LOCUS       XM_234465               5878 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus NRDE-2, necessary for RNA
            interference, domain containing (Nrde2), transcript variant X1,
            mRNA.
ACCESSION   XM_234465
VERSION     XM_234465.10
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051341.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 2, 2024 this sequence was replaced by
            NM_001427742.1.
            
            On Jan 21, 2021 this sequence version replaced XM_234465.9.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..5878
                     /gene="Nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing; Derived by automated computational analysis
                     using gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 10 ESTs, 1 long SRA read, 2
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 194 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:314381"
                     /db_xref="RGD:1565082"
     CDS             210..3707
                     /gene="Nrde2"
                     /codon_start=1
                     /product="nuclear exosome regulator NRDE2"
                     /protein_id="XP_234465.5"
                     /db_xref="GeneID:314381"
                     /db_xref="RGD:1565082"
                     /translation="MALFPAFAGVSEASGDGASRKELDWLSNPSFRVGNLTSLSRQTE
                     EVPALASEASPLTRSPLKSELSDESDTNEKLTQISKKKKKEKKKKRKHQHHKKTKRRH
                     EQSSSSGSGSDTEAGKDRASRSIRDSQESEKARQGSNAVPAAPATGHSSIWLEDIYTL
                     TDVFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGASAAKKHSH
                     RHLERYFTKKNVALLRTEGIAVCSNPEPSSSEPAPFIPVKDSADVATPVTTWLNPLGI
                     YDQSTTQWLQGQGPAEPELKQPDSQQERDSAALKARVEEFNRRVRENPRDTQLWMAFV
                     AFQDEVMRSPGIYALGEGEQEKHRKSLKLLLEKKLAVLERAIESNPSSVELKLAKLQL
                     CSEFWEPSALTKEWQKLLFLHPNNTSLWQRYLSFCQSQFGTFSVSKLHSLYGKCLSTL
                     SAVKDGSMLSHPVLPGTEEAMFGLFLQQCHFLRQAGHSEKVVSLFQAMVDFTFFKPDS
                     VKELPTKVQVEFFEPFWDSGEPRVGEKGARGWRAWMHQQERGGWVLVNPDEDDEEPEE
                     EDQEIKDKTLPRWQIWLAMERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDVGQ
                     SLIRLSSPDLQFQLIEAFLQFLGVPSGFLPPASCLYLAMDESSIFESKLYDEKPLTYF
                     NPLFSGISCVGYMEQLDCPRWTKGHNREGEEFVRNVFHLVLPLFSGKQKCQLCLSWLR
                     YEIAKVIWCLHTKKKRLKSQGKNCKKLAKSLLKEPENRNNLCLWRQYAHLEWLLGNTE
                     DARKVLDAALSMAGSSDLKDRELCELSLLYAELEVELSPDSRGATTGRAVHVLTRLTE
                     SSPCGPYTGQVSSTQVLKARKAYEHALQDCLGQSCASSPPTAESLDCLGSLVKCFMLF
                     QYLTVGIDAAVQVYRQVFSKLEGSALLEGPGPEDSASSQSVTSVLEAVTLMHTSLLRF
                     HMNICVYPLAPLRETLSDALKLYPGNQGLWRAYVQIQNKSHSANKTRRFFDTVTRSAK
                     HLEPWLFAIEAEKLRKRLVESVQRVGGREVHATIPETGLTHRIRALFENAIRSDQGGQ
                     CPLLWRMYLKFLVSLGNKERSKGVFYKALQSCPWAKVLYMDAVEYFPEELQEILDVMT
                     EKELRVRLPLEELELLLED"
ORIGIN      
        1 gcacaaggaa acagctcttt cccggcctca cttttttccc ctcctcccct ctctaccctt
       61 tgggtctcgg caccacctaa cccagggtta agccccatcg ggtgctcaga actacatttc
      121 ccagagggct tcgcgagtca gcgtcctcca atcagagctc tccagacggc gccatttctg
      181 tggcggaagt ggtggtgcgg cctgtgatca tggcgctgtt cccggccttc gcgggcgtaa
      241 gtgaggcctc cggtgatgga gcatccagga aagagttaga ctggctgagc aacccaagct
      301 ttcgtgttgg aaatctcacg tctctgagcc gacaaactga agaggtcccg gcccttgctt
      361 ctgaagcgtc accactgaca aggagtccgt tgaagtcaga gctctcagat gagagtgaca
