LOCUS       NM_145098               3862 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus neuropilin 1 (Nrp1), transcript variant 1, mRNA.
ACCESSION   NM_145098
VERSION     NM_145098.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3862)
  AUTHORS   Gomez,K., Duran,P., Tonello,R., Allen,H.N., Boinon,L.,
            Calderon-Rivera,A., Loya-Lopez,S., Nelson,T.S., Ran,D., Moutal,A.,
            Bunnett,N.W. and Khanna,R.
  TITLE     Neuropilin-1 is essential for vascular endothelial growth factor
            A-mediated increase of sensory neuron activity and development of
            pain-like behaviors
  JOURNAL   Pain 164 (12), 2696-2710 (2023)
   PUBMED   37366599
  REMARK    GeneRIF: Neuropilin-1 is essential for vascular endothelial growth
            factor A-mediated increase of sensory neuron activity and
            development of pain-like behaviors.
REFERENCE   2  (bases 1 to 3862)
  AUTHORS   Zhang,X., Wu,D., Tian,Y., Chen,X., Lan,J., Wei,F., Li,Y., Luo,Y.
            and Sun,X.
  TITLE     Ganoderma lucidum polysaccharides ameliorate
            lipopolysaccharide-induced acute pneumonia via inhibiting
            NRP1-mediated inflammation
  JOURNAL   Pharm Biol 60 (1), 2201-2209 (2022)
   PUBMED   36373992
REFERENCE   3  (bases 1 to 3862)
  AUTHORS   Lim,K.H., Yang,S., Kim,S.H. and Joo,J.Y.
  TITLE     Identifying New COVID-19 Receptor Neuropilin-1 in Severe
            Alzheimer's Disease Patients Group Brain Using Genome-Wide
            Association Study Approach
  JOURNAL   Front Genet 12, 741175 (2021)
   PUBMED   34745215
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3862)
  AUTHORS   Wu,C.T., Lidsky,P.V., Xiao,Y., Lee,I.T., Cheng,R., Nakayama,T.,
            Jiang,S., Demeter,J., Bevacqua,R.J., Chang,C.A., Whitener,R.L.,
            Stalder,A.K., Zhu,B., Chen,H., Goltsev,Y., Tzankov,A., Nayak,J.V.,
            Nolan,G.P., Matter,M.S., Andino,R. and Jackson,P.K.
  TITLE     SARS-CoV-2 infects human pancreatic beta cells and elicits beta
            cell impairment
  JOURNAL   Cell Metab 33 (8), 1565-1576 (2021)
   PUBMED   34081912
REFERENCE   5  (bases 1 to 3862)
  AUTHORS   Kuai,F., Zhou,L., Zhou,J., Sun,X. and Dong,W.
  TITLE     Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate
            neuropilin-1 to aggravate cerebral ischemia-reperfusion injury
            through regulating the nuclear factor kappaB p65 signaling
  JOURNAL   Aging (Albany NY) 13 (6), 9071-9084 (2021)
   PUBMED   33675584
  REMARK    GeneRIF: Long non-coding RNA THRIL inhibits miRNA-24-3p to
            upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion
            injury through regulating the nuclear factor kappaB p65 signaling.
REFERENCE   6  (bases 1 to 3862)
  AUTHORS   Halder,J.B., Zhao,X., Soker,S., Paria,B.C., Klagsbrun,M., Das,S.K.
            and Dey,S.K.
  TITLE     Differential expression of VEGF isoforms and VEGF(164)-specific
            receptor neuropilin-1 in the mouse uterus suggests a role for
            VEGF(164) in vascular permeability and angiogenesis during
            implantation
  JOURNAL   Genesis 26 (3), 213-224 (2000)
   PUBMED   10705382
REFERENCE   7  (bases 1 to 3862)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   8  (bases 1 to 3862)
  AUTHORS   Soker,S., Takashima,S., Miao,H.Q., Neufeld,G. and Klagsbrun,M.
  TITLE     Neuropilin-1 is expressed by endothelial and tumor cells as an
            isoform-specific receptor for vascular endothelial growth factor
  JOURNAL   Cell 92 (6), 735-745 (1998)
   PUBMED   9529250
REFERENCE   9  (bases 1 to 3862)
  AUTHORS   Kolodkin,A.L., Levengood,D.V., Rowe,E.G., Tai,Y.T., Giger,R.J. and
            Ginty,D.D.
