LOCUS       NM_013150              10798 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus neuronal cell adhesion molecule (Nrcam), mRNA.
ACCESSION   NM_013150 XM_343056
VERSION     NM_013150.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10798)
  AUTHORS   Mao,S., Zhang,S., Zhou,Z., Shi,X., Huang,T., Feng,W., Yao,C., Gu,X.
            and Yu,B.
  TITLE     Alternative RNA splicing associated with axon regeneration after
            rat peripheral nerve injury
  JOURNAL   Exp Neurol 308, 80-89 (2018)
   PUBMED   29981323
  REMARK    GeneRIF: We identified a key alternative splicing event of Nrcam
            (Nrcam-S) as an important candidate in promoting axon regeneration
REFERENCE   2  (bases 1 to 10798)
  AUTHORS   Demyanenko,G.P., Mohan,V., Zhang,X., Brennaman,L.H., Dharbal,K.E.,
            Tran,T.S., Manis,P.B. and Maness,P.F.
  TITLE     Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced
            dendritic spine remodeling
  JOURNAL   J Neurosci 34 (34), 11274-11287 (2014)
   PUBMED   25143608
REFERENCE   3  (bases 1 to 10798)
  AUTHORS   Feinberg,K., Eshed-Eisenbach,Y., Frechter,S., Amor,V., Salomon,D.,
            Sabanay,H., Dupree,J.L., Grumet,M., Brophy,P.J., Shrager,P. and
            Peles,E.
  TITLE     A glial signal consisting of gliomedin and NrCAM clusters axonal
            Na+ channels during the formation of nodes of Ranvier
  JOURNAL   Neuron 65 (4), 490-502 (2010)
   PUBMED   20188654
REFERENCE   4  (bases 1 to 10798)
  AUTHORS   Hedstrom,K.L., Xu,X., Ogawa,Y., Frischknecht,R., Seidenbecher,C.I.,
            Shrager,P. and Rasband,M.N.
  TITLE     Neurofascin assembles a specialized extracellular matrix at the
            axon initial segment
  JOURNAL   J Cell Biol 178 (5), 875-886 (2007)
   PUBMED   17709431
REFERENCE   5  (bases 1 to 10798)
  AUTHORS   Dirks,P., Thomas,U. and Montag,D.
  TITLE     The cytoplasmic domain of NrCAM binds to PDZ domains of
            synapse-associated proteins SAP90/PSD95 and SAP97
  JOURNAL   Eur J Neurosci 24 (1), 25-31 (2006)
   PUBMED   16882004
REFERENCE   6  (bases 1 to 10798)
  AUTHORS   Aitkenhead,M., Wang,S.J., Nakatsu,M.N., Mestas,J., Heard,C. and
            Hughes,C.C.
  TITLE     Identification of endothelial cell genes expressed in an in vitro
            model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM
  JOURNAL   Microvasc Res 63 (2), 159-171 (2002)
   PUBMED   11866539
REFERENCE   7  (bases 1 to 10798)
  AUTHORS   Backer,S., Sakurai,T., Grumet,M., Sotelo,C. and Bloch-Gallego,E.
  TITLE     Nr-CAM and TAG-1 are expressed in distinct populations of
            developing precerebellar and cerebellar neurons
  JOURNAL   Neuroscience 113 (4), 743-748 (2002)
   PUBMED   12182881
REFERENCE   8  (bases 1 to 10798)
  AUTHORS   Jenkins,S.M. and Bennett,V.
  TITLE     Ankyrin-G coordinates assembly of the spectrin-based membrane
            skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje
            neuron initial segments
  JOURNAL   J Cell Biol 155 (5), 739-746 (2001)
   PUBMED   11724816
REFERENCE   9  (bases 1 to 10798)
  AUTHORS   Davis,J.Q., Lambert,S. and Bennett,V.
