LOCUS       NM_030869               3341 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus neuropilin 2 (Nrp2), mRNA.
ACCESSION   NM_030869
VERSION     NM_030869.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Li,Y., Tong,F., Zhang,Y., Cai,Y., Ding,J., Wang,Q. and Wang,X.
  TITLE     Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by
            Regulating Axon Collateral Formation Through CRMP2 in a Rat Model
            of Epilepsy
  JOURNAL   Mol Neurobiol 59 (11), 6817-6833 (2022)
   PUBMED   36044155
  REMARK    GeneRIF: Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by
            Regulating Axon Collateral Formation Through CRMP2 in a Rat Model
            of Epilepsy.
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Lim,K.H., Yang,S., Kim,S.H. and Joo,J.Y.
  TITLE     Identifying New COVID-19 Receptor Neuropilin-1 in Severe
            Alzheimer's Disease Patients Group Brain Using Genome-Wide
            Association Study Approach
  JOURNAL   Front Genet 12, 741175 (2021)
   PUBMED   34745215
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Chang,X., Yang,Q., Zhang,C., Zhang,Y., Liang,X., Liu,Y. and Xu,G.
  TITLE     Roles for VEGF-C/NRP-2 axis in regulating renal tubular epithelial
            cell survival and autophagy during serum deprivation
  JOURNAL   Cell Biochem Funct 37 (4), 290-300 (2019)
   PUBMED   31211440
  REMARK    GeneRIF: VEGF-C/NRP-2 may mediate autophagy by regulating the
            phosphorylation of 4EBP1 and P70S6K; VEGF-C treatment may be
            identified as a therapeutic target in renal injury repair due to
            its capacity to promote tubular cell survival in the future
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   Pellet-Many,C., Mehta,V., Fields,L., Mahmoud,M., Lowe,V., Evans,I.,
            Ruivo,J. and Zachary,I.
  TITLE     Neuropilins 1 and 2 mediate neointimal hyperplasia and
            re-endothelialization following arterial injury
  JOURNAL   Cardiovasc Res 108 (2), 288-298 (2015)
   PUBMED   26410366
  REMARK    GeneRIF: important role in the regulation of neointimal hyperplasia
            by modulating vascular smooth muscle cell migration and
            proliferation
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Plein,A., Calmont,A., Fantin,A., Denti,L., Anderson,N.A.,
            Scambler,P.J. and Ruhrberg,C.
  TITLE     Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac
            outflow tract septation
  JOURNAL   J Clin Invest 125 (7), 2661-2676 (2015)
   PUBMED   26053665
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Gitler,A.D., Lu,M.M. and Epstein,J.A.
  TITLE     PlexinD1 and semaphorin signaling are required in endothelial cells
            for cardiovascular development
  JOURNAL   Dev Cell 7 (1), 107-116 (2004)
   PUBMED   15239958
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Gu,C., Rodriguez,E.R., Reimert,D.V., Shu,T., Fritzsch,B.,
            Richards,L.J., Kolodkin,A.L. and Ginty,D.D.
  TITLE     Neuropilin-1 conveys semaphorin and VEGF signaling during neural
            and cardiovascular development
  JOURNAL   Dev Cell 5 (1), 45-57 (2003)
   PUBMED   12852851
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Shimakawa,S., Suzuki,S., Miyamoto,R., Takitani,K., Tanaka,K.,
            Tanabe,T., Wakamiya,E., Nakamura,F., Kuno,M., Matsuura,S.,
            Watanabe,Y. and Tamai,H.
  TITLE     Neuropilin-2 is overexpressed in the rat brain after limbic
            seizures
  JOURNAL   Brain Res 956 (1), 67-73 (2002)
   PUBMED   12426047
  REMARK    GeneRIF: neuropilin-2 is overexpressed in the rat brain after
            limbic seizures
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Cloutier,J.F., Giger,R.J., Koentges,G., Dulac,C., Kolodkin,A.L. and
            Ginty,D.D.
  TITLE     Neuropilin-2 mediates axonal fasciculation, zonal segregation, but
            not axonal convergence, of primary accessory olfactory neurons
  JOURNAL   Neuron 33 (6), 877-892 (2002)
   PUBMED   11906695
  REMARK    GeneRIF: Npn-2 and candidate pheromone receptors play distinct and
            complementary roles in promoting the wiring and patterning of
            sensory neurons in the accessory olfactory system.
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Kolodkin,A.L., Levengood,D.V., Rowe,E.G., Tai,Y.T., Giger,R.J. and
            Ginty,D.D.