  TITLE     Neuropilin is a semaphorin III receptor
  JOURNAL   Cell 90 (4), 753-762 (1997)
   PUBMED   9288754
REFERENCE   10 (bases 1 to 3862)
  AUTHORS   He,Z. and Tessier-Lavigne,M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085689.1.
            
            On Nov 15, 2004 this sequence version replaced NM_145098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3862
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /note="neuropilin 1"
                     /db_xref="GeneID:246331"
                     /db_xref="RGD:621588"
     exon            1..78
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            79..613
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..3309
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; vascular endothelial cell growth factor 165
                     receptor"
                     /codon_start=1
                     /product="neuropilin-1 isoform 1 precursor"
                     /protein_id="NP_659566.1"
                     /db_xref="GeneID:246331"
                     /db_xref="RGD:621588"
                     /translation="MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGY
                     PHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGK
                     FCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKS
                     PGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFP
                     EVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCM
                     EALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLR
                     FVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVF
                     GVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITAS
                     NQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHREN
                     KVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYP
                     ERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGT
                     TVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGP
                     IQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKL
                     HYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDI
                     SINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPI
                     LITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLN
                     PQSNYSEA"
     exon            614..788
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            789..970
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1198
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1354
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1521
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1677
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1822
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2154
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2299
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2404
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2464
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2602
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2874
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2971
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3022
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3841
                     /gene="Nrp1"
                     /gene_synonym="Nrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgactcaggc gtttgactcc cagccttctg gcacgcccaa cccacccggt cttccataag
       61 ggtcagagaa ccaaagagac aacccggacc tcctctgggc gccagctcct cggctccaac
      121 ccgtccagaa tcaagcggga tttttttttt ctttccctct agaaattggc tttggtgtgt
      181 cgcccgccct ctcccctcct cctcgcaact cctcccctct ttttttcctc cttcttcttc
      241 ttcctgagac atggcccggg cagtggctcc tggaagagga acaagtgtgg gaaaagggag
      301 aggaaatcgg agctaaatga caggatgcag gcgacttgag acacaaaaag agacgcgctt
      361 ctcgcgaatt caggcattgc ctcgccgcta gccttccccg ccaagaccgg ctgaggattt
      421 tatggttctt aagcggactt aagagcgttg tttcggattg ttaagattcc cgtttgctgg
      481 gttttcctcc ctcaatcgtg ctctcccgcg gctgcctggg gactggctcg gcgaaggagg
      541 atggagaggg ggctgccgtt gctgtgcgcc acgctcgccc ttgccctcgc cctggcgggc
