LOCUS       NM_080766               1326 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NRAS proto-oncogene, GTPase (Nras), mRNA.
ACCESSION   NM_080766 XM_346631
VERSION     NM_080766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Nakagawa,R., Muroyama,R., Saeki,C., Oikawa,T., Kaise,Y., Koike,K.,
            Arai,J., Nakano,M., Matsubara,Y., Takano,K., Hirata,Y., Saruta,M.,
            Zeniya,M. and Kato,N.
  TITLE     CD4+ T cells from patients with primary biliary cholangitis show T
            cell activation and differentially expressed T-cell receptor
            repertoires
  JOURNAL   Hepatol Res 49 (6), 653-662 (2019)
   PUBMED   30690835
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Dietrich,P., Gaza,A., Wormser,L., Fritz,V., Hellerbrand,C. and
            Bosserhoff,A.K.
  TITLE     Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Is a Novel
            Prognostic Marker and Contributes to Sorafenib Resistance in
            Hepatocellular Carcinoma
  JOURNAL   Neoplasia 21 (3), 257-268 (2019)
   PUBMED   30685691
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Yin,C., Zhu,B., Zhang,T., Liu,T., Chen,S., Liu,Y., Li,X., Miao,X.,
            Li,S., Mi,X., Zhang,J., Li,L., Wei,G., Xu,Z.X., Gao,X., Huang,C.,
            Wei,Z., Goding,C.R., Wang,P., Deng,X. and Cui,R.
  TITLE     Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven
            Melanomagenesis
  JOURNAL   Cell 176 (5), 1113-1127 (2019)
   PUBMED   30712867
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Adler,N.R., Wolfe,R., Kelly,J.W., Haydon,A., McArthur,G.A.,
            McLean,C.A. and Mar,V.J.
  TITLE     Tumour mutation status and sites of metastasis in patients with
            cutaneous melanoma
  JOURNAL   Br J Cancer 117 (7), 1026-1035 (2017)
   PUBMED   28787433
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Fujiyoshi,K., Yamamoto,G., Takenoya,T., Takahashi,A., Arai,Y.,
            Yamada,M., Kakuta,M., Yamaguchi,K., Akagi,Y., Nishimura,Y.,
            Sakamoto,H. and Akagi,K.
  TITLE     Metastatic Pattern of Stage IV Colorectal Cancer with
            High-Frequency Microsatellite Instability as a Prognostic Factor
  JOURNAL   Anticancer Res 37 (1), 239-247 (2017)
   PUBMED   28011498
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Masui,T., Mann,A.M., Borgeson,C.D., Garland,E.M., Okamura,T.,
            Fujii,H., Pelling,J.C. and Cohen,S.M.
  TITLE     Sequencing analysis of Ha-, Ki-, and N-ras genes in rat urinary
            bladder tumors induced by
            N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium
            saccharin
  JOURNAL   Teratog Carcinog Mutagen 13 (5), 225-233 (1993)
   PUBMED   7905676
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Fujimoto,Y., Ishizaka,Y., Tahira,T., Sone,H., Takahashi,H.,
            Enomoto,K., Mori,M., Sugimura,T. and Nagao,M.
  TITLE     Possible involvement of c-myc but not ras genes in hepatocellular
            carcinomas developing after spontaneous hepatitis in LEC rats
  JOURNAL   Mol Carcinog 4 (4), 269-274 (1991)
   PUBMED   1714740
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   McMahon,G., Davis,E.F., Huber,L.J., Kim,Y. and Wogan,G.N.
  TITLE     Characterization of c-Ki-ras and N-ras oncogenes in aflatoxin
            B1-induced rat liver tumors
  JOURNAL   Proc Natl Acad Sci U S A 87 (3), 1104-1108 (1990)
   PUBMED   2105496
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Hu,L.F., Wang,L.P., Ju,L.W., Huang,L.H., Li,X.L., Li,X.Z. and
            Gu,J.R.
  TITLE     Expression of N-ras gene in human primary hepatocarcinoma
  JOURNAL   Sci Sin B 29 (2), 181-186 (1986)
   PUBMED   3018923
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098659.1.
            
            On Aug 12, 2007 this sequence version replaced NM_080766.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098659.1, SRR8487231.30993.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1326
                     /gene="Nras"
                     /note="NRAS proto-oncogene, GTPase"
                     /db_xref="GeneID:24605"
                     /db_xref="RGD:3205"
     exon            1..85
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     exon            86..213
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..672
                     /gene="Nras"
                     /EC_number="3.6.5.2"
                     /note="transforming protein N-Ras; neuroblastoma ras
                     oncogene; neuroblastoma RAS viral (v-ras) oncogene
                     homolog; neuroblastoma RAS viral oncogene homolog"
                     /codon_start=1
                     /product="GTPase NRas"
                     /protein_id="NP_542944.1"
                     /db_xref="GeneID:24605"
                     /db_xref="RGD:3205"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKR
                     VKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLV
                     REIRQYRMKKLNSSEDGTQGCMGLPCVVM"
     exon            214..392
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     exon            393..552
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     exon            553..676
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     exon            677..718
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1304
                     /gene="Nras"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgttcatg gcggtttcgg ggtctccaac agcttctcag gttgaaatcc aaaagcctcc
       61 cgaggcgggg tctgcggagt ttgagatttt tgcaggtgtg aaatgactga gtacaaactg
      121 gtggtggttg gagcaggtgg cgttgggaaa agtgctttga caatccagct aatccagaac
      181 cactttgtgg atgaatatga tcccaccata gaggattctt accgaaaaca agtggtgatt
      241 gacggtgaga cctgtctact ggacatactg gacacagctg gacaagagga gtacagtgcc
      301 atgagagacc aatacatgag gacaggcgaa gggttcctct gtgtgtttgc catcaataat
      361 agcaaatcct ttgcagatat taacctctac agggagcaaa ttaagcgcgt gaaagactct
      421 gatgatgtac ccatggtgct ggtagggaac aagtgtgact tgccaacaag gacagttgac
      481 acaaagcaag cccacgagct ggccaagagt tatggaattc cattcattga aacctcagcc
      541 aagacccgac agggtgtgga ggatgccttt tacacgcttg taagggagat acgccagtac
      601 cggatgaaga agctcaacag cagtgaggat ggcactcaag gctgtatggg gctgccctgt
      661 gtggtgatgt agtaagaccc tttaaaagtt ctgtcatcag aaacgagcca ctttcaagcc
      721 tcactgatgc cctggttctg acatccctgg aggagacgtg tttctgctgc tctctgcatc
      781 tcagagaagc tcctgcttcc tgcttcccca acttagttac tgagcacagc catctaacct
      841 gagacctctt cagaataact acctcctcac tcggctgtcc gaccagagaa atgaacctgt
      901 ttctccccag tagttctctg ccctgggttt cccctagaaa caaacacacc tgccagctgg
      961 ctttgtcctc cgaaaagcag tttacattga tgcagagaac caaactatag acaagcaatt
     1021 ctgttgtcaa cagtttctta agctctaagg taacaattgc tggtgatttc cccctttgcc
     1081 cccaactgtt gaacttggcc ttgttagttt tgggggaaat gtcaaaaatt aatctcttcc
     1141 cgagaataga attagtgttg ctgattgcct gatttgcaat gtgatcagct atattctata
     1201 agctggcgtc tgctctgtat tcataaatgc aaacatgagt actgacgtaa gtgcatccct
     1261 agtcttctca gctgcatgca attaaatcca acgttcacaa caaaaaaaaa aaaaaaaaaa
     1321 aaaaaa
//
