LOCUS       NM_053846               6670 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus neurexin 2 (Nrxn2), mRNA.
ACCESSION   NM_053846 XM_017588663 XM_346567
VERSION     NM_053846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6670)
  AUTHORS   Xu,L., Feng,Q., Deng,H., Zhang,X., Ni,H. and Yao,M.
  TITLE     Neurexin-2 is a potential regulator of inflammatory pain in the
            spinal dorsal horn of rats
  JOURNAL   J Cell Mol Med 24 (23), 13623-13633 (2020)
   PUBMED   33164324
  REMARK    GeneRIF: Neurexin-2 is a potential regulator of inflammatory pain
            in the spinal dorsal horn of rats.
REFERENCE   2  (bases 1 to 6670)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   3  (bases 1 to 6670)
  AUTHORS   Gauthier,J., Siddiqui,T.J., Huashan,P., Yokomaku,D., Hamdan,F.F.,
            Champagne,N., Lapointe,M., Spiegelman,D., Noreau,A.,
            Lafreniere,R.G., Fathalli,F., Joober,R., Krebs,M.O., DeLisi,L.E.,
            Mottron,L., Fombonne,E., Michaud,J.L., Drapeau,P., Carbonetto,S.,
            Craig,A.M. and Rouleau,G.A.
  TITLE     Truncating mutations in NRXN2 and NRXN1 in autism spectrum
            disorders and schizophrenia
  JOURNAL   Hum Genet 130 (4), 563-573 (2011)
   PUBMED   21424692
REFERENCE   4  (bases 1 to 6670)
  AUTHORS   Suckow,A.T., Comoletti,D., Waldrop,M.A., Mosedale,M., Egodage,S.,
            Taylor,P. and Chessler,S.D.
  TITLE     Expression of neurexin, neuroligin, and their cytoplasmic binding
            partners in the pancreatic beta-cells and the involvement of
            neuroligin in insulin secretion
  JOURNAL   Endocrinology 149 (12), 6006-6017 (2008)
   PUBMED   18755801
  REMARK    GeneRIF: Data show beta-cell expression of the neurexin 2, and
            demonstrate that the neurexins are expressed outside the central
            nervous system and help confer an inhibitory synaptic-like
            phenotype onto the beta-cell surface.
REFERENCE   5  (bases 1 to 6670)
  AUTHORS   Koehnke,J., Jin,X., Trbovic,N., Katsamba,P.S., Brasch,J.,
            Ahlsen,G., Scheiffele,P., Honig,B., Palmer,A.G. 3rd and Shapiro,L.
  TITLE     Crystal structures of beta-neurexin 1 and beta-neurexin 2
            ectodomains and dynamics of splice insertion sequence 4
  JOURNAL   Structure 16 (3), 410-421 (2008)
   PUBMED   18334216
  REMARK    GeneRIF: beta-NRX insertion sequence 4 may function in roles
            independent of neuroligin binding.
REFERENCE   6  (bases 1 to 6670)
  AUTHORS   Hata,Y., Butz,S. and Sudhof,T.C.
  TITLE     CASK: a novel dlg/PSD95 homolog with an N-terminal
            calmodulin-dependent protein kinase domain identified by
            interaction with neurexins
  JOURNAL   J Neurosci 16 (8), 2488-2494 (1996)
   PUBMED   8786425
REFERENCE   7  (bases 1 to 6670)
  AUTHORS   Ichtchenko,K., Nguyen,T. and Sudhof,T.C.
  TITLE     Structures, alternative splicing, and neurexin binding of multiple
            neuroligins
  JOURNAL   J Biol Chem 271 (5), 2676-2682 (1996)
   PUBMED   8576240
REFERENCE   8  (bases 1 to 6670)
  AUTHORS   Ullrich,B., Ushkaryov,Y.A. and Sudhof,T.C.
  TITLE     Cartography of neurexins: more than 1000 isoforms generated by
            alternative splicing and expressed in distinct subsets of neurons
  JOURNAL   Neuron 14 (3), 497-507 (1995)
   PUBMED   7695896
REFERENCE   9  (bases 1 to 6670)
  AUTHORS   Ushkaryov,Y.A., Hata,Y., Ichtchenko,K., Moomaw,C., Afendis,S.,
            Slaughter,C.A. and Sudhof,T.C.
