LOCUS       XM_017600398            9561 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus neuregulin 3 (Nrg3), transcript
            variant X1, mRNA.
ACCESSION   XM_017600398
VERSION     XM_017600398.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017600398.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017600398.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..9561
                     /gene="Nrg3"
                     /note="neuregulin 3; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 7 ESTs, 2 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 35 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:498596"
                     /db_xref="RGD:1559678"
     CDS             138..2321
                     /gene="Nrg3"
                     /codon_start=1
                     /product="pro-neuregulin-3, membrane-bound isoform isoform
                     X1"
                     /protein_id="XP_017455887.2"
                     /db_xref="GeneID:498596"
                     /db_xref="RGD:1559678"
                     /translation="MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAAAAAGGGPDG
                     GGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYV
                     PTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSTGGAASSRTPNRIST
                     RLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTSPFFSSSTPGSRPPMPG
                     APSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTTPETS
                     TSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVR
                     CDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKS
                     KKQAKQIQEHLKESQNGKNYSLKASSTMTKSESLMKSHVQLQNYSKADRHPVTALEKI
                     MESSFTAPQLFPEVTSDRGSQPIKHHSRSISSCGSPGQRSGMLHRNTFRRTPPSPRSR
                     LGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYASNGLR
                     TQQNASINMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSVGLEETCMQMPGIS
                     DVKSIKWCKNSYSADIVNASIPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDYE
                     LASMETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSVLTK"
ORIGIN      
        1 catgcggccg ccgcggccgc tgcctgagcc ggagcccgcc gccgccggag cccgcgcccg
       61 cgcccgcgcc cggcccgcgc ggccccatgc ctctggcgcg gccctcgggg gggcgaaggt
      121 gaagatcggc tcctaggatg agtgaagggg cggccggtgc ctcgccacct ggtgccgctt
      181 cggcagccgc cgcctcagcc gaggagggca ccgcggcggc tgcggcggcg gcggcggcgg
      241 cggcggcggc gggcgggggc ccggacggcg gcggagaagg ggcggccgaa cccccccggg
      301 agttacgctg tagcgactgc atcgtgtgga accggcagca gacgtggttg tgcgtggtgc
      361 ctctgttcat cggcttcatc ggcctggggc tcagcctcat gctgcttaaa tggatcgttg
      421 taggctccgt caaggagtac gtgcccacgg acttggtgga ctccaaggga atgggccagg
      481 accccttctt cctctccaag cccagctcgt tccccaaggc tatggaaacc accaccacaa
