LOCUS       NM_001106036            1908 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neural retina leucine zipper (Nrl), mRNA.
ACCESSION   NM_001106036 XM_001055469 XM_224189
VERSION     NM_001106036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Hernan,I., Gamundi,M.J., Borras,E., Maseras,M., Garcia-Sandoval,B.,
            Blanco-Kelly,F., Ayuso,C. and Carballo,M.
  TITLE     Novel p.M96T variant of NRL and shRNA-based suppression and
            replacement of NRL mutants associated with autosomal dominant
            retinitis pigmentosa
  JOURNAL   Clin Genet 82 (5), 446-452 (2012)
   PUBMED   21981118
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Kanda,A., Friedman,J.S., Nishiguchi,K.M. and Swaroop,A.
  TITLE     Retinopathy mutations in the bZIP protein NRL alter phosphorylation
            and transcriptional activity
  JOURNAL   Hum Mutat 28 (6), 589-598 (2007)
   PUBMED   17335001
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Khanna,H., Akimoto,M., Siffroi-Fernandez,S., Friedman,J.S.,
            Hicks,D. and Swaroop,A.
  TITLE     Retinoic acid regulates the expression of photoreceptor
            transcription factor NRL
  JOURNAL   J Biol Chem 281 (37), 27327-27334 (2006)
   PUBMED   16854989
  REMARK    GeneRIF: signaling by RA via RA receptors regulates the expression
            of NRL, providing a framework for delineating early steps in
            photoreceptor cell fate determination
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Peng,G.H., Ahmad,O., Ahmad,F., Liu,J. and Chen,S.
  TITLE     The photoreceptor-specific nuclear receptor Nr2e3 interacts with
            Crx and exerts opposing effects on the transcription of rod versus
            cone genes
  JOURNAL   Hum Mol Genet 14 (6), 747-764 (2005)
   PUBMED   15689355
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   DeAngelis,M.M., Grimsby,J.L., Sandberg,M.A., Berson,E.L. and
            Dryja,T.P.
  TITLE     Novel mutations in the NRL gene and associated clinical findings in
            patients with dominant retinitis pigmentosa
  JOURNAL   Arch Ophthalmol 120 (3), 369-375 (2002)
   PUBMED   11879142
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Mears,A.J., Kondo,M., Swain,P.K., Takada,Y., Bush,R.A.,
            Saunders,T.L., Sieving,P.A. and Swaroop,A.
  TITLE     Nrl is required for rod photoreceptor development
  JOURNAL   Nat Genet 29 (4), 447-452 (2001)
   PUBMED   11694879
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Swain,P.K., Hicks,D., Mears,A.J., Apel,I.J., Smith,J.E., John,S.K.,
            Hendrickson,A., Milam,A.H. and Swaroop,A.
  TITLE     Multiple phosphorylated isoforms of NRL are expressed in rod
            photoreceptors
  JOURNAL   J Biol Chem 276 (39), 36824-36830 (2001)
   PUBMED   11477108
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Mitton,K.P., Swain,P.K., Chen,S., Xu,S., Zack,D.J. and Swaroop,A.
  TITLE     The leucine zipper of NRL interacts with the CRX homeodomain. A
            possible mechanism of transcriptional synergy in rhodopsin
            regulation
  JOURNAL   J Biol Chem 275 (38), 29794-29799 (2000)
   PUBMED   10887186
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Rehemtulla,A., Warwar,R., Kumar,R., Ji,X., Zack,D.J. and Swaroop,A.
