LOCUS       NM_001100708            1898 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nuclear respiratory factor 1 (Nrf1), mRNA.
ACCESSION   NM_001100708 XM_001062755 XM_231566
VERSION     NM_001100708.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Niu,N., Li,H., Du,X., Wang,C., Li,J., Yang,J., Liu,C., Yang,S.,
            Zhu,Y. and Zhao,W.
  TITLE     Effects of NRF-1 and PGC-1alpha cooperation on HIF-1alpha and rat
            cardiomyocyte apoptosis under hypoxia
  JOURNAL   Gene 834, 146565 (2022)
   PUBMED   35569770
  REMARK    GeneRIF: Effects of NRF-1 and PGC-1alpha cooperation on HIF-1alpha
            and rat cardiomyocyte apoptosis under hypoxia.
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Pejon,T.M.M., Faria,V.S., Gobatto,C.A., Manchado-Gobatto,F.B.,
            Scariot,P.P.M., Cornachione,A.S. and Beck,W.R.
  TITLE     Effect of 12-wk Training in Ovariectomised Rats on PGC-1alpha,
            NRF-1 and Energy Substrates
  JOURNAL   Int J Sports Med 43 (7), 632-641 (2022)
   PUBMED   35180801
  REMARK    GeneRIF: Effect of 12-wk Training in Ovariectomised Rats on
            PGC-1alpha, NRF-1 and Energy Substrates.
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Li,H., Niu,N., Yang,J., Dong,F., Zhang,T., Li,S. and Zhao,W.
  TITLE     Nuclear respiratory factor 1 protects H9C2 cells against
            hypoxia-induced apoptosis via the death receptor pathway and
            mitochondrial pathway
  JOURNAL   Cell Biol Int 45 (8), 1784-1796 (2021)
   PUBMED   33913583
  REMARK    GeneRIF: Nuclear respiratory factor 1 protects H9C2 cells against
            hypoxia-induced apoptosis via the death receptor pathway and
            mitochondrial pathway.
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Li,Y., Yu,X.J., Xiao,T., Chi,H.L., Zhu,G.Q. and Kang,Y.M.
  TITLE     Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus
            Alleviates Hypertension Through Intervention of Superoxide
            Production-Removal Balance and Mitochondrial Function
  JOURNAL   Cardiovasc Toxicol 21 (6), 472-489 (2021)
   PUBMED   33582931
  REMARK    GeneRIF: Nrf1 Knock-Down in the Hypothalamic Paraventricular
            Nucleus Alleviates Hypertension Through Intervention of Superoxide
            Production-Removal Balance and Mitochondrial Function.
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Wang,X., Huang,L., Jiang,S., Cheng,K., Wang,D., Luo,Q., Wu,X. and
            Zhu,L.
  TITLE     Testosterone attenuates pulmonary epithelial inflammation in male
            rats of COPD model through preventing NRF1-derived NF-kappaB
            signaling
  JOURNAL   J Mol Cell Biol 13 (2), 128-140 (2021)
   PUBMED   33475136
  REMARK    GeneRIF: Testosterone attenuates pulmonary epithelial inflammation
            in male rats of COPD model through preventing NRF1-derived
            NF-kappaB signaling.
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Suliman,H.B., Carraway,M.S., Welty-Wolf,K.E., Whorton,A.R. and
            Piantadosi,C.A.
  TITLE     Lipopolysaccharide stimulates mitochondrial biogenesis via
            activation of nuclear respiratory factor-1
  JOURNAL   J Biol Chem 278 (42), 41510-41518 (2003)
   PUBMED   12902348
  REMARK    GeneRIF: oxidative stress stimulates mitochondrial biogenesis in
            part via nuclear respiratory factor 1 (NRF-1) activation and
            corresponding to recovery events after LPS-induced liver damage.
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Maraia,R.J. and Intine,R.V.
  TITLE     Recognition of nascent RNA by the human La antigen: conserved and
            divergent features of structure and function
  JOURNAL   Mol Cell Biol 21 (2), 367-379 (2001)
   PUBMED   11134326
  REMARK    Review article
REFERENCE   8  (bases 1 to 1898)
  AUTHORS   Xia,Y., Buja,L.M. and McMillin,J.B.
  TITLE     Activation of the cytochrome c gene by electrical stimulation in
            neonatal rat cardiac myocytes. Role of NRF-1 and c-Jun
  JOURNAL   J Biol Chem 273 (20), 12593-12598 (1998)
   PUBMED   9575220
REFERENCE   9  (bases 1 to 1898)
  AUTHORS   Koyama,H., Kurokawa,T., Nonami,T., Nakao,A., Sugiyama,S.,
            Murakami,T., Shimomura,Y. and Takagi,H.
  TITLE     Increases in the mitochondrial DNA replication and transcription in
            the remnant liver of rats
  JOURNAL   Biochem Biophys Res Commun 243 (3), 858-861 (1998)
   PUBMED   9501001
REFERENCE   10 (bases 1 to 1898)
  AUTHORS   Gopalakrishnan,L. and Scarpulla,R.C.
