LOCUS       NP_001258047             700 aa            linear   ROD 05-MAY-2025
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001258047
VERSION     NP_001258047.1
DBSOURCE    REFSEQ: accession NM_001271118.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 700)
  AUTHORS   Yuan,J., Xu,B., Ma,J., Pang,X., Fu,Y., Liang,M., Wang,M., Pan,Y.,
            Duan,Y., Tang,M., Zhu,B., Laher,I. and Li,S.
  TITLE     MOTS-c and aerobic exercise induce cardiac physiological adaptation
            via NRG1/ErbB4/CEBPbeta modification in rats
  JOURNAL   Life Sci 315, 121330 (2023)
   PUBMED   36584915
  REMARK    GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological
            adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
REFERENCE   2  (residues 1 to 700)
  AUTHORS   Wang,Y.K., Yang,W.X., Liu,R., Guo,J.B., Zhang,Y.M., Li,K., Lu,Y.
            and Wang,J.
  TITLE     Changes in Type II NRG-1 Expression during Regeneration Following
            Autologous Nerve Transplantation in Rats
  JOURNAL   Turk Neurosurg 33 (1), 18-24 (2023)
   PUBMED   35416257
  REMARK    GeneRIF: Changes in Type II NRG-1 Expression during Regeneration
            Following Autologous Nerve Transplantation in Rats.
REFERENCE   3  (residues 1 to 700)
  AUTHORS   Banerjee,S., Mishra,S., Xu,W., Thompson,W.E. and Chowdhury,I.
  TITLE     Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell
  JOURNAL   J Ovarian Res 15 (1), 86 (2022)
   PUBMED   35883098
  REMARK    GeneRIF: Neuregulin-1 signaling regulates cytokines and chemokines
            expression and secretion in granulosa cell.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 700)
  AUTHORS   Li,S., Wang,M., Ma,J., Pang,X., Yuan,J., Pan,Y., Fu,Y. and Laher,I.
  TITLE     MOTS-c and Exercise Restore Cardiac Function by Activating of
            NRG1-ErbB Signaling in Diabetic Rats
  JOURNAL   Front Endocrinol (Lausanne) 13, 812032 (2022)
   PUBMED   35370955
  REMARK    GeneRIF: MOTS-c and Exercise Restore Cardiac Function by Activating
            of NRG1-ErbB Signaling in Diabetic Rats.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 700)
  AUTHORS   Xu,L., Li,Z., Rong,J. and Lang,L.
  TITLE     Effect of regulation of the NRG1/ErbB4 signaling pathway on the
            visual cortex synaptic plasticity of amblyopic adult rats
  JOURNAL   J Biochem Mol Toxicol 35 (9), e22841 (2021)
   PUBMED   34273906
  REMARK    GeneRIF: Effect of regulation of the NRG1/ErbB4 signaling pathway
            on the visual cortex synaptic plasticity of amblyopic adult rats.
REFERENCE   6  (residues 1 to 700)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   7  (residues 1 to 700)
  AUTHORS   Sliwkowski,M.X., Schaefer,G., Akita,R.W., Lofgren,J.A.,
            Fitzpatrick,V.D., Nuijens,A., Fendly,B.M., Cerione,R.A.,
            Vandlen,R.L. and Carraway,K.L. 3rd.
  TITLE     Coexpression of erbB2 and erbB3 proteins reconstitutes a high
            affinity receptor for heregulin
  JOURNAL   J Biol Chem 269 (20), 14661-14665 (1994)
   PUBMED   7514177
REFERENCE   8  (residues 1 to 700)
  AUTHORS   Wen,D., Suggs,S.V., Karunagaran,D., Liu,N., Cupples,R.L., Luo,Y.,
            Janssen,A.M., Ben-Baruch,N., Trollinger,D.B., Jacobsen,V.L. et al.
  TITLE     Structural and functional aspects of the multiplicity of Neu
            differentiation factors
  JOURNAL   Mol Cell Biol 14 (3), 1909-1919 (1994)
   PUBMED   7509448
REFERENCE   9  (residues 1 to 700)
  AUTHORS   Wen,D., Peles,E., Cupples,R., Suggs,S.V., Bacus,S.S., Luo,Y.,
            Trail,G., Hu,S., Silbiger,S.M., Levy,R.B. et al.
  TITLE     Neu differentiation factor: a transmembrane glycoprotein containing
            an EGF domain and an immunoglobulin homology unit
  JOURNAL   Cell 69 (3), 559-572 (1992)
   PUBMED   1349853
REFERENCE   10 (residues 1 to 700)
  AUTHORS   Peles,E., Bacus,S.S., Koski,R.A., Lu,H.S., Wen,D., Ogden,S.G.,
            Levy,R.B. and Yarden,Y.
  TITLE     Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein
            that induces differentiation of mammary tumor cells
  JOURNAL   Cell 69 (1), 205-216 (1992)
   PUBMED   1348215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF194438.1, SRR26643298.71836.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     Protein         1..700
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     1"
                     /note="neuregulin 1 type III beta 3; pro-NRG1; glial
                     growth factor"
                     /calculated_mol_wt=76270
     Region          246..276
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          328..682
                     /region_name="Neuregulin"
                     /note="Neuregulin intracellular region; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..700
                     /gene="Nrg1"
                     /coded_by="NM_001271118.3:622..2724"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:112400"
                     /db_xref="RGD:621341"
ORIGIN      
        1 meiyspdmse vaggrsssps tqlsaapsld glpaaeehip dthtedersp gllglavpcc
       61 vcleaerlrg clnsekiciv pilaclvslc lciaglkwvf vdkifeydsp thldpgglgq
      121 dpvisldpta apailvssea ytspvskaqs eagahvtvqg dhaavaseps avptrknrls
      181 afppfhstap pfpspartpe vrtpksgtqp qttetnlqta pklstststt gtshlikcae
      241 kektfcvngg ecftvkdlsn psrylckcpn eftgdrcqny vmasfykhlg iefmeaeely
      301 qkrvltitgi ciallvvgim cvvaycktkk qrqklhdrlr qslrsersnl vniangphhp
      361 npppenvqlv nqyvsknvis sehivereve tsfstshyts tahhsttvtq tpshswsngh
      421 tesiisesns vimmssvens rhsspaggpr grlhglggpr dnsflrhare tpdsyrdsph
      481 seryvsamtt parmspvdfh tpsspkspps emsppvssmt vsmpsvavsp fveeerplll
      541 vtpprlrekk ydhhpqqlns fhhnpahqst slppsplriv edeeyettqe yesvqepvkk
      601 vtnsrrakrt kpnghianrl emdsntssvs snsesetede rvgedtpflg iqnplaasle
      661 vapafrlaes rtnpagrfst qeelqarlss vianqdpiav
//
