LOCUS       NM_001191552            7230 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus nuclear receptor binding SET domain protein 2
            (Nsd2), mRNA.
ACCESSION   NM_001191552 XM_002728122 XM_039092428
VERSION     NM_001191552.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7230)
  AUTHORS   Guan,S., Li,L., Chen,W.S., Jiang,W.Y., Ding,Y., Zhao,L.L.,
            Shi,Y.F., Wang,J., Gui,Q., Xu,C.C., Cheng,Y. and Zhang,W.
  TITLE     Circular RNA WHSC1 exerts oncogenic properties by regulating
            miR-7/TAB2 in lung cancer
  JOURNAL   J Cell Mol Med 25 (20), 9784-9795 (2021)
   PUBMED   34551195
REFERENCE   2  (bases 1 to 7230)
  AUTHORS   Zhou,X.L., Liu,Z.B., Zhu,R.R., Huang,H., Xu,Q.R., Xu,H., Zeng,L.,
            Li,Y.Y., Huang,C.H., Wu,Q.C. and Liu,J.C.
  TITLE     NSD2 silencing alleviates pulmonary arterial hypertension by
            inhibiting trehalose metabolism and autophagy
  JOURNAL   Clin Sci (Lond) 133 (9), 1085-1096 (2019)
   PUBMED   31040165
  REMARK    GeneRIF: NSD2-regulated trehalose mainly affected ABC transporters,
            mineral absorption, protein digestion and absorption, metabolic
            pathways, and aminoacyl-tRNA biosynthesis
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7230)
  AUTHORS   Pei,H., Wu,X., Liu,T., Yu,K., Jelinek,D.F. and Lou,Z.
  TITLE     The histone methyltransferase MMSET regulates class switch
            recombination
  JOURNAL   J Immunol 190 (2), 756-763 (2013)
   PUBMED   23241889
REFERENCE   4  (bases 1 to 7230)
  AUTHORS   Nimura,K., Ura,K., Shiratori,H., Ikawa,M., Okabe,M., Schwartz,R.J.
            and Kaneda,Y.
  TITLE     A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to
            Wolf-Hirschhorn syndrome
  JOURNAL   Nature 460 (7252), 287-291 (2009)
   PUBMED   19483677
REFERENCE   5  (bases 1 to 7230)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Jul 27, 2021 this sequence version replaced
            XM_039092428.1, NM_001191552.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643293.57514.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000014.1  81135726-81135864   c
            140-209             JAXUCZ010000014.1  81134878-81134947   c
            210-254             JAXUCZ010000014.1  81132000-81132044   c
            255-296             JAXUCZ010000014.1  81126352-81126393   c
            297-330             JAXUCZ010000014.1  81122989-81123022   c
            331-956             JAXUCZ010000014.1  81109853-81110478   c
            957-1119            JAXUCZ010000014.1  81107421-81107583   c
            1120-1286           JAXUCZ010000014.1  81100710-81100876   c
            1287-1769           JAXUCZ010000014.1  81099639-81100121   c
            1770-1914           JAXUCZ010000014.1  81093866-81094010   c
            1915-2033           JAXUCZ010000014.1  81090340-81090458   c
            2034-2115           JAXUCZ010000014.1  81086793-81086874   c
            2116-2240           JAXUCZ010000014.1  81085575-81085699   c
            2241-2372           JAXUCZ010000014.1  81075415-81075546   c
            2373-2496           JAXUCZ010000014.1  81074491-81074614   c
            2497-2697           JAXUCZ010000014.1  81073490-81073690   c
            2698-2877           JAXUCZ010000014.1  81072531-81072710   c
            2878-3034           JAXUCZ010000014.1  81072016-81072172   c
            3035-3240           JAXUCZ010000014.1  81071683-81071888   c
            3241-3344           JAXUCZ010000014.1  81070075-81070178   c
