LOCUS       NM_001271118            3721 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus neuregulin 1 (Nrg1), transcript variant 1, mRNA.
ACCESSION   NM_001271118
VERSION     NM_001271118.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Wang,Y.K., Yang,W.X., Liu,R., Guo,J.B., Zhang,Y.M., Li,K., Lu,Y.
            and Wang,J.
  TITLE     Changes in Type II NRG-1 Expression during Regeneration Following
            Autologous Nerve Transplantation in Rats
  JOURNAL   Turk Neurosurg 33 (1), 18-24 (2023)
   PUBMED   35416257
  REMARK    GeneRIF: Changes in Type II NRG-1 Expression during Regeneration
            Following Autologous Nerve Transplantation in Rats.
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Banerjee,S., Mishra,S., Xu,W., Thompson,W.E. and Chowdhury,I.
  TITLE     Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell
  JOURNAL   J Ovarian Res 15 (1), 86 (2022)
   PUBMED   35883098
  REMARK    GeneRIF: Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Sliwkowski,M.X., Schaefer,G., Akita,R.W., Lofgren,J.A.,
            Fitzpatrick,V.D., Nuijens,A., Fendly,B.M., Cerione,R.A.,
            Vandlen,R.L. and Carraway,K.L. 3rd.
  TITLE     Coexpression of erbB2 and erbB3 proteins reconstitutes a high
            affinity receptor for heregulin
  JOURNAL   J Biol Chem 269 (20), 14661-14665 (1994)
   PUBMED   7514177
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Wen,D., Suggs,S.V., Karunagaran,D., Liu,N., Cupples,R.L., Luo,Y.,
            Janssen,A.M., Ben-Baruch,N., Trollinger,D.B., Jacobsen,V.L. et al.
  TITLE     Structural and functional aspects of the multiplicity of Neu
            differentiation factors
  JOURNAL   Mol Cell Biol 14 (3), 1909-1919 (1994)
   PUBMED   7509448
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Wen,D., Peles,E., Cupples,R., Suggs,S.V., Bacus,S.S., Luo,Y.,
            Trail,G., Hu,S., Silbiger,S.M., Levy,R.B. et al.
  TITLE     Neu differentiation factor: a transmembrane glycoprotein containing
            an EGF domain and an immunoglobulin homology unit
  JOURNAL   Cell 69 (3), 559-572 (1992)
   PUBMED   1349853
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Peles,E., Bacus,S.S., Koski,R.A., Lu,H.S., Wen,D., Ogden,S.G.,
            Levy,R.B. and Yarden,Y.
  TITLE     Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein
            that induces differentiation of mammary tumor cells
  JOURNAL   Cell 69 (1), 205-216 (1992)
   PUBMED   1348215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000283.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001271118.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001271118.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF194438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1291              JACYVU010000283.1  9373470-9374760
            1292-1421           JACYVU010000283.1  9440586-9440715
            1422-1480           JACYVU010000283.1  9452397-9452455
            1481-1504           JACYVU010000283.1  9458835-9458858
            1505-1607           JACYVU010000283.1  9463612-9463714
            1608-1734           JACYVU010000283.1  9465226-9465352
            1735-1865           JACYVU010000283.1  9467526-9467656
            1866-2069           JACYVU010000283.1  9468393-9468596
            2070-3721           JACYVU010000283.1  9471255-9472906
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..3721
                     /gene="Nrg1"
