LOCUS       NM_053346               1611 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus neuritin 1 (Nrn1), mRNA.
ACCESSION   NM_053346 XM_003751668
VERSION     NM_053346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Liu,J., Guan,X., Zheng,S., Shi,J., Wang,X., Shen,Z., Chen,Z.,
            Liao,C. and Zhang,Z.
  TITLE     Neuritin accelerates Schwann cell dedifferentiation via
            PI3K/Akt/mTOR signalling pathway during Wallerian degeneration
  JOURNAL   J Cell Mol Med 28 (16), e70012 (2024)
   PUBMED   39187917
  REMARK    GeneRIF: Neuritin accelerates Schwann cell dedifferentiation via
            PI3K/Akt/mTOR signalling pathway during Wallerian degeneration.
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Huang,T., Li,H., Zhang,S., Liu,F., Wang,D. and Xu,J.
  TITLE     Nrn1 Overexpression Attenuates Retinal Ganglion Cell Apoptosis,
            Promotes Axonal Regeneration, and Improves Visual Function
            Following Optic Nerve Crush in Rats
  JOURNAL   J Mol Neurosci 71 (1), 66-79 (2021)
   PUBMED   32607759
  REMARK    GeneRIF: Nrn1 Overexpression Attenuates Retinal Ganglion Cell
            Apoptosis, Promotes Axonal Regeneration, and Improves Visual
            Function Following Optic Nerve Crush in Rats.
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Wan,K., Mao,F., Li,Q., Wang,L., Wei,Z., Wang,P., Liao,X., Xu,M.,
            Huang,J., Pan,Z., Wang,C., Luo,J., Gao,R. and Gan,S.
  TITLE     Neuritin-overexpressing transgenic mice demonstrate enhanced
            neuroregeneration capacity and improved spatial learning and memory
            recovery after ischemia-reperfusion injury
  JOURNAL   Aging (Albany NY) 13 (2), 2681-2699 (2020)
   PUBMED   33323541
  REMARK    GeneRIF: Neuritin-overexpressing transgenic mice demonstrate
            enhanced neuroregeneration capacity and improved spatial learning
            and memory recovery after ischemia-reperfusion injury.
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Gomes,C., Lee,S.J., Gardiner,A.S., Smith,T., Sahoo,P.K., Patel,P.,
            Thames,E., Rodriguez,R., Taylor,R., Yoo,S., Heise,T., Kar,A.N.,
            Perrone-Bizzozero,N. and Twiss,J.L.
  TITLE     Axonal localization of neuritin/CPG15 mRNA is limited by
            competition for HuD binding
  JOURNAL   J Cell Sci 130 (21), 3650-3662 (2017)
   PUBMED   28871047
  REMARK    GeneRIF: The data indicate that endogenous Nrn1 and Gap43 mRNAs
            compete for binding to HuD for their axonal localization and
            activity of the Nrn1 3'UTR.
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Yuan,W., Cui,L., Li,G., Wang,N., Zhang,P., Zhang,Y., Yu,N.,
            Wang,H., Zhu,J., Yang,L. and Huang,J.
  TITLE     Recombinant neuritin affects the senescence, apoptosis,
            proliferation, and migration of rat bone marrow-derived mesenchymal
            stem cells
  JOURNAL   Biotechnol Lett 39 (11), 1649-1655 (2017)
   PUBMED   28852892
  REMARK    GeneRIF: Recombinant neuritin affects the senescence, apoptosis,
            proliferation, migration of rat bone marrow-derived mesenchymal
            stem cells. These findings offer new insight into neuritin function
            outside of the nervous system.
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Chen,X., Tian,C.H., Chen,J., Wang,Y.C. and Lin,J.Y.
  TITLE     [The expression of Neuritin protein in the visual cortex of
            monocular form deprived adult rats]
  JOURNAL   Zhonghua Yan Ke Za Zhi 47 (9), 829-833 (2011)
   PUBMED   22177131
  REMARK    GeneRIF: The expression of Neuritin protein in the visual cortex of
            rats in the monocular deprived group was considerably lower than
            that of the normal control group.
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Fujino,T., Wu,Z., Lin,W.C., Phillips,M.A. and Nedivi,E.
  TITLE     cpg15 and cpg15-2 constitute a family of activity-regulated ligands
            expressed differentially in the nervous system to promote neurite
            growth and neuronal survival
  JOURNAL   J Comp Neurol 507 (5), 1831-1845 (2008)
   PUBMED   18265009
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Karamoysoyli,E., Burnand,R.C., Tomlinson,D.R. and Gardiner,N.J.
  TITLE     Neuritin mediates nerve growth factor-induced axonal regeneration
            and is deficient in experimental diabetic neuropathy
  JOURNAL   Diabetes 57 (1), 181-189 (2008)
   PUBMED   17909094
  REMARK    GeneRIF: Manipulation of neuritin levels in diabetes may provide a
            potential target for therapeutic intervention in the management of
            neuropathy.
REFERENCE   9  (bases 1 to 1611)
  AUTHORS   Cottrell,J.R., Borok,E., Horvath,T.L. and Nedivi,E.