            3345-3614           JAXUCZ010000014.1  81069487-81069756   c
            3615-3731           JAXUCZ010000014.1  81067832-81067948   c
            3732-3873           JAXUCZ010000014.1  81064007-81064148   c
            3874-3980           JAXUCZ010000014.1  81063638-81063744   c
            3981-4185           JAXUCZ010000014.1  81061882-81062086   c
            4186-7230           JAXUCZ010000014.1  81057727-81060771   c
FEATURES             Location/Qualifiers
     source          1..7230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..7230
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /note="nuclear receptor binding SET domain protein 2"
                     /db_xref="GeneID:680537"
                     /db_xref="RGD:1307955"
     exon            1..139
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..209
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..254
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..296
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..330
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..956
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..4457
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /EC_number="2.1.1.354"
                     /note="probable histone-lysine N-methyltransferase NSD2;
                     Wolf-Hirschhorn syndrome candidate 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase NSD2"
                     /protein_id="NP_001178481.2"
                     /db_xref="GeneID:680537"
                     /db_xref="RGD:1307955"
                     /translation="MEFSIRKSPLSVQKVVKCMKMKQAPEILGSANGKTQNCEVNHEC
                     SVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFNGEPGAHDTKLCFET
                     QEVKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDGAADMSQSEENGQK
                     SDNKTRRNRKRSIKYDSLLEQGLVEAALVSKISSPEDKKIPVKKESCPNSGRDRDLLL
                     KYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWI
                     FEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRAQWEMGIVQAEEAAS
                     MSVEERKAKFTFLYVGDQLRLNPQVAKEAGIATEPLGEMVDSSVANEEAAVDPGTMRE
                     EDIPVKRRRRAKRSSSAENQEGDPGTEKSTPPKMADAEPKRGVGSPAGRKRSTGSASR
                     SRKGDSAAQFLVFCQKHRDEVVAEHPDASEEEIEELLGSQWSMLNEKQKARYNTKFSL
                     MISAQSEEDSGNTSGKKRTHTKRTDDPPEDVDVEDAPRKRLRTDKHSLRKRETITDKT
                     ARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSSSPSASLT
                     ENEVSDNPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLCEKTGSLLLC
                     EGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFVCKESKMEVKRCMVNQCGKFYH
                     EACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDAC
                     LAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPD
                     CLSIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHE
                     IGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEI
                     KLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDS
                     ECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEF
                     VNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQP
                     NCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGD
                     RPKTSTSLSSEEKSKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKA
                     YHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFRSTQDGQ
                     SYCCEHDLRADSANNTKTEKPFLDSLKAKGKRKKRRCWRRVTDGK"
     exon            957..1119
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1286
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1769
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1914
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2033
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2115
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2240
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2372
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2496
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2697
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2877
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3034
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3240
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3344
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3614
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3731
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3873
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..3980
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4185
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..7230
                     /gene="Nsd2"
                     /gene_synonym="RGD1565590; Whsc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcccgccg ctgccgccgc cgccccctcc tgtttccctg ccctccgcgg cctcgcgccc
       61 gctgccaccg ccgccgccgc cgccgccgcc gccggacagc cgctgccgga cagcagccgg
      121 aggatgcgac gctgcgcagc tcaggacgag gtttgacatt gacgacgaaa cggtatgaaa
      181 tcggatgttc tgacgggaat cattttcagg aagcctctgt tttggaagta ccctgttttg
      241 gaaggctcgt gtagtgctgt atgacagtgc ttagtgccac caggcaggtg ggagaaagtc
      301 aaatggatcg aagtaccttt cactatctcg tgttctaaga accaaagcat ctgggctgga
      361 tggaatttag catcagaaaa agtcctcttt ctgttcagaa agttgtaaag tgcatgaaga
      421 tgaagcaggc accagaaatc cttggcagtg caaatggaaa gactcagaac tgtgaagtga
      481 atcacgaatg ttctgtattc ctcagcaaag ctcagctttc taacagccta caggaggggg
      541 tcatgcagaa atttaacggg catgatgcac tcccctttct tccagcagag aagttgaaag
      601 atcttacttc ttgtgtgttt aatggagaac ctggtgctca tgatactaag ttgtgttttg
      661 agacccagga agtaaaagga attgggacac cacccaatac tactcctatc aaaaatggct
      721 ctccagaaat taaactgaaa atcaccaaaa catacatgaa tgggaaacct ctctttgaat
      781 cttcaatttg tggtgatggc gctgctgata tgtctcagtc agaagaaaat ggacaaaaat
      841 cggataataa gactaggagg aacaggaaga ggagcataaa atatgactct ttgctggagc
      901 agggccttgt ggaagcagct ttagtgtcca agatctcaag tcctgaagat aaaaagattc
      961 cagttaagaa ggagtcctgt ccaaatagtg gcagagacag agacctcttg ttaaaataca
     1021 acgttggtga tttggtgtgg tccaaagtgt caggttaccc ttggtggcct tgcatggttt
     1081 ctgctgatcc actccttcac aatcatacca aacttaaagg tcagaaaaaa agtgcacgcc
     1141 agtatcatgt acaattcttt ggtgatgccc cagaaagagc ttggatattt gagaagagcc
     1201 ttgttgcttt tgaaggagaa gaacaatttg aaaaattatg ccaagaaagt gccaagcagg
     1261 cacccacgaa agctgagaaa atcaagttgt tgaaacctat ttcagggaga ttgagagccc
     1321 agtgggaaat gggcattgtc caggctgagg aagctgctag catgtcagta gaggagcgga
     1381 aagccaagtt tactttcctt tatgtggggg accaactgcg cctcaaccct caagtggcta
     1441 aggaggctgg cattgctaca gaacctttgg gagaaatggt ggactcttca gtggccaatg
     1501 aagaagctgc tgtagaccct gggactatga gagaagagga cattcccgta aagagaaggc
     1561 gaagagccaa aaggtctagt tctgctgaga accaggaagg agaccccggc acagaaaaga
     1621 gtacacctcc aaagatggcg gatgctgaac ctaagagagg cgtaggttct cctgccggga