      421 ctaatgagaa gctcacacag ataagcaaga aaaagaagaa agagaaaaag aagaaaagga
      481 aacaccagca ccacaagaaa accaagagga gacacgagca gtcgagcagc agtgggtccg
      541 ggtcagacac agaggctggg aaggacaggg cttcccgaag tatcagggat agccaagagt
      601 ctgagaaagc ccgtcaagga agtaatgctg ttcctgctgc tcctgctact ggacatagct
      661 ccatttggct ggaagatatt tacactctga cagacgtctt caggacagat aagaaaccag
      721 atcctgccaa ctgggagtat aaatctctgt atcgtgggga tatagcaagg tacaagagga
      781 agggagactc ctgcctgggt atcaacccta agaagcagtg tatatcttgg gaaggggctt
      841 ctgcagcaaa gaagcactca cacagacacc tggagcgcta ttttaccaag aagaatgtgg
      901 cattgttacg aactgagggg attgccgtgt gcagtaaccc tgagccctcc tcctctgagc
      961 cagccccatt catcccagtg aaggactctg ccgatgtggc tactcctgtt acaacatggc
     1021 tgaatcctct gggcatttat gatcagtcta ccacacagtg gttacaaggg cagggtccag
     1081 cagagccaga gttaaagcag ccagactcac agcaggagag ggacagtgct gctcttaagg
     1141 ccagagtgga agagtttaac aggagagttc gggaaaaccc tcgggacacg cagctatgga
     1201 tggcattcgt ggctttccag gatgaagtca tgaggagtcc tggcatctat gctcttgggg
     1261 aaggagagca ggagaagcac aggaagtccc tgaagctcct cctggagaag aagctggctg
     1321 tactggagcg ggccatcgag agcaacccaa gcagcgtgga gctgaagctc gccaagttgc
     1381 agctgtgctc agaattctgg gagcctagtg cgctgaccaa ggagtggcag aagctcctct
     1441 tcctgcaccc caacaacaca agcctgtggc agcgctatct ctccttttgc cagagtcagt
     1501 ttggcacctt ttctgtgtcc aaactccaca gtctatatgg caagtgcttg agtaccttgt
     1561 ctgctgttaa agacggcagc atgttatccc accctgtgtt gccgggcact gaggaggcca
     1621 tgtttgggct ctttcttcag cagtgccact ttctacggca ggctggccac tcggagaagg
     1681 tcgtctctct gttccaggcc atggttgact tcaccttctt caagcctgac agtgtgaaag
     1741 agctgcccac aaaagtgcag gtggaattct ttgaaccctt ctgggacagc ggagagcccc
     1801 gtgttgggga gaagggagcc cgaggctggc gggcgtggat gcaccagcag gagcgtggtg
     1861 gctgggtgct tgtcaaccca gatgaggatg acgaggagcc ggaagaagag gaccaagaga
     1921 taaaagacaa gaccctgccc aggtggcaga tctggcttgc tatggaacgt tctcgagacc
     1981 agaggcactg gcgtccctgg cgccctgata agaccaagaa gcaaacggag gaagactgtg
     2041 aggaccccga gagacaggtg ctgtttgatg acgttgggca atctttgatc agactttcca
     2101 gcccagatct tcagttccag ctcattgagg cctttctgca gttcctgggt gtaccttctg
     2161 gcttccttcc cccagcctcc tgcctttatc tggccatgga cgagagtagc atctttgaga
     2221 gtaaacttta tgatgaaaag cccttgactt acttcaaccc tttattttct ggcattagct
     2281 gtgtgggcta catggaacag ttggattgtc ctcgctggac caaaggtcac aaccgagagg
     2341 gcgaggagtt tgtccgcaat gtcttccacc tggtgctgcc tctgttctca ggcaagcaga
     2401 agtgccagct ctgcctctct tggttacggt acgagattgc caaggtcatt tggtgtctac
     2461 acactaaaaa gaagagattg aagtctcagg gaaagaactg caaaaagcta gccaagagtc
     2521 tcctcaagga gccagaaaac cgcaacaacc tctgcctctg gaggcagtat gcacacctgg
     2581 agtggttgct cggcaacaca gaggatgcca gaaaggtgtt ggatgcagcc ctcagcatgg
     2641 caggcagcag cgacctgaag gaccgggagc tctgtgagct cagtctgctc tatgctgagc
     2701 tggaggtaga gctgtctcct gactcgagag gagccaccac aggccgtgcc gtccacgtac
     2761 taactcggct gacggagagc agcccctgtg ggccctacac tgggcaggtc tcgtccactc
     2821 aggttctgaa agcccggaag gcttatgagc atgcgctgca ggactgtctg ggacagagct
     2881 gtgcctccag cccacctact gcagagtcgt tggactgcct gggtagcctg gtcaaatgct
     2941 tcatgctctt ccagtatttg actgtaggaa ttgacgctgc tgtgcaggtg tacagacagg
     3001 tgttttccaa gctggagggc tctgctctcc tggaaggccc ggggccagag gacagtgcca
     3061 gctcccagag tgtgaccagt gttctcgagg ccgtcaccct gatgcacaca agcctgctgc
