LOCUS       NM_001191109             732 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus neuregulin 4 (Nrg4), mRNA.
ACCESSION   NM_001191109 XM_001076144
VERSION     NM_001191109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 732)
  AUTHORS   Yang Z, Yaling W, Tao L, Mingyue R and Yongjun L.
  TITLE     Cardioprotective effect of NRG-4 gene expression on spontaneous
            hypertension rats and its mechanism through mediating the
            activation of ErbB signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (1), 89-101 (2022)
   PUBMED   35809324
  REMARK    GeneRIF: Cardioprotective effect of NRG-4 gene expression on
            spontaneous hypertension rats and its mechanism through mediating
            the activation of ErbB signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 732)
  AUTHORS   Montero JC, Rodriguez-Barrueco R, Ocana A, Diaz-Rodriguez E,
            Esparis-Ogando A and Pandiella A.
  TITLE     Neuregulins and cancer
  JOURNAL   Clin Cancer Res 14 (11), 3237-3241 (2008)
   PUBMED   18519747
  REMARK    Review article
REFERENCE   3  (bases 1 to 732)
  AUTHORS   Higashide T, McLaren MJ and Inana G.
  TITLE     Localization of HRG4, a photoreceptor protein homologous to
            Unc-119, in ribbon synapse
  JOURNAL   Invest Ophthalmol Vis Sci 39 (5), 690-698 (1998)
   PUBMED   9538874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Oct 26, 2023 this sequence was replaced by
            NM_001191109.3.
            
            On Apr 27, 2021 this sequence version replaced NM_001191109.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: FM097866.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JACYVU010000198.1  17472226-17472325   c
            101-164             JACYVU010000198.1  17471326-17471389   c
            165-258             JACYVU010000198.1  17469739-17469832   c
            259-405             JACYVU010000198.1  17429681-17429827   c
            406-485             JACYVU010000198.1  17422276-17422355   c
            486-564             JACYVU010000198.1  17414733-17414811   c
            565-732             JACYVU010000198.1  17406204-17406371   c
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..732
                     /gene="Nrg4"
                     /note="neuregulin 4"
                     /db_xref="GeneID:690919"
                     /db_xref="RGD:1589860"
     exon            1..100
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            101..164
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..502
                     /gene="Nrg4"
                     /codon_start=1
                     /product="pro-neuregulin-4, membrane-bound isoform"
                     /protein_id="NP_001178038.1"
                     /db_xref="GeneID:690919"
                     /db_xref="RGD:1589860"
                     /translation="MPTDHEQPCGPRHRSFCLNGGICYVIPTIPSPFCRCIENYTGAR
                     CEEVFLPSSSIQSKSNLSAAFLALAVLVTLAIVALCFLCRKGHLQRASSVQCEISLVE
                     TGNTSARHSHREH"
     exon            165..258
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            259..405
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..485
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..564
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            565..732
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagtcacca ctgccgaagt cctcagcgtt caaaaacttg tgaaacgctg catgtctagc
       61 aaaatttact ttttttatgg gaatataaat ttttgttgag gtgctgtttc aaccctaatc
      121 ctcccaccaa gaatgaaact atttgaaaat taagatgcca acagatcacg agcagccctg
      181 tggtcccagg cacaggtcat tttgcctgaa tggggggatt tgttatgtga ttcctactat
      241 ccccagccca ttctgtaggt gcattgaaaa ttatacgggt gctcgttgcg aagaggtttt
      301 tctcccaagt tccagcatcc aaagcaaaag taacctgtcg gcagctttct tggcgctggc
      361 ggtcctcgtc actcttgcca tcgtggcgct ctgcttcctg tgcaggaagg gccaccttca
      421 gagagccagt tcagtccagt gtgagatcag cctggtggag acaggcaata ccagtgcccg
      481 ccacagccac agagagcact gaagacatcc ccagtgaagg gcattattac ctacaaaggc
      541 agattgtgga ccacacaaga gaagcctcac tcggatgact tcttcatctt caggagcaac
      601 accacaagga ggaccagagc tgtgaaatat accaacgggt agtgctgaag gagcctgatt
      661 ctgacattct taaaaaacaa taaacccaag tttagctctt tgactgccag cagaattatg
      721 tttagtgagc at
//