      601 gctttccgca gcgataaatg tggcgggact ataaaaattg aaaacccggg gtaccttaca
      661 tctcccggct accctcattc ttaccatcca agtgagaaat gtgaatggct aatccaagct
      721 ccggagccct accagagaat catgatcaac ttcaacccac atttcgattt ggaggacaga
      781 gactgcaagt atgactatgt ggaagtgatc gatggagaga atgaaggtgg ccgcctgtgg
      841 gggaagttct gtgggaagat cgcaccttca cctgtggtgt cttcagggcc atttctcttc
      901 atcaaatttg tctctgacta tgagacccac ggggcaggat tttccatccg ctatgaaatc
      961 ttcaagagag ggcccgaatg ttctcagaac tatacagcac ctactggagt gataaagtcc
     1021 cctgggttcc ctgaaaaata ccccaacagc ttggagtgca cctacatcat ctttgcacca
     1081 aagatgtctg agataatcct agagtttgaa agttttgacc tggagcaaga ctcaaatcct
     1141 cccggaggag tgttctgtcg ctatgaccgg ctggagatct gggatggatt ccctgaagtt
     1201 ggccctcaca ttgggcgtta ctgtgggcag aaaactcctg gccggatccg ctcctcttca
     1261 ggcattctat ccatggtctt ctacactgac agcgcaatag caaaggaagg tttctcagcc
     1321 aactacagcg tgctgcagag cagcatctct gaagatttca agtgtatgga ggctctgggc
     1381 atggaatctg gagagatcca ttctgaccag atcactgcat cttcccagta tggtaccaac
     1441 tggtctgttg agcgctcccg cctgaactac cctgaaaacg ggtggacacc aggagaggac
     1501 tcctacaggg agtggatcca ggtggacttg ggcctcctgc gattcgttac tgctgtgggg
     1561 acacagggtg ccatttccaa ggaaaccaag aagaaatatt atgtcaagac ttacagagta
     1621 gacatcagct ccaacggaga ggactggatc accctgaagg agggaaataa agccattatc
     1681 tttcagggaa acaccaatcc cacggatgtt gtctttggag ttttccccaa accactgata
     1741 actcgatttg tccgaatcaa acctgcatcc tgggaaactg gaatatctat gagatttgaa
     1801 gtttatggct gcaagataac agattaccct tgctctggaa tgttgggcat ggtgtctgga
     1861 cttatttcag actcccagat tacagcatcc aaccaaggag acaggaactg gatgccagaa
     1921 aacatccgcc tggtgaccag tcgaaccggc tgggccctgc caccctcacc ccacccatac
     1981 atcaatgaat ggctccaagt ggacctggga gatgagaaga tagtaagagg tgtcatcatt
     2041 caaggtggga agcaccgaga aaacaaagtg ttcatgagga agttcaagat cgcctacagt
     2101 aacaatggtt ctgactggaa aatgatcatg gatgacagca agcgcaaggc taagtctttt
     2161 gaaggcaaca acaactatga cacacctgag ctccgggcct ttacacctct ctccacaaga
     2221 ttcatcagga tctaccccga gagagccaca catagtgggc tcggactgag gatggagcta
     2281 ctgggctgtg aagtagaagt gcctacagct ggacccacga cacccaatgg gaaccccgtg
     2341 gacgagtgtg acgatgacca ggccaactgc cacagtggca caggtgatga cttccagctc
     2401 acaggaggca ccactgtcct ggccacagag aagccaacca ttatagacag caccatccaa
     2461 tcagagttcc cgacatacgg ttttaactgc gagtttggct ggggctctca caagacattc
     2521 tgccactggg aacatgacag ccacgcgcag ctcaggtgga gggtgctgac cagcaagacg
     2581 gggcccattc aggaccacac aggagatggc aacttcatct attcccaagc tgatgaaaat
     2641 cagaaaggca aagtagcccg cctggtgagc cctgtggtct attcccagag ttctgcccac
     2701 tgcatgacct tctggtatca catgtccggc tctcatgtgg gtacactgag ggtcaaactg
     2761 cactaccaga agccagagga atatgatcaa ctggtctgga tggtggtcgg gcaccaagga
     2821 gaccactgga aggaagggcg tgtcttgctg cacaaatctc tgaaactgta tcaggttatt
     2881 tttgaaggtg aaatcggaaa aggaaacctc ggtgggattg ctgtggatga tatcagtatt
     2941 aacaaccaca ttcctcagga ggactgtgca aaaccaacag acctagataa aaagaacaca
     3001 gaaattaaaa tagatgaaac agggagcacc ccaggatatg aagaagggaa aggcgacaag
     3061 aacatctcca ggaagccagg caatgtgctt aagaccctgg accccatcct gatcaccatc
     3121 atagccatga gtgccctggg ggtgctcctg ggtgcagtct gtggagttgt gctgtactgt
     3181 gcctgttggc acaatgggat gtcggaaagg aacctatctg ccctggagaa ctataacttt
     3241 gaacttgtgg atggtgtaaa gttgaaaaaa gataaactga acccacagag taattactca
     3301 gaggcgtgaa ggcacggagc tggagggaac aagggaggag cgcggcagga gaacagtgga
     3361 ggcgcaggga ctctgttact ctgctttcac tgtaagctgg gaagggcggg gactctgtta
     3421 ctccgctttc actgtaagct cggaagggca tccgcgatgc catgccaggc ttttctcagg
     3481 agcttcaatg agcatcacct acagacacaa gcaggtgact gcggtaacaa caggaatcat
     3541 gtacagcctg ctttcttctc ttggtttcgt ttgggtaatc agaagccagt tgagaccaag
     3601 tgtgactgac ttcatggttc atcctacttg gccccctttt tcctctcttt ctccttaccc
     3661 tgtggtggat tcttctcgga aactgcaaaa tccaagatgc tggcactagg cgttgttcag
     3721 tgggctcttt cgatggacat gtgacctata gcccagtgcc tagagcatat tagcataacc
     3781 acatttcagg ggacaccaat gtccgctttt gcatcgctac gtgcagcgag cacaggaaaa
     3841 aaaaaaaaaa aaaaaaaaaa aa
//
