LOCUS       NM_024140               1373 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus neurogranin (Nrgn), mRNA.
ACCESSION   NM_024140
VERSION     NM_024140.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Svirsky,S.E., Henchir,J., Li,Y., Carlson,S.W. and Dixon,C.E.
  TITLE     Temporal-Specific Sex and Injury-Dependent Changes on
            Neurogranin-Associated Synaptic Signaling After Controlled Cortical
            Impact in Rats
  JOURNAL   Mol Neurobiol 61 (9), 7256-7268 (2024)
   PUBMED   38376763
  REMARK    GeneRIF: Temporal-Specific Sex and Injury-Dependent Changes on
            Neurogranin-Associated Synaptic Signaling After Controlled Cortical
            Impact in Rats.
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Zhao,Y.H., Wu,Z.X., Zhao,X., Jiang,J. and Jiang,R.
  TITLE     Low androgen level impairs erectile function of rat by regulating
            the Ng/CaN/AKT/eNOS pathway in penile corpus cavernosum
  JOURNAL   Andrology 10 (6), 1189-1196 (2022)
   PUBMED   35678097
  REMARK    GeneRIF: Low androgen level impairs erectile function of rat by
            regulating the Ng/CaN/AKT/eNOS pathway in penile corpus cavernosum.
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Svirsky,S., Henchir,J., Li,Y., Ma,X., Carlson,S. and Dixon,C.E.
  TITLE     Neurogranin Protein Expression Is Reduced after Controlled Cortical
            Impact in Rats
  JOURNAL   J Neurotrauma 37 (7), 939-949 (2020)
   PUBMED   31691647
  REMARK    GeneRIF: Neurogranin Protein Expression Is Reduced after Controlled
            Cortical Impact in Rats.
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Garrido-Garcia,A., de Andres,R., Jimenez-Pompa,A., Soriano,P.,
            Sanz-Fuentes,D., Martinez-Blanco,E. and Diez-Guerra,F.J.
  TITLE     Neurogranin Expression Is Regulated by Synaptic Activity and
            Promotes Synaptogenesis in Cultured Hippocampal Neurons
  JOURNAL   Mol Neurobiol 56 (11), 7321-7337 (2019)
   PUBMED   31020616
  REMARK    GeneRIF: Ng expression is regulated by synaptic activity and that
            Ng promotes the synaptogenesis process.
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Petersen,A. and Gerges,N.Z.
  TITLE     Neurogranin regulates CaM dynamics at dendritic spines
  JOURNAL   Sci Rep 5, 11135 (2015)
   PUBMED   26084473
  REMARK    GeneRIF: these data indicate that Ng-mediated enhancement of
            synaptic strength is due to its ability to target, rather than
            sequester, CaM within dendritic spines.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Neuner-Jehle,M., Rhyner,T.A. and Borbely,A.A.
  TITLE     Sleep deprivation differentially alters the mRNA and protein levels
            of neurogranin in rat brain
  JOURNAL   Brain Res 685 (1-2), 143-153 (1995)
   PUBMED   7583240
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Sato,T., Xiao,D.M., Li,H., Huang,F.L. and Huang,K.P.
  TITLE     Structure and regulation of the gene encoding the neuron-specific
            protein kinase C substrate neurogranin (RC3 protein)
  JOURNAL   J Biol Chem 270 (17), 10314-10322 (1995)
   PUBMED   7730337
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Fedorov,N.B., Pasinelli,P., Oestreicher,A.B., DeGraan,P.N. and
            Reymann,K.G.
  TITLE     Antibodies to postsynaptic PKC substrate neurogranin prevent
            long-term potentiation in hippocampal CA1 neurons
  JOURNAL   Eur J Neurosci 7 (4), 819-822 (1995)
   PUBMED   7620629
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Watson,J.B., Sutcliffe,J.G. and Fisher,R.S.