  TITLE     Molecular composition of the node of Ranvier: identification of
            ankyrin-binding cell adhesion molecules neurofascin (mucin+/third
            FNIII domain-) and NrCAM at nodal axon segments
  JOURNAL   J Cell Biol 135 (5), 1355-1367 (1996)
   PUBMED   8947556
REFERENCE   10 (bases 1 to 10798)
  AUTHORS   Davis,J.Q. and Bennett,V.
  TITLE     Ankyrin binding activity shared by the neurofascin/L1/NrCAM family
            of nervous system cell adhesion molecules
  JOURNAL   J Biol Chem 269 (44), 27163-27166 (1994)
   PUBMED   7961622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 15, 2021 this sequence version replaced NM_013150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY574277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000006.1  67129817-67129988
            173-316             JAXUCZ010000006.1  67190597-67190740
            317-373             JAXUCZ010000006.1  67272044-67272100
            374-575             JAXUCZ010000006.1  67347283-67347484
            576-593             JAXUCZ010000006.1  67349563-67349580
            594-699             JAXUCZ010000006.1  67351726-67351831
            700-896             JAXUCZ010000006.1  67353863-67354059
            897-1019            JAXUCZ010000006.1  67355096-67355218
            1020-1190           JAXUCZ010000006.1  67365453-67365623
            1191-1247           JAXUCZ010000006.1  67366098-67366154
            1248-1359           JAXUCZ010000006.1  67367909-67368020
            1360-1544           JAXUCZ010000006.1  67370183-67370367
            1545-1676           JAXUCZ010000006.1  67371578-67371709
            1677-1820           JAXUCZ010000006.1  67378764-67378907
            1821-1932           JAXUCZ010000006.1  67381390-67381501
            1933-2099           JAXUCZ010000006.1  67382863-67383029
            2100-2247           JAXUCZ010000006.1  67383126-67383273
            2248-2372           JAXUCZ010000006.1  67384919-67385043
            2373-2402           JAXUCZ010000006.1  67385467-67385496
            2403-2504           JAXUCZ010000006.1  67387206-67387307
            2505-2702           JAXUCZ010000006.1  67389181-67389378
            2703-2773           JAXUCZ010000006.1  67389476-67389546
            2774-2999           JAXUCZ010000006.1  67390660-67390885
            3000-3115           JAXUCZ010000006.1  67391359-67391474
            3116-3320           JAXUCZ010000006.1  67392989-67393193
            3321-3443           JAXUCZ010000006.1  67395012-67395134
            3444-3620           JAXUCZ010000006.1  67395723-67395899
            3621-3656           JAXUCZ010000006.1  67397214-67397249
            3657-3782           JAXUCZ010000006.1  67403627-67403752
            3783-3935           JAXUCZ010000006.1  67404802-67404954
            3936-4067           JAXUCZ010000006.1  67409958-67410089
            4068-4146           JAXUCZ010000006.1  67411580-67411658
            4147-10798          JAXUCZ010000006.1  67418859-67425510
FEATURES             Location/Qualifiers