  TITLE     The basic motif-leucine zipper transcription factor Nrl can
            positively regulate rhodopsin gene expression
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 191-195 (1996)
   PUBMED   8552602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_001106036.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760434, SAMN06680419
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000015.1  32981322-32981442   c
            122-530             JAXUCZ010000015.1  32979413-32979821   c
            531-1908            JAXUCZ010000015.1  32977023-32978400   c
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1908
                     /gene="Nrl"
                     /note="neural retina leucine zipper"
                     /db_xref="GeneID:290221"
                     /db_xref="RGD:1305197"
     exon            1..121
                     /gene="Nrl"
                     /inference="alignment:Splign:2.1.0"
     exon            122..530
                     /gene="Nrl"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..863
                     /gene="Nrl"
                     /codon_start=1
                     /product="neural retina-specific leucine zipper protein"
                     /protein_id="NP_001099506.1"
                     /db_xref="GeneID:290221"
                     /db_xref="RGD:1305197"
                     /translation="MALPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPY
                     SSVPPSPTFSEPGMVGNSEAPRPAGLEELYWLATLQQQLGADEVLGLSPDEAVELLQS
                     QGPVSVEGPHGYYSGSPGETGAPNVQLPERFSDAALVSMSVRELNRQLRGCGRDEALR
                     LKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKA
                     RCDRLTSGGPGSDDHTHLFL"
     exon            531..1908
                     /gene="Nrl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcccccttg ttccgaatac agggacacca gaccctgctc tatggagtgc ctagtctctg
       61 ggggagctgt gcagttctgg ttctgacggt gactacgagg tctctgccat tctaaaagtg
      121 aacctctctc tctgctcagt cccagaatgg ctcttccccc cagtcccttg gctatggaat
      181 atgttaatga ctttgacttg atgaagtttg aaataaagcg ggagccttct gagggccggt
      241 ccggagtccc cacagcctca ctgggctcta caccgtacag ttcagtgcct ccctcaccca
      301 ccttcagtga gccaggcatg gtgggcaaca gcgaggcccc taggcccgca ggcctggagg
      361 agctatactg gctggccacc ctgcagcagc agttgggggc cgatgaggtt ctggggctga
      421 gtcctgatga ggctgtggaa ctactgcaga gccagggccc ggtctctgta gaagggcctc
      481 atggctacta ttcagggagc ccaggagaga caggagcccc gaatgtgcag ttgcccgaga
      541 gattttcaga cgccgcgctg gtctcgatgt cggtgcgcga gttgaaccgg cagctgcggg
      601 gctgcgggcg cgacgaggct ctgcggctga agcagaggcg ccgcacgctc aagaaccgcg
      661 gctacgcgca ggcctgtcgc tccaagcggc tgcagcagcg gcgcgggctg gaggccgagc
      721 gcgcccgcct agccgcacag ctggatgccc tacgggcgga ggtggcccgc ctggctcgag
      781 agcgcgacct ctacaaggcc cgctgtgacc ggctgacttc cggtggccct gggtccgacg
      841 accacacaca cctcttcctc tgagccacta gggcagtggg tgtggcggtt tggcaagtgg
      901 ctgggttgat ggccatggta caggagagga agcccactaa ccaaatcgct acctgtggtc
      961 ctgtatgttc atacaaacat ccccaaactt ctgaccctcg tggcatgcca gaagttagat
     1021 gctggtcctt tgctggagac gagtcccctt cccttttgca ggtcacgact cttcatgatt
     1081 tagggtactg aattctgtag gggctagtgc ctgtactgag ggtggaggtg tgggggaagg
     1141 gtaggcagca tgctgaatgg gaggaggggg aggaggaaga ggaggaagag gaggagggag
     1201 aggaggagga ggagggagag gaggaggagg agggagagga ggaggaggag ggagaggagg
     1261 aagaggggtg cagctcccct ctcggtatag tttttaattc aaggttttca acccgtaatg
     1321 cactgatgct gtaattaaca atgaagctgc atttccacca aatctttgaa ctcctggatt
     1381 tgtcaagatt tcaattcccc taaacaaaca gtaatagttc atctggaaat gcttttctct
     1441 gctccactca gtggccttta gagtccaaag cagcagaaca agtgtcctgg atgggagcct
     1501 ggtgaactgg gcactagtct caactgtgtc acaggctgtc tgtctgtcac cttgagcaaa
     1561 gcgactgcca taaggtttct tccacttgga ctggatggct tccaacactg ttctagtttt
     1621 ggcccgtcta atggtctccc caagaggggc caagatgact gtaccaaagg gacatcctgt
     1681 tctgctgccc cagcttccag gctgtgactt aggcatggct gcttggaaac tctcccttgc
     1741 ctaggctcta agtggtcccc tgctaggcgt ccttggcctt caaactgcag agggtgctct
     1801 tgttacctcc tgtttcttag agctggagtg agacctcaca ggataactaa ccgggagctg
     1861 agagactgtg gcttttgtga attaaacctc aagtccaaga aaaactaa
//