  TITLE     Neuropilin is a semaphorin III receptor
  JOURNAL   Cell 90 (4), 753-762 (1997)
   PUBMED   9288754
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_030869.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               JAXUCZ010000009.1  71617254-71617607
            355-532             JAXUCZ010000009.1  71632787-71632964
            533-714             JAXUCZ010000009.1  71651785-71651966
            715-945             JAXUCZ010000009.1  71657543-71657773
            946-1101            JAXUCZ010000009.1  71658741-71658896
            1102-1271           JAXUCZ010000009.1  71660517-71660686
            1272-1427           JAXUCZ010000009.1  71662472-71662627
            1428-1572           JAXUCZ010000009.1  71674763-71674907
            1573-1922           JAXUCZ010000009.1  71676663-71677012
            1923-2067           JAXUCZ010000009.1  71678858-71679002
            2068-2184           JAXUCZ010000009.1  71682937-71683053
            2185-2325           JAXUCZ010000009.1  71685943-71686083
            2326-2588           JAXUCZ010000009.1  71697636-71697898
            2589-2685           JAXUCZ010000009.1  71699443-71699539
            2686-2706           JAXUCZ010000009.1  71700693-71700713
            2707-2757           JAXUCZ010000009.1  71725940-71725990
            2758-3341           JAXUCZ010000009.1  71728569-71729152
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..3341
                     /gene="Nrp2"
                     /note="neuropilin 2"
                     /db_xref="GeneID:81527"
                     /db_xref="RGD:621442"
     exon            1..354
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..3059
                     /gene="Nrp2"
                     /note="vascular endothelial cell growth factor 165
                     receptor 2"
                     /codon_start=1
                     /product="neuropilin-2 precursor"
                     /protein_id="NP_110496.1"
                     /db_xref="GeneID:81527"
                     /db_xref="RGD:621442"
                     /translation="MDMFPLTWIFLALYFSGHKVRSQQDPPCGGRLNSKDAGYITSPG
                     YPQDYPSHQNCEWVVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLG
                     KHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTI
                     ESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDG
                     IPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPPENFQ
                     CNAPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNVDSNKEYLQVDLR
                     FLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATE
                     LVLNKLHTPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQI
                     SASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARG
                     GDSITAMEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFEPV
                     PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDAT
                     ECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWMYDRAKWLQSTWISSANPNDRTFPD
                     DKNFLKLQSDGGREGQFGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREARQES
                     KLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLE
                     NCMEPISAFAVDIPEIHGGEGYEDEIDDDYEGDWNNSSSTSGAGSPSSGKEKSWLYTL
                     DPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKV
                     KINHQKCCSEA"
     exon            355..532
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..714
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..945
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1101
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1271
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1427
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1572
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1922
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2067
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2184
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2325
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2588
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2685
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2706
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2757
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..3341