     source          1..10798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q21"
     gene            1..10798
                     /gene="Nrcam"
                     /note="neuronal cell adhesion molecule"
                     /db_xref="GeneID:497815"
                     /db_xref="RGD:3209"
     exon            1..172
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            173..316
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            317..373
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            374..575
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..4384
                     /gene="Nrcam"
                     /note="neuron-glia-CAM-related cell adhesion molecule;
                     nr-CAM; rBravo; ng-CAM-related; ngCAM-related cell
                     adhesion molecule; ankyrin-binding cell adhesion molecule
                     NrCAM; neuronal surface protein Bravo"
                     /codon_start=1
                     /product="neuronal cell adhesion molecule precursor"
                     /protein_id="NP_037282.2"
                     /db_xref="GeneID:497815"
                     /db_xref="RGD:3209"
                     /translation="MQLKTMPKKKPLSAGRAPLFLFLCQMISALDVPLDPKLLDDLVQ
                     PPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGSG
                     TLVINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKERLEPIILRSG
                     QSLVLPCRPPIGLPPAIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYIC
                     YARFNHTQTIQQKQPISLKVISVDELNDTIAANLSDTEFYGAKSSKERPPTFLTPEGN
                     ESHKEELRGNVLSLECIAEGLPTPVIYWIKEDGTLPVNRTFYRNFKKTLQIIHVSEAD
                     SGNYQCIAKNALGAVHHTISVTVKAAPYWIVAPHNLVLSPGENGTLICRANGNPKPRI
                     SWLTNGVPVEIALDDPSRKIDGDTIMFSNVQESSSAVYQCNASNKYGYLLANAFVNVL
                     AEPPRILTSANTLYQVIANRPALLDCAFFGSPMPTIEWFKGTKGSALHEDIYVLHDNG
                     TLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTRFIKQPEYAVVQRGSKVSFE
                     CKVKHDHTLIPTILWLKDNGELPNDERFSVDKDHLVVSDVKDEDGGTYTCAANTTLDS
                     VSASAVLRVVAPTPTPAPIYDVPNPPFDLELTNQLDKSVQLTWTPGDDNNSPITKFII
                     EYEDAMHEAGLWRHQAEVSGTQTTAQLKLSPYVNYSFRVMAENSIGRSVPSEASEQYL
                     TKAAEPDQNPTAVEGLGTEPDNLVITWKPLNGFQSNGPGLQYKVSWRQKDGDDEWTSV
                     VVANVSKYIVSGTPTFVPYLIKVQALNDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSV
                     VNSTLAEAHWDPVPPKSVRGHLQGYRIYYWKAQSSSKRNRRHIEKKILTFQGSKTHGM
                     LPGLQPYSHYVLNVRVVNGKGEGPASADRGFHTPEGVPSAPSSLKIVNPTLDSLTLEW
                     DPPSHPNGILTEYILKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYA
                     QTSVGSGSQITEEAITTVDEAGILPPDVGAGKVRAVSPRIGNVTAAAAETYANISWEY
                     EGPEHVKFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAEGDSGFVS
                     SEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKE
                     DAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGV
                     NGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV"
     exon            576..593