      541 ctacttctac cacgtccccc gccaccccct ctaccggcgg cgctgcttct tccaggacgc
      601 ctaaccggat tagcacccgc ttgaccacca tcacgcgggc acccacccgc ttccctgggc
      661 accgggtgcc catccgggct agcccgcgct ctacgaccgc acggaacact gctgcccctc
      721 cgacggtcct gtccaccacg tcccctttct tcagtagcag cacgccaggc tcccgacccc
      781 cgatgccagg agcccccagt acgcaggcga tgccttcctg gcccactgca gcgtatgcta
      841 cctcctccta tctccacgac tccactccct cctggaccct atcacccttt caggatgctg
      901 ccgccgcctc ttcctcctca ccctcttcca cctcctccac caccaccacc accccagaaa
      961 ctagcaccag ccccaaattt catactacaa catactccac tgaacgatct gagcacttca
     1021 aaccctgtcg agacaaggac ctggcgtatt gtctcaatga cggtgaatgc tttgtgattg
     1081 agaccctgac aggatcccat aagcactgtc ggtgcaagga aggctaccaa ggagtccgtt
     1141 gtgatcaatt tctgccgaaa actgactcca tcttatcgga tccaacagac cacttgggga
     1201 ttgaattcat ggagagtgaa gacgtttatc aaaggcaggt gctgtcaatt tcatgtatca
     1261 tctttggaat tgtcatcgtg ggcatgttct gtgctgcctt ctacttcaaa agcaaaaaac
     1321 aagctaaaca aatccaggag catctgaaag aatcgcagaa tgggaaaaat tacagcctga
     1381 aggcatccag cacaatgacg aagtctgaga gcttgatgaa gagccatgtc caactacaaa
     1441 attattccaa ggcagatagg catcctgtga ctgcgctgga gaaaataatg gagtcaagtt
     1501 ttacagctcc ccagttgttc ccagaggtta cttctgaccg aggaagccag cctatcaagc
     1561 accacagcag aagtatttct tcttgtggca gcccaggaca aaggagtggg atgttgcata
     1621 ggaatacttt cagaaggaca ccaccctcac cccgaagtcg actgggtggt attgtaggac
     1681 cagcatatca acaacttgaa gaatcaagaa ttccagacca ggatacgata ccttgccaag
     1741 ggatagaggt caggaagact atatcccacc tgcctataca gctgtggtgt gttgaaagac
     1801 ccctggactt aaagtatgca tccaatggtt taagaaccca acaaaatgca tcaataaata
     1861 tgcaactgcc ttcaagagag acaaacccct attttaatag cttggatcaa aaggacctgg
     1921 tgggttattt atccccaagg gccaattcgg tgcccatcat cccgtcggtg ggtctagaag
     1981 aaacctgcat gcaaatgcca gggatttctg acgtcaaaag cattaaatgg tgcaaaaact
     2041 cctactctgc tgacattgtc aatgcgagta ttccagtcag cgattgtctt ctagaagaac
     2101 agcaagaagt gaaaatatta ctagagaccg tgcaggaaca gatccggatt ctgactgatg
     2161 ccagacggtc agaagactac gaactggcca gcatggaaac tgaggatagt gcgagcgaaa
     2221 acacagcctt tctccctctg agtcccacgg ccaaatcaga acgagaggca caatttgtct
     2281 taagaaatga aattcaaaga gactctgtgc taaccaagtg actggagatg tagggatctg
     2341 tgcattctat gctttgctta acaggaagga gaggaaatta aatacaaatt atttatatgc
     2401 attaatttaa gagcatctac ttagaagaaa ccaaatagtc tgccgccctc atatcatagt
     2461 gttttttaac aaaatatttt tttaaaggga aagaagcgtt tcaggagtga taaagcttac
     2521 cactaaagct ttaggggaga attctgaatc caatttcagt tagtccttac actgtcctct
     2581 ttggctcttg gaagatttgg caaattccaa cctttggtcc catactgcca gtgtctatat
     2641 aaaaaagaaa ctggtgttct cctagtgtca aagagatgaa gtttattcca agggcatatg
     2701 tgccagttaa acagatagtc ctggccattt gactcttgag ttccaacccc taaatttctc
