LOCUS       NM_001271126            3276 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus neuregulin 1 (Nrg1), transcript variant 9, mRNA.
ACCESSION   NM_001271126
VERSION     NM_001271126.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   2  (bases 1 to 3276)
  AUTHORS   Wang,Y.K., Yang,W.X., Liu,R., Guo,J.B., Zhang,Y.M., Li,K., Lu,Y.
            and Wang,J.
  TITLE     Changes in Type II NRG-1 Expression during Regeneration Following
            Autologous Nerve Transplantation in Rats
  JOURNAL   Turk Neurosurg 33 (1), 18-24 (2023)
   PUBMED   35416257
  REMARK    GeneRIF: Changes in Type II NRG-1 Expression during Regeneration
            Following Autologous Nerve Transplantation in Rats.
REFERENCE   3  (bases 1 to 3276)
  AUTHORS   Banerjee,S., Mishra,S., Xu,W., Thompson,W.E. and Chowdhury,I.
  TITLE     Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell
  JOURNAL   J Ovarian Res 15 (1), 86 (2022)
   PUBMED   35883098
  REMARK    GeneRIF: Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3276)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3276)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   6  (bases 1 to 3276)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   7  (bases 1 to 3276)
  AUTHORS   Sliwkowski,M.X., Schaefer,G., Akita,R.W., Lofgren,J.A.,
            Fitzpatrick,V.D., Nuijens,A., Fendly,B.M., Cerione,R.A.,
            Vandlen,R.L. and Carraway,K.L. 3rd.
  TITLE     Coexpression of erbB2 and erbB3 proteins reconstitutes a high
            affinity receptor for heregulin
  JOURNAL   J Biol Chem 269 (20), 14661-14665 (1994)
   PUBMED   7514177
REFERENCE   8  (bases 1 to 3276)
  AUTHORS   Wen,D., Suggs,S.V., Karunagaran,D., Liu,N., Cupples,R.L., Luo,Y.,
            Janssen,A.M., Ben-Baruch,N., Trollinger,D.B., Jacobsen,V.L. et al.
  TITLE     Structural and functional aspects of the multiplicity of Neu
            differentiation factors
  JOURNAL   Mol Cell Biol 14 (3), 1909-1919 (1994)
   PUBMED   7509448
REFERENCE   9  (bases 1 to 3276)
  AUTHORS   Wen,D., Peles,E., Cupples,R., Suggs,S.V., Bacus,S.S., Luo,Y.,
            Trail,G., Hu,S., Silbiger,S.M., Levy,R.B. et al.
  TITLE     Neu differentiation factor: a transmembrane glycoprotein containing
            an EGF domain and an immunoglobulin homology unit
  JOURNAL   Cell 69 (3), 559-572 (1992)
   PUBMED   1349853
REFERENCE   10 (bases 1 to 3276)
  AUTHORS   Peles,E., Bacus,S.S., Koski,R.A., Lu,H.S., Wen,D., Ogden,S.G.,
            Levy,R.B. and Yarden,Y.
  TITLE     Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein
            that induces differentiation of mammary tumor cells
  JOURNAL   Cell 69 (1), 205-216 (1992)
   PUBMED   1348215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000283.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001271126.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001271126.1.