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            594..699
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            700..896
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1019
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1190
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1247
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1359
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1544
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1676
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1820
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1932
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2099
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2247
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2372
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2402
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2504
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2702
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2773
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2999
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3115
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3320
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3443
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3620
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3656
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3782
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3935
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4067
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4146
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4147..10798
                     /gene="Nrcam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccgcag tccgagcctc agacgcgcga gcgcgaggga ccgtgcaggg acagagagac
       61 tggggcagct ggaggcgaca gctttggaag cttcaggaaa tacgcacgac agctgcactc
      121 tgcggtcttg ggcagtagcg ccccggcagg gcggtgggcg cggcacaaaa acgagttttt
      181 gtgatactct ccagtgaaac ccagaacccc tgtttgctga aggctgcttt cagctgttga
      241 catcaccctg agaaaaggtg gacttctgaa atcagggtag cattaggagg ttctggaccc
      301 tgaggatctt ctgaagagca atgctaagac aacctttcgc ttaaggaatt aaaaagaaat
      361 atcacttcat cagtcccctg catgaaaaat tatttaaaca ctgcacacaa atcttctgag
      421 gaagaagaaa aggaaattcc gtgcgtgggt ctcagcagga gtaccgctga tgcagcttaa
      481 aaccatgccg aagaagaagc ccttgtctgc aggcagagcg cccctgtttc tcttcctgtg
      541 ccagatgatc agcgctctgg atgttcctct tgatccaaag ctccttgatg acttggtaca
      601 gcctccaact atcactcaac agtcaccaaa agactacatc attgacccac gggagaatat
      661 tgtaatccaa tgtgaggcca aagggaaacc tcctccaagc ttttcctgga ctcgtaacgg
      721 aacacatttt gacatagaca aagaccctct ggtcactatg aagcctggct caggaaccct
      781 tgtcatcaac atcatgagtg aaggaaaggc ggagacctat gaaggggttt accagtgcac
      841 tgcaaggaat gagcgcggag ctgctgtctc caataacatt gttgtccgcc cctctaggtc
      901 acccttgtgg accaaggaaa gacttgaacc aataatcctc cgaagtggtc agtcactagt
      961 actaccatgt aggcctccaa ttggattacc accggccata atattttgga tggataactc
     1021 ctttcaaaga ctgccacaga gtgagcgggt ttcccaagga ctgaatggag acctttactt