                     /note="neuregulin 1"
                     /db_xref="GeneID:112400"
                     /db_xref="RGD:621341"
     exon            1..1291
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..2724
                     /gene="Nrg1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuregulin 1 type III beta 3; pro-NRG1; glial growth
                     factor"
                     /codon_start=1
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     1"
                     /protein_id="NP_001258047.1"
                     /db_xref="GeneID:112400"
                     /db_xref="RGD:621341"
                     /translation="MEIYSPDMSEVAGGRSSSPSTQLSAAPSLDGLPAAEEHIPDTHT
                     EDERSPGLLGLAVPCCVCLEAERLRGCLNSEKICIVPILACLVSLCLCIAGLKWVFVD
                     KIFEYDSPTHLDPGGLGQDPVISLDPTAAPAILVSSEAYTSPVSKAQSEAGAHVTVQG
                     DHAAVASEPSAVPTRKNRLSAFPPFHSTAPPFPSPARTPEVRTPKSGTQPQTTETNLQ
                     TAPKLSTSTSTTGTSHLIKCAEKEKTFCVNGGECFTVKDLSNPSRYLCKCPNEFTGDR
                     CQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQK
                     LHDRLRQSLRSERSNLVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETS
                     FSTSHYTSTAHHSTTVTQTPSHSWSNGHTESIISESNSVIMMSSVENSRHSSPAGGPR
                     GRLHGLGGPRDNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
                     PSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPA
                     HQSTSLPPSPLRIVEDEEYETTQEYESVQEPVKKVTNSRRAKRTKPNGHIANRLEMDS
                     NTSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQE
                     ELQARLSSVIANQDPIAV"
     exon            1292..1421
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1480
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1504
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1607
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1734
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1865
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2069
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3721
                     /gene="Nrg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgatgctca gagggcaggc acctgctgct ctgtaatgat tcagcctctt tcagccgctg
       61 cgttaacacg acaggatgct gttgctactg tcgctgctgc ctctcctgcc gccgccgctg
      121 ctgccgccgc cgcctcctct ggtcttgctt ttgcttttac ttctcctgca tgacagttgt
      181 tttcttcctc taagcagaca ccagcttcag acgcttgagg tgagaaacat gcctttcagt
      241 ttgggatact ggtttactta atcggctagg cggcagcttg cttcctattt tggtcccctg
      301 ccttcttgac caacccggca tggtttggag aagcatttga aagaactgaa aaagtgtccc
      361 agaaacaaca gctcaagata tttcggtaca cttctatttc atagttgcta gaagcccttt
      421 ctttttcgtt ttttttttct ttttcttttt ctttttcttt ttccttttcc tgcttcctcc
      481 taagctctgg tactttgggt aattgccttg gacttgggtg ccttatcgat ttccccctcc
      541 aagatgctgt atcatttggt tggggggagc tctgcgtggt aatgcactgt gagagaggcc
      601 aggccttctg gaggtgagcc gatggagatt tattccccag acatgtctga ggtagctggc
      661 gggaggtcct ccagcccctc cactcagctg agtgcagccc catctcttga tgggcttccg
      721 gcagcggagg aacatatacc agacacccac acagaagatg agagaagccc tggactcctg
      781 ggcctggcgg tgccctgctg tgtgtgcctg gaagctgagc gcctgagagg gtgtctcaac
      841 tccgagaaga tctgcattgt tcccattctg gcttgcctag tcagcctctg cctctgcatt
      901 gctggcctga agtgggtatt tgtggacaag atatttgaat acgactctcc tacccacctt
      961 gaccctgggg ggttaggcca ggaccctgtg atttctctgg atccaactgc tgccccagcc
