LOCUS       NM_053399                671 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus neurturin (Nrtn), mRNA.
ACCESSION   NM_053399 XM_343665
VERSION     NM_053399.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 671)
  AUTHORS   Mostafaee,H., Idoon,F., Mohasel-Roodi,M., Alipour,F., Lotfi,N. and
            Sadeghi,A.
  TITLE     The effects of induced type I diabetes on developmental regulation
            of GDNF, NRTN, and NCAM proteins in the dentate gyrus of male rat
            offspring
  JOURNAL   J Chem Neuroanat 136, 102391 (2024)
   PUBMED   38219812
  REMARK    GeneRIF: The effects of induced type I diabetes on developmental
            regulation of GDNF, NRTN, and NCAM proteins in the dentate gyrus of
            male rat offspring.
REFERENCE   2  (bases 1 to 671)
  AUTHORS   Nencini,S., Ringuet,M., Kim,D.H., Greenhill,C. and Ivanusic,J.J.
  TITLE     GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent
            Neurons and Contribute to Inflammatory Bone Pain
  JOURNAL   J Neurosci 38 (21), 4899-4911 (2018)
   PUBMED   29712778
  REMARK    GeneRIF: We have shown evidence of a role for GDNF, neurturin, and
            artemin in the activation and sensitization of bone afferent
            neurons, and that sequestering these ligands reduces pain behavior
            in a model of inflammatory bone pain
REFERENCE   3  (bases 1 to 671)
  AUTHORS   Wan,G., Zhou,L., Lim,Q.'., Wong,Y.H. and Too,H.P.
  TITLE     Cyclic AMP signalling through PKA but not Epac is essential for
            neurturin-induced biphasic ERK1/2 activation and neurite outgrowths
            through GFRalpha2 isoforms
  JOURNAL   Cell Signal 23 (11), 1727-1737 (2011)
   PUBMED   21723942
  REMARK    GeneRIF: Cyclic AMP signalling through PKA but not Epac is
            essential for neurturin-induced biphasic ERK1/2 activation and
            neurite outgrowths through GFRalpha2 isoforms.
REFERENCE   4  (bases 1 to 671)
  AUTHORS   Ramaswamy,S., McBride,J.L., Herzog,C.D., Brandon,E., Gasmi,M.,
            Bartus,R.T. and Kordower,J.H.
  TITLE     Neurturin gene therapy improves motor function and prevents death
            of striatal neurons in a 3-nitropropionic acid rat model of
            Huntington's disease
  JOURNAL   Neurobiol Dis 26 (2), 375-384 (2007)
   PUBMED   17336076
  REMARK    GeneRIF: These data support the concept that AAV2-Neurturin might
            be a valuable treatment for patients with Huntington's disease
REFERENCE   5  (bases 1 to 671)
  AUTHORS   Maroldt,H., Kaplinovsky,T. and Cunningham,A.M.
  TITLE     Immunohistochemical expression of two members of the GDNF family of
            growth factors and their receptors in the olfactory system
  JOURNAL   J Neurocytol 34 (3-5), 241-255 (2005)
   PUBMED   16841166
  REMARK    GeneRIF: GDNF and neurturin play different physiological roles in
            the olfactory neuronal system
REFERENCE   6  (bases 1 to 671)
  AUTHORS   Oiwa,Y., Yoshimura,R., Nakai,K. and Itakura,T.
  TITLE     Dopaminergic neuroprotection and regeneration by neurturin assessed
            by using behavioral, biochemical and histochemical measurements in
            a model of progressive Parkinson's disease
  JOURNAL   Brain Res 947 (2), 271-283 (2002)
   PUBMED   12176170
  REMARK    GeneRIF: Neurturin protects nigral dopaminergic neurons and
            promotes axonal regeneration in an animal model of Parkinson
            disease.
REFERENCE   7  (bases 1 to 671)
  AUTHORS   Stover,T., Gong,T.L., Cho,Y., Altschuler,R.A. and Lomax,M.I.
