LOCUS       NM_001106090            4863 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear receptor binding SET domain protein 3
            (Nsd3), mRNA.
ACCESSION   NM_001106090 XM_001062803 XM_214371
VERSION     NM_001106090.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4863)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   2  (bases 1 to 4863)
  AUTHORS   Rahman,S., Sowa,M.E., Ottinger,M., Smith,J.A., Shi,Y., Harper,J.W.
            and Howley,P.M.
  TITLE     The Brd4 extraterminal domain confers transcription activation
            independent of pTEFb by recruiting multiple proteins, including
            NSD3
  JOURNAL   Mol Cell Biol 31 (13), 2641-2652 (2011)
   PUBMED   21555454
REFERENCE   3  (bases 1 to 4863)
  AUTHORS   Kim,S.M., Kee,H.J., Eom,G.H., Choe,N.W., Kim,J.Y., Kim,Y.S.,
            Kim,S.K., Kook,H., Kook,H. and Seo,S.B.
  TITLE     Characterization of a novel WHSC1-associated SET domain protein
            with H3K4 and H3K27 methyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 345 (1), 318-323 (2006)
   PUBMED   16682010
REFERENCE   4  (bases 1 to 4863)
  AUTHORS   Rosati,R., La Starza,R., Veronese,A., Aventin,A., Schwienbacher,C.,
            Vallespi,T., Negrini,M., Martelli,M.F. and Mecucci,C.
  TITLE     NUP98 is fused to the NSD3 gene in acute myeloid leukemia
            associated with t(8;11)(p11.2;p15)
  JOURNAL   Blood 99 (10), 3857-3860 (2002)
   PUBMED   11986249
  REMARK    Erratum:[Blood 2002 Aug 15;100(4):1132]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473970.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062803.1, XM_214371.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760396, SAMEA5760434
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..4863
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /note="nuclear receptor binding SET domain protein 3"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
     exon            1..404
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..4585
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /EC_number="2.1.1.354"
                     /note="Wolf-Hirschhorn syndrome candidate 1-like 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD3"
                     /protein_id="NP_001099560.1"
                     /db_xref="GeneID:290831"
                     /db_xref="RGD:1308980"
                     /translation="MASRIMGNTIQQPPQLIDSANIRQEDAFDNNSDIVEDGGPTPFE
                     ATLQQGFQCPPATEDLPPLTNGYPPSISLYETQTKYPPYSQYPNGSANGFGAVRNFSP
                     TDYYHSEIPNTRPHEILEKPSPPQPPPPPLLPPPPPPVPQTVIPKKTGSPEIKLKITK
                     TIQNGRELFESSLCGDLLNEVQASEHLKSKHESRKEKRKKSSRHESSRSEERKSHKVP
                     KLEPEGQNRPNERVDPAPEKPREEPVLKEAVPVQPILSSVPTTETSTGVKFQVGDLVW
                     SKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGH
                     EQYEELLAEAAKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALQMTREERVEQYT
                     FIYIDKQPEESPSQAKKSVTSKAEVKKPRRPRSVGNSQPEQTSAGEVASPQSSTDPRR
                     QSQRRHTSVEEDGPPPVKIAWRTAAARKSLPASITMHKGSLDLHKCNMSPVVKIEQVF
                     ALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISSPSQRNEKSTPSASPPEAT
                     SGSAGPVEKKQQRRSIRTRSESEKSTEVVSKKKIKKEQVETSPQASLKTGLQKGASEI
                     SDSCKPLKKRSRASTDVETASCTYRDTSDSDSRGPSDGQVGFGKQVDSPSAAADADAS
                     DAQSVDSSLSRRGVGLSKKDTVCQVCENTGDSLVACEGECCRHFHPECLGLAAVPEGR
                     FTCEECETGQHPCFSCKVSGKDVKRCSVSVCGKFYHEACVRKFPTAIFESKGFRCPQH
                     CCSSCSMEKDIHKASKGRMMKCLRCPIAYHFGDACVAAGSVSVSSHILICSNHSKRSS
                     HSAAINVGFCFVCARGGRLLCCESCPASFHPECLSIDMPEGCWNCNDCKAGKKLHYKQ
                     IVWVKLGNYRQVSQADRKWWPAETCSPRSVPLNIQGLKHGVGDFPVLFFGSHDYYWVH
                     QGRVFPYVEGDTNFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKTSRKP
                     PPYKHIKANKVIGKVQIQVADLSEIPRCNCKPGDENPCGLESECLNRMSQYECHPQVC
                     PAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRL
                     RIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVG
                     LFALCDIPAGMELTFNYNLDCLGNGRTVCHCGADNCSGFLGVRPKSACTSAADEKTKN
                     AKLKKRRRGKAEAKQIHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE
                     CPWHQCDECGSAAISFCEFCPHSFCKAHEKGALVPSALEGRLCCSNHDPASPVSPEYW
                     SKMRCKWESQDGGEEVKE"
     exon            405..1072
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1144
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1307
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1462
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1978
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2105
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2206
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2252
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2383
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2512
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2639
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2837
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3008
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3189
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3392
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3505
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3775
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3892
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4034
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4141
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4142..4343
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4863
                     /gene="Nsd3"
                     /gene_synonym="Whsc1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcgctgt ggcccgcggc ccgggatgca gtcgcgctga cgtcctcctg gttacccaca
       61 agcctctgta ccccagtgcg ggcaggaaga gggcaaccgg gtccagtgcc tgcccgggag
      121 gacggggtgc cttctgagcc ggacgcgaac tctgcccagt accccccagt acttgtaaac
      181 tggcagccac ccgtctctca ctgccccggc tcaggctctc gtcctaacgt actacccggt
      241 gtctgggacg cggaggccag ggcgctctgc tgacagctgt caggctgtca tcgactccca
      301 agcctcggct ctccccggtc tgcgtcattg cgtaccggtc attaggttct tcctaacatc
      361 taggaattgt agagcagggc cactcgaata ccatatggcg tctaggatca tgggaaacac
      421 aattcagcaa ccacctcaac tcattgactc ggccaatatc cgccaggagg atgcctttga
      481 taacaacagt gacattgttg aagatggtgg cccgacaccc ttcgaagcta ctttgcaaca
      541 aggtttccaa tgtccacctg caacagaaga ccttcctcca ctcacaaacg gctacccacc
      601 gtccatcagc ttgtatgaga ctcaaaccaa atacccgcca tatagccagt atcccaatgg
      661 gtcagccaac ggttttggtg cagttagaaa ctttagtcct actgactatt accattcaga
      721 aattccaaac acaagaccac atgaaattct ggaaaaaccg tctcccccac agcctcctcc
      781 tcctcctctt cttcctcctc ctcctcctcc ggtaccacaa actgtgattc caaagaagac
      841 aggctcaccc gagattaaac taaaaataac caaaactatc cagaatggca gggaattgtt
      901 tgagtcctcc ctctgtggag accttttaaa cgaagtacag gccagtgagc acttaaagtc
      961 aaagcacgaa agcagaaagg aaaagaggaa aaaaagcagc agacacgagt catcgagatc
     1021 cgaagagcga aagtcacaca aggtccccaa gttagagcca gaggggcaga atagaccaaa
     1081 tgagagggtg gaccctgcac cagaaaagcc aagagaagag ccagtgctca aagaggccgt
     1141 cccggttcag ccaatactgt cttctgttcc aacaacagaa acgtccactg gtgttaagtt
     1201 ccaggttggt gatcttgttt ggtccaaggt gggaacctat ccttggtggc cttgtatggt
     1261 ttcaagtgat ccccagcttg aggtccatac caaaattaac acaagaggtg cccgggagta
     1321 tcatgtccag ttttttagca accagccaga gagggcatgg gttcatgaga agcgggtacg
     1381 ggagtataaa ggtcacgaac agtatgaaga gttactagca gaggcagcca aacaagccag
     1441 caaccattct gaaaagcaaa agattcggaa accccgacct cagagagaac gcgcccagtg
     1501 ggatattggc attgctcacg cagagaaagc attgcagatg acacgagagg aaagggtaga
     1561 acagtacacg ttcatctata tcgataagca gccagaagag tctccgtccc aagcaaagaa
     1621 gagtgttacc tctaaggcgg aagtcaagaa accccgaagg cccagatctg tggggaacag
     1681 tcagccagaa cagaccagtg ctggggaggt ggcttcccca cagtcgagta ctgaccctcg