     1021 attttggtat catctgaggc atacacttca cctgtctcta aggctcagtc tgaagctggg
     1081 gctcatgtta cagtacaagg tgaccatgct gctgtggcct ctgaaccttc agcagtaccg
     1141 acccggaaga accggctgtc tgcttttcct ccctttcact ctactgcacc gcccttccct
     1201 tctccagctc ggacccctga ggtgagaaca cccaagtcag gaactcagcc acaaacaaca
     1261 gaaactaacc tgcaaactgc tcctaaactt tccacatcga catccacgac tgggaccagc
     1321 catctcataa agtgcgcgga gaaggagaaa actttctgtg tgaatggggg cgagtgcttc
     1381 acggtgaagg acctgtcaaa cccgtcaaga tacttgtgca agtgcccaaa tgagtttact
     1441 ggtgatcgtt gccaaaacta cgtaatggcc agcttctaca agcatcttgg gattgaattt
     1501 atggaagcgg aggaactcta ccagaagagg gtgctgacaa ttactggcat ctgtatcgcc
     1561 ctgctggtgg tcggcatcat gtgtgtggtg gcctactgca aaaccaagaa gcagcggcag
     1621 aagcttcatg atcggcttcg gcagagtctt cggtcagaac ggagcaacct ggtgaacata
     1681 gcgaatgggc ctcaccaccc aaacccaccg ccagagaacg tgcagctggt gaatcaatac
     1741 gtatctaaaa acgtcatctc cagtgagcat attgttgaga gagaagtgga gacttccttt
     1801 tccaccagtc attacacttc cacagcccat cactccacga ctgtcaccca gactcctagt
     1861 cacagctgga gtaatgggca cacggagagc atcatttcag aaagcaactc cgtaatcatg
     1921 atgtcttcgg tagagaacag caggcacagc agtcccgccg ggggcccacg aggacgtctt
     1981 catggcctgg gaggccctcg tgataacagc ttcctcaggc atgccagaga aacccctgac
     2041 tcctacagag actctcctca tagcgaaagg tatgtatcag ccatgaccac cccggctcgt
     2101 atgtcacctg tagatttcca cacgccaagc tcccctaaat cgcccccttc ggaaatgtct
     2161 ccacccgtgt ccagcatgac ggtgtcaatg ccctctgtgg cagtcagccc ctttgtggaa
     2221 gaagagaggc ctctgctgct tgtgacgcca ccaaggctac gggagaagaa atatgatcat
     2281 cacccccagc aactcaactc ctttcatcac aaccctgcac atcagagtac cagcctcccc
     2341 cctagcccac tgaggatagt ggaggatgag gagtacgaga cgacccagga gtatgagtca
     2401 gttcaagagc ccgttaagaa agtcaccaat agccggcggg ccaaaagaac caagcccaat
     2461 ggccacattg ccaataggtt ggaaatggac agcaacacaa gttctgtgag cagtaactca
     2521 gaaagtgaga cagaagacga aagagtaggt gaagacacac cattcctggg catacagaac
     2581 cccctggcag ccagccttga ggtggcccct gccttccgtc tggctgagag caggactaac
     2641 ccagcaggcc gcttctccac acaggaggaa ttacaggcca ggctgtctag tgtaatcgct
     2701 aaccaagacc ctattgctgt ataaaaccta aataaacaca tagattcacc tgtaaaactt
     2761 tattttatat aataaagtat ttcaccttaa attaaacaat ttattttatt ttagcagttc
     2821 tgcaaataga aaacaggaag aaaaaaaact tttataaatt aaatatatgt atgtaaaaat
     2881 gtgttatgtg ccatatgtag caatttttta cagtatttca aaaacgagaa agatatcaat
     2941 ggtgccttta tgttctgtta tgtcgagagc aagttttata aagttatggt gatttctttt
     3001 tcacagtatt tcagcaaaac ctcccatata ttcagtttct gctggctttt tgtgcattgc
     3061 attatgatgt tgactggatg tatggtttgc aaggctagca gctagctcgc gctctctctc
     3121 tctctctctc tgtctctgtc tctctctctc tctctctctc tctctctctc tctctctctc
     3181 tctctctctc tctctctctc tctctgtgtc tgtctctctc tctgcttccc gtagctccca
     3241 accagtactg tcttggactg gcacatccat ccaaatacct ttctactttg tatgaagttt
     3301 tctttgcttt cccaatatga aatgagttct ctctactctg tcagccaaag gtttgcttca
     3361 ctggactctg agataatagt agacccagca gcatgctact attatgtata gcaggaaact
     3421 gcaccaagta atgtccaata ataggaagaa agtaatactg tgattttaaa aaaaaaacaa
     3481 actatattat taatcagaag acagcttgct cttggtaaaa ggagctacca ttgactctaa
     3541 ttttgacttt ttagttattg ttcttgacaa agagtaacag cttcaagtac agcctagaaa
     3601 aaaaatgggt tctggcttgc tatcaggata aatctatcga cgtagataga ttcaactcag
     3661 tttcactttc tgtcttgggg gaaatgatcc agccactcat atgacgacca accaaccaca
     3721 g
//