  TITLE     Expression of the GDNF family members and their receptors in the
            mature rat cochlea
  JOURNAL   Brain Res Mol Brain Res 76 (1), 25-35 (2000)
   PUBMED   10719212
REFERENCE   8  (bases 1 to 671)
  AUTHORS   Heuckeroth,R.O., Enomoto,H., Grider,J.R., Golden,J.P., Hanke,J.A.,
            Jackman,A., Molliver,D.C., Bardgett,M.E., Snider,W.D., Johnson,E.M.
            Jr. and Milbrandt,J.
  TITLE     Gene targeting reveals a critical role for neurturin in the
            development and maintenance of enteric, sensory, and
            parasympathetic neurons
  JOURNAL   Neuron 22 (2), 253-263 (1999)
   PUBMED   10069332
REFERENCE   9  (bases 1 to 671)
  AUTHORS   Doray,B., Salomon,R., Amiel,J., Pelet,A., Touraine,R., Billaud,M.,
            Attie,T., Bachy,B., Munnich,A. and Lyonnet,S.
  TITLE     Mutation of the RET ligand, neurturin, supports multigenic
            inheritance in Hirschsprung disease
  JOURNAL   Hum Mol Genet 7 (9), 1449-1452 (1998)
   PUBMED   9700200
  REMARK    Erratum:[Hum Mol Genet 1998 Oct;7(11):1831]
REFERENCE   10 (bases 1 to 671)
  AUTHORS   Baloh,R.H., Gorodinsky,A., Golden,J.P., Tansey,M.G., Keck,C.L.,
            Popescu,N.C., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     GFRalpha3 is an orphan member of the GDNF/neurturin/persephin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5801-5806 (1998)
   PUBMED   9576965
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY190603.1.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_053399.2.
            
            On Jan 1, 2004 this sequence version replaced XM_343665.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY190603.1, BP482733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680425, SAMN09767680
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..671
                     /gene="Nrtn"
                     /note="neurturin"
                     /db_xref="GeneID:84423"
                     /db_xref="RGD:621494"
     exon            1..172
                     /gene="Nrtn"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..591
                     /gene="Nrtn"
                     /codon_start=1
                     /product="neurturin"
                     /protein_id="NP_445851.1"
                     /db_xref="GeneID:84423"
                     /db_xref="RGD:621494"
                     /translation="MRCWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPP
                     RTLDARIARLAQYRALLQGAPDAVELRELSPWVARPSGPRRRAGPRRRRARPGSRPCG
                     LRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRKERVRAH
                     PCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV"
     exon            173..671
                     /gene="Nrtn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggatgaggt gctggaaggc ggcggccctg gtgtcgctca tctgcagctc cctgctgtct
       61 gtctggatgt gccaggaggg tctgctcttg ggtcaccgcc tgggacccgc gctcgctcct
      121 ctgcgacgcc ctccacgcac cctggacgcc cgcatcgccc gcctggccca gtatcgcgct
      181 ctgctgcagg gcgcccccga cgcggtggag cttcgagaac tttctccctg ggttgcccgt
      241 ccctcggggc cgcgccgtcg agcgggtccc cggcgtcggc gtgcgcggcc aggctcgcga
      301 ccgtgcgggc tgcgcgagct cgaggtgcgt gtgagcgagc tgggtctggg ctacacgtcg
      361 gacgaaaccg tcctgttccg ctactgcgca ggcgcgtgcg aggcggccat acgcatctac
      421 gacctgggcc tgcggcgcct gcgccagcga cgacgcgtgc gcaaagagcg ggtgcgagcg
      481 cacccgtgct gccgcccgac ggcctacgag gacgaggtgt ccttcctgga cgtacacagc
      541 cgctaccaca cgctgcaaga gctgtcggcg cgggagtgcg cgtgcgtgtg atgctacctc
      601 acgccccgac ctgcaaaggg gccctggcga ctttcaggag aactgaattc acataaagtg
      661 tggggaactc g
//