  TITLE     Conserved domain structure of beta-neurexins. Unusual cleaved
            signal sequences in receptor-like neuronal cell-surface proteins
  JOURNAL   J Biol Chem 269 (16), 11987-11992 (1994)
   PUBMED   8163501
REFERENCE   10 (bases 1 to 6670)
  AUTHORS   Ushkaryov,Y.A., Petrenko,A.G., Geppert,M. and Sudhof,T.C.
  TITLE     Neurexins: synaptic cell surface proteins related to the
            alpha-latrotoxin receptor and laminin
  JOURNAL   Science 257 (5066), 50-56 (1992)
   PUBMED   1621094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_017588663.1, NM_053846.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000001.1  213155673-213155909
            238-1211            JAXUCZ010000001.1  213164972-213165945
            1212-1229           JAXUCZ010000001.1  213181315-213181332
            1230-1259           JAXUCZ010000001.1  213185939-213185968
            1260-1331           JAXUCZ010000001.1  213188124-213188195
            1332-1633           JAXUCZ010000001.1  213192470-213192771
            1634-1678           JAXUCZ010000001.1  213201355-213201399
            1679-1840           JAXUCZ010000001.1  213209650-213209811
            1841-2279           JAXUCZ010000001.1  213210687-213211125
            2280-2666           JAXUCZ010000001.1  213219142-213219528
            2667-2870           JAXUCZ010000001.1  213219697-213219900
            2871-2897           JAXUCZ010000001.1  213226551-213226577
            2898-3017           JAXUCZ010000001.1  213227939-213228058
            3018-3399           JAXUCZ010000001.1  213228389-213228770
            3400-3590           JAXUCZ010000001.1  213229467-213229657
            3591-3764           JAXUCZ010000001.1  213230796-213230969
            3765-3884           JAXUCZ010000001.1  213231337-213231456
            3885-4066           JAXUCZ010000001.1  213242800-213242981
            4067-4238           JAXUCZ010000001.1  213247757-213247928
            4239-4328           JAXUCZ010000001.1  213251573-213251662
            4329-4654           JAXUCZ010000001.1  213254702-213255027
            4655-4733           JAXUCZ010000001.1  213256989-213257067
            4734-6670           JAXUCZ010000001.1  213269590-213271526
FEATURES             Location/Qualifiers
     source          1..6670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..6670
                     /gene="Nrxn2"
                     /note="neurexin 2"
                     /db_xref="GeneID:116595"
                     /db_xref="RGD:620211"
     exon            1..237
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            238..1211
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..5620
                     /gene="Nrxn2"
                     /note="neurexin-2-beta; neurexin-2-alpha; neurexin
                     II-beta; neurexin II-alpha"
                     /codon_start=1
                     /product="neurexin-2-beta precursor"
                     /protein_id="NP_446298.2"
                     /db_xref="GeneID:116595"
                     /db_xref="RGD:620211"
                     /translation="MALGSRWRPPPQLPPLLLLLALVAGVRGLEFGGGPGQWARYARW
                     AGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQ
                     LDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVR
                     LSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGL
                     CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAG
                     DVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSA
                     DYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAM
                     VNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGC
                     LKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPR
                     WSAKRTGSISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSSQRADYFAMELLDGYLYLL
                     LDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLES
                     ELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV
                     APFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMY
                     MKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDC
                     LRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLE
                     FHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRA
                     IVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK
                     GYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA
                     RNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQ
                     VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGA
                     LITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIF
                     NVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAI
                     ARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
                     LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTR
                     RGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPV
                     ATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASG
                     FASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLLA
                     PSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSVPGFPRLP
                     TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY
                     QVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV"
     exon            1212..1229
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1259
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1331
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1633
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1678
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1840
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2279
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2666
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2870
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2897
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3017
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3399
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3590
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3591..3764
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3884
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..4066
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4238
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..4328
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4654
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4655..4733
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4734..6670
                     /gene="Nrxn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtgctga tgctgccgtc agtcggtgtt gcagggatgc ggcggcggga gcagccgccc
       61 tgactctcag agcatcctcc tccgagcggc accgcggcgg ggcgggcggg gacgcggcag
      121 ggaccaggag gcgcgaggcg gacgataccg ctggtcccgg atctgttacc tgccgtagac
      181 ccagcggtct cgaggctcgg atccccaccc ttcagctcct ggcgccccca gaaccaggcg
      241 tccctccccc accttccatc cgagcccgct gcgggggagg ggctccaccg cccccgtcgc
      301 cggcgttgcc ttccggggac gtggacacgt gagccccagc ggctgggtcc atggcattgt
      361 gaatcgacga gggagccccg ctccgcgcga ggggcgcccg gccccctccc cgccccatgc
      421 gcccgcggct ctgaagcctg agcggggccg ggggccgggc ggcgtcgggg ccgccggagg
      481 catggctctc gggagtcggt ggcgaccgcc accccagttg ccgccgctgc tgttgttgct
      541 ggcgctggtg gcaggcgtcc gtggcttgga gtttggcggc ggccccgggc agtgggctcg
      601 ctacgcgcgc tgggcaggcg cggcgagcac cggcgagctc agcttcagcc tgcgcaccaa
