LOCUS       NM_031981               1450 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NSFL1 cofactor (Nsfl1c), mRNA.
ACCESSION   NM_031981
VERSION     NM_031981.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Kress,E., Schwager,F., Holtackers,R., Seiler,J., Prodon,F.,
            Zanin,E., Eiteneuer,A., Toya,M., Sugimoto,A., Meyer,H., Meraldi,P.
            and Gotta,M.
  TITLE     The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by
            limiting the centrosomal recruitment of Aurora A
  JOURNAL   J Cell Biol 201 (4), 559-575 (2013)
   PUBMED   23649807
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Koulajian,K., Desai,T., Liu,G.C., Ivovic,A., Patterson,J.N.,
            Tang,C., El-Benna,J., Joseph,J.W., Scholey,J.W. and Giacca,A.
  TITLE     NADPH oxidase inhibition prevents beta cell dysfunction induced by
            prolonged elevation of oleate in rodents
  JOURNAL   Diabetologia 56 (5), 1078-1087 (2013)
   PUBMED   23429921
  REMARK    GeneRIF: Data suggest that NADPH oxidase-derived cytosolic
            superoxide is increased in islets upon oleate infusion and leads to
            beta cell dysfunction; whole-body NADPH oxidase inhibition (via
            apocynin) decreases superoxide and restores islet function.
REFERENCE   3  (bases 1 to 1450)
  AUTHORS   Tain,Y.L., Chen,C.C., Lee,C.T., Kao,Y.H., Sheen,J.M., Yu,H.R. and
            Huang,L.T.
  TITLE     Melatonin regulates L-arginine transport and NADPH oxidase in young
            rats with bile duct ligation: role of protein kinase C
  JOURNAL   Pediatr Res 73 (4 Pt 1), 395-401 (2013)
   PUBMED   23295407
  REMARK    GeneRIF: In the kidneys of bile duct ligated rats melatonin
            inhibits protein kinase C beta to reduce p47phox superoxide
            production.
REFERENCE   4  (bases 1 to 1450)
  AUTHORS   Kaneko,Y., Tamura,K., Totsukawa,G. and Kondo,H.
  TITLE     Isolation of a point-mutated p47 lacking binding affinity to
            p97ATPase
  JOURNAL   FEBS Lett 584 (18), 3873-3877 (2010)
   PUBMED   20691684
  REMARK    GeneRIF: p47(F253S) could not form a complex with p97 and did not
            cause any cisternal regrowth in an in vitro Golgi reassembly assay.
REFERENCE   5  (bases 1 to 1450)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   6  (bases 1 to 1450)
  AUTHORS   Meyer,H.H., Kondo,H. and Warren,G.
  TITLE     The p47 co-factor regulates the ATPase activity of the membrane
            fusion protein, p97
  JOURNAL   FEBS Lett 437 (3), 255-257 (1998)
   PUBMED   9824302
REFERENCE   7  (bases 1 to 1450)
  AUTHORS   Rabouille,C., Kondo,H., Newman,R., Hui,N., Freemont,P. and
            Warren,G.
  TITLE     Syntaxin 5 is a common component of the NSF- and p97-mediated
            reassembly pathways of Golgi cisternae from mitotic Golgi fragments
            in vitro
  JOURNAL   Cell 92 (5), 603-610 (1998)
   PUBMED   9506515
REFERENCE   8  (bases 1 to 1450)
  AUTHORS   Alsheimer,M., Imamichi,Y., Heid,H. and Benavente,R.
  TITLE     Molecular characterization and expression pattern of XY
            body-associated protein XY40 of the rat
  JOURNAL   Chromosoma 106 (5), 308-314 (1997)
   PUBMED   9297509
REFERENCE   9  (bases 1 to 1450)
  AUTHORS   Kondo,H., Rabouille,C., Newman,R., Levine,T.P., Pappin,D.,
            Freemont,P. and Warren,G.
  TITLE     p47 is a cofactor for p97-mediated membrane fusion
  JOURNAL   Nature 388 (6637), 75-78 (1997)
   PUBMED   9214505
REFERENCE   10 (bases 1 to 1450)
  AUTHORS   Smith,A. and Benavente,R.
  TITLE     Meiosis-specific protein selectively associated with sex
            chromosomes of rat pachytene spermatocytes
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6938-6942 (1992)
   PUBMED   1495983
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB002086.1.
