LOCUS       NM_021742               1931 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus nuclear receptor subfamily 5, group A, member 2
            (Nr5a2), mRNA.
ACCESSION   NM_021742
VERSION     NM_021742.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Ma,B., Qiao,H., Guo,Y., Wei,J., Yang,Q., Feng,X. and Li,Z.
  TITLE     TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and
            LRH-1-dependent CYP19 expression in rat Leydig cellsdagger
  JOURNAL   Biol Reprod 108 (5), 778-790 (2023)
   PUBMED   36857632
  REMARK    GeneRIF: TGF-beta1 induced activations of Smad2 and miRNAs inhibit
            SF-1- and LRH-1-dependent CYP19 expression in rat Leydig
            cellsdagger.
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Zhang,T., Yu,F., Guo,L., Chen,M., Yuan,X. and Wu,B.
  TITLE     Small Heterodimer Partner Regulates Circadian Cytochromes p450 and
            Drug-Induced Hepatotoxicity
  JOURNAL   Theranostics 8 (19), 5246-5258 (2018)
   PUBMED   30555544
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Schwaderer,J., Gaiser,A.K., Phan,T.S., Delgado,M.E. and Brunner,T.
  TITLE     Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand
            transcription and associated T-cell effector functions
  JOURNAL   Cell Death Dis 8 (4), e2745 (2017)
   PUBMED   28406481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Lai,W.A., Yeh,Y.T., Fang,W.L., Wu,L.S., Harada,N., Wang,P.H.,
            Ke,F.C., Lee,W.L. and Hwang,J.J.
  TITLE     Calcineurin and CRTC2 mediate FSH and TGFbeta1 upregulation of
            Cyp19a1 and Nr5a in ovary granulosa cells
  JOURNAL   J Mol Endocrinol 53 (2), 259-270 (2014)
   PUBMED   25057110
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Hale,M.A., Swift,G.H., Hoang,C.Q., Deering,T.G., Masui,T.,
            Lee,Y.K., Xue,J. and MacDonald,R.J.
  TITLE     The nuclear hormone receptor family member NR5A2 controls aspects
            of multipotent progenitor cell formation and acinar differentiation
            during pancreatic organogenesis
  JOURNAL   Development 141 (16), 3123-3133 (2014)
   PUBMED   25063451
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Pezzi,V., Sirianni,R., Chimento,A., Maggiolini,M., Bourguiba,S.,
            Delalande,C., Carreau,S., Ando,S., Simpson,E.R. and Clyne,C.D.
  TITLE     Differential expression of steroidogenic factor-1/adrenal 4 binding
            protein and liver receptor homolog-1 (LRH-1)/fetoprotein
            transcription factor in the rat testis: LRH-1 as a potential
            regulator of testicular aromatase expression
  JOURNAL   Endocrinology 145 (5), 2186-2196 (2004)
   PUBMED   14736734
  REMARK    GeneRIF: evidence provided that LRH-1 plays an important role in
            the regulation of aromatase expression in Leydig cells
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Falender,A.E., Lanz,R., Malenfant,D., Belanger,L. and Richards,J.S.
  TITLE     Differential expression of steroidogenic factor-1 and FTF/LRH-1 in
            the rodent ovary
  JOURNAL   Endocrinology 144 (8), 3598-3610 (2003)
   PUBMED   12865342
  REMARK    GeneRIF: data indicate that granulosa cells of small and
            preovulatory follicles express both SF-1 and FTF/LRH-1 and that
            each orphan receptor may regulate target gene expression in these
            cells
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Liu,D.L., Liu,W.Z., Li,Q.L., Wang,H.M., Qian,D., Treuter,E. and
            Zhu,C.
  TITLE     Expression and functional analysis of liver receptor homologue 1 as
            a potential steroidogenic factor in rat ovary
  JOURNAL   Biol Reprod 69 (2), 508-517 (2003)
   PUBMED   12672674
  REMARK    GeneRIF: Liver receptor homologue 1 (LRH-1) is a member of the
            nuclear receptor superfamily originally found in liver cells. LRH-1
            participates in regulation of cholesterol metabolism and bile acid
            synthesis. Recent studies have shown that LRH-1 is even more highl
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Chen,F., Ma,L., Dawson,P.A., Sinal,C.J., Sehayek,E., Gonzalez,F.J.,
            Breslow,J., Ananthanarayanan,M. and Shneider,B.L.
  TITLE     Liver receptor homologue-1 mediates species- and cell line-specific
            bile acid-dependent negative feedback regulation of the apical
            sodium-dependent bile acid transporter
  JOURNAL   J Biol Chem 278 (22), 19909-19916 (2003)
   PUBMED   12456679
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Galarneau,L., Pare,J.F., Allard,D., Hamel,D., Levesque,L.,
            Tugwood,J.D., Green,S. and Belanger,L.