                     /gene="Nrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccataca cgcgtttggg tttgaagagg aaactggtct ccgcttcccc agcttgctcc
       61 ctctttgctg atttcagggg ctatctctta gtgaggtgga gatattccag caagaataaa
      121 ggtgaaggca gacggacctc caggacgcag gaggaaaacg ctgatcatta gagacctttg
      181 cagaagacac cacaaggaag aaaattagag aggaaaaaca caaagacata attatacgag
      241 atcccaccaa cctagccctg gagagagcct ctctgtcaaa aatggatatg tttcctctca
      301 cctggatttt cttagctctg tacttttcgg gacacaaagt gagaagccag caagatccgc
      361 cctgcggagg tcggctgaat tccaaagatg ctggctatat cacttcccca ggttaccccc
      421 aggactatcc ctctcaccag aactgtgagt gggttgtcta tgcccccgaa cccaaccaga
      481 agattgtcct caacttcaac cctcactttg aaatcgagaa gcatgactgc aagtatgact
      541 tcattgagat tcgggatgga gacagtgagt cagctgacct cctgggcaag cactgtggga
      601 acattgcccc tcccaccatc atctcttccg gctccgtgtt atatatcaag ttcacatcag
      661 actacgcccg gcagggggca ggtttctccc tacgctatga gatcttcaaa acaggctctg
      721 aagattgttc caagaacttt acaagcccca atgggaccat tgaatctcca gggtttccag
      781 agaaatatcc acacaatctg gactgtacct tcaccatcct ggccaaaccc aggatggaga
      841 tcatcctaca gttcctgacc tttgacctgg agcatgaccc tctacaagtg ggggaaggag
      901 actgtaaata tgactggctg gacatctggg atggcattcc acatgttggg cctctgattg
      961 gcaagtactg tgggacgaaa acaccctcca aactccgctc gtccacaggg atcctctccc
     1021 tgacctttca caccgacatg gccgtggcca aggatggctt ctcagcacgt tactatttgg
     1081 tccaccaaga accacctgag aactttcagt gcaatgcccc tctgggaatg gagtctggcc
     1141 ggattgctaa tgaacagatc agtgcctcat ccaccttctc tgatgggagg tggactcctc
     1201 aacagagcag gctccatggt gatgacaatg gctggacacc caacgtggat tccaacaagg
     1261 agtatctcca ggtggacctg cgcttcctaa ccatgctcac agccattgca acacaaggag
     1321 ccatttccag ggagacccag aagggctact acgtcaaatc gtacaagctg gaagtcagca
     1381 caaacgggga agattggatg gtctaccggc atggcaaaaa ccacaaggta ttccaggcta
     1441 acaatgatgc caccgagttg gttctgaaca agctgcacac gccgctgttg actcgtttca
     1501 tcaggatccg cccgcagacg tggcatttgg gcatagccct tcgactggag ctctttggtt
     1561 gccgggtcac agatgcaccc tgctccaaca tgctgggaat gctctcgggc ctcattgctg
     1621 atacccagat ctctgcctcc tccacccgag agtacctctg gagccccagt gctgcccgcc
     1681 tggttagcag ccgctctggc tggttccctc ggaaccctca agcccagcca ggtgaagaat
     1741 ggcttcaggt ggatcttggg acacccaaga cggtgaaagg cgtcatcatc cagggggccc
     1801 gaggaggaga cagtatcact gccatggaag ccagggcatt tgtacgcaag ttcaaagtct
     1861 cctacagcct aaatggcaag gactgggaat atatccagga ccccaggact cagcagccaa
     1921 agctgtttga agggaacatg cactatgaca cccccgacat ccgaaggttc gagccagttc
     1981 cagcacagta cgtgcgggta tacccagaga ggtggtcacc agcgggcatc gggatgaggc
     2041 tggaggtcct gggctgtgac tggacagact caaagcccac agtggagacg ctgggaccca
     2101 ccgtaaagag tgaagagacc accaccccat atcccatgga tgaggatgcc acggagtgtg
     2161 gggaaaactg cagctttgag gatgacaaag atttgcaact tccttcagga ttcaactgca
     2221 actttgattt tcctgaagag acctgtggtt ggatgtacga ccgtgccaag tggctgcaga
     2281 gtacctggat cagcagtgcc aaccctaacg acagaacgtt tccagatgac aagaacttcc
     2341 tgaaactaca gagcgacggc ggacgagagg gccagtttgg gcggctcatc agcccaccag
     2401 tgcacctgcc ccgaagccct gtgtgcatgg agttccaata ccaagccatg ggcggccacg
     2461 gggtggcact gcaggtggtt cgggaagcca gacaggaaag caaactcctt tgggtcatcc
     2521 gcgaggacca gggcagcgag tggaagcatg gacgcattat cctgcccagc tatgacatgg
     2581 agtatcagat cgtattcgag ggagtgatcg ggaaagggcg atccggagag atttccatcg
     2641 acgacattcg gataagcacc gatgtcccac tggagaactg catggaaccc atctcggctt
     2701 ttgcagtgga catcccagaa atccatgggg gagagggcta tgaagatgag attgatgatg
     2761 actatgaagg agattggaac aactcttcct ctacctcagg ggctggtagt ccctcatctg
     2821 gcaaagaaaa gagctggctg tacacactgg accccatcct gatcaccatc attgccatga
     2881 gctcgctggg tgtcctgctg ggggccacct gtgcgggcct cctcctctac tgcacctgct
     2941 cctactctgg cctgagttcg agaagctgca ccacactgga gaactacaac tttgagctct
     3001 acgacggcct caagcacaag gtcaagatca atcaccagaa gtgctgctcg gaggcatgac
     3061 cgattgtgtc tgaatcgctt ctggcgtttc attccagcga gaggggctag ggaagattac
     3121 tttttttttc ctttggaaac tgaatgccat aatctggatc aaaccgatcc agaatactga
     3181 aggtatggac agaacagaca ggccagtcta ggagaaagga agatgcagcc gtgaagggga
     3241 tcattgccca cagaggacag tggtggtcaa gttaatgcag gaaccgggcc cgtgttctct
     3301 gccgggacac agacaggagc gcatctcctc ggagtcaaca g
//