      661 cgccacgcgc gcgctgctgc tctacctgga cgacggcggc gactgcgact tcctggagct
      721 gctgctggtg gacgggcgcc tgcggctgcg cttcacgctg tcttgcgccg agcccgccac
      781 gctgcagttg gacacgccgg tggccgacga ccgctggcac atggtgctgc tgacccgcga
      841 cgcgcggcgc acggcgctgg cggtggacgg cgaagcccgt gcggccgagg tgcgctcaaa
      901 gcggcgcgag atgcaggtgg ccagcgacct gttcgtgggc ggcatcccac ccgacgtgcg
      961 cctgtctgcg ctcacgctca gcaccgtcaa gtacgagccg cctttccgcg gcctcctggc
     1021 caacctgaag ctgggcgagc ggccgccggc gctgctgggt agccagggtc tgcgcggtgc
     1081 ggccgccgac cccctgtgcg cgcccgcacg caatccctgc gccaacggcg gcctctgcac
     1141 cgtgctagcc cccggcgagg tgggctgcga ctgcagccac actggcttcg gcggcaagtt
     1201 ctgcagtgaa gaggaacacc ccatggaagg tccggctcac ctgacgttaa acagcgaagt
     1261 agggtcctta ctgttctccg aggggggggc cgggagagga ggagccggcg atgtgcacca
     1321 gccaacaaaa ggcaaggagg aatttgtggc aaccttcaag ggcaatgagt tcttctgcta
     1381 cgacctgtca cacaacccga tccagagcag cactgatgag atcacactgg ccttccgcac
     1441 cctgcagcgc aacgggctga tgctgcacac ggggaagtcg gctgactacg tcaacctgtc
     1501 cctcaagtcc ggggctgtct ggctggtcat caacctaggc tcaggtgcct tcgaggccct
     1561 cgtggaaccc gtcaatggca agttcaacga caacgcctgg cacgacgtcc gggttacccg
     1621 aaacctgcgc cagcacgcag ggattggaca cgctatggta aacaaactgc attatctggt
     1681 gaccatctcg gtggacggga tcctgaccac cacaggctac acgcaggagg attacaccat
     1741 gctgggctct gatgacttct tctacattgg gggcagcccc aacacagccg acctgcctgg
     1801 ctcccctgtc agcaacaact tcatgggctg tctcaaggac gtggtctaca agaataatga
     1861 cttcaagctg gagctatctc gactggctaa ggaaggggac ccgaagatga agctgcaggg
     1921 ggatttgtct ttccgttgtg aggacgtggc tgccttggac cctgtgacct tcgagagtcc
     1981 tgaggccttt gtcgcactgc cccgctggag cgccaagcgc actggttcta tctccctgga
     2041 cttcagaacc acggagccca atgggttgct gctcttcagc cagggccggc gggctggggc
     2101 cggggtaggc agccacagtt ccagccagag ggccgactac tttgccatgg agctattgga
     2161 tggctacctc tatcttctgc tggacatggg ctctgggggc atcaagctgc gggcgtccag
     2221 ccgcaaggtc aacgacggcg aatggtgcca cgtggacttc cagagggatg ggcgcaaagg
     2281 ctccatctct gtgaacagcc gcagtacacc attcttggcc acaggagaga gtgaggtcct
     2341 ggacctggag agtgagctgt acctgggcgg tctccctgag gggggccgag tggacctgcc
     2401 attgcctcct gaggtgtgga cagctgctct ccgggctggc tacgtgggct gcgtgcgaga
     2461 cctcttcata gatggacgga gtcgagatct ccggggcctg gctgaggcac agggagctgt
     2521 gggcgttgca cctttctgct ctcgggagac cctgaagcag tgtgcatcgg ccccctgtcg
     2581 taatggtggc atctgtcgag agggctggaa ccggttcgtc tgtgattgca tcgggactgg
     2641 ctttctgggt cgggtctgcg agagagaggc cacagtctta agctatgatg gctccatgta
     2701 catgaagatc atgctgccca atgccatgca cacggaagca gaggatgtgt ccctgcgatt
     2761 catgtcccag agggcttatg gactcatgat ggccaccacc tctagggagt cggccgacac
     2821 tctgcgtctc gagctggacg gggggcagat gaagctcaca gtcaacctcg actgcctgcg
     2881 cgtcggctgc gcacccagta aaggccccga gaccctcttt gcggggcaca agctcaacga
     2941 caatgagtgg cacacggtga gggtggtacg gcgtggcaag agcctgcagc tgtctgtgga
     3001 caacgtgact gtggagggac agatggcagg agcccacacg cggctggagt tccacaacat
     3061 cgagacaggc atcatgacag agcgacggtt tatctctgtg gtgccctcca acttcatcgg
     3121 ccacctgagc gggctggtgt tcaatggtca accctacatg gaccagtgca aagatggaga
     3181 catcacctac tgtgagctta atgcccgctt tgggctgcgt gccatcgtgg ctgatcctgt
     3241 taccttcaag agtcgcagta gctacctggc gttggccacg ctccaagcct atgcctccat
     3301 gcacctcttc ttccagttca agaccacagc ccctgatgga cttctgctgt tcaactcagg
     3361 caacggcaat gacttcattg tcatcgagct ggtcaagggg tacatccact acgtgtttga
     3421 cctgggaaat ggcccgtcct tgatgaaggg aaactcagac aaaccagtta atgacaacca
     3481 gtggcacaac gtggtggtgt ccagggaccc aggcaacgtg cacacgctga agattgactc
     3541 ccgcacggtc acgcagcatt ccaacggtgc ccgaaatctg gatctcaaag gggagttgta
     3601 catcggtggc ctgagcaaga acatgttcag caacctgcca aagctggtgg cctctcggga
