LOCUS       NM_001419560            2163 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuronal regeneration related protein (Nrep),
            transcript variant 1, mRNA.
ACCESSION   NM_001419560 XM_039096942
VERSION     NM_001419560.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Jiang,J., Wang,J., Li,C., Mo,L. and Huang,D.
  TITLE     P311 knockdown alleviates hyperoxia-induced injury by inactivating
            the Smad3 signaling pathway in type II alveolar epithelial cells
  JOURNAL   Mol Cell Biochem 478 (2), 277-284 (2023)
   PUBMED   35779227
  REMARK    GeneRIF: P311 knockdown alleviates hyperoxia-induced injury by
            inactivating the Smad3 signaling pathway in type II alveolar
            epithelial cells.
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Qi,F.H., Cai,P.P., Liu,X. and Si,G.M.
  TITLE     Adenovirus-mediated P311 ameliorates renal fibrosis through
            inhibition of epithelial-mesenchymal transition via
            TGF-beta1-Smad-ILK pathway in unilateral ureteral obstruction rats
  JOURNAL   Int J Mol Med 41 (5), 3015-3023 (2018)
   PUBMED   29436600
  REMARK    GeneRIF: P311 may be involved in the pathogenesis of renal fibrosis
            by blocking TGF-beta1-mediated epithelial-mesenchymal transition
            via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion
            kidneys.
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Qi,F., Cai,P., Liu,X., Peng,M. and Si,G.
  TITLE     Adenovirus-mediated P311 inhibits TGF-beta1-induced
            epithelial-mesenchymal transition in NRK-52E cells via
            TGF-beta1-Smad-ILK pathway
  JOURNAL   Biosci Trends 9 (5), 299-306 (2015)
   PUBMED   26559022
  REMARK    GeneRIF: efficiently blocked Smad-ILK pathway activation and
            attenuated epithelial-mesenchymal transition induced by TGF-beta1
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Zhang,Y., Ma,X., Xie,X., Sun,G., Liang,W., Li,X., Wang,F.,
            Zhang,L., Yan,B. and Fan,J.
  TITLE     Role of P311 in interleukin-1alpha-induced epithelial to
            myofibroblast transition in kidney tubular epithelial cells
  JOURNAL   Ren Fail 37 (8), 1384-1389 (2015)
   PUBMED   26335191
  REMARK    GeneRIF: P311 gene, together with alpha-SMA and TGF-beta1 genes,
            was induced in the process of Tubular epithelial-myofibroblast
            transition (TEMT) in rat.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Fujitani,M., Yamagishi,S., Che,Y.H., Hata,K., Kubo,T., Ino,H.,
            Tohyama,M. and Yamashita,T.
  TITLE     P311 accelerates nerve regeneration of the axotomized facial nerve
  JOURNAL   J Neurochem 91 (3), 737-744 (2004)
   PUBMED   15485502
  REMARK    GeneRIF: identified a gene, previously designated P311,
            up-regulated in axotomized facial motoneurons; ectopically
            expressed P311 localizes in the cytoplasm and the nucleus;
            over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells
            to differentiate [P311]
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Paliwal,S., Shi,J., Dhru,U., Zhou,Y. and Schuger,L.