     1081 ctccaatgtc ctcccagagg acacccgtga ggactacatc tgctatgcca gatttaatca
     1141 cactcaaaca attcaacaga aacaacctat ttctctgaag gtgatttcag tggatgaatt
     1201 gaatgacact atagctgcta atttgagtga cactgagttt tatggtgcta aatctagtaa
     1261 agagaggcca ccaacatttc taactccaga gggcaatgaa agtcacaagg aggaattaag
     1321 aggaaacgtg ctttccctgg agtgcattgc agaaggccta cctactccag ttatttactg
     1381 gatcaaggaa gatggaacgc ttcctgtcaa ccggacgttt tatcggaact ttaagaaaac
     1441 cttgcagatc attcatgtct ctgaagcaga ctctggaaat tatcagtgca tagcaaaaaa
     1501 cgcattggga gccgtccatc ataccatttc tgtcacagtt aaagcggctc cctactggat
     1561 tgttgcacct cacaacctcg tgctttcccc aggggagaat gggaccctca tctgcagagc
     1621 taacggcaac ccaaaaccca gaattagctg gttaacaaat ggagtcccag tagaaattgc
     1681 tctcgatgac cccagccgaa aaatcgatgg tgataccatt atgttttcaa atgttcaaga
     1741 aagctcaagt gcggtttatc agtgcaatgc ctctaacaaa tatggatatt tactagcaaa
     1801 tgcatttgta aatgtgctcg ctgaaccacc tcggattctt acctcagcaa acacactgta
     1861 ccaggtcatt gcaaaccggc ctgctttgct ggactgtgcc ttctttgggt ctcctatgcc
     1921 taccattgag tggtttaaag gaactaaagg aagcgctctt cacgaagaca tttatgtttt
     1981 acatgataac ggaacgctag aaattcctgt ggcccaaaag gatagtacag ggacatatac
     2041 ttgtgtcgca aggaataaat tagggatggc aaagaatgaa gttcacttgg aaatcaaaga
     2101 tccaaccagg ttcattaaac aacctgaata tgcagtcgtt cagaggggga gcaaggtttc
     2161 ctttgaatgc aaagtgaaac acgaccacac cttaatcccc accattctgt ggctgaagga
     2221 caatggagag ctgcccaatg atgaaaggtt ctctgtcgac aaggaccatc tggtggtctc
     2281 tgacgtaaag gatgaagatg gtgggaccta cacatgtgca gccaacacaa cgctggacag
     2341 tgtttcagcc agcgccgtgc tcagggtggt cgctcctact ccaactccag cccccattta
     2401 cgatgtcccg aatcctccct ttgatttaga attgaccaat caacttgaca aaagtgttca
     2461 gctgacatgg accccaggcg atgacaacaa tagtcccatt acaaaattca tcatcgagta
     2521 tgaagatgca atgcatgagg cagggctgtg gcgccaccag gcggaagttt ctggaacgca
     2581 gaccacagcc cagctgaagc tgtctcccta tgtgaactac tccttccgag tcatggcgga
     2641 gaacagcatc gggaggagtg tgccaagcga ggcatcggag cagtatctta caaaggccgc
     2701 ggaaccagac cagaatccca cggctgtgga aggactaggg acagagccgg acaacttggt
     2761 gatcacatgg aagcccctga atggttttca atcgaatggg cccggcctcc agtacaaagt
     2821 gagctggcgt cagaaagatg gtgacgatga atggacgtct gtggttgtgg ccaatgtatc
     2881 caaatacatt gtttctggca caccaacttt tgtcccatac ctgataaaag ttcaagccct
     2941 gaatgatgtg ggctttgctc cagagccagc tgcagtcatg ggacattccg gagaagacct
     3001 tccaatggtg gctcctggaa atgtgcgtgt cagtgtggtg aacagcacct tggcagaggc
     3061 acactgggac cctgtacctc ccaagagtgt ccgaggacac ttacaaggct accggattta
     3121 ctactggaag gctcagagct catctaaaag aaacagacgc cacattgaga agaagatcct
     3181 caccttccag ggcagcaaga ctcacggcat gctgccaggg ctgcaacctt acagtcacta
     3241 tgttctcaat gtccgagtgg tcaatgggaa aggggagggc ccagccagcg ccgacagagg
     3301 cttccatact ccagagggag tccctagtgc tccctcatct ttgaaaattg ttaatcctac
     3361 actggactct ctcactttgg aatgggaccc tccaagccac ccaaatggta tcctgactga
     3421 atacatctta aaatatcagc caattaatag cacacacgaa ctaggccctc tggtagattt