            
            Transcript Variant: This variant (9) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (9)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY995221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               JACYVU010000283.1  9285738-9286181
            445-622             JACYVU010000283.1  9330203-9330380
            623-744             JACYVU010000283.1  9339056-9339177
            745-795             JACYVU010000283.1  9345212-9345262
            796-846             JACYVU010000283.1  9348254-9348304
            847-976             JACYVU010000283.1  9440586-9440715
            977-1035            JACYVU010000283.1  9452397-9452455
            1036-1059           JACYVU010000283.1  9458835-9458858
            1060-1162           JACYVU010000283.1  9463612-9463714
            1163-1289           JACYVU010000283.1  9465226-9465352
            1290-1420           JACYVU010000283.1  9467526-9467656
            1421-1624           JACYVU010000283.1  9468393-9468596
            1625-3276           JACYVU010000283.1  9471255-9472906
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..3276
                     /gene="Nrg1"
                     /note="neuregulin 1"
                     /db_xref="GeneID:112400"
                     /db_xref="RGD:621341"
     exon            1..444
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..2279
                     /gene="Nrg1"
                     /note="isoform 9 is encoded by transcript variant 9;
                     neuregulin 1 type III beta 3; pro-NRG1; glial growth
                     factor"
                     /codon_start=1
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     9"
                     /protein_id="NP_001258055.1"
                     /db_xref="GeneID:112400"
                     /db_xref="RGD:621341"
                     /translation="MSERKEGRGKGKGKKKDRGSRGKPGPAEGDPSPALPPRLKEMKS
                     QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPENIKIQKKPGKSELRINKA
                     SLADSGEYMCKVISKLGNDSASANITIVESNEFITGMPASTETAYVSSESPIRISVST
                     EGANTSSSTSTSTTGTSHLIKCAEKEKTFCVNGGECFTVKDLSNPSRYLCKCPNEFTG
                     DRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQR
                     QKLHDRLRQSLRSERSNLVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVE
                     TSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESIISESNSVIMMSSVENSRHSSPAGG
                     PRGRLHGLGGPRDNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPK
                     SPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHN
                     PAHQSTSLPPSPLRIVEDEEYETTQEYESVQEPVKKVTNSRRAKRTKPNGHIANRLEM
                     DSNTSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFST
                     QEELQARLSSVIANQDPIAV"
     exon            445..622
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..744
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..795
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..846
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..976
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1035
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1059
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1162
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1289
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1420
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1624
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..3276
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcag ctgccgggag atgcgagcgc agaccggatt gtgatcacct ttccctcttc
       61 gggctgtaag agagcgagac aagccaccga agcgaggcca ctccagagcc ggcagcggag
      121 ggacccggga cactagagca gctccgagcc actccagact gagcggacgc tccaggtgat
      181 cgagtccacg ctgcttcctg caggcgacag gcgacgcctc ccgagcagcc cggccactgg
