LOCUS       NM_012993               3580 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus nardilysin convertase (Nrdc), mRNA.
ACCESSION   NM_012993
VERSION     NM_012993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3580)
  AUTHORS   Yoon,W.H., Sandoval,H., Nagarkar-Jaiswal,S., Jaiswal,M.,
            Yamamoto,S., Haelterman,N.A., Putluri,N., Putluri,V., Sreekumar,A.,
            Tos,T., Aksoy,A., Donti,T., Graham,B.H., Ohno,M., Nishi,E.,
            Hunter,J., Muzny,D.M., Carmichael,J., Shen,J., Arboleda,V.A.,
            Nelson,S.F., Wangler,M.F., Karaca,E., Lupski,J.R. and Bellen,H.J.
  TITLE     Loss of Nardilysin, a Mitochondrial Co-chaperone for
            alpha-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and
            Neurodegeneration
  JOURNAL   Neuron 93 (1), 115-131 (2017)
   PUBMED   28017472
REFERENCE   2  (bases 1 to 3580)
  AUTHORS   Hiraoka,Y., Matsuoka,T., Ohno,M., Nakamura,K., Saijo,S.,
            Matsumura,S., Nishi,K., Sakamoto,J., Chen,P.M., Inoue,K.,
            Fushiki,T., Kita,T., Kimura,T. and Nishi,E.
  TITLE     Critical roles of nardilysin in the maintenance of body temperature
            homoeostasis
  JOURNAL   Nat Commun 5, 3224 (2014)
   PUBMED   24492630
REFERENCE   3  (bases 1 to 3580)
  AUTHORS   Hiraoka,Y., Yoshida,K., Ohno,M., Matsuoka,T., Kita,T. and Nishi,E.
  TITLE     Ectodomain shedding of TNF-alpha is enhanced by nardilysin via
            activation of ADAM proteases
  JOURNAL   Biochem Biophys Res Commun 370 (1), 154-158 (2008)
   PUBMED   18355445
REFERENCE   4  (bases 1 to 3580)
  AUTHORS   Chow,K.M., Ma,Z., Cai,J., Pierce,W.M. and Hersh,L.B.
  TITLE     Nardilysin facilitates complex formation between mitochondrial
            malate dehydrogenase and citrate synthase
  JOURNAL   Biochim Biophys Acta 1723 (1-3), 292-301 (2005)
   PUBMED   15809022
REFERENCE   5  (bases 1 to 3580)
  AUTHORS   Hospital,V., Prat,A., Joulie,C., Cherif,D., Day,R. and Cohen,P.
  TITLE     Human and rat testis express two mRNA species encoding variants of
            NRD convertase, a metalloendopeptidase of the insulinase family
  JOURNAL   Biochem J 327 (Pt 3) (Pt 3), 773-779 (1997)
   PUBMED   9581555
REFERENCE   6  (bases 1 to 3580)
  AUTHORS   Pierotti,A.R., Prat,A., Chesneau,V., Gaudoux,F., Leseney,A.M.,
            Foulon,T. and Cohen,P.
  TITLE     N-arginine dibasic convertase, a metalloendopeptidase as a
            prototype of a class of processing enzymes
  JOURNAL   Proc Natl Acad Sci U S A 91 (13), 6078-6082 (1994)
   PUBMED   8016118
REFERENCE   7  (bases 1 to 3580)
  AUTHORS   Chesneau,V., Pierotti,A.R., Prat,A., Gaudoux,F., Foulon,T. and
            Cohen,P.
