LOCUS       NM_207607                756 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NS5A (hepatitis C virus) transactivated protein 4
            like 1 (Ns5atp4l1), mRNA.
ACCESSION   NM_207607 XM_231257
VERSION     NM_207607.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 756)
  AUTHORS   Choi JW, Kim JW, Nguyen LP, Nguyen HC, Park EM, Choi DH, Han KM,
            Kang SM, Tark D, Lim YS and Hwang SB.
  TITLE     Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1
            to Promote Hepatitis C Virus Propagation
  JOURNAL   Mol Cells 43 (5), 469-478 (2020)
   PUBMED   32344996
  REMARK    GeneRIF: Nonstructural NS5A Protein Regulates LIM and SH3 Domain
            Protein 1 to Promote Hepatitis C Virus Propagation.
REFERENCE   2  (bases 1 to 756)
  AUTHORS   Li H, Yang X, Yang G, Hong Z, Zhou L, Yin P, Xiao Y, Chen L, Chung
            RT and Zhang L.
  TITLE     Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a
            phosphatidylinositol 4-phosphate-enriched microenvironment
  JOURNAL   J Virol 88 (11), 5956-5966 (2014)
   PUBMED   24623438
  REMARK    GeneRIF: Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a
            phosphatidylinositol 4-phosphate-enriched microenvironment.
REFERENCE   3  (bases 1 to 756)
  AUTHORS   Helbig KJ, Eyre NS, Yip E, Narayana S, Li K, Fiches G, McCartney
            EM, Jangra RK, Lemon SM and Beard MR.
  TITLE     The antiviral protein viperin inhibits hepatitis C virus
            replication via interaction with nonstructural protein 5A
  JOURNAL   Hepatology 54 (5), 1506-1517 (2011)
   PUBMED   22045669
  REMARK    GeneRIF: We propose that viperin interacts with NS5A and the host
            factor, VAP-A, to limit hepatitis C virus replication at the
            replication complex.
REFERENCE   4  (bases 1 to 756)
  AUTHORS   Masaki T, Suzuki R, Murakami K, Aizaki H, Ishii K, Murayama A, Date
            T, Matsuura Y, Miyamura T, Wakita T and Suzuki T.
  TITLE     Interaction of hepatitis C virus nonstructural protein 5A with core
            protein is critical for the production of infectious virus
            particles
  JOURNAL   J Virol 82 (16), 7964-7976 (2008)
   PUBMED   18524832
  REMARK    GeneRIF: NS5A plays a key role in regulating the early phase of HCV
            particle formation by interacting with core protein and its
            C-terminal serine cluster is a determinant of the NS5A-core
            interaction
REFERENCE   5  (bases 1 to 756)
  AUTHORS   Dal Pero F, Di Maira G, Marin O, Bortoletto G, Pinna LA, Alberti A,
            Ruzzene M and Gerotto M.
  TITLE     Heterogeneity of CK2 phosphorylation sites in the NS5A protein of
            different hepatitis C virus genotypes
  JOURNAL   J Hepatol 47 (6), 768-776 (2007)
   PUBMED   17923166
  REMARK    GeneRIF: The number of predicted CK2 sites correlated with the
            degree of in vitro and in vivo phosphorylation of NS5A by CK2.
            CK2-dependent phosphorylation of NS5A is heterogeneous among
            different HCV genotypes and clinical isolates.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY533136.1.
            
            On Aug 30, 2004 this sequence version replaced XM_231257.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY533136.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..756
                     /gene="Ns5atp4l1"
                     /gene_synonym="NICE-3; Ns5atp4"
                     /note="NS5A (hepatitis C virus) transactivated protein 4
                     like 1"
                     /db_xref="GeneID:311934"
                     /db_xref="RGD:1303202"
     CDS             1..756
                     /gene="Ns5atp4l1"
                     /gene_synonym="NICE-3; Ns5atp4"
                     /codon_start=1
                     /product="NS5A (hepatitis C virus) transactivated protein
                     4"
                     /protein_id="NP_997490.1"
                     /db_xref="GeneID:311934"
                     /db_xref="RGD:1303202"
                     /translation="MASSSNWLSGVNVVLVTAYGSLVFVLLFIFVKKQIMRFALKSSR
                     GPHAPVGHNAPKDLKEEIDIQLSRVQDIKYEAQLLADDDTRLLQLKTQGDQSCYNYLY
                     RMKALDAIRASEIPFHAEGRHLCSLMGKNYYLLDLRNTSTPFKGVPKTLTDTLLDGYE
                     TARNGTGVFGQSEYLRYQEALSELVTVVKARIGRSQRQHQSAAKDLTESSEMSPKTIQ
                     VTYLSSSQKSKRPKHFLELKSFKDNYSTLESSL"
     exon            1..756
                     /gene="Ns5atp4l1"
                     /gene_synonym="NICE-3; Ns5atp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgtcta gtagtaactg gctgtccgga gtgaatgtcg ttcttgtgac ggcgtacggg
       61 agcctggtat tcgtactgct gtttattttt gtgaagaaac aaatcatgcg ctttgcattg
      121 aaatctagta ggggacctca tgcccctgtg ggacacaatg ccccgaagga cttaaaagag
      181 gagatcgata ttcagctatc cagagttcag gatatcaagt atgaagcgca gctccttgca
      241 gatgatgata ccagactact acagctgaaa acccaggggg atcaaagttg ctacaactat
      301 ctgtacagga tgaaagctct agatgccatc cgtgcctctg agatcccatt tcacgctgaa
      361 ggccggcacc tctgttcttt aatgggtaag aattactact tgctagatct gcggaacact
      421 agcactcctt ttaagggtgt tccaaagacc ctcactgata ccctcctgga cggatatgag
      481 acagctcgca atgggacagg ggtctttggc cagagcgagt acttgcgtta tcaggaggcc
      541 ttgagtgagc tggtcactgt ggtcaaagca cgaattgggc gctctcagag acaacaccag
      601 tcagcagcta aagacctaac tgagtcgtct gaaatgtcgc caaaaaccat tcaggtcacg
      661 tatctgtcct ccagtcagaa gagcaaacgc cctaagcact tcctcgaact gaagagcttt
      721 aaagacaact acagcacact ggagagctct ctgtga
//