     3481 aaaaattcct gccaacaaga cacgctggac tttgaaaaat ttaaatttca gcactcggta
     3541 caagttctac ttctatgcac aaacatcagt gggatcgggc agtcagatca cagaggaagc
     3601 aataacaact gtggacgaag ctggtattct tccacctgat gtaggtgcag gcaaagtccg
     3661 tgcagtaagt cccaggatcg gcaatgtcac tgctgcagct gctgagacgt atgccaatat
     3721 cagttgggaa tatgagggac cagagcatgt gaagttttat gttgaatatg gtgtagcagg
     3781 cagcaaagaa gaatggagga aagaaattgt aaatggttct cggagcttct ttgggttaaa
     3841 gggtctaatg ccaggaacag catacaaagt ccgagttggt gctgaggggg actctggttt
     3901 tgtgagttca gaggatgtgt ttgagacagg accagcaatg gcaagtcggc aagtggatat
     3961 tgcgacccaa ggctggttca taggtctaat gtgtgctgtt gccctcctca tcttaatttt
     4021 gctaatcgtt tgcttcatca gaagaaacaa gggtggtaaa tatccagtta aagaaaagga
     4081 ggatgctcac gcagaccctg aaatccagcc catgaaggag gatgacggaa cgtttggaga
     4141 atatagtgat gcagaagatc acaagccttt gaaaaaggga agtcgaacac cttcagacag
     4201 gactgtgaaa aaagaagata gtgatgacag cctggttgac tatggcgagg gggtgaatgg
     4261 ccaattcaat gaggatggct cctttatcgg acaatacagt ggtaagaaag agaaagaacc
     4321 agcagaggga aatgaaagct cagaggcccc ttctcctgtc aacgcaatga actcctttgt
     4381 ttaagtcttt aagctctgtg ccaatgtccc atctctctgg aatggttttc ctgaacactt
     4441 gtcatccctc tcatactatg gacatatggg tagaaagaat gtttcctgcg gtatatgagt
     4501 attataagaa cagagcaaga acataactca gtcagatgat atgttaatat gaactggggt
     4561 gaaaaggcat actttttgtt cagagtgggt tttctcaatt tcctcggaac tgattaaaaa
     4621 gaactacaac atcgtcaata gcttacatta ttccctgtgc aggatacagt tcaataagat
     4681 gcatgaaaca tgctgcacag aggacatagc tgtgtatgtg attgcgacgt ggttgggtac
     4741 ttcgttgaca ctatcctcag ctgaacccta aatatgaatt ccgttgtcat tgtggagagt
     4801 gttactgtag tgttctctag ggcttcaatg tctctgtgga cattgttgtg aaactcgtga
     4861 ctatgtctag ctgttgttag tctttttgag agactgttag gaacagtatg tacagtatat
     4921 acttgctaca tgagttactt atgacagttg catccgctaa tgctcaccgc gacgttgtca
     4981 cctgatcttt gctccatact tcctaggctt cttaaccttc caggggttac agcaacagtg
     5041 ttccacatcc tacacagtct ctgtccagtc ctgggggggg ggcataagca ttgcatattg
     5101 tgacaccttc tggcctttgt gccatactca aagaattgaa atcaaagctc tcaagtgaaa
     5161 ttttaaattt tagtccagaa aatgcagggc aagacacacg cagtgccttc agacaataag
     5221 cattccccga ctcctgtgtt ctgtatcggc cagtgtgggc aactccatcc catgctactg
     5281 ttgttgttgg aaaggaactt ttcagaggca gagacaatga gaactgaaat gctggaaact
     5341 gtgaaaggaa gaacaagttt atgtgaaggg gcttttcccc acaaatatca accccaaaac
     5401 tctgtcattg acaggagcac atgagggttt cgtggtcttt tgtggtttct agccaaacaa
     5461 gtcaggttga aaaagaaaaa tggtatgttt agaaatggat agaaaaccta acggttgcag
     5521 aagtaaaatt gtacaacagc atgccaaaag tactacatta ttcactctac ctagacaaac
     5581 tttcaaattc tgcagcattc aaattgtgta tgcaaattag gacaggcaca ctccagaatc
     5641 tgagacatct gacaagcgct taattaggcc aacagtcaag ggaattacac ctacagtcta
     5701 aagaacaaat gcatatatcc tatcatagcc ataaacaatt tgtatgaaat ggcttacctc
     5761 caatacaaaa gtctatgaca acctatggtt gaaggaatgc tcaatttcat ttgccaataa
     5821 attggtttct cataacttgc atcaagttta attttaagta aagcctttta tatgtaggta
     5881 ttctgttgaa tttgtaaata tacttaaaat gtagaagcta tatgcttata ggtgttacgt
