LOCUS       NM_001143750            2555 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Notch-regulated ankyrin repeat protein (Nrarp),
            mRNA.
ACCESSION   NM_001143750 XM_001077307 XM_006227200 XM_575080
VERSION     NM_001143750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Zhu,P., Wang,Y., Du,Y., He,L., Huang,G., Zhang,G., Yan,X. and
            Fan,Z.
  TITLE     C8orf4 negatively regulates self-renewal of liver cancer stem cells
            via suppression of NOTCH2 signalling
  JOURNAL   Nat Commun 6, 7122 (2015)
   PUBMED   25985737
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Zhang,C., Hou,D. and Feng,X.
  TITLE     Mir-181b Functions as Anti-Apoptotic Gene in Post-Status
            Epilepticus via Modulation of Nrarp and Notch Signaling Pathway
  JOURNAL   Ann Clin Lab Sci 45 (5), 550-555 (2015)
   PUBMED   26586707
  REMARK    GeneRIF: MiR-181b negatively regulated Nrarp as an anti-apoptotic
            gene via Notch signaling pathway in hippocampus.
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Krebs,L.T., Bradley,C.K., Norton,C.R., Xu,J., Oram,K.F.,
            Starling,C., Deftos,M.L., Bevan,M.J. and Gridley,T.
  TITLE     The Notch-regulated ankyrin repeat protein is required for proper
            anterior-posterior somite patterning in mice
  JOURNAL   Genesis 50 (4), 366-374 (2012)
   PUBMED   21998026
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Kim,W., Matsui,T., Yamao,M., Ishibashi,M., Tamada,K., Takumi,T.,
            Kohno,K., Oba,S., Ishii,S., Sakumura,Y. and Bessho,Y.
  TITLE     The period of the somite segmentation clock is sensitive to Notch
            activity
  JOURNAL   Mol Biol Cell 22 (18), 3541-3549 (2011)
   PUBMED   21795391
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Phng,L.K., Potente,M., Leslie,J.D., Babbage,J., Nyqvist,D.,
            Lobov,I., Ondr,J.K., Rao,S., Lang,R.A., Thurston,G. and Gerhardt,H.
  TITLE     Nrarp coordinates endothelial Notch and Wnt signaling to control
            vessel density in angiogenesis
  JOURNAL   Dev Cell 16 (1), 70-82 (2009)
   PUBMED   19154719
REFERENCE   6  (bases 1 to 2555)
  AUTHORS   Yun,T.J. and Bevan,M.J.
  TITLE     Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling:
            multiple Notch1 signaling pathways involved in T cell development
  JOURNAL   J Immunol 170 (12), 5834-5841 (2003)
   PUBMED   12794108
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Apr 11, 2014 this sequence version replaced
            XM_006227200.1, XM_001077307.1, XM_575080.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: CO384857.1, SRR26643297.10308.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2555              JAXUCZ010000003.1  28390745-28393299
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2555
                     /gene="Nrarp"
                     /note="Notch-regulated ankyrin repeat protein"
                     /db_xref="GeneID:499745"
                     /db_xref="RGD:1591939"
     exon            1..2555
                     /gene="Nrarp"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..698
                     /gene="Nrarp"
                     /note="Maternal Effect Lethal family member (mel-11)-like"
                     /codon_start=1
                     /product="notch-regulated ankyrin repeat-containing
                     protein"
                     /protein_id="NP_001137222.1"
                     /db_xref="GeneID:499745"