     2761 ttcatcaatg ctctctctac aggctacgtc atgtcaagga atgtagtgct ttgtatttga
     2821 ttttcaaaga atggcaagaa aacatgagca ggagggaaga cagaaaatag gagtaatccg
     2881 ggcaaaacta gctactctca tgtgccattt ttctctgtaa ttgaaagcac agaatctcag
     2941 agggaggtgt gaaattattg taggaaaaga gacaaaatga cagcgtcgtg ttactaaaat
     3001 catgctaata gaaatgtttt actcggagag tgtttagaag ctctgaaagg gcacctctgt
     3061 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgctcgcgc gcgcgcgcac
     3121 ctgtgtgcac aggtgtgagg gcgcaagtgt tgtggccttg ctcacccaag cacatatgct
     3181 atatgcacat gtgttccctg tacgtatgtg tgtgcatgtg tgtgtgtgtg tgtattaaag
     3241 cttgctaaaa tttgttctga aacatcaggg aagctaatat tcagaagaga tttccccctt
     3301 tagatctttt cactttaaat tttccattaa atgtaaattt ggttagcgag ttcttgaacc
     3361 aaggtaactt gcatggtggg gtcttacaaa actcttgaca atgtttagac cattttctga
     3421 tgtgaataat atttaaaagg atagcctttg gctggtggaa atcagcatca caaagcaaat
     3481 taatggagga tgtgtttatt ttgaatcatt taacttaaat tattggcaca agccaatcat
     3541 caaattgaca gttgactatt ttatttctcg tcatcctcat tgctaattta cagcaagtct
     3601 gctccgtgta gacagaagca ctggcttctg tggttaacat ggaaggaata aattgttgaa
     3661 aatcacaaat cccagactat tcagttcaca agcaatgccc ccaagcaaca aattgtgttg
     3721 tatgttcatt tggaataaag caatattttt accactgcta aggtgaactg aaacctctcc
     3781 tgaagacgtg tctgttttat tttcccttct tttcgtgggg cattcaagga aactagtgtt
     3841 cacataccca gtctctatcc aattattggt ggtgttgtta tgtttacact gtttaaaata
     3901 aaaaggcaca gtatttgaaa gtacataaaa gattgctttt actgtagttt ggggaaagtt
     3961 tatttaaaaa tttcattggt ttctctctca agcagagaaa acatactatt cgtttttgag
     4021 gtaagtttgt gttaaatata ctgcaaatta ttatctgtga acattcattg atatgagata
     4081 gaataccatc tagggaatag aaaaagcttt aaaaaactga tcaaaaaggt tcaataggaa
     4141 actgaggtct tggatattga aaacactttt gatgaaaacc tacattgtat ctgacaaagt
     4201 tgcatggcat tatttgtaac tcctagagtt tgattgcttt gagtagagca gtaagattgt
     4261 tcgcatcttc caacattgtg aatttttatt atcctctttt tcaacttagt tttatttgaa
     4321 aacatttgct atttatgaaa atcttagaag gtttttgtag gtgtataaaa tcctgaaaat
     4381 tgaacatcta ctgaaccatt atgttgttat ttaagctatc aaataccaga agccacactg
     4441 gtgttttgaa gtcaactttt tgggattgta ttggcttttg tttttatttg ttattttgtt
     4501 gtttctttgt tttttcttgt ttcatctttc tttccttctt tctttctttc ttcccttctt
     4561 tctttctttc cctttctctc tctctttctc actctctttc attcctttat ccttaaaaca
     4621 ttaaatatca ttaatctaaa gattccattc tctaggagaa caggtactct gaggaagtga
     4681 ttttacaaaa ataaataaat aaataaataa ataaacaaaa acacagtaag atcaatataa
     4741 cttatcccga tatagcatat tactttaata aaaactgtat atcatttgat tatgctacaa
     4801 gtcttcccac cacatgctga aaataacaag gatcaggcaa attcaatgac catgtgacag
     4861 aaagtttaca gttattggta ttttctgaat actcaagtca gaatcttcca cagaaatagc
     4921 tattcgtggt agttacagga agtactcctg caaagagtat aagctcaaag ggcacatctt
     4981 aggtcaccaa cagacaagtg gcacttgcag aatgcactga gactttctac ctaaacctga