     1681 ggaaaaggtc cacaggatct gcctcacgga gcagaaaggg agactcagca gcccagttct
     1741 tagtcttttg tcaaaaacac agggatgagg tcgtagctga acacccagat gcctcagagg
     1801 aggagattga agaattgctt gggtcccaat ggagcatgct caatgaaaag cagaaagcac
     1861 gatataatac aaagttttcc ctaatgatct ctgcccagtc tgaagaagac tctggaaata
     1921 ccagtgggaa aaaaaggacc cacacaaaaa ggacagatga ccctcctgag gatgtggatg
     1981 tagaagacgc acccaggaaa agacttagga cagataagca cagtcttcgg aagagagaga
     2041 caatcaccga caaaacggcc agaacgagct cgtacaaggc tatagaggca gcctcctcac
     2101 tcaagagcca ggcagcaacg aaaaatttgt ctgatgcttg caaaccactg aagaagcgaa
     2161 atcgggcttc tgcaacagcg tcttcagcac ttgggtttaa caaaagttca tctccttctg
     2221 catccttaac tgagaatgag gtctcagaca acccaggaga tgaaccgtca gagtctccgt
     2281 atgaaagtgc agatgaaaca cagactgaag cgtccgtctc atctaagaaa tctgaaagag
     2341 gaatggctgc caaaaaggag tacgtgtgtc agctgtgtga gaagacaggc agtctcttac
     2401 tgtgtgaagg cccctgttgt ggagcattcc acttagcctg ccttggactt tcccagagac
     2461 cagaaggaag attcacctgc actgaatgtg cctcagggat tcactcatgc ttcgtatgta
     2521 aagaaagcaa gatggaggtg aaacgctgta tggtaaacca atgtggaaag ttttaccatg
     2581 aagcctgtgt gaaaaaatac cctctcactg tgtttgagag ccgaggcttt cgctgtcctc
     2641 tccacagctg tatgagctgc catgcctcaa acccttcaaa tccgcggcca tcaaaaggta
     2701 aaatgatgcg gtgcgtccga tgccctgtcg cctatcatgg cggggatgcc tgcctggcag
     2761 cgggatgttc cgtgattgct tctaacagca taatctgcac aggccacttc actgcccgca
     2821 aggggaagcg gcaccacact catgtcaatg tgagctggtg cttcgtgtgc tccaaagggg
     2881 gaagccttct gtgctgcgag gcctgtccgg cagccttcca ccctgattgt ttgagcatcg
     2941 agatgcctga tggcagctgg ttctgcaatg actgccgagc tgggaagaag ctccactttc
     3001 aagacatcat ttgggtcaaa cttgggaact acagatggtg gccagcagaa gtttgccatc
     3061 ccaaaaatgt tcccccaaat attcagaaaa tgaagcacga gattggagaa ttccctgtgt
     3121 ttttcttcgg gtctaaagat tattactgga cgcatcaggc acgagtgttc ccatacatgg
     3181 agggggaccg gggcagccgc taccaggggg tcagagggat tggaagagtc ttcaagaacg
     3241 cattgcaaga agccgaagct cgttttaatg aaatcaaact tcagcgggaa gcccgagaaa
     3301 cacaggagag tgagagaaag cctccaccat acaagcatat caaggtgaat aaaccttatg
     3361 gtaaagtcca gatctataca gctgacattt ctgaaatccc aaaatgcaac tgtaagccca
     3421 cggatgagaa cccctgtggc tctgattcag agtgtctaaa caggatgcta atgtttgagt
     3481 gccacccgca ggtgtgccct gcaggggaat attgccagaa ccagtgtttc actaagcgcc
     3541 agtacccgga gaccaagatc atcaagaccg atggcaaagg gtggggcctg gttgccaaaa
     3601 gggacatcag aaagggagaa tttgttaatg agtatgttgg cgaactgatt gatgaagagg
     3661 agtgtatggc aagaatcaaa tatgcacatg agaatgacat cactcacttt tacatgctca
     3721 ccatagacaa ggaccgcata attgatgctg gccccaaagg gaattactcg cggttcatga
     3781 accatagctg ccagcccaac tgtgagaccc tgaagtggac agtgaatggg gacacacggg
     3841 ttggcctgtt tgctgtgtgc gacatccctg caggtacaga gctgactttc aactataacc
     3901 tcgattgttt gggcaatgaa aagacagtct gtcggtgtgg agcctccaac tgtagtgggt
     3961 tccttggaga cagaccaaag acatcaacat ccctttcttc agaggaaaag agtaaaaagg
     4021 ccaagaagaa aaccaggagg cgcagagcca agggtgaagg aaagcggcag tcagaggacg
     4081 aatgcttccg ctgtggtgat ggcggacaac tggtgctgtg tgaccgcaag ttctgcacca
     4141 aggcctacca cctatcctgc ttgggcttgg gcaagcggcc ctttgggaag tgggaatgtc
     4201 cttggcatca ctgtgatgtg tgtggcaaac cttctacctc attttgccac ctctgcccca
     4261 actcattctg taaggaacac caagatggga ctgctttccg ctccacccag gatgggcaat
     4321 cctactgctg tgagcatgac ctgagggcag actctgcaaa taataccaag actgagaaac
     4381 cctttctaga ctcactcaag gcgaagggga agaggaagaa aaggcggtgc tggcgaaggg
     4441 tcacagacgg caaatagcgc ttggtcagat cctggggtgg tgtggggcag ccagtcctgc