     3121 gattccacat gaacatttgt gtgtaccctc tggctccact ccgagagacc ctctcagacg
     3181 ctttaaagct gtatccaggc aaccagggtc tttggagggc ttacgtgcag attcagaata
     3241 agtcccacag tgctaacaag accagaagat tctttgacac agtcactagg tctgccaagc
     3301 atttggagcc ttggctgttt gcaatcgaag ctgagaagct gaggaaaagg ctggtggaat
     3361 ctgttcagag ggtaggtggc agggaggtcc atgctacaat ccccgagact ggtcttacgc
     3421 atcggatcag agctttgttt gaaaatgcaa tccggagcga ccagggtggc cagtgcccgc
     3481 tgctgtggag gatgtatttg aaatttttgg tttccttagg aaacaaagaa aggagcaaag
     3541 gtgtgttcta caaggccctc cagagctgtc cttgggcaaa ggtgctgtac atggacgccg
     3601 tggagtattt cccagaggag ctgcaggaga tcctggatgt gatgactgag aaggagctcc
     3661 gtgtgcgcct gcccctcgag gagctggagc tgctgctgga ggattagact agggctgtgc
     3721 agcctgcaga gcccagagcc gcagcctcgc gaggccttcc tccatggtct ggtggggttt
     3781 gggtgcatcg ctttacatat tatatatgtg atctctgtac agacggagat gccagtgata
     3841 aaccttttgt ggttgacatg tatgtacctc cttattccct ctgtccacca cacttggccc
     3901 ctcacactgc ttgtgtccag gatcctggtc tcggcctctg accctggagt gccactgaga
     3961 tctccctcct cccctgggct gatgagcaga gatacatagt tctctctctg ccacccagaa
     4021 caggagatgg ttgtttacta tttcctgtct tgggtcatag gtgtggcaag tttattatta
     4081 tttctctagc cttgctctgg tgacagctgt ctttgggggt ccatagggac ccttgggtct
     4141 gcctttcact ggagcccagc tgatcatgtg ctcagtacgg tgtgcaaatc cttgggcagc
     4201 accctctgta ggaaccttgc tgtcacgtga cctcagagca gagtctgttc ccaacagccg
     4261 acctcacctg gtgtagagca cctgtcttga gaatgcagtc actttttact gaggggcagc
     4321 tctgtagcac agcttctgcc catggctgtt tagcttggct ggagggatgg cttgcctgta
     4381 tttacggcag gaatgcccac agggattgca gagctgcttt ctggatattt tgaaacaggg
     4441 tggccttgaa ctcttgcttc tcctgcactt gcctcctggg cattaatatt ctatttctgc
     4501 ttatgttggg atttagacac cggccttaca ctgtcctgta gatggctccc ccttctgtgt
     4561 acacgtttct tacccttggt ctcggacact ccaagcctag tggcatcctc agggctgaat
     4621 tttgaagctg tttagcttct catggagacc atctaagcag actacccact ctgcacagcc
     4681 acctacatgg agatatccct gggtggacag gaactcctcc ccacgcccag gtagccacac
     4741 cctagacctg gaacctgtga atatcctgta gagtccggga tgcacatgag gtccacagag
     4801 gcagaaggag cattgagaag ttaatgccag tcacacctat acaattaagt ctggactata
     4861 catgaagcct gggctacatt tgaagatctt aatggcagaa atcaagtgag aaggctgtcc
     4921 tggggtgtca gtctggtcag gagactcttg gaaggtgaaa aaggaaagta gaaaggggtg
     4981 gagagggaga gaaaataaaa gaggacccag agcttgacct gctcttctaa ctttgaagat
     5041 ggagggtgct aggatccagg agtcagggtg gcctctacaa ggtgggaaag gccctcagtt
     5101 gccagccagt actgaccaca gcccatggct ataaggagct gaccactcag acctcaagga
     5161 aactattttt ctctctcgag cattcagaaa ggggtacagt agatatcaag acagtagctt
     5221 tctgagtggt ctttcgacaa cctatacact aagataaatt tgtacctgag tcatggtggc
     5281 aaaaggagag gaagaggcct tccctccata ggccacctac ctccttgtgg ctgtaaggaa
     5341 ccatctgtta aaggaaatac taagtgttga ggtttatgaa cccagaactg aggcaggcat
     5401 agttgggaaa agattcttca ctgactcctc agggatctcc ccctcttggg aacacgcacg
     5461 gcccaatgtg gaggctctag ttagcccaca gtaaagcagt tccttcagcc acattaactt
     5521 agccttttcc attcaaagac cattggcctt gtggctccac ctgaggcact gctttggaaa
     5581 tacgaagtgg gctccttgtg gttgccaatg ggcttcccta atacagggtc cccccatctg
     5641 ctgcagtgaa agtgcacgct tatgctgact accttcctgt caacttgaca gaagccagtc
     5701 tcttgggaga tggaacttta cagagaaagt gcctccatca gatcggcctg tcttaagtct
     5761 atgggatttt cttaataaat gaatgatttg tggggttggg gatttagctc agtggtagag
     5821 cgcttgccta ggaagcgcaa ggccctgggt tcggtcccca gctccgaaaa aaaaaaaa
//