     5041 tctggcaaat acctgagcca tcattgcttt gtccctcaag ctcatgtact tactagagca
     5101 tggtgatttc tacaccatac ctctgaattt acttcatttt cctcatcttt attttgggaa
     5161 cagatatttg taattaaata aggaacatag acatcatcaa ctggagactg aacatcaccc
     5221 attatatttt tgctttagtc atttttctgg tgtgtgtttt ttatatgaca aaatatttcc
     5281 aattactggt agctattgtg gaatgctttt gaccaattga tgttagtaag gtagagtaga
     5341 aatgatcttg gagaattagc atctggtttc tctcttccta tgtatattaa acactctttc
     5401 agactctact gcactacctt gctgtgaatt aaggtgaatt tatcacacat ccagtgactc
     5461 acatcatttc taataacaat tgaggaggta tagaagtcca ttcctcttgg gccttcacac
     5521 agtagttaga taacatgctg accaaaaaga gtaaaaggga caaagagact tcagaatatt
     5581 ccctgagtca tgaaatggat agctgcaatt ttagaagggt cctggtaccc aaagttgagg
     5641 ctgtcaatga ccaggtctcc acaagaatgc attcaaccct tgcagccact tcccaacact
     5701 tactttgtca catggtgcta taggaaataa caaatcctta atgtatgtgt gtggagggtg
     5761 aggtgatctc tgattccagc cctgtgaacc tgagattaag tgctaagaaa ccagtctcaa
     5821 atgagtatac agtataccta gaaacacagc agggcagggg agggattttt atttgacctt
     5881 ttggtatctg ggaaacattt tatatataat gaatactttt tattattatt caattgtata
     5941 gctttagtac agtgttttca acagatagca tgtctatgct gtttgtatct tgtcttcaga
     6001 aattcagtcc tcattccagg caagacaagt ctaaggtttc taggctgttc tcaattttat
     6061 aaacacttag tttgcccggg gaaataaaac tttcaaataa gctttatcac ttccttttct
     6121 ttcactcttt ctcttttaaa gaaatactga gggtaaagga agaacattcc cttttatttt
     6181 ctttttttga tcgacatcat ccatttttca ctcttcggtt tctactagga ctatgcccaa
     6241 aatataaata ttacatttgg gtgcttactt gggtatcctt atcttttatt tatttgaaga
     6301 acaccaagtg gttacctcat ggaatcccat aaaagcttca cagaaagata aatggcaatg
     6361 gttcatcaga aaaccatttt cagttcattc tctttcttag cgaaacttaa atatttttga
     6421 attagaaatc tcacaaaatc caatactgaa atatgttaga ttattttttc ttaaatttgc
     6481 aattaaatga tttacataaa tgattactgt ctatttgtat aattgcctca aaggcttttt
     6541 tttaatttaa atatattcta acaatgccta tgacctatgg taacactgaa ctctagtaag
     6601 ggcagagtga ttagggaggg caagatactc tatgcactaa tgtcacacac ccaggtcaaa
     6661 tcactgacac aatgaccata caaacagtag agagcagttt tcttgccctt tgataattgt
     6721 ttatgaattc ctgtattgat tgcatgtgta ttgttgccaa aggaagaact gtgtgaaaag
     6781 aaacaacctg gttttgttga aaatgaatta gacataaata tctttgtgaa agtttctaac
     6841 atgcagataa gaacggtctc ttgaccacat ctgctctata aggtatgtaa tgatctactt
     6901 catctttttt ttttggtcaa tcatcttgtt ctccattctt tccaggtttt atatgctcat
     6961 tcgacactac tcttcatgta gtccatgcct acagatctat ctcacaaagt cttacgaaag
     7021 ccctgaccta atcaaccaat aagattggca tgtgtaacag cacaggccat ggattaaaag
     7081 gtttgttgct atggttctac ttagggcaaa tttaccaagg tcaggtgatg aaaaagagat
     7141 agcaaagaaa cacctgattc tgaaactgga gactcccagg tcaaactttg cttcccattt
     7201 gtcttaaatg aaatgtcaga gtttttcaat aacagagcaa tgcctctcta caccaggcag
     7261 gagaccatga ctgtgtcctt aatttacaga ggtactagac agatgcattt tgtacaaaaa