     5941 gcaaataaat acacaagcga tgttgatgtt ctgccgtgtg agacgtaagc tcattgatga
     6001 atgcagagtg tgggtccagg aaacatgcaa atacctttca tggcattttg gtttttaggt
     6061 tcttttttct tttcttccac tctgcttttg gctgtgaaac tgaaatagtg aactttttct
     6121 acccacttct tcagcccata gctggctgaa atcctcagtg ttttgcctat ggagtacatt
     6181 aggatttgtc gcttgacatc tttgatgtgt acagagaaag cttgttttaa agtgatcccc
     6241 aaatgaagtg gccctaaata ctctcatgtc ttcatattta ctccccacaa accagcttat
     6301 ctattgaaaa tacaaaataa caaaacaggc ttgactcaac atcagaaagc acaaagacaa
     6361 aagttacttc aatttgttag tgtcttcaga gaaaaataaa tatgaagttt ctgctcttcc
     6421 ataactatgg atgctaaatt tctctgtgca tgaagaagtc acgcctgtag ataactacag
     6481 attttctatt aaaaatgaaa aattaagtgt gtttttaaag ctcttcctct tttgtactta
     6541 atcatgttcc tggtggagtg tggatgtgta gcaggggtag cagagtagga caatgcgact
     6601 ggactcccat ttgaaaagca acaggtaaac agcccagctc ttgtgagttc ttgcttcttc
     6661 aaacctgtac ttccaactgg tttttaagaa cttctgactt ttttgtttca tttttaaaag
     6721 acttaggact ttatcacaaa agtaaaaata aggttagggc tagttaagca ggaagagata
     6781 gcaccaatct tttgcaaaca ggtgaacaaa tctggttcta tgttgtgtct caaaaaagcc
     6841 tgattgcttg tgccctgccc atacagccag tgcagtcctc ctcagccaag gtcaatttgt
     6901 atctcttaca ctcatactta ttacaaatat gtcatctaca tcctttagtc caccttcatt
     6961 tcttctgtct ccaagctgta tagctgtgca aacatccaag cctagcagtt atccacattc
     7021 catcacctgc cccttagtca caggcccctt gtcccagcag tgcatccagg aaacttacct
     7081 gctttgcact ctcagagtta tctaggtatc atgctatgaa agtgaatcag agctgtcata
     7141 tatggctcag tgttcttccc agagaggaca tgttggctgc tctcttggac cctctcagac
     7201 cctctgttct ctgtcttcat tgtgggccag attagcaaac cttagcctcg ctctacatca
     7261 tggcctggct ctgtggcaac agggtctttg aaactacaag catgatctca agaaagattt
     7321 tgtagttata ggcctgcatc aaccatcttc ttcacagagt tttaatggct ttcgaggtga
     7381 ggggagtcta ggaactcaag agattttcac ccacagaatg aacactccca cttgagatgt
     7441 ttcaacggct aaccaccaga gggagcctgt gctttattct gggcagaaga aacatgctag
     7501 agaaagtggg ctaaggacac tggctgaatc ggtttggata attaaatgat gacctgatgg
     7561 tgcagaaaat gatcgcctgc tccaactagg gaaatgagat tgcagctctc cctagtgagt
     7621 tcatagctcc agagtggagt catgagtgtg tgagcctttt gcatagtttt ttctcttgac
     7681 tgggtcaagg tgagtcaggg gaagagttgc ccccagtcca ctggccatgt ttgtcatgtg
     7741 taggggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg gtgtgacaat aaggaaagtg
     7801 agtccttaaa atggcttcac atcctttcac atagacaaaa atgatactat ttttgtctgc
     7861 caccaatggt ttgatatttt attattaaat aaaacacaca aaaatagttt aaacactgcc
     7921 ctcagctcgt atgatgcatt gaggagacag gagagaaaag cagagaatat cactgtagta
     7981 tttgtactga atagtggctt agtgggatgg agcaatcagt cccacggaga agtaaggatt
     8041 cattgtccaa tcccaccagc agtgtggccc gcagagacac ctcctcttgc tattcactcc
     8101 acatctgttt cctcagtcag accatgatgg ggcagctagt gcctaatatg cctttctagt
     8161 ttaagctggt gcatcctagt aatgaaacaa agcaatctga gtacttgtta aagccaggaa
     8221 aaagcccaag caaaaccagg tgtgagtcct gctcccatgg agcctggaac ctagtgtttg
     8281 aagacaggtg taatcagatg acttcctgcg tggatgcaag tcctcactta ggtaagagct