     3661 tggctttcag ggctgcctgg cttctgtgga cctcaacggg cgcctcccag acctcatcgc
     3721 agacgccctg caccgaatcg ggcaggtgga gaggggctgt gatggcccca gtaccacctg
     3781 caccgaagag tcctgtgcca accagggcgt ctgcctgcag cagtgggacg gctttacctg
     3841 tgactgcacc atgacttcct atggaggccc tgtctgcaat gaccctggga ccacatacat
     3901 ctttgggaag gggggagcgc tcatcaccta tacatggcct cccaatgacc gacccagcac
     3961 aaggatggac cgcctggccg taggcttcag cacccaccag cggagcgctg tgctggtacg
     4021 cgtggacagt gcctccggcc tcggggacta cctgcagctg cacattgacc agggcactgt
     4081 tggggtgatt tttaatgtgg gcacggatga cattacaatt gatgagccca acgccatcgt
     4141 gagcgacggc aaatatcacg tggtgcgctt cactcgaagt ggtggcaatg ccaccttgca
     4201 ggtggacagc tggccagtca acgagcggta cccggcaggg aactttgata acgagcgcct
     4261 ggcgattgct agacagagaa tcccctaccg gcttggtcga gtagtagatg aatggctgct
     4321 cgacaaagga cgccagctga ccatcttcaa cagccaggct gccatcaaga tagggggccg
     4381 ggatcagggc cgccccttcc agggccaggt gtccggcctc tactacaatg ggctcaaggt
     4441 actggcgctg gccgccgaga gcgaccccaa tgtgcggacc gaaggccacc tgcgcctagt
     4501 aggggaaggg ccgtccgtgc tgctcagtgc agagaccact gccaccactc tgctggccga
     4561 catggccacc accatcatgg agaccaccac caccatggcc accaccacta ctcgccgggg
     4621 ccgctccccc acaatgaggg acagcaccac ccagaacaca gatgaccttc tggtggcctc
     4681 ggctgagtgt ccaagtgatg atgaggacct ggaggagtgt gagcctagta ctggaggaga
     4741 gttaatattg cccattatca cggaggactc cttagacccc cctcccgtgg ccacccggtc
     4801 ccccttcgtg cccccgcccc ccaccttcta cccctttctc acgggcgtgg gtgccaccca
     4861 agacaccctg cctccgcccg ccgcgcgccg cccgtcctcc gggggcccgt gtcaggccga
     4921 gcgcgacgac agcgactgcg aggagcccgt ggaagcctcg ggcttcgcct ccggggaggt
     4981 ctttgactcc agcctccccc ccacggacga cgaggacttt tacaccacct tccccttggt
     5041 cacggaccgc accaccctcc tgtcaccccg caagcccgcg ccccgaccta acctcaggac
     5101 agatggggcc acgggcgccc ccggggtgct acttgcgccc tccgccccag cccccaacct
     5161 gcccgcgggc aaaatgaacc accgagaccc actgcagccg ctgctggaga acccacccct
     5221 ggggcctggg gtccccacgg ccttcgagcc gcggcggccg cctcccctgc gccccggcgt
     5281 gacctcagtc cccggtttcc cccgtctgcc cacagccaac cccacgggtc cgggggagcg
     5341 cggcccgccg ggcgcggtgg aagtgatccg cgaatccagc agcaccacgg gcatggtggt
     5401 gggcatcgtg gcggcggcgg cgctctgcat ccttatcctt ctctacgcca tgtacaagta
     5461 ccgcaaccgc gacgagggct cctaccaagt ggaccagagc cggaattaca tcagtaactc
     5521 ggcccagagc aatggggcag tggtgaagga gaaggccccc gctgccccca agacgcccag
     5581 caaggccaag aagaacaaag acaaagagta ttacgtctga gcacccagtc caggcaccgc
     5641 gccccactgc cagctgctcc tcccgggaag gcccgggagg agggtgcggc cctctccctg
     5701 cagggggatc tggggaccct ctccccggct gcctcaggct tctcccacga agaggaaacg
     5761 caaaaagaaa aggaatataa ctactacgtg ctcatcccct tccctcccac tgccctcggc
     5821 gccgcactgt cagctctggg gctggctgtc ctccgctctg cgcctgtcag gcagggcacg
     5881 tgctcacagc cctgggttga tttatttttt taaggggcgt agttttattt tggtggggct
     5941 gggcgggaag gaaggctggg gttttgtaaa gtgtccactg cgccgttcgt ttatttccct
     6001 cgattttctt cttcctccca gctcctcccg ccttccttct tcgcagccct cctgtcctgg
     6061 ttcaggcttg ctgtgtcttt tgtccctacc ctcctccacc ccatcccccc tttctttcct
     6121 tttcttttct cttcttttcc tttctttctt ttttaaattc tgttttctct gcttcccttc
     6181 ctttgggttt ccagagtcgc tgggagaaga agggtgggct tgggtggctg gggccgggca
     6241 gtggggctca ttcccctggt gccgcaagtc ccctcgtgag gagaaactcc tgcctgggtc
     6301 tgcccaagga ttgggcttgg acctggccaa ggcctgttgt gtgtgtcgct gccgggcaac
     6361 gtgcattgct gggaagccgc tggaggagcg gggtgggggg cggggggagg gggaaaggca
     6421 aatgcagata tatattaaaa acaaataacc gaggtaccag agctgcgtct gtggcaccag
     6481 ctcgctgcag gcgcagagga tggtgggagt gaggctgtgt ctgcggatgg ctggggtcac
     6541 ttctccgccc atgggctccc tgctccccca gttttttttc tctttgttaa caaatgtgtc
     6601 tgagtcttgg aaaacacccc aaacccggaa atgtgtggga aaaagaaaac aaaaactttc
     6661 caaattccaa
//