     7321 gcaaaacatg tatattgatg ctctccagta tttgcatctc acattttttt gttggtttgt
     7381 aggaaagagt agtgccgtgt ggcacagaat atcagtgaat atacaattgt gtgcctcagt
     7441 ttactggact tgattatagg tatttattac tacacttggc acaactcaaa ctgttaaaaa
     7501 taaattctca aatattgaat aaattctcaa ttgacactta gactttaagc ttaaaaataa
     7561 tcctaatgtt gggggcacca aaaatcagtg tgtacataat gagttttctt cacagttgct
     7621 attttgacaa atcagaacca gcatgcttct tcagtaccat ccagactagc actgggtttc
     7681 ctatttctat ttcttttggt cacgatcccc aataaaattg aaattctttc cgtgttcgat
     7741 aaaacaatct gaaatgttaa aatattttag tcaaagacat aaaattccag ttgtgtcatg
     7801 atttcaattc ataaggattc tatgcagtag ttttacaaat taaactaggg ggaaatcaca
     7861 ttgattgtat ttgattttga tattatttag aggtctgatg aaccactgag acaactgcaa
     7921 tatattctac atcgacggta tgtacttttt tttttacaac aaacaagtgt aaatgcttta
     7981 caaaactaca tgcacacaga gcactaatct gtgttaaata tcaaccccat ggaagacctt
     8041 ggatcaaata tctctcatta agaaatgcat gcagcaaaaa aaaaatgtgt tctggtttgc
     8101 tctgactttt atccttcaaa acctgctatt gagtgatatt ttgtcaacaa aaatctagag
     8161 ggtagataca tttgttcaaa caaataaatg gggggaacat aaattttcat cctaaaaatt
     8221 gctgcatctt cacgtgcagc tactgtaaat gtacaataat aattagaagg aaatgttttg
     8281 gctcatattt ttcacaaata tccacttgtg gatatctatt ctgatgaaat cttagaaaac
     8341 aacacatgaa tttcagaatc agcattatga cttcatcaga tatatttctg tctggtggga
     8401 gaccctggcc accatcacat aagtgagtgc cttggcagcc tttggtgcat ctaggaattc
     8461 agattctttc atgttgttat cttgttttgc tttataaaat gggtattttc atggaaaaga
     8521 agagaccaat gcagtttact catttttgtt gttttagcga gggataagct aggaacgttt
     8581 taaatgtaaa atggtaagga agttctccac tttagccaag gctagttagt tttctgtcta
     8641 ttgttaacag acattcccag gttggaattg ttcttattgt agttctctcc atgttcttga
     8701 aggtaaccaa ggatcatcaa tttaagtaaa aagaaggaaa gtatgcaaaa ctaaaaggct
     8761 cttttttaaa cagcaaatta tgaagaatca ctagcaaatt atatccataa aggattgaga
     8821 taaaatgttt gcttcctata actcaaaaga tacaaacaga agcaaatgtc aagcaaatat
     8881 atttgttctc ataacggttc ttataacaaa gtggattttt aaaaaaatct cttttctgaa
     8941 attgatactt cattctataa agcatttcac ctttatagga ttattaacac gatattattt
     9001 atacccattg aatgtgtatt tattctaaaa tctttggaac acctcttaca atttgacaca
     9061 gaatgaatga aattctatac ttatttcttc acaaggatct attttttcat attccttttt
     9121 acctagctgt tattttctca ctgatgactt acatttgata cttcatagtt taagctaaac
     9181 ttaaaagaag ctaccaaaca tggaacaaca cagacatttc cttaaactaa accatgtgat
     9241 gtaaaccgaa tttgtcttgg gtccaaacac tctaaatagc tgaaaagcat tttccaacca
     9301 gagaactgtt gtggcattct tttgtgtaat tgtgggaagg ctgtacagtt tatttcactt
     9361 aaaaaaatct gaaaggaata agcaccattg aaaatcttct gtttaccaaa aataaaagac
     9421 ccaatacccc caaacatttc cacacaggat gatttaaaga atgatatgtt tcttttgcat
     9481 tcattttatg ttgttctcct gaaattaatg tcacttaaag tgtgaagaat aataaattaa
     9541 tctgtcattc cttcaaatat a
//