  TITLE     N-arginine dibasic convertase (NRD convertase): a newcomer to the
            family of processing endopeptidases. An overview
  JOURNAL   Biochimie 76 (3-4), 234-240 (1994)
   PUBMED   7819328
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L27124.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012993.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3580              L27124.1           2-3581
FEATURES             Location/Qualifiers
     source          1..3580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3580
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /note="nardilysin convertase"
                     /db_xref="GeneID:25499"
                     /db_xref="RGD:3210"
     exon            1..395
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..3549
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /EC_number="3.4.24.61"
                     /note="NRD-C; NRD convertase; N-arginine dibasic
                     convertase 1; nardilysin 1 (N-arginine dibasic
                     convertase); nardilysin, N-arginine dibasic convertase,
                     NRD convertase 1; nardilysin, N-arginine dibasic
                     convertase 1"
                     /codon_start=1
                     /product="nardilysin precursor"
                     /protein_id="NP_037125.1"
                     /db_xref="GeneID:25499"
                     /db_xref="RGD:3210"
                     /translation="MLRRVAVAAVFATGRKLRCEAGRDVTAVGRIEARGLCEESAKPF
                     PTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRSLSNVGDPEIIK
                     SPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEGEEEEEEEED
                     DDDDDDEDSGAEIQDDDEEGFDDEEEFDDDEHDDDDLDNEENELEELEERVEARKKTT
                     EKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNA
                     STDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDA
                     NRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTL
                     VVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHA
                     LTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQ
                     NSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHY
                     QEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLS
                     GANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNSDLHLPAENKYIATDFTLKA
                     FDCPETEYPAKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFV
                     NILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSST
                     PAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLL
                     NFVKDFKSQLFVEGLVQGNVTSTESMDFLRYVVDKLNFVPLEREMPVQFQVVELPSGH
                     HLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYH
                     VYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVT
                     ALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRG
                     PGSKMLSVHVVGYGKYELEEDGAPVCEDPNSREGMQLIYLPPSPLLAESTTPITDIRA
                     FTATLSLFPYHKIVK"
     exon            396..726
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..808
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..962
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1036
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1132
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1255
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1313
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1387
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1457
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1535
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1656
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1715
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1770
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1875
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1999
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2086
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2206
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2258
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2409
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2537
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2700
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2732
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2871
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2919
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..2972
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3056
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3147
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3264
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3354