            
            On Feb 21, 2013 this sequence version replaced NM_031981.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002086.1, BC072464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1450              AB002086.1         1-1450
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1450
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /note="NSFL1 cofactor"
                     /db_xref="GeneID:83809"
                     /db_xref="RGD:619952"
     exon            1..213
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1221
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /note="p97 cofactor p47; XY body-associated protein XY40;
                     NSFL1 (p97) cofactor (p47)"
                     /codon_start=1
                     /product="NSFL1 cofactor p47"
                     /protein_id="NP_114187.1"
                     /db_xref="GeneID:83809"
                     /db_xref="RGD:619952"
                     /translation="MAEERQDALREFVAVTGAEEDRARFFLESAGWDLQIALASFYED
                     GGDEDIVTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEEEEEEEGQRFYAGGSERS
                     GQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPFAGGGYRLGAA
                     PEEESAYVAGERRRHSGQDVHVVLKLWKTGFSLDNGDLRSYQDPSNAQFLESIRRGEV
                     PAELRRLAHGGQVNLDMEDHRDEDFVKPKGAFKAFTGEGQKLGSTAPQVLNTSSPAQQ
                     AENEAKASSSILINEAEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVDARPAMAA
                     TSFVLMTTFPNKELADENQTLKEANLLNAVIVQRLT"
     exon            214..311
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            312..386
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            387..552
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            553..645
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            646..755
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            756..893
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1058
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1450
                     /gene="Nsfl1c"
                     /gene_synonym="p47; XY40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaggcgcc ctgccgctgg acactgtaga acggcgggcg gaacgcagac ctgggttcgg
       61 gctgttgcag tgtccgccgg agcggtttgg ggagtgcacg gggtgaagat ggcggaggag
      121 cggcaggacg cgttgaggga gttcgtggcg gtgacgggcg ctgaggagga ccgggcccgt
      181 ttcttcttgg agtcagctgg ctgggacctg cagattgcac ttgcaagctt ttatgaggat
      241 ggaggggatg aagacattgt gaccatttca caggcaaccc caagttcagt gtccagaggc
      301 acagctccta gtgataatag agtaacatcc ttcagagacc tcattcatga ccaagatgaa
      361 gaggaagagg aagaagaggg acagaggttt tatgctgggg gctcagagag aagtggacag
      421 cagattgttg gtcctccccg gaagaaaagt cccaacgagc tggtggatga tctgtttaag
      481 ggtgccaaag agcatggggc tgtagctgtg gaacgagtga ccaagagccc tggagagacc
      541 agtaaaccga gaccatttgc aggagggggc taccgccttg gagcagcacc agaagaggag
      601 tctgcctatg tggcaggaga aaggaggcgg cattcaggcc aggatgttca tgtagtgcta
      661 aagctctgga aaactggatt cagcctagac aatggtgacc ttagaagcta ccaagaccca
      721 tccaatgccc agtttctgga gtctatccgt agaggggagg ttcctgcaga gcttcggagg
      781 ttagctcacg gtgggcaggt gaacttggat atggaggatc atcgggacga ggacttcgtg
      841 aagcccaagg gagctttcaa agccttcact ggcgagggcc agaaactagg cagcacggcc
      901 ccgcaggttt taaacaccag ctctccagcc cagcaagcag aaaatgaagc caaagctagc
      961 tcgtccatct taatcaatga ggcagaacct accacgaaca tccaaatccg actggcagat
     1021 ggcgggagac tggtgcagaa attcaaccac agccacagga tcagcgacat ccggctcttc
     1081 atcgtggatg cacggccggc tatggctgcc accagttttg tccttatgac taccttccct
     1141 aacaaagagc tggctgatga gaaccaaacc ctgaaggaag ccaatcttct caacgctgtc
     1201 atcgtgcagc ggttaacata accgcccagc tgctgcctca cctccctatg tgtcccccat
     1261 gactgtggcc atgcccgtgg ggattacctc ctgccccctg tacacctagc tcttccagtg
     1321 ccacgtctcg tccgtagctc tggattctta gacttcagtt ggacatttgt tttctcttta
     1381 gttgtatttc ctgggttttt gtgatgatca atggacttta aagaaaaaaa ataaaaaaca
     1441 caaaaaattg
//