                     /db_xref="RGD:1591939"
                     /translation="MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNV
                     NSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLY
                     LITKAKYAASGR"
ORIGIN      
        1 aactgttttg caaagggacg cgggtggagt tccgctggag cgaagcctaa cctcgaaggg
       61 accacgactg cgagtgtcgc ggcctcccgg ctactccagg tcctgcgaac cagcactcag
      121 ccctgtcgcc cgcccgcttg ggcgcggctg gatgcagcag gggtcccgcg cctgcggccc
      181 tcggccccca gcgcccggag tgcgcagagg cggcgtgcgg ggcccgaggg cgcagcgccc
      241 tccatgcgcc gaggcgtacc tcgagacacg ccccgagaca gcccggggcc cgcattgcag
      301 ccgccgcccg cgctgagccg gggcgcggcc cggggcccta gctctgcggc agcatgagcc
      361 aagccgagct gtccacctgc tcggcgccac agacgcagcg catcttccag gaagcggtgc
      421 gcaagggcaa cacacaggag cttcagtcgc tgctgcagaa catgactaac tgcgaattca
      481 acgtgaactc gttcgggccg gagggccaga cagcactaca ccagtcagtc atcgacggca
      541 acctggagct ggtgaagctg ctagtcaaat tcggcgcaga catccgccta gccaaccgcg
      601 acggctggag cgcactgcac atcgccgctt tcgggggcca ccaggacatc gtgctctatc
      661 tcatcaccaa ggccaagtac gcggccagcg gccggtgata gccaccccga ccccggaccc
      721 tggcctcacc tgcgtcgtct ctgctgtacc ttcccgccaa ctacctcggt gtgcgccagg
      781 tttgctggtc cgcgtggaaa tcgggctagg tctctatgtc cacggccacg accaaagtag
      841 cgcgtccgtg gcccccttag ttcgagcctc cgcaatagag cgcctcccct gggcagtctt
      901 ctgagccccg cagggcccca gagccttccc acggcccccg accgcctaga gggtgggggc
      961 ggggcgcagg ctccagtcca ttttgaaatt tgagtctcac accgggagac ttcggaatcc
     1021 cgagataccg gatcctccgc ttgaaatgtt ttctccggaa ggtgaaagac gcgggcggac
     1081 tcgcgctccc gccgccgccc gtgagacccg cccgcccgca ctgtggctcc cacaactggc
     1141 ggccgccaag cagccactac cgggctccac catctgcgcg ccctctcacg agggaagggg
     1201 acgctccggg ttcctgatgt cctcaactat ttatcacgtg tgtgtatatt tgtgggtgaa
     1261 gtttgtgcgc ctgagttttt tgtttggaaa tattgtgcgt ggttatggga gaaagatgca
     1321 tttttttttc cttaaaacta aaaacttgag tctaccattt cttggttgca ctgaaaatac
     1381 cgcctagtcc tatggttttc ccattgctag cccctccccc accaagtccc taatcttcca
     1441 cacctcattc ctctgttatt ctccctggat tctgagttca gggagcccag aatctatctc
     1501 cctttccctt cccgtgagag gccaccattc tccacaccag ctggtttagc aaagttccaa
     1561 agggaccttg aagcccgcgt ggctgggacg tggggattct gagagcatgt tacccttcct
     1621 agtgacttct attatagtta atagtcggtt gcacactttt ttaaaaaagt aaatgaattt
     1681 gccacaagta aatgtcataa catttatgac agaatataaa atattaacat attttaagcc
     1741 aagttttagg tgtatttttt gaatcttggt tatgaaccca attttaaagg gcgttgtatc
     1801 cagcgttgtg aaggctgttg tgtacccata tttatatttt tataaaattc ctataaagac
     1861 tgtgaatctc tcatggtatt gctgaatgag tggaagggct gccgtgacct ttctgccttc
     1921 cccagccccc tccccaccct caagcctatt atgatcagag gatcctgcca tgagggaggg
     1981 gctgtgccaa ggaccagggc tggaggaggt gtggagtgtc acttgctgtc tctggaagga
     2041 gacttcctgg tttctgtgat tccaatttcc tatgcaaccc cacacccctt tttgttttga
     2101 ttctggggaa taaaagggag gctgaattat tcaaatttaa atgaggtttc cccttcgtag
     2161 aagtgctgct gaccctgcgt acaaaaatgg ggagcacttg aggacacagg tgggtggggc
     2221 cctttgtgct gcctggtcct tctctttggt cttctacact tttatgaacc agtgtgggag
     2281 gaacagtgat aatgtgaaag tggcaaacat tgagacaagc acagattact tcagaaggag
     2341 ttctctatgg tttttcttca tgcaaatgcc tttttaatta tgttaattaa tgttaagact
     2401 tcctagacct atgttgaagc ttcagatggg tcttggtctg gtctcttcta tctgtatgaa
     2461 gtctggcaca ctcctgagcg tatgatatag acttgtagcc catcgtgaaa aatttataaa
     2521 taaatttttc attgctcttt ttatattaaa aaaaa
//