  TITLE     CPG2: a brain- and synapse-specific protein that regulates the
            endocytosis of glutamate receptors
  JOURNAL   Neuron 44 (4), 677-690 (2004)
   PUBMED   15541315
REFERENCE   10 (bases 1 to 1611)
  AUTHORS   Naeve,G.S., Ramakrishnan,M., Kramer,R., Hevroni,D., Citri,Y. and
            Theill,L.E.
  TITLE     Neuritin: a gene induced by neural activity and neurotrophins that
            promotes neuritogenesis
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2648-2653 (1997)
   PUBMED   9122250
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053346.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88958.1, BC087582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000017.1  28335426-28335667
            243-387             JAXUCZ010000017.1  28339659-28339803
            388-1611            JAXUCZ010000017.1  28343131-28344354
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1611
                     /gene="Nrn1"
                     /gene_synonym="Nrn"
                     /note="neuritin 1"
                     /db_xref="GeneID:83834"
                     /db_xref="RGD:621586"
     exon            1..242
                     /gene="Nrn1"
                     /gene_synonym="Nrn"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..616
                     /gene="Nrn1"
                     /gene_synonym="Nrn"
                     /codon_start=1
                     /product="neuritin precursor"
                     /protein_id="NP_445798.1"
                     /db_xref="GeneID:83834"
                     /db_xref="RGD:621586"
                     /translation="MGLKLNGRYISLILAVQIAYLVQAVRAAGKCDAVFKGFSDCLLK
                     LGDSMANYPQGLDDKTNIKTVCTYWEDFHSCTVTALTDCQEGAKDMWDKLRKESKNLN
                     IQGSLFELCGSGNGAAGSLLPALSVLLVSLSAALATWLSF"
     exon            243..387
                     /gene="Nrn1"
                     /gene_synonym="Nrn"
                     /inference="alignment:Splign:2.1.0"
     exon            388..1611
                     /gene="Nrn1"
                     /gene_synonym="Nrn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctctcgc tctctttctg tctcttcctc gctccctctc tttctctcct ccctctgcct
       61 tcccagtgca taaagtctct gtcgctcccg gaacttgttg gcaatgccta tttttcagct
      121 ttcccccgcg ttctctaaac taactattta aaggtctgcg gtcgcaaatg gtttgactaa
      181 acgtaggatg ggacttaagt tgaacggcag atatatttca ctgatcctcg cggtgcaaat
      241 agcttacctg gtgcaggccg tgagagcagc aggcaagtgc gatgcagtct ttaagggctt
      301 ttcagactgt ttgctcaagc tgggtgacag catggccaac tacccgcagg gcctggacga
      361 caagacgaac atcaagaccg tgtgcacata ctgggaggat ttccacagct gcacggtcac
      421 agctcttacg gattgccagg aaggggcgaa agatatgtgg gataaactga gaaaagaatc
      481 gaaaaacctc aatatccaag gcagcttatt cgaactctgc ggcagcggca acggggcggc
      541 ggggtccctg ctcccggcgc tttccgtgct cctggtgtct ctctcggcag ctttagcgac
      601 ctggctttcc ttctgagcac ggggccgggt cccccctccg ctcacccacc cacactcact
      661 ccatgctccc ggaaatcgag aggaagagcc attcgttctc taaggacgtt gtgattctct
      721 gtgatattga aaacactcat atgggattgt gggaaatcct gtttctctct tttttttttt
      781 taattttttt tttattttgg ttgagtcctt gtgttttagt tgccaaatgt taccgatcag
      841 tgagcaaagc aagcacagcc aaaatcggac ctcaccttaa gtccgtcttc acacaaaaat
      901 aagaaaacgg caaactcacc cccattttta attttgtttt taattttact tacttattta
      961 tttatttatt ttttggcaaa agaatctcag gaatggccct gggccaccta ctatattaat
     1021 catgttgata acatgaaaaa tgatgggctc ctcctaatga gaaagcgagg agaggagaag
     1081 gccaggggaa tgagctcaag agtgatgccc acgtggggag catctggtga ataatcgctc
     1141 acgtctttct tccacagtac cttgttttga tcatttccac agcacatttc tcctccagaa
     1201 acgcgaaaaa cacaagcgtg tgggttctgc atttttaagg ataagagaga gaaagaggtt
     1261 gggtatagta ggacaggttg tcagaagaga tgctgctatg gtcacgaggg gccggtttca
     1321 cctgctattg tcgtcgcctc cttcagttcc actgccttta tgtcccctcc tctctcttgt
     1381 tttagctgtt acacatacag taatacctga atatccaacg gtatagttca caagggggta
     1441 atcaatgtta aatctaaaat agaatttaaa aaaaaaagat tttgacataa aagagccttg
     1501 attttaaaaa aaaagagaga gatgtaattt aaaaagttta ttataaatta aattcagcaa
     1561 aaatttgcta caaagtatag agaagtataa aataaaagtt attgtttgaa a
//