  TITLE     Localization of the protein kinase C
            phosphorylation/calmodulin-binding substrate RC3 in dendritic
            spines of neostriatal neurons
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8581-8585 (1992)
   PUBMED   1528865
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Watson,J.B., Battenberg,E.F., Wong,K.K., Bloom,F.E. and
            Sutcliffe,J.G.
  TITLE     Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA
            encoding a novel 78 residue protein
  JOURNAL   J Neurosci Res 26 (4), 397-408 (1990)
   PUBMED   2231781
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_024140.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L09119.1, FQ099606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000008.1  45452154-45452417   c
            265-491             JAXUCZ010000008.1  45445683-45445909   c
            492-509             JAXUCZ010000008.1  45445464-45445481   c
            510-1373            JAXUCZ010000008.1  45444223-45445086   c
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1373
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /note="neurogranin"
                     /db_xref="GeneID:64356"
                     /db_xref="RGD:61833"
     exon            1..264
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..486
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /note="neurogranin (protein kinase C substrate, RC3);
                     protein kinase C substrate 7.5 kDa protein; ng"
                     /codon_start=1
                     /product="neurogranin"
                     /protein_id="NP_077054.1"
                     /db_xref="GeneID:64356"
                     /db_xref="RGD:61833"
                     /translation="MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARK
                     KIKSGECGRKGPGPGGPGGAGGARGGAGGGPSGD"
     exon            265..491
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..509
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1373
                     /gene="Nrgn"
                     /gene_synonym="BICKS; RC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccagttct ccccgcccac cctacagaaa gtgtctcctg attggctttg aggccgcagg
       61 gctcaggtta cattcgcaag agttgcggag cgcgggagac cggacccaag aggagagagg
      121 ctggttctgc accgattctg tgctggtccg ggagtgcccg acagcccctg aactaccacc
      181 cagcattgta caaacccacc cccactctga gccaggctcc accccagcca aggaccctca
      241 acaccggcaa tggactgctg cacggagagc gcctgctcca agccagacga cgatattcta
      301 gacatcccgt tggatgatcc cggagccaac gccgctgcag ccaaaatcca ggcgagtttt
      361 cggggccaca tggcgaggaa gaagataaag agtggagagt gtggccggaa gggacccggc
      421 cccgggggac caggcggagc tgggggcgcc cggggaggcg cgggcggcgg ccccagcgga
      481 gattaagcca gaactgaacg ttttagaagt tccagaggag agtcggatgc cgcgtcccct
      541 tcgcagtgac aagacttccc tactgtgttt gtgagcccct ccttcccacc aaccagccag
      601 cttcaggagc cctcccctct ccccgccgcg tcccagagat tccctctccc aggctggctt
      661 cgtcgtggcg tagccaagtc cgtgcccttt ttagctcctc agtctaacgt ggtctccttt
      721 cgccttttct ctccaccctc gtcccaaacc ccatactccc aaaaatgtcc ttttgcttca
      781 cgcccacctg tccacgcgcc cagcatgcag ctctgcctcc gcagcctcgg tgcgcttcgc
      841 tgcgcgtact gcagagggcg cccaatgcgt cgcccaagta ctctcaaaaa aaaaaaaaaa
      901 aaaaaaaaaa agaaaagaaa agaaaaaaaa gaaagaaaga aagaaaaaga aaagcaacca
      961 ccaagtcctt tcgttctgtg ggcaacgaaa gggggcgccc cgcgtctttc caccctaacc
     1021 taacctcaac ctcctaaacc tggggctagg aaagagggga agtgtttttc atggttacct
     1081 gacgacgtcc cttgctctaa tgggaagtga agtcctatcc cacacctgcc tgtcacccct
     1141 tttctcttga gaacgcgccc tgagagcagc ccctcccgct ctcctttgtt tatgcaaaag
     1201 cctccggagc gctgggaggc tggctcccgc aggaggagtc ttccgcagcc ctgaccctat
     1261 agcctctacc ccgttgggct cctggggttg tggctggaag gtttttaatc tctgcgtgtg
     1321 catgttacca tactgggttg gaatgtgaac aataaagagg aatgtctaag tgt
//