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3580
                     /gene="Nrdc"
                     /gene_synonym="Nrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagtagg aggaggaggt gggcctgggg agcgggatgt ccagcgctac gacttgctgg
       61 tgaatgctga ggagagtcgc ggttgctgca gtctttgcca ccgggaggaa gttgcggtgt
      121 gaggccgggc gggacgtcac ggctgtggga cgaatcgaag cacggggtct gtgcgaagaa
      181 tcagcgaaac cgtttcctac gctgaccatg cctggcagaa acaaggcgaa gtccacctgc
      241 agttgcccgg acctgcagcc taatggacag gacttgggcg agagcggccg ggttgctcgt
      301 ctaggagcgg atgaatctga ggaggaggga cggtctctca gtaatgtcgg ggaccctgag
      361 atcatcaagt ctcccagcga tcccaagcag taccgataca tcaaattaca gaatggcttg
      421 caggctcttt tgatttcaga tctaagtaat gtggagggta aaacaggaaa tgcaacagat
      481 gaagaggaag aggaagaaga ggaagaggag gagggggaag aggaagagga agaggaagaa
      541 gacgatgacg atgatgatga tgaagactct ggagctgaga tacaggatga tgatgaggaa
      601 ggctttgacg atgaagagga atttgatgat gatgaacatg atgatgatga tcttgataat
      661 gaggaaaatg aactggaaga actggaagag cgggtggaag ccagaaagaa aaccactgag
      721 aaacagtctg cagcggctct gtgtgttgga gttgggagct ttgctgatcc agatgacctg
      781 cctgggctgg cacacttttt ggagcacatg gtattcatgg gtagtttgaa atacccagat
      841 gagaatggat ttgatgcctt cctcaagaaa catggaggta gtgataatgc ctcaaccgat
      901 tgtgaacgca cagtctttca gtttgatgtc cagagaaagt atttcaagga agccctggat
      961 agatgggccc agttcttcat ccatccactg atgatcagag atgcaattga ccgagaggtg
     1021 gaagctgtgg acagtgagta tcagcttgca agaccttctg atgcaaacag aaaagaaatg
     1081 ttgtttggaa gtcttgctag acctggacat cctatgggga agtttttttg gggaaatgct
     1141 gagacactca agcatgaacc aaagaagaat aatattgata cacatgccag actgagagag
     1201 ttctggatgc gttactactc tgctcattac atgaccttag tagtccagtc caaagaaacc
     1261 ttggacactt tggaaaagtg ggtgacggag atcttctctc agataccaaa caatgggcta
     1321 cctaaaccaa actttagcca tttaacggat ccttttgaca caccagcatt taacaaactt
     1381 tatagagttg ttccaatcag aaaaatccat gctctgacca tcacgtgggc ccttcctccg
     1441 cagcagcaac actacagggt gaagccactt cattatatct cctggcttgt ggggcatgaa
     1501 ggcaaaggca gcatcctttc ttaccttaga aaaaagtgct gggctcttgc gttgtttggt
     1561 ggaaatggtg agacaggttt tgagcaaaat tctacctact cagtgttcag catttctatc
     1621 actctgactg atgaggggta tgagcatttt tatgaggttg ctcacactgt ctttcagtat
     1681 ttaaaaatgc tgcagaaact aggtccggag aaaagagttt ttgaagagat tcagaaaatt
     1741 gaggataatg aatttcatta ccaagaacag acagatccag ttgagtacgt ggagaacatg
     1801 tgtgagaaca tgcagctgta cccacgtcag gactttctca ctggagatca gcttctgttt
     1861 gagtacaagc cagaagtcat tgccgaggcc cttaatcagc tagttcctca aaaggcaaat
     1921 ctcgtgcttc tgtctggtgc taacgaggga agatgtgacc tcaaggagaa gtggtttggg
     1981 actcagtaca gcatagaaga tattgaaaac tcttggactg aactgtggaa gagcaatttt
     2041 gacttaaatt cagaccttca tctaccagct gaaaacaaat acatagccac ggactttaca
     2101 ttgaaggctt ttgattgccc tgaaactgaa taccctgcta aaattgtgaa taccccacaa
     2161 ggttgcctgt ggtataagaa agacaacaaa ttcaaaatcc ccaaagccta tatacgattt
     2221 catctgatct cacctttgat acagaaatct gcagcaaatg ttgtcctctt cgacatcttc
     2281 gtcaacattc ttactcacaa ccttgctgag ccagcctatg aagccgatgt ggcccagctg
     2341 gagtataaac tggtagccgg agagcacggt ttaatcatcc gagtgaaggg attcaaccac
     2401 aaactacctc tgctcttcca gctcatcatt gactacctga ctgagttcag ctccacgccc
     2461 gctgtcttca ccatgataac tgagcagctg aagaagacct acttcaacat cctcatcaag
     2521 cctgagactc tggccaaaga tgtgcggctt ttaattctgg aatattcccg ctggtctatg
     2581 attgacaagt accgagcttt gatggatggc ctttcccttg agtctctgct aaactttgtc
     2641 aaggatttta aatcccaact ctttgttgag ggcctggtgc aagggaatgt caccagcacg
     2701 gaatcgatgg atttcctaag atacgttgtt gacaagctga acttcgtgcc cctggagcgg
     2761 gagatgcccg tgcagttcca ggtggtggag ctgccgagcg gccaccacct gtgcaaagtc
     2821 agagccctga ataaggggga cgccaactct gaagtcactg tgtactacca gtcaggtaca
     2881 aggagtctga gagaatacac gctcatggag ctgcttgtga tgcacatgga ggagccctgc
     2941 tttgacttcc ttcgaaccaa gcagaccctt gggtaccacg tctacccgac ctgtaggaac
     3001 acatctggca ttctaggatt ttctgtaact gttgggactc aggcaaccaa atacaactct
     3061 gaaactgttg acaagaagat agaagaattt ctttccagct ttgaggagaa gattgagaac
     3121 ctcacagagg atgcattcaa tactcaggtc acagctctga tcaagttgaa agagtgtgag
     3181 gacacccacc tcggggagga ggtggacagg aactggaatg aagtggtgac acagcagtat
     3241 ctctttgacc gccttgccca tgagattgaa gcgctgaagt ctttctcaaa gtcagacctg
     3301 gtcagttggt tcaaggctca cagaggacct gggagtaaaa tgctcagcgt tcatgttgtt
     3361 ggatatggga agtatgaact ggaagaggac ggcgctcccg tttgtgagga tccgaattct
     3421 cgtgaaggga tgcagctaat ctacctgcca ccctctcctc tcctggcaga gtccaccacc
     3481 cccattactg acatcagggc cttcacagcg acgctcagcc tcttccccta ccataagata
     3541 gtcaaataaa ctgcagtctc actggcctga agcaacttgt
//
