LOCUS       NM_139259                871 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus neurotrophin receptor associated death domain
            (Nradd), mRNA.
ACCESSION   NM_139259
VERSION     NM_139259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Gowrishankar,K., Zeidler,M.G. and Vincenz,C.
  TITLE     Release of a membrane-bound death domain by gamma-secretase
            processing of the p75NTR homolog NRADD
  JOURNAL   J Cell Sci 117 (Pt 18), 4099-4111 (2004)
   PUBMED   15280425
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Wang,X., Shao,Z., Zetoune,F.S., Zeidler,M.G., Gowrishankar,K. and
            Vincenz,C.
  TITLE     NRADD, a novel membrane protein with a death domain involved in
            mediating apoptosis in response to ER stress
  JOURNAL   Cell Death Differ 10 (5), 580-591 (2003)
   PUBMED   12728256
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Frankowski,H., Castro-Obregon,S., del Rio,G., Rao,R.V. and
            Bredesen,D.E.
  TITLE     PLAIDD, a type II death domain protein that interacts with p75
            neurotrophin receptor
  JOURNAL   Neuromolecular Med 1 (3), 153-170 (2002)
   PUBMED   12095158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF497263.1.
            
            On Aug 31, 2012 this sequence version replaced NM_139259.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF497263.1, SRR8487230.65671.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               AF497263.1         5-875
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="neurotrophin receptor associated death domain"
                     /db_xref="GeneID:246143"
                     /db_xref="RGD:708524"
     exon            1..89
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            90..221
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /note="p75-like apoptosis-inducing death domain protein
                     PLAIDD; neurotrophin receptor homolog-2; neurotrophin
                     receptor-alike death domain protein"
                     /codon_start=1
                     /product="death domain-containing membrane protein NRADD"
                     /protein_id="NP_640352.1"
                     /db_xref="GeneID:246143"
                     /db_xref="RGD:708524"
                     /translation="MLHNVSKGVVYSDTALKGQDGDREGMWVGAGGALAPNTSSLFPP
                     EPPGASSNIIPVYCALLATVVLGLLAYVAFKCWRSRKQRQQLAKARTVELGDPDRDQR
                     HGDSSVFVDSPHGLEPCIPSQGPHADLGCRLYLHIPQQQQEEVQRLLILGEPAKGWRG
                     LAGQLGYQAEAVETMACDQDPAYALLRDWAAQEGSGATLRVLEDALTAIGREDVVQVL
                     SSPAEGCSVV"
     exon            222..411
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            412..554
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            555..871
                     /gene="Nradd"
                     /gene_synonym="NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagaccg gaacctgccc tctccaggga ctcccgtcgc cttcctagct gagtggatcc
       61 tagcacccct ggaggggtgg ccgcagaaga gttccttctg gactcagaga agcaggatcc
      121 aggctccatc agctcagttc ccctccacca agaaacagcc cagcgagcag tacctggtgg
      181 cgccatgctt cataacgtca gcaaaggtgt ggtgtattca gatacagccc tgaaggggca
      241 ggatggggac agggaaggaa tgtgggtagg agctggggga gccctagccc ccaatacctc
      301 ctccctattt ccccctgagc ctccaggggc ctcaagcaac atcattcctg tctactgtgc
      361 tctcctagct actgtagtcc ttggtctgct tgcctatgtg gccttcaaat gctggcgctc
      421 acgtaagcaa agacaacagt tggctaaagc gcggactgta gagctggggg accctgaccg
      481 ggaccaaagg catggtgaca gcagtgtctt cgtggattct cctcatggtc tggagccctg
      541 tattcccagc cagggaccac atgcagacct tggctgccga ctttacctgc atattccaca
      601 gcagcagcag gaggaagtcc agaggctctt gatattgggg gaacctgcca agggctggcg
      661 ggggctggca ggccaactgg gctaccaagc tgaagctgtg gaaaccatgg cctgtgacca
      721 ggacccagcc tatgccctgc taagggactg ggctgctcaa gaaggcagtg gagcaaccct
      781 cagagtgcta gaggatgctc tgactgccat aggccgagaa gatgtggtcc aggttttgag
      841 ctcaccagct gagggctgct ctgtggtgtg a
//