  TITLE     The alpha1-fetoprotein locus is activated by a nuclear receptor of
            the Drosophila FTZ-F1 family
  JOURNAL   Mol Cell Biol 16 (7), 3853-3865 (1996)
   PUBMED   8668203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB012960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB012960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1931
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /note="nuclear receptor subfamily 5, group A, member 2"
                     /db_xref="GeneID:60349"
                     /db_xref="RGD:68353"
     exon            1..154
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1773
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /note="liver receptor homolog 1; FTZ-F1 beta2 protein;
                     fetoprotein transcription factor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 5 group A member 2"
                     /protein_id="NP_068510.1"
                     /db_xref="GeneID:60349"
                     /db_xref="RGD:68353"
                     /translation="MSASSITGDFQDFLKHGLPAIAPAPGSETPHSPKLEEKHREKRA
                     GLPDRHRRPIPARSRLVMLPKVETEASGLVRSHGEQGQMPENMQVSQFKMVNYSYDED
                     LEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCP
                     YCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMS
                     QVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHGSLHG
                     YQPYGHFPNRAIKSEYPDPYSSSPESMMGYSYMDGYQTSSPASIPHLILELLKCEPDE
                     PQVQAKIMAYLQQEQNNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDD
                     QMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSSIISNTEVAFNNLLSLA
                     QELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENFQLVEGVQEQVNAALLDYTLCNY
                     PQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA"
     exon            155..217
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..355
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..474
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..616
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1257
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1377
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1525
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1931
                     /gene="Nr5a2"
                     /gene_synonym="Ftf; Lrh-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaggtcac aaaatatgac aggctgcaac cttccccacg ttcaatgatt tctgcagtaa
       61 gccaaaggac tgccaataat ttcgctaaga atgtctgcta gttcgattac tggggatttt
      121 caagactttc ttaagcatgg acttccagct attgcacctg caccaggatc agagactcca
      181 cactccccca aacttgagga aaaacaccgg gaaaaacgtg ctgggcttcc ggaccgacac
      241 cgacggccca ttcccgcccg cagccgcctt gtcatgctgc ccaaagtgga gacggaagcc
      301 tcaggactgg tccgatcgca tggggaacag gggcagatgc cggaaaacat gcaagtgtct
      361 caatttaaaa tggtgaatta ctcctatgat gaagatctgg aagagctgtg tcctgtgtgt
      421 ggcgataaag tatctgggta tcattacggt ctcctcacct gtgaaagctg caagggtttc
      481 tttaagcgaa cagtccaaaa ccagaaaagg tacacgtgca tagagaacca gaactgccaa
      541 attgacaaga cacagagaaa acgatgtcct tactgtcggt tcaaaaaatg tatcgacgtt
      601 ggaatgaagc tggaggccgt gagagctgac cgcatgcgag gaggcagaaa taagttcggg
      661 ccaatgtaca agagagacag ggccttgaaa cagcagaaga aagccctcat tcgagccaat
      721 ggacttaagc tggaagccat gtctcaggtg atccaagcga tgccctcaga cctgacctct
      781 gcaattcaga acattcattc tgcctccaaa ggcctacctc tgagccatgt agccttgcct
      841 ccgacagact atgacagaag tccctttgtc acttctccca ttagcatgac aatgccacct
      901 catggcagtc tgcatggtta ccaaccatat ggtcactttc ctaatcgggc catcaagtct
      961 gagtacccag acccctactc cagctcgcca gagtcaatga tgggctactc ctacatggat
     1021 ggttaccaga caagctcccc ggcaagcatc cctcatctga tattggaact tttgaagtgt
     1081 gaacccgatg agcctcaagt tcaagcgaaa atcatggctt acctacagca agagcagaat
     1141 aaccggaaca ggcaggaaaa gctgagcgcg tttgggctct tgtgcaaaat ggcggaccag
     1201 accctgttct ccattgttga gtgggccagg agtagtatct tcttcaggga actgaaggtt
     1261 gatgaccaaa tgaagctgct tcagaactgc tggagtgagc tcttgatcct ggatcacatt
     1321 taccggcaag tagcacatgg gaaggaaggg acaatcttcc tggttaccgg agaacacgtg
     1381 gactactcca gcatcatctc aaacacagaa gtcgcattca acaacctcct gagcctcgcc
     1441 caggagctcg tggtgagact ccgttccctt cagtttgatc agcgggagtt tgtgtgtctg
     1501 aagttcctgg tgctgttcag ctcagatgtc aagaatcttg agaacttcca gctggtggaa
     1561 ggcgtccaag agcaggtcaa tgctgccctg ctggactaca cactttgcaa ctacccacaa
     1621 caaactgaga aatttggaca actgcttctt cgactaccag aaatccgggc aatcagcaaa
     1681 caggcagaag actacctgta ctacaagcac gtgaatgggg atgtgcccta caataacctt
     1741 ctcattgaaa tgctgcacgc caaaagagcc taagttccca cccctagacc cttgctctag
     1801 ggacagagac tggagggaga agaagaggag gaggaggaag gaagacaaac aatgctctga
     1861 actgctccaa gcaatgctaa ttacaaactt ggtttaaaga cactgaattt tgaaagcata
     1921 ataatgaata g
//