      241 ctcttcccct cctgggacaa acttttctgc aagcccttgg accaaacttg tcgcgcgtca
      301 ccgtcaccca accgggtccg cgtagagcgc tcatcttcgg cgagatgtct gagcgcaaag
      361 aaggcagagg caaggggaag ggcaagaaga aggaccgggg atcccgcggg aagcccgggc
      421 ccgccgaggg cgacccgagc ccagcactgc ctcccagatt gaaagaaatg aagagccagg
      481 agtcagctgc aggctccaag ctagtgctcc ggtgcgaaac cagctccgag tactcctcac
      541 tcagattcaa atggttcaag aatgggaacg agctgaaccg caaaaataaa ccagaaaaca
      601 tcaagataca gaagaagcca gggaagtcag agcttcgaat taacaaagca tccctggctg
      661 actctggaga gtatatgtgc aaagtgatca gcaagttagg aaatgacagt gcctctgcca
      721 acatcaccat tgttgagtca aacgagttca tcactggcat gccagcctcg actgagacag
      781 cctatgtgtc ctcagagtct cccattagaa tctcagtttc aacagaaggc gcaaacactt
      841 cttcatccac atcgacatcc acgactggga ccagccatct cataaagtgc gcggagaagg
      901 agaaaacttt ctgtgtgaat gggggcgagt gcttcacggt gaaggacctg tcaaacccgt
      961 caagatactt gtgcaagtgc ccaaatgagt ttactggtga tcgttgccaa aactacgtaa
     1021 tggccagctt ctacaagcat cttgggattg aatttatgga agcggaggaa ctctaccaga
     1081 agagggtgct gacaattact ggcatctgta tcgccctgct ggtggtcggc atcatgtgtg
     1141 tggtggccta ctgcaaaacc aagaagcagc ggcagaagct tcatgatcgg cttcggcaga
     1201 gtcttcggtc agaacggagc aacctggtga acatagcgaa tgggcctcac cacccaaacc
     1261 caccgccaga gaacgtgcag ctggtgaatc aatacgtatc taaaaacgtc atctccagtg
     1321 agcatattgt tgagagagaa gtggagactt ccttttccac cagtcattac acttccacag
     1381 cccatcactc cacgactgtc acccagactc ctagtcacag ctggagtaat gggcacacgg
     1441 agagcatcat ttcagaaagc aactccgtaa tcatgatgtc ttcggtagag aacagcaggc
     1501 acagcagtcc cgccgggggc ccacgaggac gtcttcatgg cctgggaggc cctcgtgata
     1561 acagcttcct caggcatgcc agagaaaccc ctgactccta cagagactct cctcatagcg
     1621 aaaggtatgt atcagccatg accaccccgg ctcgtatgtc acctgtagat ttccacacgc
     1681 caagctcccc taaatcgccc ccttcggaaa tgtctccacc cgtgtccagc atgacggtgt
     1741 caatgccctc tgtggcagtc agcccctttg tggaagaaga gaggcctctg ctgcttgtga
     1801 cgccaccaag gctacgggag aagaaatatg atcatcaccc ccagcaactc aactcctttc
     1861 atcacaaccc tgcacatcag agtaccagcc tcccccctag cccactgagg atagtggagg
     1921 atgaggagta cgagacgacc caggagtatg agtcagttca agagcccgtt aagaaagtca
     1981 ccaatagccg gcgggccaaa agaaccaagc ccaatggcca cattgccaat aggttggaaa
     2041 tggacagcaa cacaagttct gtgagcagta actcagaaag tgagacagaa gacgaaagag
     2101 taggtgaaga cacaccattc ctgggcatac agaaccccct ggcagccagc cttgaggtgg
     2161 cccctgcctt ccgtctggct gagagcagga ctaacccagc aggccgcttc tccacacagg
     2221 aggaattaca ggccaggctg tctagtgtaa tcgctaacca agaccctatt gctgtataaa
     2281 acctaaataa acacatagat tcacctgtaa aactttattt tatataataa agtatttcac
     2341 cttaaattaa acaatttatt ttattttagc agttctgcaa atagaaaaca ggaagaaaaa
     2401 aaacttttat aaattaaata tatgtatgta aaaatgtgtt atgtgccata tgtagcaatt
     2461 ttttacagta tttcaaaaac gagaaagata tcaatggtgc ctttatgttc tgttatgtcg
     2521 agagcaagtt ttataaagtt atggtgattt ctttttcaca gtatttcagc aaaacctccc
     2581 atatattcag tttctgctgg ctttttgtgc attgcattat gatgttgact ggatgtatgg
     2641 tttgcaaggc tagcagctag ctcgcgctct ctctctctct ctctctgtct ctgtctctct
     2701 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     2761 gtgtctgtct ctctctctgc ttcccgtagc tcccaaccag tactgtcttg gactggcaca
     2821 tccatccaaa tacctttcta ctttgtatga agttttcttt gctttcccaa tatgaaatga
     2881 gttctctcta ctctgtcagc caaaggtttg cttcactgga ctctgagata atagtagacc
     2941 cagcagcatg ctactattat gtatagcagg aaactgcacc aagtaatgtc caataatagg
     3001 aagaaagtaa tactgtgatt ttaaaaaaaa aacaaactat attattaatc agaagacagc
     3061 ttgctcttgg taaaaggagc taccattgac tctaattttg actttttagt tattgttctt
     3121 gacaaagagt aacagcttca agtacagcct agaaaaaaaa tgggttctgg cttgctatca
     3181 ggataaatct atcgacgtag atagattcaa ctcagtttca ctttctgtct tgggggaaat
     3241 gatccagcca ctcatatgac gaccaaccaa ccacag
//