     8341 cagaagggaa agaaagcata aagaaacggt agtggtagtg tcctcctgct aggtatggtg
     8401 gtcagggaag cagctccgag gaaggaaagg tactctgaaa ggagaaagtc aagaagaagc
     8461 catagaaaat caaggggcca aagctagcaa gcaaggccag catgcttgcc tagaggcaga
     8521 gaccaggcta tgccgtgttt gaggatcatg tgacaagcat ctgcatttag tcaagaagca
     8581 atgaaaatgg aggagtgagc aaagggtcaa ggaacttcta cgattaagag cacaagatta
     8641 agccgtgggg tccagaggaa attgccaaga agagaacatg agctagatgg cggaggatga
     8701 cagatgagcc agaaactctc agtgtagtgc ccaggagaag gagaagagcc gtctctagga
     8761 gaccagttac caggacctgg ttgtcactgg aaagcaggag gctgtgttga ggtagaagtg
     8821 agggaaagat cattgcacaa acaaaagtag gggtttctgc cttggtttgg atacctcccc
     8881 ctgacagatg ccacccatta gtcaccccta tctcgtcttt ccctgctatc tactgatttc
     8941 aaaagctcag gtgtctcaga gacaaacagg ctcttgcacg agtctccagt gcttcggtta
     9001 tcagccaccc tcaaagtttc atggttaaaa tggtttgcac taatagcagg agaaatatat
     9061 gaggataatt ggaaaagcca ccactgactg gatagtgcat cctttgttcc ttctatggct
     9121 gtaaaattcc ccagtctcgc tcagtgtgtt ctgtagaccg tgtcttcctt cagctctaag
     9181 tgtggggcgc attgttgcag caggtgactc aacaacaaaa cagaatccaa cagacgttat
     9241 cagctgctca ttgaaatcac ctaccagtat taaaaactca attcttgttc acccccgccc
     9301 acaaagtcat tcttttcatt atctgatctg tggcttgacc atcattaggg aaaaaaatca
     9361 cagatgattc tagtgtgtag ccaaagtgga aattggtatt gacaagatta tcccgtgcta
     9421 ctgtgcaaac agtcagggag cagtatttta aataggttcc tcaacagagc ccaagggtgg
     9481 acttcaaatt cacttctatt ccccacataa aatgaatcta gagagaacag acccccctca
     9541 tacattgctg atgggaatat aaaatggttc ggccactttg gagaagagtt tagcaatttt
     9601 ttaaaaacat tgaatataaa tttactatgt gatcacagtt caactcataa gtctagactc
     9661 aagagagaga aatgaaaacc tacatctagc cacaggcttg cacatacatg ttcagaatgt
     9721 gtcaaccata gcgtctagaa aacaacccca gtggctgtgg gcagacaagc agctgaacaa
     9781 aatgagtata tcatgtgtac agatgctaaa gctgtgaagt cagatggaat actgcttggc
     9841 aggtcatgta acggattgac gcatacaaca gtgtgagaaa ctccaaaaat atcaaaacgt
     9901 aaaagtcaag cacaaagccc gatattctaa tttacttaaa atgtccaaaa aaaaaaaaag
     9961 acaaacctgt gaaagcctga ggtagattgg tgtctccagc tgaaggaggt ggaggcaaag
    10021 attaacttca aattggtgtg aggtctcttc ttggagtatg aaaaaattct gaagttttat
    10081 agttaaaaca agtgaacgat ggtatcaagt gattcttcag taaagcttgt atgcatctga
    10141 agagtgaata gagttatgta taatgaggat gggatgagtg catccccaca ccatggacct
    10201 atttcctgtt tcctcaagga tgctgcaagg tcatcaactc cagatgttcc cacagaacag
    10261 tagcatcaca ttccttgact gctccaattg gaatagaaat aactattgga atagctttga
    10321 tagtaaagga agaaaccaga tactcttcat aagagaaaac aacaacaaac ttcaaaaagt
    10381 tcaaatgccc atcatagctt agtggctata caaattgtaa aatgaatacc actttcagac
    10441 caggagtcaa cagtaagcac aaaccctggg tacaagtgtc atgtgcctct gagtgaaagg
    10501 agccagacac agaggttttg ttactgtgaa acattggggc aggtggaact accatacaag
    10561 gacagggagc cgatgtggga ctgtggggaa gtgaagtttg caaagggatt tgcggctgag
    10621 atgcattgag aacttctaca gatgatggga ggagtccatg tgtcaattgt gaggatagct
    10681 agagggttat ttgttcatca ggacccaaat ctatatgctt aaagtaagtg tgcattgtta
    10741 tatatgttgt atctcaataa agttggtttt gaaaggaaaa taaactggac aaaagtga
//