  TITLE     P311 binds to the latency associated protein and downregulates the
            expression of TGF-beta1 and TGF-beta2
  JOURNAL   Biochem Biophys Res Commun 315 (4), 1104-1109 (2004)
   PUBMED   14985127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Apr 7, 2023 this sequence version replaced XM_039096942.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.41026.1,
                                           SRR26360172.55306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000018.1  25320565-25320742   c
            179-222             JAXUCZ010000018.1  25320066-25320109   c
            223-286             JAXUCZ010000018.1  25318744-25318807   c
            287-364             JAXUCZ010000018.1  25297254-25297331   c
            365-2163            JAXUCZ010000018.1  25291219-25293017   c
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..2163
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:338475"
                     /db_xref="RGD:631411"
     exon            1..178
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /inference="alignment:Splign:2.1.0"
     exon            179..222
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /inference="alignment:Splign:2.1.0"
     exon            223..286
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..490
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /note="neuronal protein 3.1; protein p311"
                     /codon_start=1
                     /product="neuronal regeneration-related protein"
                     /protein_id="NP_001406489.1"
                     /db_xref="GeneID:338475"
                     /db_xref="RGD:631411"
                     /translation="MVYYPELLVWVSQEPFPYKEMEGGLTKGRLPVPKEVNRKKMDEP
                     IAASLIPPGNHEPGSPAIGYLHPF"
     exon            287..364
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /inference="alignment:Splign:2.1.0"
     exon            365..2163
                     /gene="Nrep"
                     /gene_synonym="P311"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcggaga tcccgccaga gtgcgcgcag agctcccggg gctgctcggc gcgttcccat
       61 cccccacaac ccccagggcc cggtgcccta cggcggcgac ggcgcgggtg cgggggccgg
      121 ggagcgcgcg cgtgttggcc gcgcgcccac ggggccgcga gccgccgatt cctgccgagt
      181 gtagagagca gagagagtga acagggagcg gggcttttgt ctgttggtct ccctggactg
      241 aagaagggga gaatagaagc ccaagactat taagattctc aaaatggttt actacccaga
      301 actcttggtc tgggtcagcc aggagccatt tccatacaag gaaatggagg gaggtcttac
      361 taagggaaga cttcctgtgc ctaaggaagt gaaccgcaag aagatggatg agcccatcgc
      421 tgcctcgctg attccgccgg gcaaccatga acccggctcc ccagctatcg gttacctcca
      481 ccctttttaa tcgtcacacc tccatttgta ttgcatacgg tgtatggggt tttgatgagg
      541 tcttggtatc atatatggga tttttttttt ctgtgtaaat catcaaatat aagaagaaac
      601 tatgggactc taagcctggc tttagagaat ttacagtgga caaataggtt tcatcaaacc
      661 agtttttaat cattctgact caagtgaaaa cactcagaat ttcacactgt gaatccacgt
      721 ttacaacccc tacaggtggg ccttcaggcc tggttcgcta caacaatgtc ttccacaact
      781 caaaactcct actgcgctca cacgaccggt ccactcctgc ctttcgtcac agctcccgac
      841 tgcttcttgc agaggctgag agtccccccc actttttttt tcatttagat gtaacaagcc
      901 tagtagttta agttcatcga ttgtctgtat acctctatat tttacccatg tactcttttg
      961 ctgtatagaa gtagtttgaa actcattgtt tccttgtggt aagtgactga gacgctgcca
     1021 cagggcctga gacactgatg aatggtgcta ttttggactt tcaacatgct ccttggcgag
     1081 gtagctctga cggagttgtt tttaatttcc atgttctaag aaggtgttgg tactctgttt
     1141 cccggaatgt tcttctctag actggactga cttgttttcc ttgtgtcttg agtgtggctt
     1201 tcttcttcag tgttgtaggc tgagcggatg ctaccaagag tgtgagaggc tgtcctctcg
     1261 tgactggccc tgggtggatg tgcagtcacg gtagcgggag caatcacaaa actgtaattg
     1321 acctaccaga actcttcctt tctgcagcct cacccgcctg acttagaaaa agaaaagcaa
     1381 taattttttt ccaggcgttt cgaggttatt tctttggaat ctttttgttt gactagatat
     1441 cctgggggtg gggggtgggg gggagaggta aaaggtcctt ttttttttct ttaataagtg
     1501 ccccgtggga aaaatccaaa gtactggcat ttgagtagga atttaaaaat tatccctttc
     1561 ccaaagttga aattggaaaa gtgtctttat aaaatagtga taatgatgat ggtggtggtg
     1621 gtggtggtgg tggtggtgat ggtggtgatg aagatgaaaa gcaaaacaac ctttttgata
     1681 agcaaggtat agattttaca tttttgtcct tgctcccaat gaaatggata aacaaaaata
     1741 aaatctgaca atgccgtctc ttcacggaat gttgttgtgt tagccggact gaaagcccac
     1801 cttaattttt atataacgtc tttagctctt cctttgacag ggcaggcctt gttctgaact
     1861 gtttgcgctt ctgactgtta gacaccaatg acgcatgcac tgtccctctc attctctctt
     1921 gcttcccctc tggcctgagt ttcttgtgca tcctccctac ccccacctct gttagggtag
     1981 atatatcagc tatgtaaata gagcaaggaa acggtattgt gcatttgtgg catttacgta
     2041 gagttgcagt tgtacgctgc tgaaaacgca ggcttttgta acatgtggtc cttccataag
     2101 tacccaatgt attttagcta ttttagtcgt atttgttcaa taaatatgca agctataagg
     2161 taa
//
