LOCUS       NM_134415               1053 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus NSA2 ribosome biogenesis factor (Nsa2), mRNA.
ACCESSION   NM_134415 XM_231263
VERSION     NM_134415.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1053)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1053)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1053)
  AUTHORS   Shahni,R., Gnudi,L., King,A., Jones,P. and Malik,A.N.
  TITLE     Elevated levels of renal and circulating Nop-7-associated 2 (NSA2)
            in rat and mouse models of diabetes, in mesangial cells in vitro
            and in patients with diabetic nephropathy
  JOURNAL   Diabetologia 55 (3), 825-834 (2012)
   PUBMED   22095236
  REMARK    GeneRIF: Data suggest that renal and circulating NSA2 levels are
            increased in hyperglycemia in experimental models of diabetes, and
            that circulating NSA2 is elevated in diabetic nephropathy patients
            with albuminuria.
REFERENCE   4  (bases 1 to 1053)
  AUTHORS   Sandhu,H., Dehnen,W., Roller,M., Abel,J. and Unfried,K.
  TITLE     mRNA expression patterns in different stages of asbestos-induced
            carcinogenesis in rats
  JOURNAL   Carcinogenesis 21 (5), 1023-1029 (2000)
   PUBMED   10783328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR473148.1, BC098657.1, BP486932.1 and BP485557.1.
            
            On Mar 10, 2007 this sequence version replaced NM_134415.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226635.1, FQ214845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 CR473148.1         211-219             c
            10-788              BC098657.1         1-779
            789-947             BP486932.1         284-442
            948-1043            BC098657.1         939-1034
            1044-1053           BP485557.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1053
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /note="NSA2 ribosome biogenesis factor"
                     /db_xref="GeneID:171456"
                     /db_xref="RGD:621335"
     exon            1..101
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..881
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /note="TGF beta-inducible nuclear protein;
                     TGF-beta-inducible nuclear protein 1; NSA2 ribosome
                     biogenesis homolog"
                     /codon_start=1
                     /product="ribosome biogenesis protein NSA2 homolog"
                     /protein_id="NP_599242.2"
                     /db_xref="GeneID:171456"
                     /db_xref="RGD:621335"
                     /translation="MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIG
                     LKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKDDEKTPQGAVPAYLLDREGQSRAKVL
                     SNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGF
                     TRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGT
                     VIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV"
     exon            102..289
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..440
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..620
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..813
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1052
                     /gene="Nsa2"
                     /gene_synonym="Cdk105; Tinp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctgagtg aagcaggctc gtgggccagt ggtaacactg ggattaagaa gtttttagaa
       61 cccgggaggt cgcggaccgc tgcttcgcgg ctgtcatcat gccacaaaat gaatatattg
      121 aattgcaccg caaacgatat ggatatcgtt tggattacca tgagaaaaag agaaagaaag
      181 aaggtcggga ggcccatgaa cgttcaaaga aagcaaaaaa aatgatcggc ctgaaggcta
      241 agctctacca taaacagcgc catgccgaga aaatacaaat gaaaaagacc attaagatgc
      301 atgagaagag aaacaccaag cagaaggatg acgagaagac tccacaggga gcagtccctg
      361 cctacctgct agacagagag gggcagtcaa gagcaaaagt actttccaac atgattaagc
      421 agaagcggaa agaaaaggcg ggaaaatggg aggtccctct acccaaagtt cgtgcccaag
      481 gagaaacaga agtattgaaa gttattcgaa caggaaaaag aaaaaagaag gcatggaaga
      541 gaatggttac aaaagtctgc tttgttggtg atggttttac aagaaaacca cctaaatatg
      601 aaaggttcat taggccaatg ggtctacgtt tcaaaaaagc ccatgtcaca caccctgagc
      661 tgaaagctac cttttgcctg cctatactcg gtgtgaaaaa gaacccctcc tccccgttat
      721 atacaaccct gggtgtgatc accaaaggga cagtcattga agtgaatgta agcgagctgg
      781 gccttgtgac acaaggaggc aaggtcattt ggggaaagta tgctcaagtt accaacaatc
      841 ctgaaaatga tgggtgcata aatgcagtct tgctggtttg acagtgacat catacaagtc
      901 actccactca ctacggaaga ctacagtgtc aggaaaacac catcgctgtg atccttctga
      961 actaccaatc agccttaccc catgtgcagt catcaggaag tatttattaa actgtaaagg
     1021 aaaataaaac actgcccaat ttacagttgg caa
//