  TITLE     Structure, expression, and chromosomal assignment of the human gene
            encoding nuclear respiratory factor 1
  JOURNAL   J Biol Chem 270 (30), 18019-18025 (1995)
   PUBMED   7629110
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161956.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_231566.4, XM_001062755.1.
            
            Summary: This gene encodes a protein that homodimerizes and
            functions as a transcription factor which activates the expression
            of some key metabolic genes regulating cellular growth and nuclear
            genes required for respiration, heme biosynthesis, and
            mitochondrial DNA transcription and replication. Confusion has
            occurred in bibliographic databases for genes in the 'nuclear
            respiratory factor' and 'nuclear factor (erythroid-derived 2)-like'
            families due to a shared symbol or alias of Nrf1. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132275
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1898
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /note="nuclear respiratory factor 1"
                     /db_xref="GeneID:312195"
                     /db_xref="RGD:1304603"
     exon            1..75
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            76..233
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            234..468
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1850
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /codon_start=1
                     /product="nuclear respiratory factor 1"
                     /protein_id="NP_001094178.1"
                     /db_xref="GeneID:312195"
                     /db_xref="RGD:1304603"
                     /translation="MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDS
                     PSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPS
                     IRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYK
                     SMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTG
                     RGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGRE
                     DLLYAFEDQQTQTQATTTHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADA
                     SELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAA
                     SQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANG
                     PDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQ
                     PGRAYVVEDGDIIFFKFNSPQQLKRK"
     exon            469..583
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            584..710
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            711..851
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1010
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1208
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1310
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1468
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1593
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1869
                     /gene="Nrf1"
                     /gene_synonym="Nfe2l1_retired"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcaggagg ctgcgaggag ccggcgcggt cgcagtctcc acggcgcagg cccacggtag
       61 cgcagccgct ctgaggtcga atgatctgtg gttcatatag accacatttt gtttcccact
      121 cacccattga tggacacttg ggtagctccc acctctgggc tgttgtgaat taatgctgct
      181 atgaacatgg gtgtgcacat agctctttga gaccctgctt tcagtccttc tggcagtaga
      241 tcttcatgga ggaacacgga gtgacccaaa ccgaacacat ggctaccata gaagcccatg
      301 cagtggccca gcaagttcag caggtccatg tagccactta cactgagcac agtatgctaa
      361 gtgctgatga agactcccct tcctcgcctg aggacacttc ttacgatgac tcggacatac
      421 tcaactccac ggcagctgat gaggtaactg cccatctggc tgctgcaggt cctgtgggaa
      481 tggctgctgc tgctgctgtg gcaacaggga agaaacggaa aaggcctcat gtgtttgagt
      541 ctaacccatc tatccgaaag agacagcaga cacggttgct tcggaaactc agagccacat
      601 tagatgaata tacgacacga gtgggacagc aagccattgt tctctgcatc tcaccctcca
      661 aacccaaccc tgtctttaag gtgtttggcg cagcaccttt ggagaatgtg gtgcgcaagt
      721 acaagagcat gatcctggaa gacctggagt ctgcgctggc agagcacgcc cctgcgccac
      781 aggaggttaa ttcagaactg ccccctctca ccatcgatgg gattccagtc tctgtggaca
      841 agatgaccca ggctcagctt cgggcattta tcccagagat gctcaagtac tccacaggtc
      901 ggggaaaacc aggctggggg aaagaaagct gcaagcctat ctggtggcca gaagacatcc
      961 catgggccaa tgtccgcagt gacgtccgca cagaagagca aaagcaaagg gtttcatgga
     1021 cccaagcatt acggaccata gttaaaaatt gttataagca gcatgggcgg gaggaccttc
     1081 tgtatgcttt cgaagatcag cagacacaaa ctcaggccac caccacacac agcatagccc
     1141 atctcgtacc atcacagaca gtagtacaga ccttcagcaa ccctgatggc accgtgtcgc
     1201 tcatccaggt tggtactggg gcaacagtag ccacattggc tgatgcttca gaactgccaa
     1261 ccacagtcac tgttgcccaa gtgaattatt ctgctgtggc tgatggagag gtggaacaaa
     1321 attgggccac attacagggc ggtgaaatga ccatccagac gacgcaagca tcagaggcca
     1381 cccaggcagt ggcatcactg gcagaggccg cagtggccgc ttctcaggag atgcaacagg
     1441 gagccactgt caccatggcc cttaacagtg aagctgccgc ccatgctgtc gccactctgg
     1501 ctgaagccac cttacaaggc gggggacaga tagtcctgtc tggggaaacc gcagcagccg
     1561 ttggagcact tactggagtc caagatgcta atggcccaga tggagttcat gcatggacca
     1621 tcagcaaagc cgtgacggct cctcaggctg caggaaaaat tcatacagat tttggaaagg
     1681 gattcattat ggcggaagta atgaaagacg aagatcttaa agaggagagt tctgagaacg
     1741 cagctaaggc tgctgggaag tacaaacaac caggcagagc ttacgttgtt gaagacggag
     1801 atattatctt cttcaaattt aactcgccac agcaactgaa aaggaaataa aattcagttt
     1861 ttaactttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