     1741 caggcagagc cagaggcggc acaccagtgt ggaagaggac gggccgcctc ccgttaaaat
     1801 agcctggaga acagccgccg ccaggaagtc cttaccagcc tccatcacaa tgcacaaggg
     1861 gagcctagat ctgcacaagt gtaatatgtc tccagttgtg aaaattgaac aagtgtttgc
     1921 tctccagaat gcaacaggag atgggaagtt tattgatcag tttgtttatt caacgaaggg
     1981 aattggtaac aaaacagaaa taagtgtcag ggggcaagac aggcttataa tctcttcacc
     2041 aagtcagaga aacgagaagt cgactccgag cgcgtcacct ccggaggcca catctggttc
     2101 tgcaggccca gtagaaaaga agcagcagag aagatcaatc aggactcgat ctgagtcaga
     2161 gaaatccacc gaggttgtgt caaagaagaa gatcaaaaag gagcaggttg aaacatctcc
     2221 tcaggcttcc ctgaagaccg gattacagaa aggtgccagc gagatttcag attcctgtaa
     2281 acctctaaag aaaaggagtc gcgcctcgac tgatgtggaa acggccagtt gcacgtacag
     2341 agacacatct gactccgatt ccagaggacc gagtgatggg caggtaggct ttggaaaaca
     2401 agtagatagc ccgtcagcag ctgctgatgc agatgcttct gatgcacagt cggtggactc
     2461 gagcctgtca cggagaggcg tcggcctgag taagaaggac actgtgtgtc aggtctgtga
     2521 gaacactgga gactctctcg ttgcttgtga gggggaatgc tgcagacact ttcatccgga
     2581 gtgcttgggg ctggctgcgg tccctgaggg acgcttcacc tgtgaggagt gtgagacagg
     2641 gcagcaccca tgtttttcat gtaaagtgtc tggtaaggat gtgaaacgtt gttctgttag
     2701 tgtttgtgga aagttttatc atgaagcctg tgtccgcaaa ttccccactg ccatctttga
     2761 gtcaaaagga ttccgctgtc cccagcactg ttgttcttcc tgctccatgg agaaggacat
     2821 ccacaaagcg agcaaaggcc ggatgatgaa gtgcttgaga tgcccaatcg cctaccactt
     2881 tggagatgcg tgtgtcgctg ctggaagtgt atctgtgtcc tcccacattc tcatctgtag
     2941 taaccattcc aagcggagta gtcattctgc tgctataaac gtaggctttt gtttcgtttg
     3001 tgccagaggt ggaagattgc tctgctgtga atcgtgccct gcttccttcc acccagaatg
     3061 cctgagcata gacatgcccg aaggctgctg gaattgcaat gactgtaaag ctggcaagaa
     3121 gctgcattac aaacagattg tttgggtcaa attgggaaat tacaggcaag tttcccaagc
     3181 agataggaaa tggtggcctg cagagacctg cagtcccagg tctgtgccgc tgaacatcca
     3241 gggccttaag cacggcgtgg gcgacttccc tgtgctcttc tttggctctc atgactacta
     3301 ctgggtccac caaggcagag tgtttcccta tgttgaagga gacacaaact ttgctgaggg
     3361 acagactagc attaacaaga ccttcaaaaa agcactggaa gaagctgcaa aacgtttcca
     3421 ggagttgaaa gcgcagcgag agagtaagga ggctttggag atagagaaaa cctcaagaaa
     3481 accccctccc tacaaacaca tcaaggccaa caaagtcata gggaaggtgc agatccaggt
     3541 ggctgacctg tcggagatcc cgcgctgtaa ctgcaagcct ggtgatgaaa acccatgtgg
     3601 cctggagtcg gagtgtctaa acagaatgtc acagtacgag tgtcacccgc aggtgtgccc
     3661 tgctggggac cgctgtcaga accagtgctt tacaaagagg ctgtaccccg atgcagagat
     3721 catcaaaact gagcggagag gatggggcct cagaaccaaa agaagtatta aaaaggggga
     3781 atttgtaaac gaatatgtcg gtgaactaat cgacgaggaa gagtgcagac ttcgaatcaa
     3841 gcgagcccac gagaacagtg taactaattt ttatatgtta actgttacca aggaccgtat
     3901 aattgatgct ggaccaaagg gaaattattc tcgtttcatg aaccacagtt gtaatccaaa
     3961 ctgtgagaca cagaagtgga ccgtgaatgg agatgtccga gtcgggctgt tcgctctttg
     4021 tgacatccct gcagggatgg agttaacatt taattacaac ttggactgtc tgggcaatgg
     4081 caggacagta tgccactgcg gagcagacaa ctgcagtggt ttcctaggag tgcggccaaa
     4141 gtctgcatgt acgtcagcag ctgacgagaa gacaaaaaat gccaagttaa agaagaggcg
     4201 gagaggcaaa gcagaggcca agcaaatcca tgaggattat tgttttcagt gtggggatgg
     4261 tggagagttg gtcatgtgtg acaaaaaaga ctgtcccaaa gcgtaccacc tcctatgcct
     4321 taacctgact cagccaccct acggaaagtg ggagtgcccg tggcatcagt gtgacgagtg
     4381 tggcagtgca gccatttcct tctgtgaatt ctgtccacac tccttctgta aggctcatga
     4441 aaagggggct ctggtaccct ctgcactaga aggtcgtctc tgctgctcca accatgaccc
     4501 tgcatctcct gtgtcaccgg aatactggag caagatgaga tgtaaatggg aatcccaaga
     4561 tggtggggaa gaagtaaagg agtgagaggt ggtgacttcc ttccctgcag ctcgcagtcc
     4621 cagaggcaac agagcacgca ctgtgcttgc caccatccac accgccttct aaccgatggg
     4681 agctggctca cacaggctaa agcacggtgg tgtttcctat tgtgttgttt gggggataat
     4741 ttgtggacag cagaattccc ttggtctttt cttgcctatt attgtgcttc agtgtctttg
     4801 cagtcagcaa aagaggtgtc ctcgttctta gagttgaaag ttaaaagaat gttttgtcga
     4861 taa
//
