIC
                     HSLLIQGQSCETCGIRMHLPCVAKYFQSTAEPRCPHCNDYWPHDIPEVFDPEKEREAG
                     ISKSSRKSLRTRQH"
     exon            248..394
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            395..516
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            517..594
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            595..741
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            742..858
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            859..979
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1177
                     /gene="Nsmce1"
                     /gene_synonym="RGD1307760"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaacaaaa caactcgagt agaagtgcct taagaagaga tactgctttt gtagtaccat
       61 ccacttctca tcgccttcac ctggtttctc cgtatccctg gctagcctgg aactggcaat
      121 gtaggccagg ctgcccttga actcagagag atccacctca gagcagtcca gcctcagagt
      181 gctgggatga aaggcgtgcg ccacagtgcc cggcttgcat gcagagtgct tgagcgccca
      241 tgtggatctc cttccaacat gcagggcagc acgagaagag cgggagccat gacagatgtg
      301 catcggcgct tcctccagct gctgatgact catggcgtgc tggaggagtg ggaggttagg
      361 cgcctgcaga accactgcta caaagtccac gaccgaaatg ctactgtaga taagctggag
      421 gacttcatca acaatatcaa cagtgtcctg gagtctctgt atattgagat aaagaaaggc
      481 atcacagagg atgacgggag acccatttat gcactggtga atcttgctac aacttcagtt
      541 tccaaaatgg ccacggattt tgcagaaaac gagttggatc tgtttagaaa ggctttggaa
      601 ctgatcgttg actcagaaac tggctttgct tcttcgacaa acattttgaa cctagttgac
      661 caactcaaag gtaaaaagat gaggaagaag gaagcggagc aggtgctgca gaagtttgtg
      721 cagagcaagt ggctgattga gaaggagggg gagttcacct tgcatggccg ggctatcttg
      781 gagatggagc agtttatccg agagagctac ccagatgccg tgaagatgtg taacatctgc
      841 cacagcctcc ttatccaggg tcaaagctgc gagacgtgtg gaattaggat gcacttgcct
      901 tgtgtggcca agtacttcca gtctaccgcc gagccacgct gcccccactg taatgactac
      961 tggccccacg acataccaga agtcttcgac cctgagaagg agagggaggc tggcatctcc
     1021 aagtcgagca gaaagtcctt gcggacccgg cagcactagc tttgtcctac atccttctgg
     1081 cttttggtgg gctgaccctc acagcccatt tagaactgct ggacttccct tgttggtatc
     1141 tgctcttaac atgtttttag taaatgtttc ccaatgcaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaa
//
