LOCUS       NM_022186               1812 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus nuclear receptor binding factor 2 (Nrbf2), mRNA.
ACCESSION   NM_022186
VERSION     NM_022186.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Cao,Y., Wang,Y., Abi Saab,W.F., Yang,F., Pessin,J.E. and
            Backer,J.M.
  TITLE     NRBF2 regulates macroautophagy as a component of Vps34 Complex I
  JOURNAL   Biochem J 461 (2), 315-322 (2014)
   PUBMED   24785657
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Lu,J., He,L., Behrends,C., Araki,M., Araki,K., Jun Wang,Q.,
            Catanzaro,J.M., Friedman,S.L., Zong,W.X., Fiel,M.I., Li,M. and
            Yue,Z.
  TITLE     NRBF2 regulates autophagy and prevents liver injury by modulating
            Atg14L-linked phosphatidylinositol-3 kinase III activity
  JOURNAL   Nat Commun 5, 3920 (2014)
   PUBMED   24849286
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Yasumo,H., Masuda,N., Furusawa,T., Tsukamoto,T., Sadano,H. and
            Osumi,T.
  TITLE     Nuclear receptor binding factor-2 (NRBF-2), a possible gene
            activator protein interacting with nuclear hormone receptors
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 189-197 (2000)
   PUBMED   10786636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 3, 2022 this sequence version replaced NM_022186.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024930.1, SRR26360172.2818225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000020.1  21307400-21307598
            200-284             JAXUCZ010000020.1  21317223-21317307
            285-325             JAXUCZ010000020.1  21322313-21322353
            326-1812            JAXUCZ010000020.1  21324238-21325724
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..1812
                     /gene="Nrbf2"
                     /note="nuclear receptor binding factor 2"
                     /db_xref="GeneID:58839"
                     /db_xref="RGD:61937"
     exon            1..199
                     /gene="Nrbf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1033
                     /gene="Nrbf2"
                     /note="NRBF-2"
                     /codon_start=1
                     /product="nuclear receptor-binding factor 2"
                     /protein_id="NP_071522.2"
                     /db_xref="GeneID:58839"
                     /db_xref="RGD:61937"
                     /translation="MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKATAYLSEA
                     MKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTDRDGVPHLQASH
                     RPSEDSEGQSPLLSQTYIPSTEKRLPEVQGVFDRDPDTLLFLLQQKNEPSEPCIGSKA
                     PKDDKTIIEEQATKIAELKRHVEFLVAENERLRKENKQLKAEKARLLKGPAEKELDVD
                     ADFVEKSELWGLPPHSDTATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMEL
                     SEDILKGFMND"
     exon            200..284
                     /gene="Nrbf2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..325
                     /gene="Nrbf2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..1812
                     /gene="Nrbf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgacgtcg gaggcggaag tggcgcggcc gtcgctcctg ggctctcact gccggctccg
       61 ggttctgctt ggagcctcct gccagccgcc gcgtctccct gccctcgctg cccctccatg
      121 tgcccaggtg ccgccgctcc gcctcgggcc gccgctcacc ccggggtcta tggaagtgat
      181 ggaaggaccc ctcaaccttg ctcaccaaca gagccgacgg gcagaccgtt tgttagctgc
      241 tgggaaatac gaagaagcga tttcttgtca caaaaaggcg acagcctatc tctctgaagc
      301 catgaagctg acacagtctg aacaggctca cttatcactg gaactgcaaa gggatagcca
      361 catgaagcag cttctcctca tccaggagag gtggaagaga gcgaagcgag aggagcggtt
      421 gaaagcgcag cagagcacag accgggatgg agtcccccac ctgcaggcat ctcacagacc
      481 ctctgaggac tcggaaggcc agagccctct tctttctcag acatacatcc cttccacaga
      541 gaagcgcctc cctgaggtgc agggggtctt tgacagggat ccagacacgt tgctattttt
      601 acttcagcaa aagaatgagc cgtcagagcc ctgtattgga agcaaggccc caaaagatga
      661 taagacgatt atagaggagc aggcaaccaa gattgcagag ttgaagaggc acgtggagtt
      721 ccttgtggcg gagaacgaaa gactaaggaa agaaaataaa cagctaaagg ctgaaaaggc
      781 caggctcctg aagggcccag ccgagaagga gctggatgtc gatgcggact ttgtggagaa
      841 gtcggagctg tggggcttgc cgccacactc ggacaccgcc actgcctctt ctacctggca
      901 gaagtttgca gctaacacgg ggaaagccaa ggacattcca atacccaacc tcccgcctct
      961 ggatttcccg tctccagaac tccctctgat ggagctctcg gaggacattc tgaaaggatt
     1021 catgaatgac tgaatggaag gctggccaca cagctgatcc agcagagaat acaaagggaa
     1081 agccaggccc cgggggaggc cagccatgct ggagatgctc cttcctctgg agtgctgtgg
     1141 gagaggtggc ggtgccagga cctgggaaag tcactgtgaa acatcactta tcttcttcac
     1201 gactaaagct catgattccg acttggcaga cactgaactc ttggaggtcg ctttcttatg
     1261 atacaaacca aatggctacc tggaataatt tttcaaacac ttatttttct tatcttcagg
     1321 gttaaatgta taaaagtatg tcatgtgtaa ttaatctata atgccataaa tgataatgca
     1381 aaagctaact atggtggcct gagaggctca cttgtatttg gaacatgctt tctatcatgc
     1441 gttgactgta tgcatttcat gcacattttg tttgtttgag atatggtgtg taagatacac
     1501 gcttccagac ggaactgtac gtgccacagt ttgcactact cgtaacataa tgataacctc
     1561 aagactatca ggagaaatat ttaaatttcc agtttatgaa gaaaggaacc aaattattag
     1621 ttacgctttt aaaaaaaatt accagtttac ataattaatc agggtgcatt ttcagttcta
     1681 actttgtgtt atatatgcat catttgaaaa tactgaggaa ctcttccttc gttctgaatg
     1741 atgcatgtgt gaaagtaatg ctagttagca gtatttgatt gtaagaaatc aataaaataa
     1801 ttgtgtttca ta
//