     4501 ctacagtggg aaggcgagca cggcactcac cccaaggacc caggtcatag tgctctatgt
     4561 ataggcctac ttgggtggga ggcagctcct ctcaccactg agccatcctc agcagctgtg
     4621 ctgtgtctgc actgatgctt gtcagctgca tgcttggcgg tccaggataa gcaagcctca
     4681 ctacacagcg tcacctctac acttgaatct gagaccaacg tcaaggtgcc ctcccatttc
     4741 tattttagat taaagttatg attgaagatt aactggcatg tgaaatgctt ttatcttacc
     4801 tgtaacatca agactttcct aaaggtcacc attagctctt tcctgatggt gcaggcttct
     4861 actcacacac tgccctctac tcagggcagg ctgggactca agccctgggc tccttccaat
     4921 caggattgat aattactttg ttgttttgaa acagcctatg ttctttgtat taatgtgaat
     4981 ttttcctcaa agtgctttgt ttgcactttg agtggctgtg gttgtaaggt tcctctcggg
     5041 gttttccttt ctgtggacgt gaacagtgac ggccgtgtgc ggcctgtgga gcagagcagc
     5101 tgcctttgtg tgcctgttct tctctaatgc cttttgacca ccatctgggg ggaaccttgt
     5161 acattttctt cacttggtat ttatttctgg cattttattt ccaacatacc tttgctaaaa
     5221 cttttacaca ctttaccatt taccagctaa aatgttgagt tgccaggcag ataaaagcta
     5281 ttgagcagag gaagaggtaa ccacaggatc ctggggggga cacaagacag cctgtgaacc
     5341 taggctgagc tttctgtttt gtgcatttgt ctgtggagcc ttgagctagt tgtcgcttat
     5401 ctccaccagg gcaccacctg gtctcatggt ggtcaagtct gatggtacct gtttccctat
     5461 gaggttaagt gatctcttat aacggcccag cccaaggact actggactgt cttggcagac
     5521 ttgcttctgt cctcccaggg gtacatcttg gcattggaga gcttgggaca cccagaaagg
     5581 agacctcagg ctttctactg ggagggaaat acatgcagtg catcagcaac agatggcttt
     5641 agaaaagctt caaggcaaaa aggttaaagt agccttaagt ccccgaggtt tgctgtccac
     5701 tgctgtccgg ctgtcctcta gccttgtaga attgcagtct ccatttgaac caggactgac
     5761 tattcatagt ggtcagcacc agccatgaca cctgcaagcc cagcctgtca tgagcactga
     5821 ccagtgacca tccctttggc acttctatag tagaccccaa agttgaggca gctttgcagg
     5881 tagcctgttg cttccctagg cacaggctca gttacctctg gagacaccta tttgaccaga
     5941 caagaccagg aacacttttc agtagaattt aatctggctc aaactgctct gtaaaaatat
     6001 tagatggttc ataaatttct gcaatttatg gcccaagttt ggaagactgc tggtagtgat
     6061 aggccagaca gcctcatcac acgcacatgg cccgccctga tctttggagc catggtcccc
     6121 aggctccctg gtgggcccgt ccttaaagca tcagaactgg ctttgcagta cactttgttg
     6181 aacaaattaa ctttttaaaa aaaatcttaa gtaaaaatct tgggattttt tttttttggt
     6241 tccaaattat tttatgatct ttctgaagga aatattgtga acattttaga caatttcccc
     6301 tttccaaaag tattaatgaa caagtaacac taactctgaa agccagctga agatctattt
     6361 acaaatctga ggtgatggcc tttcctacag agaccagcca caggcctagg gctgactgga
     6421 atgtaaggtg ttctgaatct gacaagaact gctactttgt gaacatctgc tccagtttct
     6481 ttttccttaa tgtgacataa acaaatgaaa gctgcccatg tcccatactc ctcaggagcc
     6541 tttggcatcc aaaaccagac agggtgttcc ctagtcagca cacacctgtg ggggaactgt
     6601 agcagttaaa accttggcac ttgtagggtg gtccatctgg caagagtgat gaggacccag
     6661 gtgctataag gaacatcctg gcacttgaat gtgaggattc ctagggtctc aggcaggcac
     6721 gcccaggttg gcatttctga tgacttccaa gtgacccctg tagcatgatg tgtgaagtgc
     6781 ccatcttcca cagagttaaa gataaaaatg ttttgattaa aattaacaca aacacctgtc
     6841 aattgccaaa tattttcatc tacatggagt gtagctgatg actgttagca gaataaaatg
     6901 ctgtgtccat gtgtatcatg gtgtcaccat cctgttgaga cgtgaaatgc cctatcagaa
     6961 attaaattta aatttaaatg tgcctattgg tgtctaaact tgatacaata taaagtcagg
     7021 ttccttttag gaatgctggg tgctgtcact aggtctgata gtgaaggctt aaaaacttga
     7081 agtttggggg gaggggggag gtaatactga aatatagatg agaattatca gttgggggga
     7141 aaatagcatt taaagtggca agttgtgttt ggaaaactgt aatgagtatt tttttattaa
     7201 aaaactttaa aggccttttt cttacactta
//
