LOCUS       NM_001024995            2505 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus negative regulator of reactive oxygen species
            (Nrros), mRNA.
ACCESSION   NM_001024995 XM_221370
VERSION     NM_001024995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Qin,Y., Garrison,B.S., Ma,W., Wang,R., Jiang,A., Li,J., Mistry,M.,
            Bronson,R.T., Santoro,D., Franco,C., Robinton,D.A., Stevens,B.,
            Rossi,D.J., Lu,C. and Springer,T.A.
  TITLE     A Milieu Molecule for TGF-beta Required for Microglia Function in
            the Nervous System
  JOURNAL   Cell 174 (1), 156-171 (2018)
   PUBMED   29909984
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Wong,K., Noubade,R., Manzanillo,P., Ota,N., Foreman,O.,
            Hackney,J.A., Friedman,B.A., Pappu,R., Scearce-Levie,K. and
            Ouyang,W.
  TITLE     Mice deficient in NRROS show abnormal microglial development and
            neurological disorders
  JOURNAL   Nat Immunol 18 (6), 633-641 (2017)
   PUBMED   28459434
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Noubade,R., Wong,K., Ota,N., Rutz,S., Eidenschenk,C., Valdez,P.A.,
            Ding,J., Peng,I., Sebrell,A., Caplazi,P., DeVoss,J., Soriano,R.H.,
            Sai,T., Lu,R., Modrusan,Z., Hackney,J. and Ouyang,W.
  TITLE     NRROS negatively regulates reactive oxygen species during host
            defence and autoimmunity
  JOURNAL   Nature 509 (7499), 235-239 (2014)
   PUBMED   24739962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091190.1.
            
            On Jun 25, 2005 this sequence version replaced XM_221370.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091190.1, CO573593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..2505
                     /gene="Nrros"
                     /gene_synonym="Garpl1; Lrrc33; RGD1310771"
                     /note="negative regulator of reactive oxygen species"
                     /db_xref="GeneID:303875"
                     /db_xref="RGD:1310771"
     exon            1..146
                     /gene="Nrros"
                     /gene_synonym="Garpl1; Lrrc33; RGD1310771"
                     /inference="alignment:Splign:2.1.0"
     exon            147..267
                     /gene="Nrros"
                     /gene_synonym="Garpl1; Lrrc33; RGD1310771"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2238
                     /gene="Nrros"
                     /gene_synonym="Garpl1; Lrrc33; RGD1310771"
                     /note="leucine-rich repeat-containing protein 33; leucine
                     rich repeat containing 33; leucine-rich repeat-containing
                     protein 33^; transforming growth factor beta activator
                     LRRC33"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC33
                     precursor"
                     /protein_id="NP_001020166.1"
                     /db_xref="GeneID:303875"
                     /db_xref="RGD:1310771"
                     /translation="MEFLPLWLCLGFHFLIVEWRSGRGTATAASQGGCKVVDRVADCR
                     SLNLASVPSGLPAHSRMLVLDANPLRVLWNHSLQAYPRLEDLSLHSCHLDRISHWAFH
                     EQGHLQNLVLADNRLSENYKESATALHTLLRLRRLDLSGNSLTEDMAALMLQNLSSLE
                     VVSLARNTLMRLDDSVFEGLERLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLP
                     CIVDFSLTQLRFLNVSYNILEWFLAAREEAAFELEILDLSHNQLLFFPLLPQCGKLHT
                     LLLQDNSMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVSLWEEFSSSDLSALRFLD
                     MSQNQLRHLPDGFLKKTPSLSHLNLNQNCLTKLHIREHEPPGALTELDLSRNQLAELH
                     LAPGLTGSLKNLRVFNLSSNQLLGVPTGLFHSASSITTLDMSHNQISLCPQTVPLDWE
                     EPSSCVDFRNMASLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGILNGSVSPLSA
                     VAPTLQVLSLRNVGLGSGAAEMDFSGFGNLRELDLSGNSLTSFPKFKGSSALQTLDLR
                     RNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQHFKTIADLSMVTCNLS
                     SKIIRVVELPEGIPQDCKWGQVDTGLFYLVLILPSCLTLLVASTVIFLTFKKPLLQVI
                     KSRCHWSSIY"
     exon            268..2482
                     /gene="Nrros"
                     /gene_synonym="Garpl1; Lrrc33; RGD1310771"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgcggc agcggcaact gctgtccagg aggcccgggc cctggagacg atgcgccccg
       61 cggagccgcc tgggcctgcg ggagcagtga gtatttcgtg cgtgggttca ccgccgagca
      121 tcgcgagcat cgctggggta ctagagagct gcacctgaga tggagttcct gcccctgtgg
      181 ctttgcctgg gttttcactt cttgattgtg gaatggagga gcggacgtgg gacagctact
      241 gcagcttccc aaggaggctg caaggtggtc gaccgagtcg ctgactgccg cagtctgaac
      301 ctcgcttcag tacccagcgg cctcccggcc cattcccgga tgctcgttct ggatgccaac
      361 cctctcaggg ttctgtggaa tcattccctc caggcctacc cacgcctgga ggacctcagc
      421 ctgcacagct gtcacctgga ccgtatcagc cactgggcct tccatgagca aggccactta
      481 caaaacctgg ttctggcaga caaccgcctc tccgagaact acaaggagtc ggccacagct
      541 ctccacaccc tgctgcgact tcgaagactg gacttgtctg gaaactccct gacagaagac
      601 atggcagctc tcatgcttca gaacctctcc tcattggagg tcgtgtcctt ggcaagaaat
      661 accctcatga ggctcgacga ctctgtcttc gagggcctgg agcgcctcgt ggagctggat
      721 ttgcagagaa actacatctt tgagatcgag ggcggtgcgt ttgacggctt gactgagctg
      781 aggcgtctca accttgccta caacaacctc ccctgcatcg tggacttcag cctcacacag
      841 ttgcggttcc tcaacgtcag ttacaacatc ctggagtggt tcctggcagc cagggaagag
      901 gcggccttcg aactggagat actggacctg tctcacaacc agctgctctt cttcccgctc
      961 ctgcctcagt gtggcaagct gcacacgctc ctgctgcagg acaacagcat gggcttctac
     1021 agggagcttt acaacacctc ctccccacag gagatggtgg cccagttcct tctcgtggat
     1081 ggtaatgtta ctaatatcac aaccgtcagc ctctgggagg agttctcctc cagcgacctg
     1141 tcagcgcttc gcttcctgga catgagccaa aaccagttgc ggcacctgcc ggatggtttc
     1201 ctgaagaaaa cgccttccct ttcccacctg aacctcaacc aaaattgcct gacgaagctc
     1261 cacattcggg agcacgagcc gccgggagcg ctcactgagc tggatctgag ccgcaaccag
     1321 ctggcagaac tgcacttggc ccctgggctc actggttccc tcaagaacct cagagtgttc
     1381 aacctgagct ccaaccagct cctgggagtc cccactggcc ttttccacag cgccagcagc
     1441 atcactacac ttgacatgag ccacaatcag atctcacttt gtccccagac agtgccctta
     1501 gactgggagg agccctccag ttgtgtggat ttcagaaaca tggcctcttt gaggagcctt
     1561 tctctggatg gctgtgggct gaaggcatta caagactgcc cattccaggg gacctccctc
     1621 actcatttag atctgtctag caactggggg attctgaatg ggagcgtcag ccctctctcg
     1681 gctgttgccc ctacattaca ggtcctgtct ctcaggaacg tgggccttgg ttctggcgct
     1741 gcagagatgg acttctctgg gtttgggaat ctgagggagt tggatctgtc aggaaattcc
     1801 ctgaccagct tccccaagtt caagggcagt tcggccctgc agactctcga cctccgcaga
     1861 aactctctca cagccctacc tcagagggtt gtgtcggagc agcctctgag gggtctgcag
     1921 accatctacc tcagccagaa cccttatgac tgctgtgggg tggagggatg gggggccctg
     1981 cagcacttca agactattgc ggacctgtcc atggtcactt gcaacctctc ttccaagatc
     2041 attcgtgtgg tagagctgcc agagggcata cctcaggact gtaagtgggg gcaggtggac
     2101 actggtctat tctacctcgt gctcattctg cccagctgcc tcaccctgct ggtggccagc
     2161 accgtcatct tcctcacttt taagaagcct ttgcttcagg tcatcaagag ccgctgtcac
     2221 tggtcctcca tatactgacc cgggtgccaa ggttagagac ttggtttgtc tctcgaggat
     2281 gcgtctctcc actgggtctt cacttgttca ggggtcaagt gtggtgcgtt gaaggtcaaa
     2341 ctaaaatttg aatgagttcc atctgcagtc ccattaactt ctctcgtcct tgtgatttat
     2401 cctcattgtc ctggtgaaat atttattaaa tgacattctg tgagaataaa gggtgcgtct
     2461 tataaatatt ttaaaaatca aaaaaaaaaa aaaaaaaaaa aaaaa
//
